DAta | National Center for Advancing Translational Sciences

ID	Title	Body
220	Clinical and Translational Science Institute of Southeast Wisconsin	Milwaukee, Wisconsin Principal Investigator Reza Shaker, M.D., Medical College of Wisconsin Website The Clinical and Translational Science Institute (CTSI) of Southeast Wisconsin is a consortium of eight partnering institutions, including four accredited academic institutions (Medical College of Wisconsin, Marquette University, Milwaukee School of Engineering, UW-Milwaukee), three healthcare systems (Children’s Hospital of Wisconsin, Froedtert Hospital, Zablocki VA Medical Center), the BloodCenter of Wisconsin plus one collaborating institution (Concordia University of Wisconsin). The CTSI works collaboratively across all partner institutions to advance the health of the community and the nation through research and discovery. The CTSI’s mission is to develop an integrated, shared home for clinical and translational research and research training, which is hallmarked by a borderless, collaborative, synergistic and robust research environment that is user friendly for investigators, patients and the community at large. Through the integration into regional and national Clinical Translational Science Award (CTSA) networks, CTSI actively works to achieve an over-arching goal of enhancing the transit of therapeutic, diagnostic and preventative interventions along the developmental pipeline. The CTSI is comprised of six components and 13 modules, working together in achieving three overall specific aims: To empower Wisconsin’s southeast CTSA hub to play a major role in the national clinical and translational research agenda by engaging with regional and national partners to: Share the core competencies and expanding the existing collaborative multi-institutional platform of the CTSA hub to engage with regional and national CTSA networks in the conduct of multisite studies. Solidify the necessary collaborative enterprise for the translation of new discoveries by strengthening the CTSA’s current institutional partnerships, expanding these associations by involving NIH, NSF and industry-funded centers of excellence and programs within the hub’s respective institutions, and forging additional collaborations with organizations throughout southeast Wisconsin whose contribution(s) compliment and support the hub’s translational mission. Enhance the overall capacity and efficiency of the hub’s clinical and translational research enterprise by collaboratively identifying and overcoming obstacles, inefficiencies and duplications through the implementation of viable solutions (i.e., Six Sigma/LEAN) supported by comprehensive tracking and evaluation techniques. To maximize the translational capabilities and impact of Wisconsin’s CTSA hub and its investigators by: Developing a diverse translational workforce that is well-trained in team science and translational/clinical research and capable of engaging the community in multiple aspects of their research through a multi-pronged approach (including KL2 and TL1 programs). Facilitating intellectual contribution(s) of the community in all aspects of translational research by engaging sectors of stakeholders in essential activities (i.e., framing community-inspired research questions, participating in advisory, advocacy and propagation boards, et al.). Catalyzing collaboration and facilitating multidisciplinary team science through innovative approaches (i.e., nucleating translational pilot projects, supporting team-building and concept development, et al.). Delivering efficient, timely services (i.e., biomedical-informatics, bio-statistics/research design and regulatory support in fostering high quality and safe translational research). To create a bi-lateral ‘health care enterprise/CTSA ecosystem’ which facilitates and broadens the reach of the hub’s translational research engine (into health systems and patient stakeholders) in order to generate/test hypotheses and implement best practices for: Completing and operationalizing the ‘Biomedical Informatics Connectome’ (BIC), thereby linking de-identified clinical data of partner health systems to an existing clinical data warehouse via a SHRINE connection to other CTSA hubs. This is a conduit for providing unprecedented connectivity (among translational/clinical and basic science investigators, stakeholders and the clinical/research infrastructure) able to be tracked by a central database. Integrating research into clinical practices of multiple hubs (i.e., adult, pediatric and veterans’ health systems) utilizing novel granting and support mechanisms. Providing opportunity for every patient to benefit from/contribute to advancing health through participation in translational research.
219	Mayo Clinic Center for Clinical and Translational Science	Rochester, Minnesota Principal Investigator Sundeep Khosla, M.D., Mayo Clinic Website The goal of the Mayo Clinic CTSA Program application is to present Mayo's vision for the integration and expansion of its innovative clinical and translational research activities, so that a highly functional academic home for clinical and translational research is developed at the Mayo Clinic. The Center for Clinical and Translational Science is founded on the Mayo Clinic's long-standing excellence in and commitment to clinical and translational research, which includes the support of key infrastructure and a commitment to career development. To achieve this goal, Mayo will take a comprehensive approach to the key elements of the CTSA Program Request for Applications and focus on enhancing: Clinical research core resources that provide innovative tools to investigators; Career development and education programs that prepare the next generation of investigators; Compliance and regulatory affairs support that ensures patient safety and privacy, and customer service-oriented approaches to support investigative teams; Community affairs support to enhance participation, diversity and community support for clinical and translational research; Collaboration with industry and clinical practices to translate research discoveries into routine clinical practice; and Continued and expanded institutional support that includes an academic home for clinical and translational research. The Mayo Clinic also proposes a consolidated governance plan that incorporates strong data-driven evaluation of each Center for Clinical and Translational Science element and the program as a whole. In principle, the CTSA Program is consistent with the historical, conceptual and philosophical underpinnings of the Mayo Clinic, and this application clearly articulates how the overarching and transformative goals of the CTSA Program can be met at Mayo. To summarize, the Mayo Clinic Center for Clinical and Translational Science will bring together all the resources of the five schools within the Mayo Clinic College of Medicine, and more than 100 years of scientific and medical research expertise, to discover innovative new methods that will speed the translation of research results into therapies, tools and patient care practices that impact all members of the local and national communities. This vision is entirely consistent with the stated mission of the Mayo Clinic to provide the best care to every patient, every day, through integrated clinical practice, education and research.
218	Johns Hopkins Institute for Clinical and Translational Research	Baltimore, Maryland Principal InvestigatorDaniel E. Ford, M.D., M.P.H., Johns Hopkins University Website The Johns Hopkins Institute for Clinical and Translational Research (ICTR) addresses obstacles in translating basic science discoveries into research in humans, translating clinical discoveries into the community and communicating experience from clinical practice back to researchers. The ICTR will create three new Translational Research Communities for investigators across multiple disciplines that focus on drugs, biologics, vaccines and devices; biomarkers and diagnostic tests; and behavioral, social and systems interventions. These communities of researchers will help prioritize clinical problems in need of new treatments, apply new technologies and methodologies, support junior investigators, work with translational partners outside of Johns Hopkins, fund pilot projects, provide regulatory assistance and promote efficient research. Another new program, The Research Studio, is both a place and a process for teams to obtain multidisciplinary guidance to solve clinical and translational research problems. The ICTR will provide research teams across the university and affiliated research institutes with a range of services in five ICTR Cores: Translational Sciences Human Subjects Research Quantitative Methodologies Clinical Research Informatics Research Participants and Community Partnerships Johns Hopkins will continue to provide rigorous, comprehensive training to graduate students, fellows, junior faculty and practicing physicians so they can lead effective and successful translational research teams. Using the Accelerating Translational Incubator Pilot grants, Johns Hopkins will encourage new translational research teams to take the risks necessary to go beyond their usual expertise and to find new collaborators, seek out new partners inside and outside the academic center, and learn new skills necessary to create the interventions the public is expecting.
217	Columbia University, Irving Institute for Clinical and Translational Research	New York, New York Principal Investigator Muredach P. Reilly, M.B., M.S., Columbia University Website The Irving Institute for Clinical and Translational Research at the Columbia University Medical Center (CUMC) was established in 2006 with the funding of one of the first 12 Clinical and Translational Science Awards. The Irving Institute evolved from a General Clinical Research Center founded in 1975 and renamed the Irving Center for Clinical Research in 1987 and, more recently, the Irving Institute for Clinical and Translational Research to acknowledge generous and sustained philanthropic gifts from Herbert and Florence Irving. Since 2006, the Irving Institute has played a vital role in transforming the research culture at CUMC and overcoming barriers to interdisciplinarity by: creating opportunities for interaction among investigators from different disciplines; establishing incentives to encourage clinical and translational research; and developing the infrastructure necessary to optimally support interdisciplinary clinical and translational research. The Irving Institute is the major provider of internal support for research at CUMC, encompassing a range of pilot awards, educational programs, free initial statistical and bioinformatics consultations, reduced rates for investigational laboratory tests, subsidized use of inpatient and outpatient facilities and research nurses, and both financial and infrastructure support for investigators, as well as nonacademic leaders who conduct research in the community. Through its training and seminar programs, the Irving Institute also serves as a major source of educational opportunities for CUMC students, faculty and other health professionals. In its current CTSA grant funding cycle and in synergy with a major Columbia University initiative in precision medicine, the Irving Institute initiated multiple new programs in precision medicine, including education, training and fellowships, an institutional biorepository, biomedical informatics, translational therapeutics, and community precision health. The vision of the Irving Institute is to: transform the culture of biomedical research enabling CUMC investigators to develop new treatments faster and deliver those treatments to patients more efficiently, effectively and safely than ever before; utilize medical research advances to benefit patients and the community, converting knowledge into practice; and to recruit, train, support and nurture the next generation of clinical and translational investigators in multi- and interdisciplinary team science environments. In the next five years with the funding of a third CTSA Program award, the Irving Institute will meet the new vision and goals of NCATS while continuing to advance the needs of its own constituents: students, scientists, clinicians, other health professionals and, most importantly, the underserved and underrepresented people the Irving Institute serves in the Northern Manhattan communities of Washington Heights/Inwood and Harlem.
216	Indiana Clinical and Translational Sciences Institute	Indianapolis, Indiana Principal InvestigatorAnantha Shekhar, M.D., Ph.D., Indiana University School of Medicine Website The Indiana Clinical and Translational Sciences Institute (CTSI) — created in 2008 through the partnership of three research universities: Indiana University, Purdue University and the University of Notre Dame — has become an essential resource for the state’s biomedical initiatives. The Indiana CTSI is an integrated home for clinical and translational research, providing easily accessible resources, services and training in a collaborative, investigator-friendly environment. The Indiana CTSI aims to: Implement a roadmap to build the ideal research environment for collaboration among participating universities, key health care providers, private sector and corporate entities, state and local agencies, and other partners. Further develop the Indiana CTSI to support the careers and research projects of translational scientists and trainees through a streamlined structure, empowered leadership and administration, coordinated partner institution resources, robust informatics infrastructure, innovative project development teams, and continuous evaluation and process improvement. Promote clinical and translational researchers’ use of the Project Assistance and Resources for Translational Scientists (PARTS) suite of new and established research support services and resources, a statewide network of technology cores, and coordinated human subject research services and facilities. Enhance the statewide education and training of the clinical and translational research workforce through the Career development Education and Research Training (CERT) suite of programs and unique educational tools.
215	Heartland Institute for Clinical and Translational Research	Kansas City, Kansas Principal InvestigatorsRichard J. Barohn, M.D., University of Kansas Medical CenterLauren S. Aaronson, Ph.D., R.N., University of Kansas Medical Center Website The University of Kansas Heartland Institute for Clinical and Translational Research, known locally as the Frontiers program, is an academic home for clinical and translational research serving Kansas and the greater Kansas City region. The vision of Frontiers is to create a novel and transformative translational research enterprise from bench to bedside to community. Drawing on many years of experience reaching the frontiers of Kansas with educational, research and health care programs, the program supports scientists and actively involves the community so that discoveries and research findings are more rapidly brought to the point of care. Frontiers also promotes innovative public/private partnerships for developing new drugs and devices and integrates patient-centered health and health systems outcomes into evidence-based risk models that inform clinical care. Through these approaches, Frontiers is improving the health of all Kansans, especially those in rural and underserved communities. The specific aims of Frontiers are to: Create a new academic home with innovative training programs for clinical and translational investigators; Provide an enhanced coordinated translational research infrastructure; and Actively engage the community in developing, testing and disseminating research. The proposed infrastructure and educational programs of Frontiers address the challenges facing clinical and translational investigators by enhancing and integrating existing resources for easier access, developing new innovative resources, and capitalizing on resources residing in research centers across the university and the region.
214	Harvard Catalyst: The Harvard Clinical and Translational Science Center	Boston, Massachusetts Principal Investigator Lee M. Nadler, M.D., Harvard University Website Established in 2008, Harvard Catalyst is dedicated to improving human health by enabling collaboration and providing tools, training and technologies to clinical and translational investigators. As a shared enterprise of Harvard University, its 11 schools and 17 academic health care centers, Harvard Catalyst resources are available to all faculty, regardless of institutional affiliation or academic degree. To this end, the CTSA Program hub serves as a convener, connector and catalyst, providing integrated resources, education and funding to speed and improve the quality of clinical and translational research at Harvard. Harvard Catalyst makes available an extensive portfolio of resources for researchers, including consultations for biostatistics, bioinformatics and regulatory support; education and training; pilot funding opportunities; clinical research services; informatics tools; and community-based population research. Research and programmatic initiatives also include child health, faculty diversity and health disparities. The organization’s innovative informatics tools — Profiles, the Shared Health Research Information Network (SHRINE) and eagle-i — have been adopted throughout the University and widely used outside Harvard to enable investigators to find collaborators, study participants and research resources. Since 2009, researchers also have benefited from the Harvard Catalyst institutional review board (IRB) cede review form, which allows investigators to request a single IRB review when conducting multisite studies. Harvard Catalyst’s goal is to transform clinical and translational research at the University by creating a “One Harvard” community and culture committed to improving health.
213	Georgetown-Howard Universities Center for Clinical and Translational Science	Washington, District of Columbia Principal Investigators Joseph G. Verbalis, M.D., Georgetown University Thomas A. Mellman, M.D., Howard University Website The Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) is a collaborative research center that includes two major universities and three affiliated hospital and research systems. The specific aims of GHUCCTS are to accelerate improvements in human health by stimulating innovative, multidisciplinary and cross-institutional research among GHUCCTS investigators; to support the careers of clinical and translational investigators through a variety of educational programs paired with focused mentorship; and to enhance local and national clinical and translational research in underserved populations, including minorities, the elderly and those with disabilities. To accomplish these aims, the GHUCCTS team integrates existing research and training programs with an innovative infrastructure to enhance practice-, laboratory- and community-based clinical and translational research. GHUCCTS includes a coordinated multi-institutional biomedical informatics infrastructure, an expanded clinical research operation with new community-based clinical research units, a new community engagement resource to support and enhance community-based research, and expanded resources in regulatory knowledge and ethics. GHUCCTS also supports collaborative research projects, using the supercomputing and translational tools of the Oak Ridge National Laboratory to explore and develop novel translational methodologies. Resource integration across the GHUCCTS institutions is accompanied by a joint research education, training and career development program, including new master's degree and scholars' programs in clinical and translational science. GHUCCTS multidisciplinary and cross-institutional research enables the Washington, D.C., community to benefit from the generation and application of new discoveries in clinical and translational science.
212	Duke Clinical and Translational Science Institute	Durham, North Carolina Principal Investigators Leigh E. Boulware, M.D., Duke University Jennifer S. Li, M.D., Duke University James O. McNamara, M.D., Duke University Website The Duke Clinical and Translational Science Institute (CTSI) is an academic hub for accelerating the translation and implementation of scientific discoveries into health benefits for patients and communities: The CTSI collaborates with schools, departments, centers, and programs across Duke, and with other organizations in our communities, to catalyze scientific discovery, innovation, and translation; develop and support a vital and diverse translational science workforce; and sustain a vibrant, transparent, and trustworthy research environment benefitting all. The CTSI is supported by the Duke School of Medicine and by a Clinical and Translational Science Award (CTSA) from the National Center for the Advancement of Translational Science, part of the National Institutes of Health. Through the national CTSA Program, the Duke CTSI is part of a network of more than 60 medical research institutions in the U.S.A. that work together to improve the translational research process. The CTSI: Creates an integrated home for clinical and translational research by providing infrastructure and resources to serve investigators and trainees across the research spectrum. Offers resources based on researchers’ common needs for education, biostatistics, biobanking, regulatory expertise, ethics, pilot funding, and recruitment assistance. Tailors offerings to specialized needs across research communities, such as early translation, proof of concept, and site- and population-based research, which require multisite trials, health services, implementation science and community-engaged research. To integrate these resources, Duke has built a new online portal for all trainees and investigators, myRESEARCHhome, and its human counterpart, myRESEARCHnavigators. These tools provide a single point of entry for all clinical and translational research at Duke, regardless of department or school. Subscribe to the Duke CTSI newsletter.
211	Dartmouth SYNERGY: The Dartmouth Clinical and Translational Science Institute	Hanover, New Hampshire Principal InvestigatorAlan I. Green, M.D., Dartmouth College Website Building on Dartmouth’s rich history of collaborative investigation and education in the clinical and translational sciences, Dartmouth SYNERGY aims to transform the institutional landscape for clinical and translational research and thus to accelerate the translation of scientific knowledge into practice and improved population health. SYNERGY will enrich Dartmouth’s translational environment in four overarching ways: Develop and ease access to specialized research infrastructure and informatics targeted to speed the translation of research discovery into improved health. SYNERGY will develop and promote technologies and resources, and it will support the implementation and dissemination of new treatments and technologies that will significantly increase the efficiency and effectiveness of research at Dartmouth. Engage community partners in collaborative, community-based studies that actively engage local stakeholders in developing, testing and disseminating research. Build Dartmouth’s scientific workforce by training a new generation of clinical and translational scientists, providing mentorship to nurture these new investigators, and ensuring that they have easy access to efficient core resources that will support innovative research projects. Create a Center for Translational Population Research, a technical and analytic resource to harness the power of Dartmouth’s population-based research across the clinical and translational research spectrum. Through these and other initiatives, SYNERGY will foster discovery, improve the infrastructure for clinical and translational science, nurture cross-disciplinary collaborative spirit, enhance translational research training, and facilitate the development of innovative and efficient solutions for translating scientific discoveries into practice and improved population health.

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