Open Opportunities

Click on the links below or scroll down to view open opportunities in each section. 

Requests for Applications

Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42- Clinical Trial Optional)
RFA-MD-23-002 · Posted Date: 01/30/2023 · SBIR/STIR

Innovations for Healthy Living - Improving Minority Health and Eliminating Health Disparities (R43/R44 - Clinical Trial Optional)
RFA-MD-23-003 · Posted Date: 01/30/2023 · SBIR/STIR

Translational Centers for Microphysiological Systems (TraCe MPS) (U2C Clinical Trials Not Allowed)
RFA-TR-23-001 · Posted Date: 12/27/2022 · Tissue Chip

Botulinum Toxin Potency Assay using Tissue Chips (BoT PATCh) (UT1, UT2 Clinical Trail Not Allowed)
RFA-TR-22-031 · Posted Date: 09/19/2022 · SBIR/STIR

Botulinum Toxin Potency Assay using Tissue Chips (BoT PATCh) (U43/U44 - Clinical Trail Not Allowed)
RFA-TR-22-032 · Posted Date: 09/19/2022 · SBIR/STIR

HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 Clinical Trial Not Allowed)
RFA-NS-23-006 · Posted Date: 09/15/2022 · HEAL

HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed)
RFA-NS-23-007 · Posted Date: 09/15/2022 · HEAL

Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required)
RFA-TR-22-029 · Posted Date: 07/13/2022 · SBIR/STIR

Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)
RFA-TR-22-030 · Posted Date: 06/28/2022 · Rare Diseases

Emergency Awards: HEAL Initiative- New Innovator Award (DP2 Clinical Trial Not Allowed)
RFA-TR-22-013 · Posted Date: 01/20/2022 · HEAL

Emergency Awards: HEAL Initiative-Early-Stage Discovery of New Pain and Opioid Use Disorder Targets Within the Understudied Druggable Proteome (R21 Clinical Trial Not Allowed)
RFA-TR-22-011 · Posted Date: 01/20/2022 · HEAL

NHLBI SBIR Phase IIB Small Market Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional)
RFA-HL-23-008 · Posted Date: 11/16/2021 · SBIR/STIR

HEAL Initiative: Analgesic Development Initial Translational Efforts [Small Molecules and Biologics] (U19 Clinical Trial Not Allowed)
RFA-NS-21-015 · Posted Date: 03/11/2021 · HEAL

Requests for Information

Request for Information (RFI): Advancing Clinical and Translational Science through Accelerating the Decentralization of Clinical Trials
NOT-TR-23-006 · Posted Date: 03/01/2023 · CTSA Program

Program Announcements

Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)
PAR-23-138 · Posted Date: 03/22/2023 · NCATS

NIH Medical Scientist Partnership Program (FM1 Clinical Trial Not Allowed)
PAR-23-109 · Posted Date: 03/10/2023 · NCATS

NIH Medical Scientist Partnership Program (FM1 Clinical Trial Not Allowed)
PAR-23-109 · Posted Date: 03/10/2023 · NIH

Diagnostic Centers of Excellence (X01 Clinical Trial Not Allowed)
PAR-23-120 · Posted Date: 03/07/2023 · NCATS

Diagnostic Centers of Excellence (X01 Clinical Trial Not Allowed)
PAR-23-120 · Posted Date: 03/07/2023 · NIH

HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed)
PAR-23-069 · Posted Date: 01/03/2023 · HEAL

NICHD Research Education Programs (R25 Clinical Trial Not Allowed)
PAR-22-224 · Posted Date: 08/24/2022 · NCATS

PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
PA-22-176 · Posted Date: 06/02/2022 · SBIR/STIR

PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
PA-22-178 · Posted Date: 06/02/2022 · SBIR/STIR

Clinical Trial Readiness for Rare Neurological and Neuromuscular Diseases (U01 Clinical Trial Not Allowed)
PAR-22-184 · Posted Date: 05/13/2022 · Rare Diseases

Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed)
PAR-22-101 · Posted Date: 02/03/2022 · Rare Diseases

Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R03 Clinical Trial Not Allowed)
PAR-22-100 · Posted Date: 02/03/2022 · Rare Diseases

Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed)
PAR-22-058 · Posted Date: 01/21/2022 · HEAL

Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed)
PAR-22-073 · Posted Date: 11/19/2021 · SBIR/STIR

Limited Competition: Ruth L. Kirschstein National Research Service Award (NRSA) Predoctoral Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program (T32 Clinical Trial Not Allowed)
PAR-21-337 · Posted Date: 09/22/2021 · CTSA Program

Limited Competition: Mentored Research Career Development Program Award in Clinical and Translational Science Awards (CTSA) Program (K12 Clinical Trial Optional)
PAR-21-336 · Posted Date: 09/20/2021 · CTSA Program

Limited Competition: NCATS Clinical and Translational Science Award (CTSA) Program Research Education Grants Programs (R25 - Clinical Trial Not Allowed)
PAR-21-339 · Posted Date: 09/20/2021 · CTSA Program

Limited Competition: High Impact Specialized Innovation Programs in Clinical and Translational Science for UM1 CTSA Hub Awards (RC2 Clinical Trials Not Allowed)
PAR-21-340 · Posted Date: 09/17/2021 · CTSA Program

Administrative Supplements to Promote Diversity in Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed
PA-21-345 · Posted Date: 09/10/2021 · SBIR/STIR

Clinical and Translational Science Award (UM1 Clinical Trial Optional)
PAR-21-293 · Posted Date: 07/30/2021 · CTSA Program

Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
PA-21-268 · Posted Date: 06/30/2021 · NCATS

NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)
PA-21-151 · Posted Date: 02/10/2021 · NCATS

Limited Competition: Small Grant Program for the NCATS Clinical and Translational Science Award (CTSA) Program (R03 Clinical Trial Optional)
PAR-21-121 · Posted Date: 01/04/2021 · CTSA Program

Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical Trial Not Allowed)
PA-21-071 · Posted Date: 11/16/2020 · NIH

Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
PA-20-272 · Posted Date: 10/09/2020 · NIH

Successor-in-Interest (Type 6 Parent Clinical Trial Optional)
PA-20-275 · Posted Date: 10/06/2020 · NIH

Drug Development Collaboratory (UG3/UH3 Clinical Trial Required)
PAR-20-301 · Posted Date: 09/18/2020 · New Therapeutic Uses

Research to Improve Native American Health (R21 Clinical Trials Optional)
PAR-20-214 · Posted Date: 08/17/2020 · NCATS

Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)
PA-20-222 · Posted Date: 05/29/2020 · NCATS

NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)
PA-20-207 · Posted Date: 05/07/2020 · NIH

Notices

Notice of Special Interest (NOSI): Administrative Supplement for Tackling Acquisition of Language in Kids (TALK) Initiative
NOT-DC-23-005 · Posted Date: 03/24/2023 · NCATS

Notice of Information: NCATS Prior Approval Process for New CTSA Program UM1 and K12 Scholar Projects that Involve Human Subjects Research
NOT-TR-23-007 · Posted Date: 03/07/2023 · CTSA Program

Notice of Special Interest (NOSI): Administrative Supplements to Enhance Software Tools for Open Science
NOT-OD-23-073 · Posted Date: 03/07/2023 · NCATS

Notice of Special Interest: Administrative Supplements to NIH-funded T32 and TL1 Training Grants to Better Integrate Behavioral and Social Sciences (BSS) with other Health-Related Sciences
NOT-OD-23-098 · Posted Date: 03/06/2023 · CTSA Program

Notice of Special Interest (NOSI): Administrative Supplements to Support the Exploration of Cloud in NIH-supported Research
NOT-OD-23-070 · Posted Date: 02/09/2023 · NCATS

Notice of Clarification to RFA-TR-22-030 “Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)”
NOT-TR-23-004 · Posted Date: 01/10/2023 · Rare Diseases

Notice of Termination for PAR-22-122: Limited Competition: Clinical and Translational Science Awards (CTSA) Consortium-Wide Centers: Resources for Rapid Demonstration and Dissemination (U24 Clinical Trials Optional)
NOT-TR-23-005 · Posted Date: 01/06/2023 · CTSA Program

Notice of NINDS Participation in RFA-TR-22-030: "Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)"
NOT-NS-23-052 · Posted Date: 12/08/2022 · Rare Diseases

Notice of Change to Award Budget for PHS 2022-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Grant Applications
NOT-OD-23-016 · Posted Date: 11/01/2022 · SBIR/STIR

Notice of Termination for NOT-TR-22-023 NCATS Notice of Special Interest (NOSI): Research through NCATS Clinical and Translational Science Award (CTSA) Program: High Impact Specialized Innovation Programs (RC2)
NOT-TR-23-002 · Posted Date: 10/25/2022 · CTSA Program

Notice of Special Interest (NOSI): Research through NCATS Clinical and Translational Science Award (CTSA) Program: High Impact Specialized Innovation Programs (RC2)
NOT-TR-23-003 · Posted Date: 10/25/2022 · CTSA Program

Notice of Change in Limited Competition: Ruth L. Kirschstein National Research Service Award (NRSA) Predoctoral Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program PAR-21-337 (T32 Clinical Trial Not Allowed)
NOT-TR-22-037 · Posted Date: 10/17/2022 · CTSA Program

Notice of Special Interest (NOSI): Administrative Supplements to NCATS CTSA Program KL2/K12 Institutional Career Development Awards as part of the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project
NOT-OD-22-192 · Posted Date: 10/03/2022 · CTSA Program

Notice of Change in Eligibility for CTSA Program Funding Opportunities: PAR-21-336 (K12), PAR-21-339 (R25), PAR-21-338 (T32), and PAR-21-337 (T32)
NOT-TR-22-035 · Posted Date: 10/03/2022 · CTSA Program

Notice of Special Interest (NOSI): Administrative Supplements to NCATS CTSA Program T32/TL1 Institutional Training Program as part of the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project
NOT-OD-22-191 · Posted Date: 09/30/2022 · CTSA Program

Notice of Change to PAR-21-293 Clinical and Translational Science Award (UM1 Clinical Trial Optional) in Award Information
NOT-TR-22-033 · Posted Date: 07/20/2022 · CTSA Program

Notice of Change to PAR-21-293 Clinical and Translational Science Award (UM1 Clinical Trial Optional) in Eligibility
NOT-TR-22-032 · Posted Date: 06/22/2022 · CTSA Program

Notice of Special Interest (NOSI): Availability of Administrative Supplements for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project
NOT-OD-22-137 · Posted Date: 06/07/2022 · CTSA Program

Notice of Special Interest (NOSI): Innovative Technologies for Research on Climate Change and Human Health Small Business Technology Transfer (R41/R42 Clinical Trial Optional)
NOT-ES-22-009 · Posted Date: 06/03/2022 · SBIR/STIR

Notice of Special Interest (NOSI): Innovative Technologies for Research on Climate Change and Human Health (R43/R44 Small Business Innovation Research (R43/R44 Clinical Trial Optional)
NOT-ES-22-010 · Posted Date: 06/03/2022 · SBIR/STIR

Notice of Correction to PAR-22-058 "Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed)"
NOT-TR-22-027 · Posted Date: 03/28/2022 · HEAL

Notice of Change in Eligibility to PAR-21-293 Clinical and Translational Science Award (UM1 Clinical Trial Optional)
NOT-TR-22-024 · Posted Date: 03/23/2022 · CTSA Program

Notice of Change in Award Information to PAR-21-293 Clinical and Translational Science Award (UM1 Clinical Trial Optional)
NOT-TR-22-025 · Posted Date: 03/21/2022 · CTSA Program

Notice of Change in Funding Opportunity Description and Application and Submission Information to PAR-21-293 Clinical and Translational Science Award (UM1 Clinical Trial Optional)
NOT-TR-22-026 · Posted Date: 03/21/2022 · CTSA Program

Notice of Intent to Publish a Funding Opportunity Announcement for Data Management and Coordinating Center (DMCC) for Rare Diseases Clinical Research Network (RDCRN) (U2C Clinical Trial Not Allowed)
NOT-TR-22-016 · Posted Date: 03/02/2022 · RDCRN

Notice of Termination of Limited Competition: Clinical and Translational Science Awards (CTSA) Consortium-Wide Centers: Resources for Rapid Demonstration and Dissemination (U24 Clinical Trials Not Allowed)
NOT-TR-22-019 · Posted Date: 03/01/2022 · CTSA Program

Notice of NIH Participation in the National Robotics Initiative (NRI)
NOT-EB-22-003 · Posted Date: 02/11/2022 · NCATS

Notice of Intent to Publish a Funding Opportunity Announcement for Diagnostic Centers of Excellence (X01 Clinical Trial Not Allowed)
NOT-NS-22-072 · Posted Date: 02/10/2022 · NCATS

Notice of Early Termination of PAR-22-057 "Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed)"
NOT-TR-22-015 · Posted Date: 01/20/2022 · HEAL

Notice of Change to Participant Eligibility, Participant Costs and Other Attachments to Funding Opportunity Announcement PAR-21-339, Limited Competition: NCATS Clinical and Translational Science Award (CTSA) Program Research Education Grants Program (R25)
NOT-TR-22-010 · Posted Date: 11/30/2021 · CTSA Program

Notice of Change to Receipt Date for CTSA Program Funding Opportunities: PAR-21-293 (UM1), PAR-21-336 (K12), PAR-21-340 (RC2), PAR-21-339 (R25), PAR-21-338 (T32), and PAR-21-337 (T32)
NOT-TR-22-007 · Posted Date: 11/12/2021 · CTSA Program

Notice of Change to Expansion of Eligibility of Optional Companion Applications for CTSA Program Funding Opportunities: PAR-21-293 (UM1), PAR-21-340 (RC2), PAR-21-339 (R25), PAR-21-338 (T32), and PAR-21-337 (T32)
NOT-TR-22-008 · Posted Date: 11/12/2021 · CTSA Program

Notice of Change to PI effort and eligibility of foreign components for PAR-21-336: Limited Competition: Mentored Research Career Development Program Award in Clinical and Translational Science Awards (CTSA) Program (K12 Clinical Trial Optional)
NOT-TR-22-009 · Posted Date: 11/10/2021 · CTSA Program

Notice of Change to the Required Tables in PAR-21-336, Limited Competition: Mentored Research Career Development Program Award in Clinical and Translational Science Awards for the Clinical and Translational Science Awards (CTSA) Program
NOT-TR-22-006 · Posted Date: 10/26/2021 · CTSA Program

Notice of Availability of Application Information for NCATS Clinical and Translational Science Award (UM1), Career Development (K12), Training (T32), Education (R25) and Specialized Innovation Program (RC2) Opportunities
NOT-TR-22-002 · Posted Date: 10/12/2021 · CTSA Program

Notice of Special Interest (NOSI): Administrative Supplement for Providing Technical and Business Assistance (TABA) Funding to SBIR/STTR Awardees (Admin Supp)
NOT-OD-21-062 · Posted Date: 03/22/2021 · SBIR/STIR

Announcement of Childcare Costs for Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellows
NOT-OD-21-069 · Posted Date: 03/01/2021 · NIH

Notice of Special Interest (NOSI): Availability of Administrative Supplements for Childcare Costs for Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellows
NOT-OD-21-070 · Posted Date: 03/01/2021 · NCATS

Notice of Special Interest (NOSI): Availability of Emergency Competitive Revisions for the Clinical and Translational Science Award (CTSA) Program to Address COVID-19 Public Health Needs
NOT-TR-21-022 · Posted Date: 02/26/2021 · CTSA Program

Notice of Special Interest (NOSI): Small Business Initiatives for Innovative Diagnostic Technology for Improving Outcomes for Maternal Health
NOT-EB-21-001 · Posted Date: 02/22/2021 · SBIR/STIR

Notice of Special Interest (NOSI): Administrative Supplements for the Clinical and Translational Science Award (CTSA) Program to Address COVID-19 Public Health Needs
NOT-TR-21-017 · Posted Date: 02/03/2021 · CTSA Program

Notice of NCATS Withdrawal from Participation in PAR-20-168, "Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (R21 Clinical Trials Not Allowed)"
NOT-TR-21-014 · Posted Date: 12/17/2020 · CTSA Program

Supplemental Information to the NIH Policy for Data Management and Sharing: Elements of an NIH Data Management and Sharing Plan
NOT-OD-21-014 · Posted Date: 10/29/2020 · NIH

Supplemental Information to the NIH Policy for Data Management and Sharing: Allowable Costs for Data Management and Sharing
NOT-OD-21-015 · Posted Date: 10/29/2020 · NIH

Supplemental Information to the NIH Policy for Data Management and Sharing: Selecting a Repository for Data Resulting from NIH-Supported Research
NOT-OD-21-016 · Posted Date: 10/29/2020 · NIH

Final NIH Policy for Data Management and Sharing
NOT-OD-21-013 · Posted Date: 10/29/2020 · NIH

Notice of Special Interest to Encourage Eligible NIH HEAL Initiative Awardees to Apply for PA-20-222: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)
NOT-NS-20-107 · Posted Date: 10/19/2020 · HEAL

Notice of NCATS Interest in Receiving Letters Requesting Permission to Submit Applications to Support Annual Microphysiological Systems Scientific Conferences (U13)
NOT-TR-21-005 · Posted Date: 10/13/2020 · Tissue Chip

Notice of Special Interest: NCCIH Administrative Supplements to NCATS CTSA Programs for Scholars Pursuing Complementary Health Research Career Development
NOT-AT-20-010 · Posted Date: 04/13/2020 · CTSA Program

Reinstatement of NIH SBIR Direct-to-Phase II Authority and Associated Updates to NCATS Platform Delivery Technologies for Nucleic Acid Therapeutics (R43/R44) Funding Opportunity Announcement
NOT-TR-19-004 · Posted Date: 10/15/2018 · SBIR/STIR

Reinstatement of NIH SBIR Direct-to-Phase II Authority and Associated Updates to NIH SBIR Omnibus Solicitations
NOT-OD-19-019 · Posted Date: 10/15/2018 · SBIR/STIR

NCATS Requests for Proposals

To find NCATS Requests for Proposals, visit FedBizOpps, type n01tr into the keyword field and click the search button.

NIH Clinical Trial Policy

Learn more about the NIH clinical trial requirements for grants and contracts and download slides that highlight policy changes.

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NCATS Policy for Support of Clinical Trial Activities

This Notice informs the research community of the NCATS policy regarding support of clinical trial activities. The policy is designed to ensure compliance with the 21st Century Cures Act (Cures Act) as well as all pertinent statutes and existing NIH and NCATS policies; and considers the urgency of developing new treatments for rare diseases.

PUBLIC NOTICE

NIH National Center for Advancing Translational Sciences (NCATS) Notice of Intent to Support a Phase III Clinical Trial for a Rare Disease or Condition

Collaborate with NCATS Scientists on the NIH HEAL Initiative

Two scientists in a lab

NCATS welcomes your NIH HEAL Initiative-related proposals to advance promising compounds and human cell-based models through preclinical development in collaboration with NCATS' intramural scientists.

NCATS’ Role in the NIH HEAL Initiative

An NIH scientist measuring dopamine releaseAs part of NIH HEAL Initiative, NCATS is applying breakthrough approaches of translational science to advance new treatments for opioid misuse and addiction and for pain. Learn more about NCATS' Role in the NIH HEAL Initiative.

CTSA Program Funding News

Learn more about current funding opportunities for the Clinical and Translational Science Awards (CTSA) Program on the CTSA Program Funding Information page, including recent announcements and frequently asked questions.