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These audio clips feature funded scientists describing research goals as part of the Discovering New Therapeutic Uses for Existing Molecules program.

 

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The Efficacy and Safety of a Selective Estrogen Receptor Beta Agonist (LY500307)

Alan Breier, M.D., Indiana University, Indianapolis

For this project, the research team will test a drug candidate that mimics estrogen’s action in the body — but without its negative side effects — to see if it is safe and relieves symptoms in patients with schizophrenia.

Runtime: 0:59
Date: June 2013
Right-click to download this clip (MP3 - 2MB)
Clip courtesy of Indiana University.

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Medication Development of a Novel Therapeutic for Smoking Cessation

Darlene H. Brunzell, Ph.D., Virginia Commonwealth University, Richmond

For this project, the team of researchers will conduct studies in rodents followed by clinical trials with cigarette smokers to test an existing compound as a potential treatment for tobacco cessation.

Runtime: 0:42
Date: June 2013
Right-click to download this clip (MP3 - 659KB)
Clip courtesy of Virginia Commonwealth University.

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A Novel Compound for Alcoholism Treatment: A Translational Strategy

Lorenzo Leggio, M.D., Ph.D., M.Sc. (NIAAA/NIDA), partner with the University of Rhode Island, Kingston

For this project, the research team will test an oral medication that blocks a hormone called ghrelin to see if the drug is safe and if it reduces alcohol dependence.

Runtime: 0:27
Date: June 2013
Right-click to download this clip(MP3 - 427KB)
Clip courtesy of NIAAA/NIDA.

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Reuse of ZD4054 for Patients with Symptomatic Peripheral Artery Disease

Brian H. Annex, M.D., University of Virginia, Charlottesville

For this project, researchers will test an investigational drug for its ability to improve blood flow in the legs of patients with peripheral artery disease, which can cause severe leg pain. This drug may relieve this pain, help patients walk further and longer, and reduce the costs of hospitalization and treatment.

Runtime: 0:44
Date: June 2013
Right-click to download this clip (MP3 - 2MB)
Clip courtesy of the University of Virginia.

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Right-click to download a transcript (1KB)

Therapeutic Strategy for LAM

N. Tony Eissa, M.D., Baylor College of Medicine, Houston

For this project, the research team aims to determine if blocking Src kinase activity using an investigational drug is safe and can reduce the growth and spread of lymphangioleiomyomatosis (LAM), a progressive lung disease.

Runtime: 0:43
Date: June 2013
Right-click to download this clip (MP3 - 2MB)
Clip courtesy of Baylor College of Medicine.

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You can listen to the audio with JavaScript turned on. To view it without JavaScript and Flash, you can access the html text-only version of the audio.

Right-click to download a transcript (1KB)

Therapeutic Strategy to Slow Progression of Calcific Aortic Valve Stenosis

Jordan D. Miller, Ph.D., Mayo Clinic, Rochester, Minnesota

For this project, the researchers will test the safety of an investigational drug in heart valve disease patients in slowing progression of stenosis, an abnormal narrowing of vessels or other structures.

Runtime: 0:34
Date: June 2013
Right-click to download this clip (MP3 - 670KB)
Clip courtesy of Mayo Clinic.

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Right-click to download a transcript (1KB)

Translational Neuroscience Optimization of GlyT1 Inhibitor

John H. Krystal, M.D., Yale University, New Haven, Connecticut

For this project, the researchers will use brain imaging studies to determine the safest dose of an experimental drug in healthy subjects and, ultimately, whether it is effective in combination with mind exercises to treat cognitive deficits in schizophrenia patients.

Runtime: 0:37
Date: June 2013
Right-click to download this clip (MP3 - 1MB)
Clip courtesy of Yale University.

This content requires the free Adobe Flash Player. Get Flash.

You can listen to the audio with JavaScript turned on. To view it without JavaScript and Flash, you can access the html text-only version of the audio.

Right-click to download a transcript (1KB)

Last updated: 03-27-2015
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