Staff Profile: Harrison C. Daly

Harrison C. Daly, Ph.D.
Harrison C. Daly, Ph.D.

Postdoctoral Visiting Fellow

Division of Preclinical Innovation
Early Translation Branch

National Center for Advancing Translational Sciences

National Institutes of Health

Email Harrison C. Daly


Harrison Daly is a postdoctoral visiting fellow in the Early Translational Branch within NCATS’ Division of Preclinical Innovation, where his current projects include target deconvolution, assay development and hit-to-lead optimization in the disease areas of cancer and chronic pain management as part of The Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®.

Prior to joining NCATS in 2021, Daly was a postdoctoral visiting fellow in the Chemical Biology Laboratory within the National Cancer Institute’s Center for Cancer Research, where he synthesized and designed small molecule, xanthene-based short-wave infrared imaging agents. Before joining NIH in 2018, Daly worked in the pharmaceutical industry as a process development chemist at Astellas Pharma Ireland.

As a recipient of an Irish Research Council (EMBARK Scheme) postgraduate scholarship, Daly earned his doctorate in organic chemistry from University College Dublin, where—under the supervision of Professor Donal F. O’Shea at the Royal College of Surgeons in Ireland—he developed BF2-azadipyrromethene bio-responsive near-infrared fluorescent imaging platforms. He earned his Bachelor of Science in medicinal chemistry and chemical biology from University College Dublin. In his final year thesis project, Daly contributed to the synthetic development of lipoxin A4 analogues as anti-inflammatory agents under the tutelage of Professor Patrick Guiry.

Research Topics

Daly’s research interests sit at the interface of translation, medicinal chemistry, chemical biology, medical imaging and human health.

Selected Publications

  1. Ketone Incorporation Extends the Emission Properties of the Xanthene Scaffold Beyond 1000 nm
  2. An EPR Strategy for Bio-Responsive Fluorescence Guided Surgery With Simulation of the Benefit for Imaging
  3. BF2-Azadipyrromethene NIR-Emissive Fluorophores With Research and Clinical Potential
  4. RGD Conjugated Cell Uptake off to on Responsive NIR-AZA Fluorophores: Applications Toward Intraoperative Fluorescence Guided Surgery
  5. PEGylated BF2-Azadipyrromethene (NIR-AZA) Fluorophores, for Intraoperative Imaging