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Staff Profile: Jason Rohde

Jason M. Rohde, Ph.D.
Jason M. Rohde, Ph.D.

Research Scientist, Chemistry (Contractor)

Division of Pre-Clinical Innovation

National Center for Advancing Translational Sciences

National Institutes of Health

E-mail Jason M. Rohde

Biography

Jason Rohde joined NCATS in 2012, where he now serves as a research scientist in medicinal chemistry. This interdisciplinary group of NCATS scientists manages a diverse target portfolio (e.g., oncology, rare metabolic diseases) and works to optimize small molecules identified in high-throughput screening campaigns aimed at interrogating promising new biological targets. 

Rohde received a Ph.D. in chemistry at the Scripps Research Institute, where he worked with Erik Sorensen, Ph.D., in natural product total synthesis (inspired by biosynthetic hypotheses). As a postdoctoral researcher in the lab of Larry Overman, Ph.D., at the University of California, Irvine, Rohde and his colleagues contributed to the total syntheses of actinophyllic acid and the nankakurines.

Research Topics

Rohde enjoys working on a diversity of new biological targets that may have the potential to address unmet medical needs. His research interests include medicinal chemistry, chemical biology, rare and neglected diseases research, synthetic methodology, and natural products research. Since joining NCATS, Rohde has developed small molecule modulators and tools for:

  • Mutant isocitrate dehydrogenase 1 (mIDH1)
  • Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)
  • Phosphoglycerate dehydrogenase (PHGDH)
  • ATPase family AAA domain-containing protein 5 (ATAD5)

Rohde recently initiated a natural product screening effort called Canvass. This pilot study aims to screen natural products, which have proven over the years to be a rich source of small molecule drugs. Using compounds from academic researchers throughout the country and various whole-cell, biological assays designed to canvass much of biology, the program’s overall goal is to rejuvenate natural product research.

Selected Publications

  1. Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans.
  2. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
  3. PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.
  4. Structure activity relationships of human galactokinase inhibitors.
  5. Total synthesis of (+/-)- and (-)-actinophyllic acid.