Staff Profile: Danilo Tagle

Danilo A. Tagle, Ph.D., M.S.
Danilo A. Tagle, Ph.D., M.S.

Associate Director for Special Initiatives

Office of the Director
Office of Special Initiatives

National Center for Advancing Translational Sciences

National Institutes of Health

Email Danilo A. Tagle


Dan Tagle is associate director for special initiatives at NCATS. He also recently served as the Center's acting deputy director, as well as the acting director of NCATS' Office of Grants Management and Scientific Review and as executive secretary to the NCATS Advisory Council and Cures Acceleration Network Review Board. Prior to joining NCATS, Tagle was a program director for neurogenetics at the National Institute of Neurological Disorders and Stroke (NINDS), where he was involved in developing programs concerning genomics-based approaches for basic and translational research in inherited brain disorders.

Prior to joining NINDS in 2001, Tagle was an investigator and section head of molecular neurogenetics at the National Human Genome Research Institute and has been involved in the highly collaborative effort toward the positional cloning of genes for Huntington’s disease, ataxia-telangiectasia and Niemann-Pick disease type C. He has served on numerous committees and advisory boards, including the editorial boards of the journals Gene and the International Journal of Biotechnology.

Tagle obtained his Ph.D. in molecular biology and genetics from Wayne State University School of Medicine in 1990. He was an NIH National Research Service Award postdoctoral fellow in human genetics in the laboratory of Francis S. Collins, M.D., Ph.D., at the University of Michigan. Tagle has authored more than 150 scientific publications and has garnered numerous awards and patents.

Research Topics

Tagle leverages key resources and expertise through partnerships with stakeholders in biomedical research, including various government agencies, nonprofits, patient advocacy groups, industry organizations, pharmaceutical corporations and others in the private sector.

Tagle leads and provides scientific and programmatic oversight and coordination to the following trans-NIH programs:

Selected Publications

  1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group
  2. A single ataxia telangiectasia gene with a product similar to PI-3 kinase
  3. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis
  4. Expanding rare disease drug trials based on shared molecular etiology
  5. Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue