Tissue Chip for Drug Screening
The Tissue Chip for Drug Screening program aims to develop bioengineered devices to improve the process of predicting whether drugs will be safe or toxic in humans.
Tissue Chip Overview
Many promising medications have failed to be safe and effective in human clinical trials despite promising preclinical studies. We are addressing this problem through the Tissue Chip for Drug Screening program. We coordinate with other NIH institutes and centers and the U.S. Food and Drug Administration (FDA).
Tissue chips are built from human cells. Also called organs-on-chips, they mimic the structure and function of our heart, kidneys, lungs and other organ systems. Scientists are developing and using tissue chips to test the potential effects of drugs on those tissues in a faster and more effective way than current methods. Learn more about these projects.
With flexible funding from the Cures Acceleration Network, we focus on developing high-need cures and reducing major barriers between research discovery and clinical trials. Our Tissue Chip for Drug Screening program aims to speed the translation of basic discoveries into the clinic. By creating an integrated human body-on-a-chip, researchers will be able to test the possible effects of a drug or other substance across the entire body before testing in people.
Because they use human cells, tissue chips are also useful research tools to study human diseases and conditions when animal models do not mirror the pathology or are unavailable. They support NIH’s position that non-animal model approaches can reduce the need for animals in research but will require further improvement to completely replace them
Tissue Chip News
Tissue Chips in Space Projects Offer Glimpses Into the Biology of Aging
March 23, 2023 - NCATS News
The NCATS-led Tissue Chips in Space program sent its final projects to the International Space Station to learn about aging-related diseases and conditions and potentially translate results into treatments that help people on Earth.Read Article
SpaceX’s Dragon Spacecraft Returns Crew and Critical Science to Earth Following Long-Duration Mission
October 2, 2023 - Media Coverage
Unlocking the Secrets of the Immune System: How Tissue Chips in Space Could Hold the Key
September 29, 2023 - Grantee/Partner News
Fiber-Infused Ink Enables 3D-Printed Heart Muscle to Beat
September 9, 2023 - Media Coverage
Stem Cell Translation Laboratory
Our experts develop methods and standards to use stem cell technology (using cells derived from skinor blood) to advance treatment approaches.
3-D Tissue Bioprinting
Our scientists are creating and using 3-D printing techniques to make tissue models that closely resemble the complex structure and organization of our cells.
Matrix Combination Screening
Our experts use matrix combination screening technology to quickly identify promising drug combinations with the most potential to help patients.