Collaborative Innovation through the CTSA Program

The NCATS CTSA Program collaborative innovation suite of awards support team-based research to develop, demonstrate and disseminate innovations that can improve the translational science process to turn laboratory, clinic and community observations into interventions and benefit public health. The suite of opportunities aims to provide support to investigators to tackle a translational science problem no one hub can solve alone or to disseminate a validated solution developed at one hub to other hubs. These collaborations test innovations in different hub settings and adapt such innovations for further dissemination within and outside the CTSA Program consortium, if appropriate. In developing the collaborative innovation funding opportunity announcements (FOAs), NCATS carefully considered input from the National Academy of Medicine (formerly the Institute of Medicine) and a report from a working group (PDF - 414KB) of the NCATS Advisory Council. The funded projects reflect the CTSA Program goals and cover a broad spectrum of translational science.

A graphic representation of the types of NCATS CTSA Program Collaborative Innovation awards and the eligibility, review type, and purpose for each.

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Funding

Notice of Special Interest: Research through NCATS’ Clinical and Translational Science Award (CTSA) Program: Collaborative Innovation Awards (U01 and R21)

  • The purpose of this Notice of Special Interest is to highlight the list of widely appreciated systematic barriers or translational science problems included in PAR-19-099 and PAR-19-100 to add the following topics of interest:
    • Rural Health: We encourage clinical and translational science research to address the significant burden of conditions that disproportionately affect rural underserved populations and contribute to the health disparities found in rural compared to urban or suburban communities.
    • Racial and Ethnic Disparities in Maternal Mortality: Pregnancy-related deaths disproportionally affect women of African, American Indian (AI) and Alaska Native (AN) descent. Collaborative, innovative and multidisciplinary translational science research projects that leverage the resources of the CTSA program to address this unmet need are needed. Examples include but are not limited to shared informatics tools, linked clinical databases and EHRs, existing collaborations with minority-serving healthcare delivery organizations, and well-developed partnerships with URM communities.
    • Applications for Machine Learning and Artificial Intelligence (AI) in Translational Science: Applicants are encouraged to collaboratively develop, demonstrate, and disseminate algorithms within the CTSA Program cloud infrastructure that ensure trustworthiness, explainability, usability, transparency, and reproducibility. Use cases in this area should focus on the development ofGood Algorithm Practices (GAPs) which includes model validation, data integrity, and generalizability. Please see “Machine Intelligence in Healthcare” for more information.
    • Veterans’ Health: Clinical and translational science research in collaboration with the Veterans Health Administration is needed to address the health burdens of veterans and to more effectively engage and enable veterans who reside in rural areas to participate in clinical and translational science research related to pain and/or OUD.

Limited Competition: Clinical and Translational Science Award (CTSA) Program: Exploratory Collaborative Innovation Awards (R21 Clinical Trial Optional)

  • This opportunity will support investigators from two or more CTSA Program hub institutions to either: 1) form new collaborations, or to 2) significantly expand the scientific scope of existing collaborations, or to 3) engage new collaborators in pre-existing collaborations to solve a translational science problem no one hub can solve alone, or disseminate a solution to a translational science problem developed at one hub to other hubs, thereby testing its robustness to different hub environments and structures and adapting it for further dissemination within and outside the CTSA Program consortium if appropriate. 

Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative Innovation Award (U01 Clinical Trial Optional)

  • This type of opportunity will support investigators from three or more CTSA Program hub institutions to either: 1) form new collaborations, or to 2) significantly expand the scientific scope of existing collaborations, or to 3) engage new collaborators in pre-existing collaborations to solve a translational science problem no one hub can solve alone, or disseminate a solution to a translational science problem developed at one hub to other hubs, thereby testing its robustness to different hub environments and structures and adapting it for further dissemination within and outside the CTSA Program consortium if appropriate.

Limited Competition: Competitive Revision Awards for the Clinical and Translational Science Award (CTSA) Program (U54 Clinical Trial Optional)

  • This opportunity is intended to support the demonstration, and/or dissemination, and/or implementation of highly innovative and impactful translational science projects that address the goals of the CTSA Program and are beyond the original scope of the approved parent project. Under this competitive revision (formerly known as competitive supplement), only applications for revisions to the UL1 award are allowed. Revisions to the linked KL2 and/or the TL1 awards are not allowed.

Expired March 2, 2019:

Limited Competition: Administrative Supplements to Enhance Network Capacity: Collaborative Opportunities for the CTSA Program (Admin Supp)

  • This type of opportunity is intended to enhance network capacity through implementing, assessing, and/or disseminating discoveries in methods, approaches, education and training in clinical and translational science. Funds will allow investigators from two or more different CTSA Program hubs to form collaborations within the CTSA Program network and/or with external partners to implement, assess and/or disseminate discoveries across the network. These activities must be within the scope of the approved aims of the parent award and provide significant advances across the translational science spectrum.

Funded Collaborative Suite of Awards

CTSA Program Collaborative Innovation Awards (CCIA)

The funded projects reflect the CTSA Program goals and cover a broad spectrum of translational science, ranging from diagnostics and clinical trial design to patient-reported outcomes and community engagement.

Administrative Supplements 

The funded supplements reflect the CTSA Program goals and disseminate local innovations ranging from informatics, training and education of the translational science workforce, methods and processes, community engagement strategies, entrepreneurship, team science, clinical trial management and recruitment, regulatory guidance, to approaches to precision medicine.