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| 3248 | Application Information | Please note: The primary source of all information regarding PAR-22-167 is the FOA itself and any notices linked therein. Anticipated Announcement and Award Dates Summary Statement Release: applicants are expected to receive the summary statement via the eRA Commons approximately 30 days before the Advisory Council Review date. Please refer to Part 1 for dates for scientific merit review, advisory council review, and earliest start date. Other Submission Requirements and Information Post submission materials: applicants are required to follow the instructions for post-submission materials as described in the policy. Resubmission Please see the NIH Resubmission Applications guide. | ||||||||
| 3249 | RIC Frequently Asked Questions (RFA-TR-15-004) | What is the purpose of the CTSA Network Recruitment Innovation Centers (RICs) funding opportunity announcement (FOA)? Can a RIC application propose working with only a subset of CTSA hubs? Can RICs work with sites other than CTSA hubs? May the RICs provide additional support to CTSA hubs for local activities, for example, via subcontracts for participating as sites in CTSA data discovery? Can several investigators or institutions collaborate to develop and implement central RIC functions? Are small businesses or other for-profit organizations eligible to apply? What is the purpose of the CTSA Network Recruitment Innovation Centers (RICs) funding opportunity announcement (FOA)? The RICs FOA is one of a suite of recent CTSA FOAs intended to build CTSA network capacity. Working in concert with each other, the Trial Innovation Centers, and network liaisons at the CTSA hubs, RICs will provide recruitment capacity through data-driven site selection and innovative recruitment plans. Can a RIC application propose working with only a subset of CTSA hubs? No. RICs will be expected to eventually work with all the CTSA hubs. Applications that propose limiting RICs to a subset of CTSA hubs will not be considered responsive to this FOA. Can RICs work with sites other than CTSA hubs? Yes. The RICs may also work with other sites, for example, when studies in rare diseases need additional sites or when additional sites are preferred to ensure adequate inclusion of underrepresented populations in clinical research. RICs may also interface with sites involved in other networks, such as PCORnet. May the RICs provide additional support to CTSA hubs for local activities, for example, via subcontracts for participating as sites in CTSA data discovery? No. Can several investigators or institutions collaborate to develop and implement central RIC functions? Yes. If an application with multiple principal investigators (PIs) is envisioned, a multiple-PI plan must be included. Applicants considering this option are advised to discuss their plan with the NCATS scientific/program contact prior to submitting their application. Are small businesses or other for-profit organizations eligible to apply? Yes. The RICs FOA is broadly inclusive of eligible organizations. Be advised that a Resource Sharing Plan must be included in the application. A successfully funded grantee must abide by the terms and conditions of the award, including the Resource and Data Sharing Plans. Please see NIH Sharing Policies and Related Guidance on NIH-Funded Research Resources. | ||||||||
| 3130 | Phenotypic Drug Discovery Resource | Through a unique collaboration with Eli Lilly and Company’s Open Innovation Drug Discovery (OIDD) program, NCATS researchers accessed Lilly’s panel of human disease-relevant assays, which are cell-based testing systems that help scientists explore the effects of small molecules on disease-related molecular processes. The approach, called phenotypic drug discovery, involves searching for agents that change cell function and is a common method for lead discovery in drug development. Background The collaborative team screened part of the NCATS Pharmaceutical Collection (NPC), which includes 3,800 approved and investigational medicines, against the OIDD assay panel, which was offered through Lilly’s OIDD platform. The OIDD testing panel consisted of assays relevant to Lilly’s areas of focus, such as cardiovascular diseases, diabetes, cancer and endocrine disorders, and was designed to help researchers uncover new starting points for early drug discovery. Testing approved drugs in the OIDD assay panel broadens scientific knowledge of the biology of these compounds. Results from this effort may enable researchers to better predict treatment outcomes, design new drug combinations, and potentially reveal new uses for existing drugs, a time- and cost-saving approach called repurposing. Testing approved drugs in the OIDD assay panel broadens scientific knowledge of the biology of these compounds. Results from this effort may enable researchers to better predict treatment outcomes, design new drug combinations, and potentially reveal new uses for existing drugs, a time- and cost-saving approach called repurposing. Results from nearly 2,500 of the NPC compounds are available online. These experiments are described in detail in a paper published July 15, 2015, in PLOS One. Access the Data* Choose a data format: Processed CSV data files and individual assay datasets Raw data Data in the format of a Semantic Knowledge Network *Data files last updated January 2016. Download CSV Data Files and Sets Compound meta data (CSV - 294KB) (see field descriptions) Assay experiment results (CSV - 4MB) (see field descriptions) Access individual assay datasets via PubChem AID 1117321. Download Raw Data Well_level_data_10022014_with_pubchem_info (TXT - 13MB): This file contains experimental data for each individual plate well, normalized between 0 and 100 percent using negative and positive controls, respectively. For screening assays, it contains one row for each screening result (each unique combination of assay, compound, concentration and run date). For concentration-response assays, it contains 10 rows for each experiment (each unique combination of assay, compound and run date). The 10 concentrations analyzed as a dose-response experiment share a common value for the CALC_RESULT_ID field. Screening results do not have CALC_RESULT_ID defined because those results are not analyzed via dose-response curves. Curve_fit_results_10022014_with_pubchem_info (TXT - 684KB): This file contains the IC50 values created by fitting concentration response curve data from the file above. Users can align results from both files via the CALC_RESULT_ID field. Download OIDD Semantic Knowledge Network Data The OIDD Semantic Knowledge Network encodes the experimental relationship between NPC compounds and OIDD assays in a standardized format that can be exported into other databases and information sources. Similarly, it also encodes relationships between compounds and assays and among other experimental data, including ChEMBL dataset mapping and classification of assays using the bioassay ontology (BAO). Users can download Semantic Knowledge Network data represented as resource description format (RDF) and save in the Turtle (.ttl) format. The beta release of these files, which includes everything in the first table below, provides the default graph of a knowledge network and one Web ontology language (OWL) file comprising one BAO module. In addition to the OIDD phenotypic assay data, protein targets and bioactivity associations from the ChEMBL database are included to facilitate queries that integrate phenotypic and biochemical data. Semantic Knowledge Network data (ZIP - 2MB) File Name Type & Size Description bao_vocabulary_assay OWL - 96KB BAO module with bioassay class hierarchy chembl_activity TTL - 9MB ChEMBL activity associations on protein targets chembl_cco TTL - 60KB ChEMBL core ontology chembl_target TTL - 288KB ChEMBL protein targets npcpd2_assay TTL - 4KB Assay labels and links npcpd2_bao TTL - 7KB Manually curated BAO classifications npcpd2_substance TTL - 174KB Substance links pubchem_assay TTL - 9KB PubChem RDF, includes titles, measure group associations pubchem_endpoint TTL - 160KB PubChem RDF, includes endpoints, activity results pubchem_substance TTL - 8MB PubChem RDF, includes compound identifiers (PubChem CIDs), measure groups, assay identifiers (PubChem AIDs) pubchem_vocabulary OWL - 12KB PubChem module with bioactivity terms Field Descriptions for CSV Data Files Compound Meta Data Field Name Description OIDD_ID Unique substance identifier assigned by Eli Lilly OIDD on receipt of substance; identical to NCGC_ID NCGC_ID Unique substance identifier assigned by NCATS; identical to identifier used in the NPC PUBCHEM_SID PubChem substance identifier TRIVIAL NAME Trivial name of drug SMILES SMILES chemical structure representation, taken from PubChem PUBCHEM_CID PubChem parent compound identifier Assay Meta Data Field Name Description OIDD_ASSAY Unique assay identifier assigned by Eli Lilly OIDD NAME Name of the assay METHOD Broad category of assay type TECHNOLOGY Technology used to implement the assay PROJECT Primary therapeutic application for assay SUBPROJECT Therapeutic application subcategory CELL_LINE Short identifier of cell line used CELL_LINE_DESCRIPTION Description of cell line used ROLE Screen, Primary, Secondary, Confirmatory or Profiling RESULT_TYPE Type of screen: IC50, EC50, %STIM, %INH DESIRED_RESULT Whether a positive outcome for the assay is ACTIVE or INACTIVE SCREENING_THRESHOLD Cut-off for determining ACTIVE/INACTIVE (not applicable to profiling assays) Assay Result Meta Data Field Name Description OIDD_ASSAY Unique assay identifier assigned by Eli Lilly OIDD NCGC_ID Unique substance identifier assigned by NCATS; identical to identifier used in the NPC CONCENTRATION Drug concentration in uM (%stimulation and %inhibition assays only) RESULT_TYPE Type of screen: IC50, EC50, %STIM, %INH RESULT_PREFIX Prefix for RESULT indicating =, < or > specified value RESULT Assay result value (IC50, EC50, %stimulation, %inhibition) RESULT_UOM % or uM OUTCOME Assay outcome: ACTIVE or INACTIVE RUN_DATE Date the assay was performed TEST_TYPE Single-Point (SP) or Concentration-Response Curve (CRC) | ||||||||
| 3123 | Stopping Metastasis in Its Tracks: New 3-D Cell Model Enables Closer Look at Cancer Progression | For hundreds of years, scientists and physicians have struggled to fight cancer. In the past half-century, the technological advances of chemotherapy and radiation therapy have enabled doctors to shrink patients’ tumors, but all too often, the tumors return and spread to other organs by way of a deadly process called metastasis. Until scientists can better understand and model this disease process, a cure for cancer seems unlikely. This challenge inspired Ernst Lengyel, M.D., Ph.D., department chair and Arthur L. and Lee G. Herbst Professor of Obstetrics and Gynecology at the University of Chicago; and Hilary Kenny, Ph.D., an assistant professor in the department, to contact NCATS. Lengyel and Kenny’s team had developed a new way to study ovarian cancer metastasis and potential treatments using a 3-D model. Historically, scientists have developed disease models by growing cells in a single layer in a laboratory. This monolayer approach is easy to construct but does not represent the complexities of the human body. As a result, many compounds that seem effective in a monolayer culture on plastic do not pass animal and human studies for safety and effectiveness. To improve the odds of success, Lengyel and Kenny’s team constructed a 3-D model of ovarian cancer metastasis using cells from patients. The team needed to optimize the model for high-throughput screening, which would enable the researchers to test many different compounds at varied concentrations at a much higher rate than could be done manually. For this next step, Lengyel approached NCATS’ Ajit Jadhav via NIH’s Molecular Libraries Program and established a collaboration that also included NCATS scientists Marc Ferrer, Ph.D.; Madhu Lal-Nag, Ph.D.; Min Shen, Ph.D.; and Matt Boxer, Ph.D. The team worked together to create, adapt and validate an innovative 3-D cell model used to identify small molecules that can prevent cancer cells from spreading to new sites in the body. The new model includes connective tissue cells and the extracellular matrix (a collection of supportive molecules outside cells), creating a more lifelike simulation of the human body environment. It represents an exciting advance in research technology, and the high-throughput screening results, published in the Feb. 5, 2015, issue of Nature Communications, illustrate the power of this scientific collaboration. Getting to the Root of the Problem Metastasis is a three-step process. First, cells from the primary cancer site travel to a new area of the body. Next, the cells latch on to healthy cells. Finally, the cancer cells invade those healthy tissues. This process of cancer cell migration, adhesion and invasion — not the original tumor — is the root cause of many patient deaths. A drug that prevents one or more of these stages of metastasis could effectively stop this deadly process in its tracks. To advance toward this ultimate goal, the NCATS-University of Chicago team first adapted and miniaturized a 3-D ovarian cancer cell culture model so they could use it in the high-throughput robotic screening system at NCATS. Just a few of the 2,420 compounds screened in the assay (test), including one called beta-escin, demonstrated an ability to prevent all three metastatic stages both in vitro (in an artificial environment) and in vivo (in whole, living organisms). Beta-escin is a naturally occurring substance derived from the seed of the horse chestnut tree and is commonly used to improve chronic venous insufficiency, a condition in which veins cannot pump enough blood back to the heart. “Beta-escin was a very surprising finding,” Lengyel said. “You can buy it online. It is currently used to treat vein disease, and its anti-metastatic effect was unexpected.” Although beta-escin has promise, Lengyel explained that it has not yet been validated in human studies and should not be considered a cure. “It’s a promising lead to pursue,” he emphasized. Innovation in 3-D Modeling In addition to the encouraging findings from the compound screening, this collaborative project yielded another important advance: the cell culture model itself. The new 3-D model has many advantages over its monolayer 2-D predecessor, and the compounds identified using the new model are more likely to succeed in in vivo trials compared with compounds selected from 2-D screens. Unlike monolayer models, the 3-D approach can reproduce cellular and genetic tumor variations, complex tissue architecture, and interactions within the tumor microenvironment. “The 3-D model we developed is a more accurate representation of cancer cells in the human body compared to 2-D models,” Lal-Nag explained. “This approach improves our ability to find drug candidates that are more likely to be successful.” Very high magnification micrograph of an ovarian clear cell carcinoma. (Credit: http://bit.ly/1GXE2mc. Copyright: http://bit.ly/1fd019p) By replacing generic cell lines with actual cells from ovarian cancer patients, the researchers introduced an element of precision medicine into the model. This specialized technique is particularly important for cancer treatments, for which the effectiveness of drugs varies widely from patient to patient. A personalized approach could reduce guesswork and unnecessary treatments. “If we can take cells from patients and develop assays with those cells, the drugs we develop should work for that patient,” said Ferrer. Applications Beyond Cancer Although the team focused on ovarian cancer to demonstrate the power of the new 3-D model, this technology could advance translational research for diseases other than cancer. “It’s a general technology that translates to many different kinds of therapeutic approaches,” Jadhav said. The potential for the new model also extends beyond therapeutic development: Its rich environment may offer basic scientists a new way of studying the underlying mechanisms of cancer and its progression. “The idea of migration, adhesion and invasion is fundamental to biology,” Jadhav said. “This could become a research tool for studying metastasis at the basic science level.” The new model represents a different way of thinking about translational research. “Sometimes people think these type of assays are not possible,” Ferrer said. “I’m hoping this paper will change people’s minds — that the community will see this work and begin thinking beyond what’s usually done. We like it when people come to us with blue-sky ideas.” Broadening the Scope In the next phase of the project, the researchers will use the 3-D model to screen 400,000 additional compounds from another library. Validated compounds from this screen will be modified using medicinal chemistry to maximize strength and minimize toxicity before testing in animals. “We hope there will be categories of compounds that act by different mechanisms, giving us an opportunity to explore these different classes of compounds,” Jadhav said. This project exemplifies the power of collaboration for the benefit of scientists and patients alike. “That’s a common theme with NCATS projects,” Jadhav explained. “The passion that other investigators have for pursuing novel ideas is matched with the passion we have toward the same shared goal.” “This advance would not have been possible without NCATS,” Lengyel added. “You would think that working with the government would be difficult, but this was seamless and a lot of fun. We are honored to work with such great scientists.” Posted May 2015 | ||||||||
| 3094 | A Pharmacological and Toxicological Evaluation of the Gene Transfer Vectors sc-rAAV2.5IL-1Ra (Rat) and scr-AAV2.5IL-1Ra (Human) in Rats | Osteoarthritis is a disease of the joints in which the cartilage that normally covers the ends of the bones, reducing friction between them, wears thin. The result is pain and loss of motion or flexibility, which can become debilitating. Osteoarthritis is the most common form of arthritis, affecting more than 25 million Americans. Women are at greater risk for the disease than men. No cure is known for osteoarthritis, but treatments exist for the pain. These scientists are developing a gene therapy for osteoarthritis, which will be injected into the affected joint. The resulting gene product works by blocking an inflammatory agent that contributes to the deterioration of the cartilage. This can allow the cartilage to heal, restoring function in the joint. Scientific Synopsis The services requested in this application form part of the development of a Phase I clinical trial in the gene therapy of osteoarthritis (OA) and are needed to support an Investigational New Drug (IND) application. The proposed clinical trial is based upon a considerable body of prior research by the PI and other key personnel in which they have developed technologies permitting gene transfer to joints in a manner that gives persistent intraarticular transgene expression. They have demonstrated an anti-arthritic effect in animal models when interleukin-1 receptor antagonist (IL-1Ra) is used as the transgene. Based on this, they have developed a clinical protocol in which a self-complementing, recombinant adeno-associated virus (AAV) vector, serotype 2.5, carrying human IL-1Ra cDNA (sc-rAAV2.5IL-1Ra) will be injected into the knee joints of human subjects with mid-stage OA. A detailed description of this protocol was submitted to the Food and Drug Administration (FDA) as part of pre-Investigational New Drug (IND) discussions. After several conference calls and exchange of information, the FDA gave a clear statement of what further preclinical studies are required before going forward with an IND application. This application requests resources to carry out the studies required by the FDA. Lead Collaborators Mayo Clinic, Rochester, Minnesota Christopher Evans, Ph.D. University of Florida, Gainesville, Florida Steven Ghivizzani, Ph.D. University of North Carolina at Chapel Hill Richard Samulski, Ph.D. University of Pittsburgh Paul Robbins, Ph.D. Public Health Impact Osteoarthritis is common, debilitating, costly and incurable. Because there is no effective treatment, it severely reduces the quality of life of millions of Americans. Gene therapy offers a novel approach to the treatment of osteoarthritis, and this proposal seeks services that are necessary before a human trial can begin. Outcomes Work on this project is complete. The investigators used BrIDGs data to file an IND application that was cleared by the FDA. Project Details Pharmacokinetic/absorption, distribution, metabolism, and excretion (PK/ADME) studies IND-directed toxicology Publication Safety and Biodistribution Assessment of sc-rAAV2.5IL-1Ra Administered via Intra-articular Injection in a Mono-iodoacetate-induced Osteoarthritis Rat Model • Molecular Therapy — Methods & Clinical Development • Jan. 13, 2016 | ||||||||
| 3024 | Work with Strategic Alliances | The NCATS Office of Strategic Alliances aims to make it easy for industry and academia to interact and partner with NCATS laboratories and scientists to speed the translation of basic science knowledge into treatments for patients. The team provides a complete array of services to support NCATS technology development and collaborative activities, including negotiation of standard forms and model agreements between NCATS and outside parties, such as universities and biopharmaceutical companies. Strategic Alliances staff also supports and manages licensing opportunities for inventions created by NCATS staff that are available to commercial partners for continued development. Opportunities for collaboration commonly take one of two forms: Open solicitations, including small business awards, collaborative research and development agreements, and program-specific opportunities. Invited collaborations to tap specific NCATS expertise or resources, such as high-throughput screening or small molecule probe development. Interested in forming a new partnership or collaboration with NCATS to improve translational research? Contact NCATSPartnerships@mail.nih.gov to get started. | ||||||||
| 3017 | New Funding Opportunities for Trial and Recruitment Innovation Centers | On May 15 and June 5, 2015, NCATS released two new Clinical and Translational Science Awards (CTSA) program funding opportunity announcements (FOAs), one for Recruitment Innovation Centers (RICs) and the other for Trial Innovation Centers (TICs). Both are aimed at overcoming key roadblocks to multisite clinical trials. CTSA hubs form a national network of medical research institutions that work together to improve the translational research process.Conducting multisite clinical research in the United States often is associated with implementation delays and high costs. This is due in part to long-standing challenges, such as historically low trial participant recruitment; complexity of obtaining approval of a single protocol by multiple institutional review boards; and few standards for executing research contracts, qualifying clinical sites and initiating study start-up procedures.“Through these new FOAs, NCATS is addressing systemic problems in translation and contributing to a collaborative national network for translational medicine,” said NCATS Director Christopher P. Austin, M.D. “These improvements are aimed at dramatically accelerating the clinical translational process and getting more treatments to more patients more quickly.”CTSA hubs collaborate to support high-quality clinical and translational research locally, regionally and nationally, fostering innovation in training, patient involvement and new methodologies. The CTSA program RICs (RFA-TR-15-004) and TICs (RFA-TR-15-002) will transform multisite clinical research by reducing delays in trial start-up, accelerating participant recruitment and standardizing certain business processes across the CTSA hubs.RIC applications are due July 22, 2015, and letters of intent are due on June 22, 2015. TIC applications are due Sept. 15, 2015, with letters of intent due on Aug. 15, 2015.“Efficient implementation of multisite clinical trials is crucial for successful translation of fundamental discoveries into patient benefit,” said Petra Kaufmann, M.D., M.Sc., NCATS director of clinical innovation. “These FOAs will not only enhance the overall conduct of clinical trials, but also help increase participation by underrepresented populations in clinical research, such as children, the elderly and minority populations.”TICs will serve as lead centers of excellence to facilitate multisite clinical trial implementation within the CTSA network. The primary objective of the TICs is to develop, demonstrate and disseminate innovative ways to increase the quality and efficiency of multisite clinical research. TICs will explore innovative approaches in streamlining trial implementation, promoting high-quality multisite trials and disseminating best practices. With these seven-year awards, NCATS anticipates spending $12 million in fiscal year (FY) 2016 to fund three TICs in response to the FOA, depending on the availability of funds. The National Institute on Aging will co-fund the TICs.The purpose of the RICs is to increase the likelihood of success for multisite clinical trials in two ways: (1) by developing informatics-driven approaches to assessing the site-specific availability of potential participants during trial planning and (2) by developing innovative approaches to participant recruitment during trial implementation. For these five-year awards, NCATS plans to fund up to two RICs in FY 2016 with up to $3 million each in total costs. The two RIC centers will work together with individual CTSA hubs to ensure that informatics approaches used to conduct feasibility assessments accurately reflect the local electronic health record environment, and that the collaboratively developed recruitment strategies are well-aligned with the local CTSA ethical and regulatory environment. The National Library of Medicine will co-fund the RICs.In developing the FOAs, NCATS carefully considered input about the CTSA program from the Institute of Medicine, a working group of the NCATS Advisory Council (PDF - 414KB), CTSA investigators, patient groups, other NIH Institutes and Centers, biotechnology and pharmaceutical development organizations, regulatory agencies, and the broader clinical and translational research community.Learn more by visiting the CTSA Funding Information page.Posted June 2015 | ||||||||
| 3016 | News Brief: Allergy Drug Could Treat Hepatitis C | A new drug can take about 14 years and $1 billion to develop. As one way to help speed the development of new disease therapies, rather than starting from scratch, NCATS researchers test existing medicines for their potential to treat other diseases. Recently, NCATS scientists, in collaboration with researchers from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), discovered that an over-the-counter drug used to treat allergy symptoms also limited hepatitis C virus (HCV) infection in human liver cells. The findings suggest that the drug, chlorcyclizine HCl (CCZ), potentially could be used to treat this chronic infection in people. Results were published April 8, 2015, in Science Translational Medicine. An estimated 185 million people worldwide suffer from HCV infection. It causes liver inflammation and often leads to serious complications such as cirrhosis, which can be fatal. Early diagnosis and treatment of HCV infection can prevent liver damage. The NCATS researchers (see sidebar) collaborated with NIDDK’s Jake Liang, M.D., in using the Center’s high-throughput screening capabilities to look for compounds that blocked viral activity in HCV-infected human liver cells. The team tested the NCATS Pharmaceutical Collection, a library containing approved and investigational drugs, and identified CCZ, an antihistamine, as a promising candidate that appeared to limit the early stages of HCV infection. The effect was enhanced when the researchers combined CCZ with existing HCV drugs, suggesting CCZ could be an effective add-on to current treatments. Next, the team gave CCZ to HCV-infected mice and found that the compound significantly reduced viral infection. The treated mice showed no signs of drug resistance, a common problem among existing HCV therapies. The study results suggest CCZ, with its well-established safety profile as an allergy drug, could be a more broadly accessible treatment for HCV infection. Scientists still have much to learn from approved drugs and their untapped potential to help researchers understand basic biology and develop treatments for unmet medical needs. In addition to HCV, other NCATS repurposing screens have identified potential drug candidates for a variety of illnesses, from blocking Ebola virus infection to reversing multiple sclerosis. The study in mice provided data that validated chlorcyclizine’s activity. Based on the results, the team worked through the Food and Drug Administration to quickly move this discovery from the lab to testing of CCZ in patients with HCV infection at the NIH Clinical Center. Posted April 2015 | ||||||||
| 2989 | Scientific Publications 2012 | December 2012 VEGF-C, VEGF-A and Related Angiogenesis Factors as Biomarkers of Allograft Vasculopathy in Cardiac Transplant Recipients • Journal of Heart and Lung Transplantation • December 26, 2012 • CTSA Use and Accuracy of Diagnostic Imaging by Hospital Type in Pediatric Appendicitis • Pediatrics • December 24, 2012 • CTSA Risk-Based Input-Output Analysis of Influenza Epidemic Consequences on Interdependent Workforce Sectors • Risk Analysis • December 24, 2012 • CTSA Incidence and Time Trends of Herpes Zoster (Shingles) in Rheumatoid Arthritis: A Population-Based Cohort Study • Arthritis Care & Research • December 21, 2012 • CTSA Urine Proteomics for Discovery of Improved Diagnostic Markers of Kawasaki Disease • EMBO Molecular Medicine • December 20, 2012 • CTSA Collaborating Functions of BLM and DNA Topoisomerase I in Regulating Human rDNA Transcription • Mutation Research • December 19, 2012 • CTSA Human Papillomavirus DNA is Rarely Detected in Colorectal Carcinomas and Not Associated with Microsatellite Instability: The Seattle Colon Cancer Family Registry • Cancer Epidemiology, Biomarkers & Prevention • December 18, 2012 • CTSA High-Performance Neuroprosthetic Control by an Individual with Tetraplegia • The Lancet • December 17, 2012 • CTSA Hypoglycemia, With or Without Insulin Therapy, Is Associated With Increased Mortality Among Hospitalized Patients • Diabetes Care • December 17, 2012 • CTSA A Bench-Level Control for Sequence-Specific siRNA Off-Target Eeffects • PLoS One • December 14, 2012 • NCGC Subjective Response to Alcohol among Alcohol-Dependent Individuals: Effects of the Mu-Opioid Receptor (OPRM1) Gene and Alcoholism Severity • Alcoholism: Clinical & Experimental Research • December 14, 2012 • CTSA Targeting High-Density Lipoproteins in the Prevention of Cardiovascular Disease? • Current Cardiology Reports • December 14, 2012 • CTSA Progression of Prehypertension to Hypertension in Adolescents • Current Hypertension Reports • December 14, 2012 • CTSA A New Model for Environmental Assessment and Exposure Reduction •Current Allergy and Asthma Reports • December 12, 2012 • CTSA Neural Network Activation During a Stop-Signal Task Discriminates Cocaine-Dependent from Non-Drug-Abusing Men • Addiction Biology • December 12, 2012 • CTSA Report on CTSA Consortium Use of the Community Engagement Consulting Service • Clinical and Translational Science • December 06, 2012 • CTSA Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors • ACS Medical Chemistry Letters • December 06, 2012 • NCGC Efficacies of Sodium Hypochlorite and Quaternary Ammonium Sanitizers for Reduction of Norovirus and Selected Bacteria during Ware-Washing Operations • PloS ONE • December 05, 2012 • CTSA Chronic Caloric Restriction Preserves Mitochondrial Function in Senescence without Increasing Mitochondrial Biogenesis • Cell Metabolism• December 05, 2012 • CTSA A Comparison of the Ability of Rilpivirine (TMC278) and Selected Analogues to Inhibit Clinically Relevant HIV-1 Reverse Transcriptase Mutants • Retrovirology • December 05, 2012 • NCGC Drug Resistance and Pseudoresistance: A Unintended Consequence of Enteric Coating Aspirin • Circulation • December 04, 2012 • CTSA Longitudinal Impact of Substance Use and Depressive Symptoms on Bone Accrual among Girls Aged 11-19 Years • Journal of Adolescent Health • December 04, 2012 • CTSA Fetal Heart Rate Predictors of Long QT Syndrome • Circulation • December 04, 2012 • CTSA Outcomes in Patients Tested for Clostridium Difficile Toxins • Diagnostic Microbiology and Infectious Disease • December 01, 2012 • CTSA A Population-Based Study of the Risk of Repeat Clinical Chorioamnionitis in Washington State, 1989 – 2008 • American Journal of Obstetrics and Gynecology • December 01, 2012 • CTSA November 2012 Tadalafil Alleviates Muscle Ischemia in Patients with Becker Muscular Dystrophy (PDF - 1MB)• Science Translational Medicine • November 29, 2012 • CTSA High-Throughput Screen Identifies Cyclic Nucleotide Analogs That Inhibit Prostatic Acid Phosphatase • Journal of Biomolecular Screening • November 27, 2012 • NCGC Gastric Bypass and Banding Equally Improve Insulin Sensitivity and β Cell Function • Journal of Clinical Investigation • November 26, 2012 • CTSA Simvastatin Inhibits Smoke-Induced Airway Epithelial Injury: Implications for COPD Therapy • European Respiratory Journal • November 22, 2012 • CTSA Comparison of Healthcare Experiences in Autistic and Non-Autistic Adults: A Cross-Sectional Online Survey Facilitated by an Academic-Community Partnership • Journal of General Internal Medicine • November 21, 2012 • CTSA Mentoring Translational Science Investigators • JAMA • November 21, 2012 • CTSA Prevalence of Fibromyalgia: A Population-based Study in Olmsted County, Minnesota, Utilizing the Rochester Epidemiology Project • Arthritis Care & Research • November 20, 2012 • CTSA When Physicians Counsel About Stress: Results of a National Study •Archives of Internal Medicine • November 19, 2012 • CTSA NIH TRND Program: Successes in Preclinical Therapeutic Development •Trends in Pharmacological Science • November 19, 2012 • TRND δ-Tocopherol Reduces Lipid Accumulation in Niemann-Pick Type C1 and Wolman Cholesterol Storage Disorders • The Journal of Biological Chemistry • November 16, 2012 • NCGC Robust Photoregulation of GABA(A) Receptors by Allosteric Modulation with a Propofol Analogue • Nature Communications • November 14, 2012 • CTSA Cigarette Warning Label Policy Alternatives and Smoking-Related Health Disparities • American Journal of Preventative Medicine • November 13, 2012 • CTSA Routine Bimanual Pelvic Examinations: Practices and Beliefs of US Obstetrician-Gynecologists • American Journal of Obstetrics & Gynecology• November 12, 2012 • CTSA Obesity in Mice with Adipocyte-Specific Deletion of Clock Component Arntl • Nature Medicine • November 11, 2012 • CTSA Vitamin D Suppression of Endoplasmic Reticulum Stress Promotes an Antiatherogenic Monoctye/Macrophage Phenotype in Type 2 Diabetic Patients • The Journal of Biological Chemistry • November 09, 2012 • CTSA Epidemiology of United States High School Sports-Related Fractures, 2008-09 to 2010-11 • The American Journal of Sports Medicine • November 09, 2012 • CTSA A Class of Tricyclic Compounds Blocking Malaria Oocyst Development and Transmission • Antimicrobial Agents and Chemotherapy • November 05, 2012 • NCGC A High-Throughput Screening Assay using Krabbe Disease Patient Cells •Analytical Biochemistry • November 05, 2012 • NCGC Efficacy and Safety of a Microsomal Triglyceride Transfer Protein Inhibitor in Patients With Homozygous Familial Hypercholesterolaemia: A Single-Arm, Open-Label, Phase 3 Study • The Lancet • November 02, 2012 • CTSA A Randomized Trial of Home Versus Clinic-Based Sexually Transmitted Disease Screening among Men • Sexually Transmitted Diseases • November 01, 2012 • CTSA Comparative Perioperative Outcomes Associated With Neuraxial Versus General Anesthesia for Simultaneous Bilateral Total Knee Arthroplasty • Regional Anesthesia and Pain Medicine • November 01, 2012 • CTSA Intranasal Hydrocodone-Acetaminophen Abuse Induced Necrosis of the Nasal Cavity and Pharynx • The Laryngoscope • November 01, 2012 • CTSA October 2012 Genes and Environment: Novel, Functional Polymorphism in the Human Cathepsin L (CTSL1) Promoter Disrupts a Xenobiotic Response Element (XRE) to Alter Transcription and Blood Pressure • Journal of Hypertension • October 30, 2012 • CTSA Can Intellectual Property Save Drug Development? • Science • October 26, 2012 • CTSA A Survey of Quantitative Descriptions of Molecular Structure • Current Topics in Medicinal Chemistry • October 25, 2012 • NCGC Diverse Small Molecule Inhibitors of Human Apurinic/Apyrimidinic Endonuclease APE1 Identified from a Screen of a Large Public Collection •PLoS One • October 23, 2012 • NCGC Identification of Novel Activators of Constitutive Active/Androstane Receptor (CAR) from FDA-Approved Drugs by Integrated Computational and Biological Approaches • Pharmaceutical Research • October 23, 2012 • NCGC The CTSA as an Exemplar Framework for Developing Multidisciplinary Translational Teams • Clinical and Translational Science • October 17, 2012 • CTSA Pseudoephedrine Sales and Seizures of Clandestine Methamphetamine Laboratories in Kentucky • JAMA • October 17, 2012 • CTSA Clinical Implications of Human Population Differences in Genome-Wide Rates of Functional Genotypes • Frontiers in Applied Genetic Epidemiology • October 17, 2012 • CTSA Leaders of NIH Program Hope to Spur New Drug Therapy Development • Clinical and Translational Science • October 16, 2012 • CTSA Comparison of Novel MLB-Clade, VA-Clade and Classic Human Astroviruses Highlights Constrained Evolution of the Classic Human Astrovirus Nonstructural Genes • Virology • October 16, 2012 • CTSA Development of a Research Participants’ Perception Survey to Improve Clinical Research • Clinical and Translational Science • October 15, 2012 • CTSA Posttraumatic Stress Disorder and Adherence to Medications in Survivors of Strokes and Transient Ischemic Attacks • Stroke • October 12, 2012 • CTSA A Call for Transparent Reporting to Optimize the Predicitive Value of Preclinical Research • Nature • October 12, 2012 • NCGC Effects of Gastric Bypass Surgery on Female Reproductive Function • Journal of Clinical Epidemiology & Metabolism • October 12, 2012 • CTSA Can Increases in the Cigarette Tax Rate be Linked to Cigarette Retail Prices? Solving Mysteries Related to the Cigarette Pricing Mechanisms in China • Tobacco Control • October 07, 2012 • CTSA Mexiletine for Symptoms and Signs of Myotonia in Nondystrophic Myotonia • JAMA • October 03, 2012 • CTSA Where is Obesity Prevention on the Map?: Distribution and Predictors of Local Health Department Prevention Activities in Relation to County-Level Obesity Prevalence in the United States • Journal of Public Health Management and Practice • October 01, 2012 • CTSA Measuring the Impact of Practice-based Research Networks (PBRNs) •Journal of the American Board of Family Medicine • October 01, 2012 • CTSA A Coincidence Reporter-Gene System for High-Throughput Screening •Nature Methods • October 01, 2012 • NCGC Clinical and Translational Scientist Career Success: Metrics for Evaluation • Clinical and Translational Science • October 01, 2012 • CTSA Training NIH K Award Recipients: The Role of the Mentor • Clinical and Translational Science • October 01, 2012 • CTSA Translation to Practice of an Intervention to Promote Colorectal Cancer Screening Among African Americans • Clinical and Translational Science • October 01, 2012 • CTSA Drug Repurposing • Chemical and Engineering News • October 01, 2012 • New Therapeutic Uses September 2012 A Randomized Trial of Sugar-Sweetened Beverages and Adolescent Body Weight • The New England Journal of Medicine • September 21, 2012 • CTSA Adverse Prognostic Impact of Intratumor Heterogeneous HER2 Gene Amplification in Patients with Esophageal Adenocarcinoma • Journal of Clinical Oncology • September 17, 2012 • CTSA Wolfram Syndrome 1 and Adenylyl cyclase 8 Interact at the Plasma Membrane to Regulate Insulin Production and Secretion • Nature Cell Biology • September 16, 2012 • CTSA Androgen Receptor on the Move: Boarding the Microtubule Expressway to the Nucleus • Cancer Research • September 15, 2012 • CTSA Comparison of Physician-, Biomarker-, and Symptom-Based Strategies for Adjustment of Inhaled Corticosteroid Therapy in Adults With Asthma: The BASALT Randomized Controlled Trial • JAMA • September 12, 2012 • CTSA Tight Glycemic Control versus Standard Care after Pediatric Cardiac Surgery • The New England Journal of Medicine • September 07, 2012 • CTSA The Short-Term Effects of Vitamin D Repletion on Cholesterol: A Randomized, Placebo-Controlled Trial • Arteriosclerosis, Thrombosis, and Vascular Biology • September 04, 2012 • CTSA Obesity and Metabolic Syndrome and Functional and Structural Brain Impairments in Adolescence • Pediatrics • September 03, 2012 • CTSA Emtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with Men. • Science Translational Medicine• September 01, 2012 • CTSA Research Subject Advocacy: Program Implementation and Evaluation at Clinical and Translational Science Award Centers • Academic Medicine • September 01, 2012 • CTSA Local Polynomial Regression for Symmetric Positive Definite Matrices •Journal of the Royal Statistical Society • September 01, 2012 • CTSA Differential Diagnosis of Jakob-Creutzfeldt Disease • Archives of Neurology • September 01, 2012 • CTSA August 2012 The Relationship between Level of Training and Accuracy of Violence Risk Assessment • Psychiatric Services • August 31, 2012 • CTSA Autocrine Function of Aldehyde Dehydrogenase 1 as a Determinant of Diet- and Sex-Specific Differences in Visceral Adiposity • Diabetes • August 28, 2012 • CTSA Pyruvate Kinase M2 Activators Promote Tetramer Formation and Suppress Tumorigenesis • Nature Chemical Biology • August 26, 2012 • Tox21 Evaluation of Cholesterol Reduction Activity of Methyl-β-cyclodextrin Using Differentiated Human Neurons and Astrocytes • Journal of Biomolecular Screening • August 24, 2012 • NCGC Firefly Luciferase in Chemical Biology: A Compendium of Inhibitors, Mechanistic Evaluation of Chemotypes, and Suggested Use As a Reporter •Chemistry and Biology • August 24, 2012 • NCGC Antibiotics in Early Life Alter the Murine Colonic Microbiome and Adiposity • Nature • August 22, 2012 • CTSA Identification of Benzodiazepine Ro5-3335 as an Inhibitor of CBF Leukemia through Quantitative High-Throughput Screen Against RUNX1-CBFβ Interaction • Proceedings of the National Academies of Sciences • August 21, 2012 • NCGC Racial Variation in the Quality of Surgical Care for Prostate Cancer •The Journal of Urology • August 17, 2012 • CTSA Cognitive Impairment in Persons with Rheumatoid Arthritis • Arthritis Care & Research • August 01, 2012 • CTSA Abnormal Tibiofemoral Kinematics Following ACL Reconstruction are Associated with Early Cartilage Matrix Degeneration Measured by MRI T1rho • Knee • August 01, 2012 • CTSA Profiling Environmental Chemicals for Activity in the Antioxidant Response Element Signaling Pathway Using a High-Throughput Screening Approach • Environmental Health Perspectives • August 01, 2012 • Tox21 A Controlled Trial of the Adjunct Use of D-cycloserine to Facilitate Cognitive Behavioral Therapy Outcomes in a Cocaine-Dependent Population • Addictive Behaviors • August 01, 2012 • CTSA Effect of Diet and Exercise, Alone or Combined, on Weight and Body Composition in Overweight-to-Obese Postmenopausal Women • Obesity • August 01, 2012 • CTSA Impact of Transarterial Therapy in Hepatitis C-Related Hepatocellular Carcinoma on Long-Term Outcomes after Liver Transplantation •American Journal of Clinical Oncology • August 01, 2012 • CTSA Clinical and Translational Research Studios: A Multidisciplinary Internal Support Program • Academic Medicine • August 01, 2012 • CTSA Depressive Symptoms in Spouses of Older Patients with Severe Sepsis •Critical Care Medicine • August 01, 2012 • CTSA The Prolonged Survival of Fibroblasts with Forced Lipid Catabolism in Visceral Fat following Encapsulation in alginate-poly-L-lysine •Biomaterials • August 01, 2012 • CTSA Randomized Trial of Behavior Therapy for Adults With Tourette Syndrome• Archives of General Psychiatry • August 01, 2012 • CTSA July 2012 Exome Sequencing Identifies Recurrent Somatic RAC1 Mutations in Melanoma • Nature Genetics • July 29, 2012 • CTSA Association of Noninvasively Measured Renal Protein Biomarkers with Histologic Feature of Lupus Nephritis • Arthritis & Rheumatism • July 27, 2012 • CTSA Risk of Cervical Precancer and Cancer Among HIV-Infected Women With Normal Cervical Cytology and No Evidence of Oncogenic HPV Infection •Journal of the American Medical Association • July 25, 2012 • CTSA Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein- 4, and gamma-glutamyl transferase activity in overweight/obese humans • Nutrition & Metabolism • July 24, 2012 • CTSA Targeting Iron Assimilation to Develop New Antibacterials • Expert Opinion on Drug Discovery • July 19, 2012 • NCGC Effect of Silymarin (Milk Thistle) on Liver Disease in Patients with Chronic Hepatitis C Unsuccessfully Treated With Interferon Therapy • Journal of the American Medical Association • July 18, 2012 • CTSA Stimulation of Host Bone Marrow Stromal Cells by Sympathetic Nerves Promotes Breast Cancer Bone Metastasis in Mice • PLoS Biology • July 17, 2012 • CTSA Patient-reported impact of symptoms in myotonic dystrophy type 1 (PRISM-1) • Neurology • July 11, 2012 • CTSA Multiple Myeloma–Associated Chromosomal Translocation Activates Orphan snorna ACA11 to Suppress Oxidative Stress • Journal of Clinical Investigation • July 02, 2012 • CTSA Feasibility and Compliance with Daily Home Electrocardiogram Monitoring of the QT Interval in Heart Transplant Recipients • Heart & Lung: The Journal of Acute and Critical Care • July 01, 2012 • CTSA June 2012 TRND Navigates the Fragmented Landscape of Rare Diseases • Chemistry & Biology • June 21, 2012 • TRND Posttraumatic Stress Disorder Prevalence and Risk of Recurrence in Acute Coronary Syndrome Patients: A Meta-Analytic Review • PLoS One • June 20, 2012 • CTSA A High-Throughput Sphingomyelinase Assay Using Natural Substrate •Analytical and Bioanalytical Chemistry • June 19, 2012 • NCGC A Clinical Trial to Maintain Glycemic Control in Youth with Type 2 Diabetes • The New England Journal of Medicine • June 14, 2012 • CTSA Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma • Cancer Cell • June 12, 2012 • NCGC Neuregulin 1-ErbB4-PI3K Signaling in Schizophrenia and Phosphoinositide 3-kinase- p110δ Inhibition as a Potential Therapeutic Strategy •Proceedings of the National Academy of Sciences • June 11, 2012 • NCGC Plasma and Tissue Concentrations of α-Tocopherol and δ-Tocopherol Following High Dose Dietary Supplementation in Mice • Nutrients • June 07, 2012 • NCGC Preliminary Competencies for Comparative Effectiveness Research •CTS: Clinical and Translational Science • June 01, 2012 • CTSA In Vivo Imaging of Endogenous Pancreatic β-Cell Mass in Healthy and Type 1 Diabetic Subjects Using18F-Fluoropropyl-Dihydrotetrabenazine and PET• Journal of Nuclear Medicine • June 01, 2012 • CTSA May 2012 Discovery, Structure–Activity Relationship, and Biological Evaluation of Noninhibitory Small Molecule Chaperones of Glucocerebrosidase •American Chemical Society Journal of Medicinal Chemistry • May 30, 2012 • NCGC siRNA Off-Target Effects in Genome-Wide Screens Identify Signaling Pathway Members • Nature Scientific Reports • May 29, 2012 • NCGC BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures • Neuron • May 24, 2012 • CTSA Oxadiazole 2-Oxides are Toxic to the Human Hookworm, Ancylostoma Ceylanicum; However, Glutathione Reductase Is Not the Primary Target •International Journal for Parasitology: Drugs and Drug Resistance • May 18, 2012 • NCGC Impact of Pediatric Epilepsy on Sleep Patterns and Behaviors in Children and Parents • Epilepsia • May 17, 2012 • CTSA Anticancer PAD Inhibitors Regulate the Autophagy Flux and the Mammalian Target of Rapamycin Complex 1 Activity • Journal of Biological Chemistry • May 17, 2012 • CTSA A Genome-Wide siRNA Screen to Identify Modulators of Insulin Sensitivity and Gluconeogenesis • PLoS One • May 09, 2012 • NCGC Cardiac Angiogenic Imbalance Leads to Peripartum Cardiomyopathy •Nature • May 09, 2012 • CTSA Researchers’ Needs for Resource Discovery and Collaboration Tools: A Qualitative Investigation of Translational Scientists • Journal of Medical Internet Research • May 06, 2012 • CTSA Divergent Transcriptional Programming of Class-Specific B Cell Memory by T-bet and RORα • Nature Immunology • May 06, 2012 • CTSA April 2012 Differential Scanning Fluorometry Signatures as Indicators of Enzyme Inhibitor Mode of Action: Case Study of Glutathione S-Transferase • PLoS One • April 30, 2012 • NCGC Exploring Structure-Activity Data Using the Landscape Paradigm • Wiley Interdisciplinary Reviews: Computational Molecular Science • April 24, 2012 • NCGC Distinct Neuropsychological Subgroups in Typically Developing Youth Inform Heterogeneity in Children with ADHD • Proceedings of the National Academy of Sciences • April 24, 2012 • CTSA Rationally Engineered Nanoparticles Target Multiple Myeloma Cells, Overcome Cell-Adhesion-Mediated Drug Resistance, and Show Enhanced Efficacy In Vivo • Blood Cancer Journal • April 20, 2012 • CTSA Blood-Derived Human iPS Cells Generate Optic Vesicle-Like Structures with the Capacity to Form Retinal Laminae and Develop Synapses •Investigative Ophthalmology and Visual Science • April 18, 2012 • CTSA Genome-Wide Meta-Analysis Identifies 56 Bone Mineral Density Loci and Reveals 14 Loci Associated with Risk of Fracture • Nature Genetics • April 15, 2012 • CTSA Adherence to Colorectal Cancer Screening: A Randomized Clinical Trial of Competing Strategies • Archives of Internal Medicine • April 09, 2012 • CTSA Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study • American Journal of Human Genetics • April 06, 2012 • CTSA High-Throughput Screening for Genes that Prevent Excess DNA Replication in Human Cells and for Molecules that Inhibit Them • Methods • April 05, 2012 • NCGC Invited Response to: Preparedness of the CTSA’s Structural and Scientific Assets to Support the Mission of the National Center for Advancing Translational Sciences (NCATS) • CTS: Clinical and Translational Science • April 04, 2012 • CTSA Niacin and Biosynthesis of PGD2 by Platelet COX-1 in Mice and Humans •Journal of Clinical Investigation • April 02, 2012 • CTSA Comparison of the Effect on Long-Term Outcomes in Patients with Thoracic Aortic Aneurysms of Taking versus Not Taking a Statin Drug •American Journal of Cardiology • April 01, 2012 • CTSA March 2012 Biological Evaluation and Structure-Activity Relationships of a Novel Class of Apurinic/Apyrimidinic Endonuclease 1 Inhibitors • Journal of Medicinal Chemistry • March 28, 2012 • NCGC Out-of-Hospital Administration of& Intravenous Glucose-Insulin-Potassium in Patients With Suspected Acute Coronary Syndromes: The IMMEDIATE Randomized Controlled Trial • JAMA • March 27, 2012 • CTSA Therapeutic Hemoglobin Levels after Gene Transfer in β-Thalassemia Mice and in Hematopoietic Cells of β-Thalassemia and Sickle Cells Disease Patients • PLoS One • March 27, 2012 • CTSA Impact of Transcendental Meditation on Left Ventricular Mass in African American Adolescents • Nature Chemical Biology • March 25, 2012 • CTSA Rapid and Orthogonal logic Gating with a Gibberellin-induced Dimerization System • Nature Chemical Biology • March 23, 2012 • CTSA Clonal Architecture of Secondary Acute Myeloid Leukemia • The New England Journal of Medicine • March 22, 2012 • CTSA Leukocytes Are Recruited through the Bronchial Circulation to the Lung in a Spontaneously Hypertensive Rat Model of COPD • PLoS One • March 21, 2012 • CTSA Characterization of Circulating Endothelial Cells in Acute Myocardial Infarction • Science Translational Medicine • March 21, 2012 • CTSA Prostaglandin d2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia • Science Translational Medicine • March 21, 2012 • CTSA Application of a Homogenous Membrane Potential Assay to Assess Mitochondrial Function • Physiological Genomics • March 20, 2012 • NCGC Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection in Primary CD4+ T Cells • PLoS One • March 20, 2012 • CTSA High-Throughput Genotoxicity Assay Identifies Antioxidants as Inducers of DNA Damage Response and Cell Death • Proceedings of the National Academy of Sciences • March 19, 2012 • NCGC Detection of "Oncometabolite" 2-Hydroxyglutarate by Magnetic Resonance Analysis as a Biomarker of IDH1/2 Mutations in Glioma • Journal of Molecular Medicine • March 17, 2012 • CTSA Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale • The New England Journal of Medicine • March 15, 2012 • CTSA Structure-Guided Design of a High Affinity Platelet Integrin αIIbβ3 Receptor Antagonist That Displaces Mg2+ from the β3 MIDAS • Science Translational Medicine • March 14, 2012 • NCGC Effect of Testosterone Supplementation with and without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men with Suppressed Testosterone Production: A Randomized Controlled Trial • JAMA • March 07, 2012 • CTSA The Effect of Gastric Bypass on the Pharmacokinetics of Serotonin Reuptake Inhibitors • American Journal of Psychiatry • March 01, 2012 • CTSA Understanding Barriers to and Facilitators of Diabetes Control and Prevention in the New York City Bangladeshi Community: A Mixed-Methods Approach • American Journal of Public Health • March 01, 2012 • CTSA Variant in the Glucokinase Regulatory Protein (GCKR) Gene Is Associated with Fatty Liver in Obese Children and Adolescents • Hepatology • March 01, 2012 • CTSA February 2012 Prevention of Pneumococcal Infection with Vaccines: An Evolving Story •JAMA • February 22, 2012 • CTSA Identification of Mammalian Protein Quality Control Factors by High-Throughput Cellular Imaging • PLoS One • February 20, 2012 • NCGC AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness • Science Translational Medicine • February 08, 2012 • CTSA Methylphenidate and Risk of Serious Cardiovascular Events in Adults •American Journal of Psychiatry • February 01, 2012 • CTSA Pattern Classification of Volitional Functional Magnetic Resonance Imaging Responses in Patients with Severe Brain Injury • Archives of Neurology • February 01, 2012 • CTSA Genetic Variants and Environmental Factors Associated with Hormonal Markers of Ovarian Reserve in Caucasian and African American Women •Human Reproduction • February 01, 2012 • CTSA Effects of Risperidone and Parent Training on Adaptive Functioning in Children With Pervasive Developmental Disorders and Serious Behavioral Problems • Journal of the American Academy of Child and Adolescent Psychology • February 01, 2012 • CTSA January 2012 Association of Industry Funding with the Outcome and Quality of Randomized Controlled Trials of Drug Therapy for Rheumatoid Arthritis •Arthritis and Rheumatism • January 24, 2012 • CTSA Quantitative High-Throughput Screening for Chemical Toxicity in a Population-based In Vitro Model • Toxicological Sciences • January 19, 2012 • Tox21 Bone-Density Testing Interval and Transition to Osteoporosis in Older Women • The New England Journal of Medicine • January 19, 2012 • CTSA Bridging Antiplatelet Therapy with Cangrelor in Patients Undergoing Cardiac Surgery: A Randomized Controlled Trial • JAMA • January 18, 2012 • CTSA High-Throughput Screening for Small Molecule Therapy for Gaucher Disease Using Patient Tissue as the Source of Mutant Glucocerebrosidase •PLoS One • January 17, 2012 • NCGC Repurposing Approved and Abandoned Drugs for the Treatment and Prevention of Cancer through Public-Private Partnership • Cancer Research • January 13, 2012 • TRND Two High-Throughput Screening Assays for Aberrant RNA-Protein Interactions in Myotonic Dystrophy Type-1 • Analytical and Bioanalytical Chemistry • January 05, 2012 • NCGC Predictors of Survival in Patients With Parkinson Disease • Archives of Neurology • January 02, 2012 • CTSA | ||||||||
| 2988 | Scientific Publications 2013 | December 2013 Liposomal siRNA Nanocarriers for Cancer Therapy • Advanced Drug Delivery Reviews • December 30, 2013 • exRNA Doing More with Less • Drug Discovery & Development • December 23, 2013 • NCATS Stem cells on bioengineered microphysiological platforms for disease modeling and drug testing • Stem Cell Research & Therapy • December 20, 2013 • Tissue Chips Use of Imaging and Biomarker Tests for Post-Treatment Care of Early-Stage Breast Cancer Survivors • Cancer • December 13, 2013 • CTSA Assessing Participant-Centered Outcomes to Improve Clinical Research • The New England Journal of Medicine • December 05, 2013 • CTSA Determination of Intracellular Fludarabine Triphosphate in Human Peripheral Blood Mononuclear Cells by LC-MS/MS • Journal of Pharmaceutical and Biomedical Analysis • December 01, 2013 • CTSA Memory Performance and fMRI Signal in Presymptomatic Familial Alzheimer's Disease • Human Brain Mapping • December 01, 2013 • CTSA Enhancement of Tenogenic Differentiation of Human Adipose Stem Cells by Tendon-derived Extracellular Matrix • Biomaterials • December 01, 2013 • CTSA A Piece of the Action: Modulation of Sensory-Motor Regions by Action Idioms and Metaphors • NeuroImage • December 01, 2013 • CTSA Multiple Listing for Pediatric Heart Transplantation in the USA: Analysis of OPTN Registry Data from 1995 through 2009 • Pediatric Transplantation • December 01, 2013 • CTSA Moderate Vitamin A Supplementation in Obese Mice Regulates Tissue Factor and Cytokine Production in a Sex-specific Manner • Archives of Biochemistry and Biophysics • December 01, 2013 • CTSA Self-Rated Health among Pregnant Women: Associations with Objective Health Indicators, Psychological Functioning, and Serum Inflammatory Markers • Annals of Behavioral Medicine • December 01, 2013 • CTSA Acute Heart Failure: Patient Characteristics and Pathophysiology •Current Heart Failure Reports • December 01, 2013 • CTSA Variants in BET1L and TNRC6B Associate with Increasing Fibroid Volume and Fibroid Type among European Americans • Human Genetics • December 01, 2013 • CTSA A Bi-National Comparative Study of Health Behaviors of Koreans in South Korea and Korean Americans in California • Journal of Immigrant and Minority Health Autosomal Dominant Retinitis Pigmentosa Secondary to Pre-mRNA Splicing-Factor Gene PRPF31 (RP11): Review of Disease Mechanism and Report of a Family with a Novel 3-Base Pair Insertion • Ophthalmic Genetics • December 01, 2013 • CTSA Left Ventricular Myocardial Performance Index Change for Detection of Acute Cellular Rejection in Pediatric Heart Transplantation • Pediatric Transplantation • December 01, 2013 • CTSA Joint Analysis of Stochastic Processes with Application to Smoking Patterns and Insomnia • Statistics in Medicine • December 01, 2013 • CTSA Candida Skin Test Reagent as a Novel Adjuvant for a Human Papillomavirus Peptide-Based Therapeutic Vaccine • Vaccine • December 01, 2013 • CTSA Correlates of Cortisol in Human Hair: Implications for Epidemiologic Studies on Health Effects of Chronic Stress • Annals of Epidemiology • December 01, 2013 • CTSA Obstructive Sleep Apnea and Intermittent Hypoxia Increase Expression of Dual Specificity Phosphatase 1 • Atherosclerosis • December 01, 2013 • CTSA Aldehyde Dehydrogenase-1a1 Induces Oncogene Suppressor Genes in B Cell Populations • Biochimica et Biophysica Acta • December 01, 2013 • CTSA Mid-Term Outcomes Following Endovascular Re-Intervention for Iliac Artery in-Stent Restenosis • Catheterization and Cardiovascular Interventions • December 01, 2013 • CTSA Prognostic Factors in Relation to Racial Disparity in Advanced Colorectal Cancer Survival • Clinical Colorectal Cancer • December 01, 2013 • CTSA State of the Evidence: Mechanical Ventilation with PEEP in Patients with Cardiogenic Shock • Heart • December 01, 2013 • CTSA Progress in MicroRNA Delivery • Journal of Controlled Release • December 01, 2013 • CTSA Adolescent Resilience: Promotive Factors That Inform Prevention • Child Development Perspectives • December 01, 2013 • CTSA November 2013 The Affordable Care Act as Translational Research • Science Translational Medicine • November 27, 2013 • CTSA High-content Genome-wide RNAi Screens Identify Regulators of Parkin Upstream of Mitophagy • Nature • November 24, 2013 • NCGC CD28 and ITK Signals Regulate Autoreactive T Cell Trafficking • Nature Medicine • November 24, 2013 • NCGC Differences in Vision between Clinic and Home and the Effect of Lighting in Older Adults With and Without Glaucoma • JAMA Ophthalmology • November 21, 2013 • CTSA High-Content Screening Identifies Small Molecules That Remove Nuclear Foci, Affect MBNL Distribution and CELF1 Protein Levels via a PKC-Independent Pathway in Myotonic Dystrophy Cell Lines • Human Molecular Genetics • November 15, 2013 • NCGC Chemical Genomics for Studying Parasite Gene Function and Interaction •Trends in Parasitology • November 09, 2013 • NCGC A Novel Chordoma Xenograft Allows In Vivo Drug Testing and Reveals the Importance of NF-κB Signaling in Chordoma Biology • PLoS One • November 06, 2013 • NCGC Fluorescent Techniques for Discovery and Characterization of Phosphopantetheinyl Transferase Inhibitors • Journal of Antibiotics • November 06, 2013 • NCGC Acid-Degradable Core-Shell Nanoparticles for Reversed Tamoxifen-Resistance in Breast Cancer by Silencing Manganese Superoxide Dismutase (MnSOD) • Biomaterials • November 01, 2013 • CTSA Assessment of Gene Expression in Peripheral Blood Using RNAseq Before and After Weight Restoration in Anorexia Nervosa • Psychiatry Research • November 01, 2013 • CTSA Proteolytically Activated Anti-Bacterial Hydrogel Microspheres • Journal of Controlled Release • November 01, 2013 • CTSA Differential Treatment of Hypertension by Primary Care Providers and Hypertension Specialists in a Barber-Based Intervention Trial to Control Hypertension in Black Men • The American Journal of Cardiology • November 01, 2013 • CTSA Predictors of Regional Variations in Hospitalizations Following Emergency Department Visits for Atrial Fibrillation • The American Journal of Cardiology • November 01, 2013 • CTSA Synthesis and Anti-Tumor Activity of Carbohydrate Analogues of the Tetrahydrofuran Containing Acetogenins • Bioorganic & Medicinal Chemistry • November 01, 2013 • CTSA Structural Patterns of the Proximal Femur in Relation to Age and Hip Fracture Risk in Women • Bone • November 01, 2013 • CTSA Childhood Socioeconomic Status, Telomere Length, and Susceptibility to Upper Respiratory Infection • Brain, Behavior, and Immunity • November 01, 2013 • CTSA Association Between Body Mass Index and Quality of Split Bowel Preparation • Clinical Gastroenterology and Hepatology • November 01, 2013 • CTSA Whole-Genome Copy Number Variation Analysis in Anophthalmia and Microphthalmia • Clinical Genetics • November 01, 2013 • CTSA Improving Heart Failure Disease Management in Skilled Nursing Facilities: Lessons Learned • Clinical Nursing Research • November 01, 2013 • CTSA Randomized Comparison of Universal and Targeted HIV Screening in the Emergency Department • Journal of Acquired Immune Deficiency Syndromes • November 01, 2013 • CTSA The General Surgeon's Quandary: Atypical Lipomatous Tumor vs Lipoma, Who Needs a Surgical Oncologist? • Journal of the American College of Surgeons • November 01, 2013 • CTSA Prevalence of Sleep Disturbances in Children with Neurofibromatosis Type 1 • Journal of Child Neurology • November 01, 2013 • CTSA The Co-Chaperones Fkbp4/5 Control Argonaute2 Expression and Facilitate RISC Assembly • RNA • November 01, 2013 • NCGC High-Sensitivity Analysis of Buprenorphine, Norbuprenorphine, Buprenorphine Glucuronide, and Norbuprenorphine Glucuronide in Plasma and Urine by Liquid Chromatography-Mass Spectrometry • Journal of Chromatography • November 01, 2013 • CTSA Pain and Other Non-Neurological Adverse Events in Children with Sickle Cell Anemia and Previous Stroke Who Received Hydroxyurea and Phlebotomy or Chronic Transfusions and Chelation: Results from the SWiTCH Clinical Trial • American Journal of Hematology • November 01, 2013 • CTSA Crowdsourced Peer- Versus Expert-Written Smoking-Cessation Messages •American Journal of Preventative Medicine • November 01, 2013 • CTSA HCC Patients Suffer Less From Geographic Differences in Organ Availability • American Journal of Transplantation • November 01, 2013 • CTSA Depression and Insomnia in Cancer: Prevalence, Risk Factors, and Effects on Cancer Outcomes • Current Psychiatry Reports • November 01, 2013 • CTSA Occurrence of Steam Pops during Irrigated RF Ablation: Novel Insights from Microwave Radiometry • Journal of Cardiovascular Electrophysiology• November 01, 2013 • CTSA Pediatric Providers' Attitudes toward Retail Clinics • The Journal of Pediatrics • November 01, 2013 • CTSA Healthcare Utilization in Chronic Liver Disease: The Importance of Pain and Prescription Opioid Use • Liver International • November 01, 2013 • CTSA Optimized 3D Ultrashort Echo Time Pulmonary MRI • Magnetic Resonance in Medicine • November 01, 2013 • CTSA Absence of Detectable HIV-1 Viremia After Treatment Cessation in an Infant • The New England Journal of Medicine • November 01, 2013 • CTSA Utilization of Morning Report by Acute Care Surgery Teams: Results from a Qualitative Study • American Journal of Surgery • November 01, 2013 • CTSA Effect of Exogenous Interferons on Rhinovirus Replication and Airway Inflammatory Responses • Annals of Allergy, Asthma & Immunology • November 01, 2013 • CTSA Confronting Safety Gaps across Labor and Delivery Teams • American Journal of Obstetrics and Gynecology • November 01, 2013 • CTSA October 2013 NCATS’ Dan Tagle Discusses Extracellular RNA in Nature Reviews Drug Discovery • Nature Reviews Drug Discovery • October 31, 2013 • exRNA Structure–Activity Relationship of Imidazopyridinium Analogues as Antagonists of Neuropeptide S Receptor • Journal of Medicinal Chemistry• October 30, 2013 • NCGC Baby's HIV 'Cure' Might Signal New Approach • Medpage Today • October 23, 2013 • CTSA Synthesis and SAR Studies of 5-(pyridin-4-yl)-1,3,4-Thiadiazol-2-Amine Derivatives as Potent Inhibitors of Bloom Helicase • Bioorganic and Medicinal Chemistry Letters • October 15, 2013 • NCGC Human Cell Toxicogenomic Analysis Linking Reactive Oxygen Species to the Toxicity of Monohaloacetic Acid Drinking Water Disinfection Byproducts • Environmental Science & Technology • October 10, 2013 • Tox21 Statins for Inflamed Gums? • MedPage Today • October 03, 2013 • CTSA Meta-analysis: Underutilisation and Disparities of Treatment among Patients with Hepatocellular Carcinoma in the United States • Alimentary Pharmacology & Therapeutics • October 01, 2013 • CTSA OPG and sRANKL Serum Levels and Incident Hip Fracture in Postmenopausal Caucasian Women in the Women's Health Initiative Observational Study • Bone • October 01, 2013 • CTSA A Comparison of Clinical Outcomes between Healthcare-associated Infections due to Community-associated Methicillin-resistant Staphylococcus Aureus Strains and Healthcare-associated Methicillin-resistant S. Aureus Strains • Epidemiology and Infection • October 01, 2013 • CTSA Weight Loss in Obese Adults 65 Years and Older: A Review of the Controversy • Experimental Gerontology • October 01, 2013 • CTSA Discussion of Treatment Trials in Intensive Care • Journal of Critical Care• October 01, 2013 • CTSA Temperature Prediction in High-speed Bone Grinding Using Motor PWM Signal • Medical Engineering & Physics • October 01, 2013 • CTSA Thermal Model to Investigate the Temperature in Bone Grinding for Skull Base Neurosurgery • Medical Engineering & Physics • October 01, 2013 • CTSA Shared Decision-making to Improve Attention-deficit Hyperactivity Disorder Care • Patient Education and Counseling • October 01, 2013 • CTSA Clinically Meaningful Measurement of Pain in Children with Sickle Cell Disease • Pediatric Blood & Cancer • October 01, 2013 • CTSA Health-care Access and Weight Change among Young Adults: The Coronary Artery Risk Development in Young Adults (CARDIA) Study • Public Health Nutrition • October 01, 2013 • CTSA Vaccination Protects Rats from Methamphetamine-induced Impairment of Behavioral Responding for Food • Vaccine • October 01, 2013 • CTSA Removing Lymph Nodes During Breast Cancer Surgery - Less Can be More • Health News Digest • October 01, 2013 • CTSA September 2013 Protection against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine • Science • September 20, 2013 • NCGC Identification of Therapeutic Candidates for Chronic Lymphocytic Leukemia from a Library of Approved Drugs • PLoS One • September 20, 2013 • NCGC Systematic Study of Mitochondrial Toxicity of Environmental Chemicals Using Quantitative High-Throughput Screening • Chemical Research in Toxicology • September 16, 2013 • Tox21 Ethical and Legal Issues in Pain Research in Cognitively Impaired Older Adults • International Journal of Nursing Studies • September 01, 2013 • CTSA Coaching Competency and (Exploratory) Structural Equation Modeling: A Substantive-Methodological Synergy • Psychology of Sport and Exercise • September 01, 2013 • CTSA Risk Factors of Non-Alcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease • Journal of Crohns & Colitis • September 01, 2013 • CTSA Immigrant Enclaves and Obesity in Preschool-aged Children in Los Angeles County • Social Science & Medicine • September 01, 2013 • CTSA Hypoglycemia as a Driver of Cardiovascular Risk in Diabetes • Current Atherosclerosis Reports • September 01, 2013 • CTSA Perceptual Demand Modulates Activation of Human Auditory Cortex in Response to Task-irrelevant Sounds • Journal of Cognitive Neuroscience • September 01, 2013 • CTSA Using Multiple Cause-of-Death Data to Improve Surveillance of Drug-Related Mortality • Journal of Public Health Management and Practice • September 01, 2013 • CTSA Provider Perceptions and Expectations of Breast Cancer Posttreatment Care: A University of California Athena Breast Health Network Project •Journal of Cancer Survivorship • September 01, 2013 • CTSA LVAD Implant as a Bridge to Heart Transplantation Is Associated with Allosensitization as Measured by Single Antigen Bead Assay •Transplantation • September 01, 2013 • CTSA Impact of Loop Electrosurgical Excision Procedure for Cervical Intraepithelial Neoplasia on HIV-1 Genital Shedding: A Prospective Cohort Study • BJOG • September 01, 2013 • CTSA Perspectives of Clinical Genetics Professionals Toward Genome Sequencing and Incidental Findings: A Survey Study • Clinical Genetics • September 01, 2013 • CTSA High HIV Testing Uptake and Linkage to Care in a Novel Program of Home-Based HIV Counseling and Testing with Facilitated Referral in KwaZulu-Natal, South Africa • Journal of Acquired Immune Deficiency Syndromes • September 01, 2013 • CTSA Protease-Activated Receptor 1 Inhibition by SCH79797 Attenuates Left Ventricular Remodeling and Profibrotic Activities of Cardiac Fibroblasts •Journal of Cardiovascular Pharmacology and Therapeutics • September 01, 2013 • CTSA Tenascin-X, Collagen, and Ehlers-Danlos Syndrome: Tenascin-X Gene Defects Can Protect Against Adverse Cardiovascular Events • Medical Hypotheses • September 01, 2013 • CTSA A High-Fat Diet Supplemented with Fish Oil Improves Metabolic Features Associated with Type 2 Diabetes • Nutrition • September 01, 2013 • CTSA Identification of an Aminothiazole with Antifungal Activity against Intracellular Histoplasma Capsulatum • Antimicrobial Agents and Chemotherapy • September 01, 2013 • CTSA Startle Response to Unpredictable Threat in Comorbid Panic Disorder and Alcohol Dependence • Neuropsychopharmacology • September 01, 2013 • CTSA Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism • Neuropsychopharmacology • September 01, 2013 • CTSA Major Blunt Trauma Evokes Selective Upregulation of Oxidative Enzymes in Circulating Leukocytes • shock • September 01, 2013 • CTSA Post-Traumatic Stress Disorder and Incidence of Coronary Heart Disease: A Twin Study • Journal of the American College of Cardiology • September 01, 2013 • CTSA Platelets Govern Pre-Metastatic Tumor Communication to Bone •Oncogene • September 01, 2013 • CTSA Temporal Relationship and Prognostic Significance of Atrial Fibrillation in Heart Failure Patients with Preserved Ejection Fraction: A Community-based Study • Circulation • September 01, 2013 • CTSA Immune Response to Intrathecal Enzyme Replacement Therapy in Mucopolysaccharidosis I Patients • Pediatric Research • September 01, 2013 • CTSA Doctoral Programs to Train Future Leaders in Clinical and Translational Science • Academic Medicine: Journal of the Association of American Medical Colleges • September 01, 2013 • CTSA The Relationship between Parent Health Literacy and Pediatric Emergency Department Utilization: A Systematic Review • Academic Pediatrics • September 01, 2013 • CTSA Prevalence, Perceptions, and Correlates of Pediatric HIV Disclosure in an HIV Treatment Program in Kenya • AIDS Care • September 01, 2013 • CTSA Community-based Treatment for Opioid-Dependent Offenders: A Pilot Study • The American Journal on Addictions • September 01, 2013 • CTSA TDP1 Repairs Nuclear and Mitochondrial DNA Damage Induced by Chain-Terminating Anticancer and Antiviral Nucleoside Analogs • Nucleic Acids Research • September 01, 2013 • NCGC A High-Throughput Screening Assay for Determining Cellular Levels of Total Tau Protein • Current Alzheimer’s Research • September 01, 2013 • NCGC Unique and Highly Selective Anticytomegalovirus Activities of Artemisinin-Derived Dimer Diphenyl Phosphate Stem from Combination of Dimer Unit and a Diphenyl Phosphate Moiety • Antimicrobial Agents and Chemotherapy • September 01, 2013 • NCGC Detection of Phospholipidosis Induction: A Cell-Based Assay in High-Throughput and High-Content Format • Journal of Biomolecular Screening• September 01, 2013 • Tox21 August 2013 Complementary and alternative medicine use in african-americans with rheumatoid arthritis • Arthritis Care & Research • August 29, 2013 • CTSA A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis • Developmental Cell • August 29, 2013 • NCGC Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells • Journal of Clinical Investigation • August 27, 2013 • CTSA A Phenotypic Compound Screening Assay for Lysosomal Storage Diseases •Journal of Biomolecular Screening • August 27, 2013 • TRND Multipoint Binding of the SLP-76 SH2 Domain to ADAP is Critical for Oligomerization of SLP-76 Singaling Complexes in Stimulated T Cells •Molecular and Cellular Biology • August 26, 2013 • NCGC Are hERG Channel Blockers Also Phospholipidosis Inducers? • Bioorganic & Medicinal Chemistry Letters • August 23, 2013 • NCGC Insulin-Dependent Diabetes Induced by Pancreatic Beta Cell Expression of IL-15 and IL-15Rα • PNAS • August 13, 2013 • NCGC Gene Delivery of Homer1c Rescues Spatial Learning in a Rodent Model of Cognitive Aging • Neurobiology of Aging • August 01, 2013 • CTSA Information Theoretic Measures of Network Coordination in High-Frequency Scalp EEG Reveal Dynamic Patterns Associated with Seizure Termination • Epilepsy Research • August 01, 2013 • CTSA Temporal Summation of Heat Pain Modulated by Isometric Exercise •Epilepsy Research • August 01, 2013 • CTSA Relations of Depressive Symptoms and Antidepressant Use to Body Mass Index and Selected Biomarkers for Diabetes and Cardiovascular Disease •American Journal of Public Health • August 01, 2013 • CTSA Pregnancy Intention and Postpartum Depression: Secondary Data Analysis from a Prospective Cohort • BJOG • August 01, 2013 • CTSA Parent Perceptions of Children's Hospital Safety Climate • BMJ Quality & Safety • August 01, 2013 • CTSA Standard Pentostatin Dose Reductions in Renal Insufficiency are Not Adequate: Selected Patients with Steroid-Refractory Acute Graft-versus-Host Disease • Clinical Pharmacokinetics • August 01, 2013 • CTSA Gene Silencing Is Golden • The Scientist • August 01, 2013 • NCGC Social Support and Religion: Mental Health Service Use and Treatment of Schizophrenia • Community Mental Health Journal • August 01, 2013 • CTSA Update on the Treatment of Juvenile Idiopathic Arthritis • Current Allergy and Asthma Reports • August 01, 2013 • CTSA Higher Dietary Lycopene Intake is Associated with Longer Cardiac Event-free Survival in Patients with Heart Failure • European Journal of Cardiovascular Nursing • August 01, 2013 • CTSA Selection for Drinking in the Dark Alters Brain Gene Coexpression Networks • Alcoholism, Clinical and Experimental Research • August 01, 2013 • CTSA Causes and Circumstances of Death in Pulmonary Arterial Hypertension •American Journal of Respiratory and Critical Care Medicine • August 01, 2013 • CTSA Pharmacokinetics and Safety of a Novel Recombinant Human von Willebrand Factor Manufactured with a Plasma-free Method: A Prospective Clinical Trial • Blood • August 01, 2013 • CTSA The Clinical Neurobiology of Drug Craving • Current Opinion in Neurobiology • August 01, 2013 • CTSA Post-Colonoscopy Recommendations after Inadequate Bowel Preparation: All in the Timing • Digestive Diseases and Sciences • August 01, 2013 • CTSA Tissue Expanders: Early Experience of a Novel Treatment Option for Perineal Herniation • Hernia • August 01, 2013 • CTSA A Semi-Automated Vascular Access System for Preclinical Models • Physics in Medicine and Biology • August 01, 2013 • CTSA Patient Demographic and Tumor Characteristics Influencing Oncologist Follow-Up Frequency in Older Breast Cancer Survivors • Annals of Surgical Oncology • August 01, 2013 • CTSA Micronutrient Deficiencies in Pediatric and Young Adult Intestinal Transplant Patients • Pediatric Transplantation • August 01, 2013 • CTSA Success Case Studies Contribute to Evaluation of Complex Research Infrastructure • Evaluation & The Health Professions • August 01, 2013 • CTSA Development of Upper Tract Stones in Patients with Congenital Neurogenic Bladder • Journal of Pediatric Urology • August 01, 2013 • CTSA Transcription Poisoning by Topoisomerase I Is Controlled by Gene Length, Splice Sites, and miR-142-3p • Cancer Research • August 01, 2013 • NCGC July 2013 Assessing NIH’s Big Idea • Science Translational Medicine • July 31, 2013 • CTSA HIV/AIDS among African-Born Residents in the United States • Journal of Immigrant and Minority Health • July 15, 2013 • CTSA Kinetic Characterization of Ebselen, Chelerythrine and Apomorphine as Glutaminase Inhibitors Corresponding • Biochemical and Biophysical Research Communications • July 10, 2013 • NCGC Phenotypic Screens as a Renewed Approach for Drug Discovery • Drug Discovery Today • July 09, 2013 • TRND The Quantitative Evaluation of the Clinical and Translational Science Awards (CTSA) Program Based on Science Mapping and Scientometric Analysis • Clinical and Translational Science • July 08, 2013 • CTSA Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome• Cancer Cell • July 08, 2013 • NCGC Urinary-Cell mRNA Profile and Acute Cellular Rejection in Kidney Allografts • The New Engalnd Journal of Medicine • July 04, 2013 • CTSA Predictors of Return to Driving After Stroke • American Journal of Physical Medicine & Rehabilitation • July 01, 2013 • CTSA Three-Dimensional Structural Analysis of the Proximal Femur in an Age-Stratified Sample of Women • Bone • July 01, 2013 • CTSA Relationship of Adiposity to Bone Volumetric Density and Microstructure in Men and Women across the Adult Lifespan • Bone • July 01, 2013 • CTSA Angiotensin II's Role in Sodium Lactate-Induced Panic-like Responses in Rats with Repeated Urocortin 1 Injections into the Basolateral Amygdala: Amygdalar Angiotensin Receptors and Panic • Progress in Neuro-psychopharmacology & Biological Psychiatry • July 01, 2013 • CTSA Tissue-Engineered Cardiac Patch for Advanced Functional Maturation of Human ESC-Derived Cardiomyocytes • Biomaterials • July 01, 2013 • CTSA Malaise, Melancholia and Madness: The Evolutionary Legacy of an Inflammatory Bias • Brain, Behavior & Immunity • July 01, 2013 • CTSA The Impact of Environmental Metals in Young Urbanites' Brains •Experimental and Toxicologic Pathology • July 01, 2013 • CTSA Decreased Health-related Quality of Life in Women with Breast Cancer is Associated with Poor Sleep • Behavioral Sleep Medicine • July 01, 2013 • CTSA Effect of ABCB1 Polymorphisms and Atorvastatin on Sitagliptin Pharmacokinetics in Healthy Volunteers • European Journal of Clinical Pharmacology • July 01, 2013 • CTSA Early Cognitive Behavioral Therapy for Depression after Cardiac Surgery •The Journal of Cardiovascular Nursing • July 01, 2013 • CTSA Long-term Trajectories of Lower Extremity Function in Older Adults: Estimating Gender Differences While Accounting for Potential Mortality Bias • The Journals of Gerontology • July 01, 2013 • CTSA A Prospective Observational Quality Improvement Study of the Sustained Effects of a Program to Reduce Unplanned Extubations in a Pediatric Intensive Care Unit • Pediatric Anesthesia • July 01, 2013 • CTSA Effect of Rotation on Perineal Lacerations in Forceps-Assisted Vaginal Deliveries • Obstetrics and Gynecology • July 01, 2013 • CTSA Gender and Ethnic Differences in the Prevalence of Type 2 Diabetes among Asian Subgroups in California • Journal of Diabetes • July 01, 2013 • CTSA A SNP in G6PC2 Predicts Insulin Secretion in Type 1 Diabetes • Acta Diabetologica • July 01, 2013 • CTSA Care of the Older Adult in the Emergency Department: Nurses Views of the Pressing Issues • The Gerontologist • July 01, 2013 • CTSA Predicting CYP2C19 Catalytic Parameters for Enantioselective Oxidations Using Artificial Neural Networks and a Chirality Code • Bioorganic & Medicinal Chemistry • July 01, 2013 • CTSA Participation in Research Involving Novel Sampling and Study Designs to Identify Acute HIV-1 Infection among Minority Men Who Have Sex with Men • AIDS Care • July 01, 2013 • CTSA Functional Disability, Cognitive Impairment, and Depression after Hospitalization for Pneumonia • The American Journal of Medicine • July 01, 2013 • CTSA The Prognostic Value of Kidney Transplant Center Report Cards •American Journal of Transplantation • July 01, 2013 • CTSA Analyzing Excess Mortality from Cancer among Individuals with Mental Illness • Cancer • July 01, 2013 • CTSA Histological Quantification of Astrocytosis after Cerebral Infarction: A Systematic Review • The International Journal of Neuroscience • July 01, 2013 • CTSA Time Course of Arthralgia among Women Initiating Aromatase Inhibitor Therapy and a Postmenopausal Comparison Group in a Prospective Cohort• Cancer • July 01, 2013 • CTSA The Influence of Hyperglycemia on the Therapeutic Effect of Exercise on Glycemic Control in Patients With Type 2 Diabetes Mellitus • JAMA Internal Medicine • July 01, 2013 • CTSA Costs of Second Allogeneic Hematopoietic Cell Transplantation •Transplantation • July 01, 2013 • CTSA The Long-Term Stability of the Human Gut Microbiota • Science • July 01, 2013 • CTSA A Microfluidic Platform for Generating Large-Scale Nearly Identical Human Microphysiological Vascularized Tissue Arrays • Lab on a Chip • July 01, 2013 • Tissue Chips Trends in Sugar-Sweetened Beverage and 100% Fruit Juice Consumption among California Children • Academic Pediatrics • July 01, 2013 • CTSA Predictors of Colorectal Cancer Screening Variation among Primary-Care Providers and Clinics • The American Journal of Gastroenterology • July 01, 2013 • CTSA Assessing Proxy Reports: Agreement between Children with Asthma and Their Caregivers on Quality of Life • Annals of Allergy, Asthma & Immunology • July 01, 2013 • CTSA Impaired Fasting Blood Glucose is Associated with Increased Eendothelin-1 Vasoconstrictor Tone • Atherosclerosis • July 01, 2013 • CTSA The Dormancy Dilemma: Quiescence versus Balanced Proliferation •Cancer Research • July 01, 2013 • New Therapeutic Uses MRI Study of Cerebral, Retinal and Choroidal Blood Flow Responses to Acute Hypertension • Experimental Eye Research • July 01, 2013 • CTSA New Sample Preparation Approach for Mass Spectrometry-based Profiling of Plasma Results in Improved Coverage of Metabolome • Journal of Chromatography • July 01, 2013 • CTSA Resting and Task-Modulated High-Frequency Brain Rhythms Measured by Scalp Encephalography in Infants with Tuberous Sclerosis Complex •Journal of Autism and Developmental Disorders • July 01, 2013 • CTSA A Collaborative Approach to Developing an Electronic Health Record Phenotyping Algorithm for Drug-induced Liver Injury • Journal of the American Medical Informatics Association • July 01, 2013 • CTSA Pretreatment EEG in Childhood Absence Epilepsy: Associations with Attention and Treatment Outcome • Neurology • July 01, 2013 • CTSA Human Factors Systems Approach to Healthcare Quality and Patient Safety • Applied Ergonomics • July 01, 2013 • CTSA Mycoplasma Genitalium and Preterm Delivery at an Urban Community Health Center • International Journal of Gynecology and Obstetrics • July 01, 2013 • CTSA Use of Theoretical Peptide Distributions in Phosphoproteome Analysis •Journal of Proteome Research • July 01, 2013 • CTSA Autonomic Response to a Visceral Stressor is Dysregulated in Irritable Bowel Syndrome and Correlates with Duration of Disease •Neurogastroenterology and Motility • July 01, 2013 • CTSA Artemisinin-Derived Dimer Phosphate Esters as Potent Anti-Cytomegalovirus (anti-CMV) and Anti-Cancer Agents: A Structure-Activity Study • Bioorganic and Medicinal Chemistry • July 01, 2013 • NCGC Improving the Human Hazard Characterization of Chemicals: A Tox21 Update • Environmental Health Perspectives • July 01, 2013 • Tox21 3-Substituted Indole Inhibitors against Francisella Tularensis Fabl Idnetified by Structure-Based Virtual Screening • Journal of Medicinal Chemistry • July 01, 2013 • NCGC June 2013 A High-Throughput Screening Assay for Assessing the Viability of Cryptococcus Neoformans Under Nutrient Starvation Conditions •Analytical and Bioanalytical Chemistry • June 30, 2013 • TRND NCATS's Nine Lives • Science-Business eXchange • June 27, 2013 • New Therapeutic Uses Integrated Phosphoproteomic and Metabolomic Profiling Reveals NPM-ALK-Mediated Phosphorylation of PKM2 and Metabolic Reprogramming in Anaplastic Large Cell Lymphoma • Blood • June 27, 2013 • NCGC Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy • PLoS ONE • June 24, 2013 • NCGC A Novel Brain Penetrant NPRS Receptor Antagonist, NCGC00185684, Blocks Alcohol-Induced ERK-Phosphorylation in the Central Amygdala and Decreases Operant Alcohol Self-Administration in Rats • Journal of Neuroscience • June 12, 2013 • NCGC Recent Developments in the Use of Differential Scanning Fluorometry in Protein and Small Molecule Discovery and Characterization • Expert Opinion on Drug Discovery • June 06, 2013 • NCGC Physicochemical Characterization of a Thermostable Alcohol Dehydrogenase from Pyrobaculum Aerophilum • PLoS One • June 05, 2013 • NCGC Multiple Cytokines and Chemokines are Associated with Rheumatoid Arthritis-related Autoimmunity in First-Degree Relatives without Rheumatoid Arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA) • Annals of the Rheumatic Disease • June 03, 2013 • CTSA Chronic Pain Management Strategies Used by Low-Income Overweight Latinos • Chronic Illness • June 03, 2013 • CTSA G-Protein Signaling Modulator-3, a Gene Linked to Autoimmune Diseases, Regulates Monocyte Function and Its Deficiency Protects from Inflammatory Arthritis • Molecular Immunology • June 01, 2013 • CTSA Osteocyte Regulation of Phosphate Homeostasis and Bone Mineralization Underlies the Pathophysiology of the Heritable Disorders of Rickets and Osteomalacia • Bone • June 01, 2013 • CTSA A Meta-Composite Software Development Approach for Translational Research • Journal of Medical Systems • June 01, 2013 • CTSA The Triterpenoid Cucurbitacin B Augments the Antiproliferative Activity of Chemotherapy in Human Breast Cancer • International Journal of Cancer • June 01, 2013 • CTSA Detection of Exosomal Biomarker by Electric Field-Induced Release and Measurement (EFIRM) • Biosensors & Bioelectronics • June 01, 2013 • CTSA The Economic Burden of Community-Associated Methicillin-Resistant Staphylococcus Aureus (CA-MRSA) • Clinical Microbiology and Infection • June 01, 2013 • CTSA Health Literacy in Korean Immigrants at Risk for Type 2 Diabetes •Journal of Immigrant and Minority Health • June 01, 2013 • CTSA Predictors of Exaggerated Exercise-Induced Systolic Blood Pressures in Young Patients after Coarctation Repair • Cardiology in the Young • June 01, 2013 • CTSA Treatment of Infrapopliteal Critical Limb Ischemia in 2013: The Wound Perfusion Approach • Current Cardiology Reports • June 01, 2013 • CTSA Declining Trend in the Use of Repeat Computed Tomography for Trauma Patients Admitted to a Level I Trauma Center for Traffic-Related Injuries• European Journal of Radiology • June 01, 2013 • CTSA Impact of a Nurse-Directed, Coordinated School Health Program to Enhance Physical Activity Behaviors and Reduce Body Mass Index among Minority Children: A Parallel-Group, Randomized Control Trial •International Journal of Nursing Studies • June 01, 2013 • CTSA Innovation in Academic Chemical Screening: Filling the Gaps in Chemical Biology • Current Opinion in Chemical Biology • June 01, 2013 • NCGC Cognitive Flexibility during Breath Alcohol Plateau is Associated with Previous Drinking Measures • Alcohol • June 01, 2013 • CTSA Lack of Association between Residual Insulin Production and Glucagon Response to Hypoglycemia in Youth with Short Duration of Type 1 Diabetes • Diabetes Care • June 01, 2013 • CTSA Systematic Evaluation of Validated Type 2 Diabetes and Glycaemic Trait Loci for Association with Insulin Clearance • Diabetologia • June 01, 2013 • CTSA Age-associated Abnormalities of Water Homeostasis • Endocrinology and Metabolism Clinics of North America • June 01, 2013 • CTSA Intestinal γδ T-Cell Lymphomas are Most Frequently of Type II Enteropathy-Associated T-Cell Type • Human Pathology • June 01, 2013 • CTSA Pharmacological Insights into the Role of P2X4 Receptors in Behavioural Regulation: Lessons from Ivermectin • International Journal of Neuropsychopharmacology • June 01, 2013 • CTSA Diabetes Management and Glycemic Control in Youth with Type 1 Diabetes: Test of a Predictive Model • Journal of Behavioral Medicine • June 01, 2013 • CTSA Branding and a Child's Brain: An fMRI Study of Neural Responses to Logos• Social Cognitive and Affective Neuroscience • June 01, 2013 • CTSA The Feasibility and Cost of Neonatal Screening for Prenatal Alcohol Exposure by Measuring Phosphatidylethanol in Dried Blood Spots •Alcoholism, Clinical and Experimental Research • June 01, 2013 • CTSA How Do Good Candidates for Trial of Labor After Cesarean (TOLAC) Who Undergo Elective Repeat Cesarean Differ from Those Who Choose TOLAC?• American Journal of Obstetrics and Gynecology • June 01, 2013 • CTSA Incidence and Time Trends of Herpes Zoster in Rheumatoid Arthritis: A Population-based Ccohort Study • Arthritis Care & Research • June 01, 2013 • CTSA A Placebo-controlled, Randomized Trial of Mesenchymal Stem Cells in COPD • Chest • June 01, 2013 • CTSA Euglycemic Progression: Worsening of Diabetic Retinopathy in Poorly Controlled Type 2 Diabetes in Minorities • Diabetes Research and Clinical Practice • June 01, 2013 • CTSA Racial Discrimination, Racial/Ethnic Segregation, and Health Behaviors in the CARDIA Study • Ethnicity & Health • June 01, 2013 • CTSA Influenza Vaccination among Cancer Survivors: Disparities in Prevalence between Blacks and Whites • Journal of Cancer Survivorship: Research and Practice • June 01, 2013 • CTSA Vitamin D and Delirium in Critically Ill Patients: A Preliminary Investigation • Journal of Critical Care • June 01, 2013 • CTSA Mind-Body Practices for Posttraumatic Stress Disorder • Journal of Investigative Medicine • June 01, 2013 • CTSA Mechanism-based Testing Strategy Using in vitro Approaches for Identification of Thyroid Hormone Disrupting Chemicals • Toxicology In Vitro • June 01, 2013 • Tox21 May 2013 In a Tough Fiscal Climate, Coping Strategies Emerge • Science • May 31, 2013 • NCATS Peroxisome Proliferation-Activated Receptor δ Agonist GW0742 Interacts Weakly with Multiple Nuclear Receptors, Including the Vitamin D Receptor • Biochemistry • May 29, 2013 • NCGC Identification of Potent Yes1 Kinase Inhibitors Using a Library Screening Approach • Bioorganic & Medicinal Chemistry Letters • May 29, 2013 • NCGC Bisphenol A Affects Androgen Receptor Function via Multiple Mechanisms• Chemico-Biological Interactions • May 25, 2013 • NCGC An Alternative Direct Compound Dispensing Method Using the HP D300 Digital Dispenser • Journal of Laboratory Automation • May 24, 2013 • NCGC Drugs in Search of Diseases • Science Translational Medicine • May 22, 2013 • New Therapeutic Uses Blinded by the UV Light: How the Focus on Transcription-coupled NER Has Distracted from Understanding the Mechanisms of Cockayne Syndrome Neurologic Disease • DNA Repair • May 15, 2013 • ORDR Integration of Fall Prevention into State Policy in Connecticut •Gerontologist • May 13, 2013 • CTSA The Tox21 Robotic Platform for Assessment of Environmental Chemicals - From Vision to Reality • Drug Discovery Today • May 13, 2013 • Tox21 Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ • The New England Journal of Medicine • May 09, 2013 • ORDR Oncogenic CSF3R Mutations in Chronic Neutrophilic Leukemia and Atypical CML • The New England Journal of Medicine • May 09, 2013 • CTSA Quantitative Assessment of Tet-induced Oxidation Products of 5-Methylcytosine in Cellular and Tissue DNA • Nucleic Acids Research • May 08, 2013 • ORDR Human Ecstasy (MDMA) Polydrug Users Have Altered Brain Activation During Semantic Processing • Psychopharmacology • May 01, 2013 • CTSA Genetic Interactions Associated with 12-Month Atrophy in Hippocampus and Entorhinal Cortex in Alzheimer's Disease Neuroimaging Initiative •Neurobiology of Aging • May 01, 2013 • CTSA Repeat Expansions in the C9ORF72 Gene Contribute to Alzheimer's disease in Caucasians • Neurobiology of Aging • May 01, 2013 • CTSA Parkinson Disease is Not Associated with C9ORF72 Repeat Expansions •Neurobiology of Aging • May 01, 2013 • CTSA Current Approaches and Future Directions in the Treatment of HER2-Positive Breast Cancer • Cancer Treatment Reviews • May 01, 2013 • CTSA Autonomy, Positive Relationships, and IL-6: Evidence for Gender-Specific Effects • British Journal of Health Psychology • May 01, 2013 • CTSA Association of Elevated Cytokines with Childhood Adversity in a Sample of Healthy Adults • Journal of Psychiatric Research • May 01, 2013 • CTSA Impulsivity is Associated with Treatment Non-Completion in Cocaine- and Methamphetamine-Dependent Patients but Differs in Nature as a Function of Stimulant-Dependence Diagnosis • Journal of Substance Abuse Treatment • May 01, 2013 • CTSA Adrenocortical Regulation, Eating in the Absence of Hunger and BMI in Young Children • Appetite • May 01, 2013 • CTSA Optimized Fluid Management Improves Outcomes of Pediatric Burn Patients • The Journal of Surgical Research • May 01, 2013 • CTSA Comorbidity-Polypharmacy Score: A Novel Adjunct in Post-Emergency Department Trauma Triage • The Journal of Surgical Research • May 01, 2013 • CTSA Renal Complications of Fabry Disease in Children • Pediatric Nephrology • May 01, 2013 • CTSA Predictors of Short-Term Postoperative Survival after Elective Colectomy in Colon Cancer Patients ≥80 Years of Age • Annals of Surgical Oncology • May 01, 2013 • CTSA Genotype-Phenotype Studies of VCP-Associated Inclusion Body Myopathy with Paget Disease of Bone and/or Frontotemporal Dementia • Clinical Genetics • May 01, 2013 • CTSA Preclinical Evaluation of MR Attenuation Correction Versus CT Attenuation Correction on a Sequential Whole-Body MR/PET Scanner •Investigative Radiology • May 01, 2013 • CTSA Exercise: Applications to Childhood ADHD • Journal of Attention Disorders• May 01, 2013 • CTSA Impact of Stepwise Hyperventilation on Cerebral Tissue Oxygen Saturation in Anesthetized Patients: A Mechanistic Study • Acta Anasthesiologica Scandinavica • May 01, 2013 • CTSA Association of Cortisol with Neuropsychological Assessment in Older Adults with Generalized Anxiety Disorder • Aging & Mental Health • May 01, 2013 • CTSA A Quantitative and Comprehensive Method to Analyze Human Milk Oligosaccharide Structures in the Urine and Feces of Infants • Analytical and Bioanalytical Chemistry • May 01, 2013 • CTSA Body Mass Index and the Prevalence, Severity, and Risk of Coronary Artery Disease: An International Multicentre Study of 13 874 Patients •European Heart Journal Cardiovascular Imaging • May 01, 2013 • CTSA Emergence of Extended-Spectrum Β-Lactam Resistance among Escherichia Coli at a US Academic Children's Hospital is Clonal at the Sequence Type Level for CTX-M-15, but Not for CMY-2 • International Journal of Antimicrobial Agents • May 01, 2013 • CTSA Macrophages in Multiple Myeloma: Emerging Concepts and Therapeutic Implications • Leukemia & Lymphoma • May 01, 2013 • CTSA "It's Like Our Own Little World": Resilience as a Factor in Participating in the Ballroom Community Subculture • AIDS and Behavior • May 01, 2013 • CTSA Protein Tyrosine Phosphatase Expression Profile of Rheumatoid Arthritis Fibroblast-like Synoviocytes: A Novel Role of SH2 Domain-Containing Phosphatase 2 as a Modulator of Invasion and Survival • Arthritis and Rheumatism • May 01, 2013 • CTSA Interprofessional Education in Team Communication: Working Together to Improve Patient Safety • BMJ Quality & Safety • May 01, 2013 • CTSA Vascular and Connective Tissue Anomalies Associated with X-Linked Periventricular Heterotopia Due to Mutations in Filamin A • European Journal of Human Genetics • May 01, 2013 • CTSA Genetic Defects in Bile Acid Conjugation Cause Fat-Soluble Vitamin Deficiency • Gastroenterology • May 01, 2013 • CTSA National Perioperative Outcomes of Pulmonary Lobectomy for Cancer in the Obese Patient: A Propensity Score Matched Analysis • The Journal of Thoracic and Cardiovascular Surgery • May 01, 2013 • CTSA April 2013 Short-Term Outcomes of Screening Mammography Using Computer-Aided Detection: A Population-Based Study of Medicare Enrollees • Annals of Internal Medicine • April 16, 2013 • CTSA Imaging Patients with Psychosis and a Mouse Model Establishes a Spreading Pattern of Hippocampal Dysfunction and Implicates Glutamate as a Driver • Neuron • April 10, 2013 • CTSA Collaborations in Translational Research Speed the Drug Pipeline •Laboratory Equipment • April 05, 2013 • NCATS Neuroinflammatory Phenotype in Early Alzheimer's Disease •Neurobiology of Aging • April 01, 2013 • CTSA Initiation of Abstinence in Adolescents Treated for Marijuana Use Disorders • Journal of Substance Abuse Treatment • April 01, 2013 • CTSA The Predictive Capacity of Personal Genome Sequencing • Science Translational Medicine • April 01, 2013 • CTSA Sample Size Requirements to Detect an Intervention by Time Interaction in Longitudinal Cluster Randomized Clinical Trials with Random Slopes •Computational Statistics & Data Analysis • April 01, 2013 • CTSA Abuse Liability and Reinforcing Efficacy of Oral Tramadol in Humans •Drug and Alcohol Dependence • April 01, 2013 • CTSA Sesame Oil Consumption Exerts a Beneficial Effect on Endothelial Function in Hypertensive Men • European Journal of Preventive Cardiology • April 01, 2013 • CTSA Buprenorphine from Detox and Beyond: Preliminary Evaluation of a Pilot Program to Increase Heroin Dependent Individuals' Engagement in a Full Continuum of Care • Journal of Substance Abuse Treatment • April 01, 2013 • CTSA Predictors of Inadequate Prenatal Care in Methamphetamine-Using Mothers in New Zealand and the United States • Maternal and Child Health Journal • April 01, 2013 • CTSA Glucocorticoids and Insulin Resistance in Children with Acute Lymphoblastic Leukemia • Pediatric Blood & Cancer • April 01, 2013 • CTSA Beyond Mineral Metabolism, Is There an Interplay Between FGF23 and Vitamin D in Innate Immunity? • Pediatric Nephrology • April 01, 2013 • CTSA Efficacy of Decitabine-Loaded Nanogels in Overcoming Cancer Drug Resistance is Mediated via Sustained DNA Methyltransferase 1 (DNMT1) Depletion • Cancer Letters • April 01, 2013 • CTSA Chronic Hyponatremia Exacerbates Multiple Manifestations of Senescence in Male Rats • Age • April 01, 2013 • CTSA Tryptophan Inhibits Biofilm Formation by Pseudomonas Aeruginosa •Antimicrobial Agents and Chemotherapy • April 01, 2013 • CTSA Aging Differentially Affects Human Skeletal Muscle Amino Acid Transporter Expression When Essential Amino Acids are Ingested after Exercise • Clinical Nutrition • April 01, 2013 • CTSA Rhinitis in Older Adults • Current Allergy and Asthma Reports • April 01, 2013 • CTSA Notch-Mediated Post-Translational Control of Ngn3 Protein Stability Regulates Pancreatic Patterning and Cell Fate Commitment •Developmental Biology • April 01, 2013 • CTSA Regulation of G-Protein Signaling Via Gnas is Required to Regulate Proximal Tubular Growth in the Xenopus Pronephros • Developmental Biology • April 01, 2013 • CTSA Hypoglycaemia-Induced Changes in Regional Brain Volume and Memory Function • Diabetic Medicine • April 01, 2013 • CTSA Connective Tissue Spectrum Abnormalities Associated with Spontaneous Cerebrospinal Fluid Leaks: A Prospective Study • European Journal of Human Genetics • April 01, 2013 • CTSA Spinal 5-HT3 Receptors Facilitate Behavioural Hypersensitivity Induced by Elevated Calcium Channel Alpha-2-Delta-1 Protein • European Journal of Pain • April 01, 2013 • CTSA Weight Loss and Improved Fitness Slow Down the Decline in Mobility in Obese Adults with Type 2 Diabetes • Evidence Based Medicine • April 01, 2013 • CTSA Outdoor Built Environment Barriers and Facilitators to Activity among Midlife and Older Adults with Mobility Disabilities • The Gerontologist • April 01, 2013 • CTSA Dietary Fat Acutely Increases Glucose Concentrations and Insulin Requirements in Patients With Type 1 Diabetes: Implications for Carbohydrate-Based Bolus Dose Calculation and Intensive Diabetes •Diabetes Care • April 01, 2013 • CTSA Piper Nigrum: Micropropagation, Antioxidative Enzyme Activities, and Chromatographic Fingerprint Analysis for Quality Control • Applied Biochemistry and Biotechnology • April 01, 2013 • CTSA A Phase 2 Study of KX2-391, an Oral Inhibitor of Src Kinase and Tubulin Polymerization, in Men with Bone-Metastatic Castration-Resistant Prostate Cancer • Cancer Chemotherapy and Pharmacology • April 01, 2013 • CTSA Optimal Threshold in CT Quantification of Emphysema • European Radiology • April 01, 2013 • CTSA Longitudinal Impact of Substance Use and Depressive Symptoms on Bone Accrual among Girls Aged 11-19 Years (April 2013) • Journal of Adolescent Health • April 01, 2013 • CTSA Comparative Effectiveness of Maxillomandibular Advancement and Uvulopalatopharyngoplasty for the Treatment of Moderate to Severe Obstructive Sleep Apnea • Journal of Oral and Maxillofacial Surgery • April 01, 2013 • CTSA The Mental Activity and eXercise (MAX) Trial: A Randomized Controlled Trial to Enhance Cognitive Function in Older Adults • JAMA Internal Medicine • April 01, 2013 • CTSA Agreement in the Scoring of Respiratory Events and Sleep Among International Sleep Centers • Sleep • April 01, 2013 • CTSA B-Cell Reconstitution for SCID: Should a Conditioning Regimen Be Used in SCID Treatment? • Journal of Allergy and Clinical Immunology • April 01, 2013 • ORDR March 2013 Genomic and Functional Characterizations of Phosphodiesterase Subtype 4D in Human Cancers • PNAS • March 27, 2013 • NCGC Methane and Hydrogen Positivity on Breath Test Is Associated with Greater Body Mass Index and Body Fat • Journal of Clinical Endocrinology and Metabolism • March 26, 2013 • CTSA Increased Brain Uptake and Oxidation of Acetate in Heavy Drinkers •Journal of Clinical Investigation • March 08, 2013 • CTSA Benefits and Costs of Improving Depression Treatment in People With Heart Disease: Comment on "Centralized, Stepped, Patient Preference-Based Treatment for Patients With Post-Acute Coronary Syndrome Depression • JAMA • March 07, 2013 • CTSA Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays • PLoS One • March 07, 2013 • NCGC Primary Ciliary Dyskinesia-Causing Mutations in Amish and Mennonite Communities • The Journal of Pediatrics • March 07, 2013 • ORDR European Lead Factory Opens for Business • Nature Reviews/Drug Discovery • March 06, 2013 • NCATS An Audience with Chris Austin • Nature Reviews/Drug Discovery • March 06, 2013 • NCATS Characteristics of the Child Behavior Checklist in Adolescents with Depression Associated with Bipolar Disorder • Journal of Affective Disorders • March 05, 2013 • CTSA A New Diagnostic Tool with the Potential to Predict Tumor Metastasis •Journal of the National Cancer Institute • March 02, 2013 • NCATS Touch Screen Performance by Individuals With and Without Motor Control Disabilities • Applied Ergonomics • March 01, 2013 • CTSA Regular Aerobic Exercise Protects Against Impaired Fasting Plasma Glucose-Associated Vascular Endothelial Dysfunction with Aging • Clinical Science • March 01, 2013 • CTSA Blunted Response to a Growth Hormone Stimulation Test is Associated with Unfavorable Cardiovascular Risk Factor Profile in Childhood Cancer Survivors • Pediatric Blood & Cancer • March 01, 2013 • CTSA Associations between Body Composition and Bone Density and Structure in Men and Women Across the Adult Age Spectrum • Bone • March 01, 2013 • CTSA Current Management of Prosthetic Joint Infections in Adults: Results of an Emerging Infections Network Survey • International Journal of Antimicrobial Agents • March 01, 2013 • CTSA Changes in Waist Circumference and Body Mass Index in the US Cardia Cohort: Fixed-Effects Associations with Self-Reported Experiences of Racial/Ethnic Discrimination • Journal of Biosocial Science • March 01, 2013 • CTSA Performance of Cystatin C-Based Equations in a Pediatric Cohort at High Risk of Kidney Injury • Pediatric Nephrology • March 01, 2013 • CTSA Rural Embedded Assistants for Community Health (REACH) Network: First-Person Accounts in a Community-University Partnership • American Journal of Community Psychology • March 01, 2013 • CTSA Mediators of Antiretroviral Adherence: A Multisite International Study •AIDS Care • March 01, 2013 • CTSA Structural Basis of Metal Hypersensitivity • Immunologic Research • March 01, 2013 • CTSA Toward Exercise as Personalized Medicine • Sports Medicine • March 01, 2013 • CTSA Electronic Health Records: A New Tool to Combat Chronic Kidney Disease?• Clinical Nephrology • March 01, 2013 • CTSA Radiation Exposure Time during MBSS: Influence of Swallowing Impairment Severity, Medical Diagnosis, Clinician Experience, and Standardized Protocol Use • Dysphagia • March 01, 2013 • CTSA Internet-Based Delphi Research: Case-Based Discussion • Environmental Management • March 01, 2013 • CTSA Assessment of Bias in Experimentally Measured Diffusion Tensor Imaging Parameters Using SIMEX • Magnetic Resonance in Medicine • March 01, 2013 • CTSA Multiple Regulatory Variants Modulate Expression of 5-Hydroxytryptamine 2A Receptors in Human Cortex • Biological Psychology • March 01, 2013 • CTSA The Community Leaders Institute: An Innovative Program to Train Community Leaders in Health Research • Academic Medicine: Journal of the Association of American Medical Colleges • March 01, 2013 • CTSA Marijuana Craving Trajectories in an Adolescent Marijuana Cessation Pharmacotherapy Trial • Addictive Behaviors • March 01, 2013 • CTSA Targeting Cessation: Understanding Barriers and Motivations to Quitting among Urban Adult Daily Tobacco Smokers • Addictive Biology • March 01, 2013 • CTSA Effects of the NK(1) Antagonist, Aprepitant, on Response to Oral and Intranasal Oxycodone in Prescription Opioid Abusers • Addictive Biology • March 01, 2013 • CTSA Optimal Nutrition in Hemodialysis Patients • Advances in Chronic Kidney Disease • March 01, 2013 • CTSA Laying the Groundwork for an HIV Prevention Intervention: A Descriptive Profile of the Los Angeles House and Ball Communities • AIDS and Behavior • March 01, 2013 • CTSA Delayed Initiation of Antiretroviral Therapy among HIV-Discordant Couples in Kenya • AIDS Care • March 01, 2013 • CTSA Youth as Partners, Participants or Passive Recipients: A Review of Children and Adolescents in Community-Based Participatory Research (CBPR) • American Journal of Community Psychology • March 01, 2013 • CTSA Tolerability of Curcumin in Pediatric Inflammatory Bowel Disease: A Forced-Dose Titration Study • Journal of Pediatric Gastroenterology and Nutrition • March 01, 2013 • CTSA Bioluminescent Assays for Cytochrome P450 Enzymes • Methods in Molecular Biology • March 01, 2013 • NCGC Estimation of Sleep Disturbances Using Wrist Actigraphy in Patients with Postural Tachycardia Syndrome • Autonomic Neuroscience • March 01, 2013 • ORDR Long Chain Fatty Acid Abnormalities in Hyper Igd Syndrome and Familial Mediterranean Fever: New Insight into Heritable Periodic Fevers •Molecular Genetics and Metabolism • March 01, 2013 • ORDR Mechanism of HERG Potassium Channel Inhibition by Tetra-N-Octylammonium Bromide and Benzethonium Chloride • Toxicology and Applied Pharmacology • March 01, 2013 • NCGC Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1 • Molecular and Cellular Biology • March 01, 2013 • NCATS February 2013 A Window into the Invisible Wound of War: Functional Neuroimaging of REM Sleep in Returning Combat Veterans with PTSD • Psychiatry Research• February 28, 2013 • CTSA High-Throughput Identification of Promiscuous Inhibitors from Screening Libraries with the Use of a Thiol-Containing Fluorescent Probe • Journal of Biomolecular Screening • February 27, 2013 • NCGC APOBEC3B Is an Enzymatic Source of Mutation in Breast Cancer •Nature • February 21, 2013 • CTSA Association Between Telomere Length and Experimentally Induced Upper Respiratory Viral Infection in Healthy Adults • JAMA • February 20, 2013 • CTSA Heart Transplant Survival Outcomes for Adriamycin-Dilated Cardiomyopathy • American Journal of Cardiology • February 15, 2013 • CTSA Human Genome-wide RNAI Screen Reveals a Role for Nuclear Pore Proteins in Poxvirus Morphogenesis • PNAS • February 15, 2013 • NCGC Inhibitors of the Yersinia Protein Tyrosine Phosphatase through High-throughput and Virtual Screening Approaches • Bioorganic and Medicinal Chemistry Letters • February 15, 2013 • NCGC Community Needs, Concerns, and Perceptions about Health Research: Findings From the Clinical and Translational Science Award Sentinel Network • American Journal of Public Health • February 14, 2013 • CTSA Drug Repurposing Gets a Boost as Academic Researchers Join the Search for Novel Uses of Existing Drugs • PNAS • February 12, 2013 • New Therapeutic Uses An End to the Myth: There is No Drug Development Pipeline • Science Translational Medicine • February 06, 2013 • NCATS The Effect of Glucagon-Like Peptide-1 Receptor Agonist Therapy on Body Mass Index in Adolescents with Severe Obesity • JAMA Pediatrics • February 04, 2013 • CTSA Predicting the Accuracy of Facial Affect Recognition: The Interaction of Child Maltreatment and Intellectual Functioning • Journal of Experimental Child Psychology • February 01, 2013 • CTSA Overexpression of Insulin-like Growth Factor 1 Receptor and Frequent Mutational Inactivation of SDHA in Wild-type SDHB-negative Gastrointestinal Stromal Tumors • Genes Chromosomes Cancer • February 01, 2013 • CTSA Confounders of Vasovagal Syncope: Orthostatic Hypotension • Cardiology Clinics • February 01, 2013 • CTSA Relation of Morbid Obesity and Female Gender to Risk of Procedural Complications in Patients Undergoing Atrial Fibrillation Ablation • The American Journal of Cardiology • February 01, 2013 • CTSA Avatar-Based Depression Self-Management Technology: Promising Approach to Improve Depressive Symptoms among Young Adults • Applied Nursing Research • February 01, 2013 • CTSA Evidence of Community Structure in Biomedical Research Grant Collaborations • Journal of Biomedical Informatics • February 01, 2013 • CTSA Report on CTSA Consortium Use of the Community Engagement Consulting Service – February 2013 • Clinical and Translational Science • February 01, 2013 • CTSA The CTSA as an Exemplar Framework for Developing Multidisciplinary Translational Teams - February 2013 • Clinical and Translational Science • February 01, 2013 • CTSA Effectiveness of Treatment Apnea-Hypopnea Index: A Mathematical Estimate of the True Apnea-Hypopnea Index in the Home Setting •Journal of Oral and Maxillofacial Surgery • February 01, 2013 • CTSA Nitric Oxide and Regulation of Heart Rate in Patients with Postural Tachycardia Syndrome and Healthy Subjects • Hypertension • February 01, 2013 • ORDR January 2013 Preventing Delirium in the Intensive Care Unit • Critical Care Clinics • January 29, 2013 • CTSA Sublingual Immunotherapy for Peanut Allergy: A Randomized, Double-blind, Placebo-controlled Multicenter Trial • Journal of Allergy and Clinial Immunology • January 23, 2013 • CTSA Circulating Neuregulin During the Transition from Sage a to Stage b/c Heart Failure in a Breast Cancer Cohort • Journal of Cardiac Failure • January 19, 2013 • CTSA Pharmaceutical Innovation Gets a Little Help from New Friends •Science Translational Medicine • January 16, 2013 • NCATS Diagnostic Inaccuracy of Smartphone Applications for Melanoma Detection• JAMA Dermatology • January 16, 2013 • CTSA Central Hemodynamics in Prehypertension: Effect of the β-Adrenergic Antagonist Nebivolol • Journal of Clinical Hypertension • January 15, 2013 • CTSA Targeting the JMJD2 Histone Demethylases to Epigenetically Control Herpesvirus Infection and Reactivation from Latency • Science Translational Medicine • January 09, 2013 • NCGC Native Kidney Function Following Liver Transplantation Using Calcineurin Inhibitors: Single-Center Analysis with 20 Years of Follow-up • Clinical Transplantation • January 07, 2013 • CTSA Pharmaceutical Profiling Case Study in Disruption • ACS Medicinal Chemistry Letters • January 07, 2013 • NCGC Autonomic Function Tests: Some Clinical Applications • Journal of Clinical Neurology • January 03, 2013 • ORDR Effects of Fructose vs. Glucose on Regional Cerebral Blood Flow in Brain Regions Involved with Appetite and Reward Pathways • Journal of the American Medical Association • January 02, 2013 • CTSA CC Genotype Donors for the Interleukin-28B Single Nucleotide Polymorphism are Associated with Better Outcomes in Hepatitis C after Liver Transplant • Liver International • January 01, 2013 • CTSA Diagnosing Postural Tachycardia Syndrome: Comparison of Tilt Testing Compared with Standing Haemodynamics • Clinical Science • January 01, 2013 • CTSA Workplace-Based Mindfulness Practice and Inflammation: A Randomized Trial • Brain, Behavior, and Immunity • January 01, 2013 • CTSA EBP50 Promotes Focal Adhesion Turnover and Vascular Smooth Muscle Cells Migration • Journal of Molecular and Cellular Cardiology • January 01, 2013 • CTSA Policies, Activities, and Structures Supporting Research Mentoring: A National Survey of Academic Health Centers With Clinical and Translational Science Awards • Academic Medicine • January 01, 2013 • CTSA Calpain Inhibitor Attenuated Optic Nerve Damage in Acute Optic Neuritis in Rats • Journal of Neurochemistry • January 01, 2013 • CTSA Outcomes after Listing with a Requirement for a Prospective Crossmatch in Pediatric Heart Transplantation • The Journal of Heart & Lung Transplantation • January 01, 2013 • CTSA Utility of C4d Immunostaining in the First Year After Pediatric and Young Adult Heart Transplantation • The Journal of Heart & Lung Transplantation • January 01, 2013 • CTSA Gait Coordination in Parkinson Disease: Effects of Step Length and Cadence Manipulations • Gait & Posture • January 01, 2013 • CTSA |
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