| ID | Title | Body | Facebook Description | Facebook image | Facebook Title | Facebook Video | Twitter Description | Twitter Image | Twitter Title | Meta tags |
|---|---|---|---|---|---|---|---|---|---|---|
| 2986 | Scientific Publications 2015 | December 2015 Treatment of Vitamin D Deficiency in Predominantly Hispanic and Black Adolescents: A Randomized Clinical Trial • Journal of Pediatrics • December 18, 2015 • CTSA Circulating Sex Hormones and Risk of Uterine Fibroids: Study of Women's Health Across the Nation (SWAN) • Journal of Clinical Endocrinology and Metabolism • December 11, 2015 • CTSA Changes in Receipt of Cancer Screening in Medicare Beneficiaries Following the Affordable Care Act • Journal of the National Cancer Institute • December 6, 2015 • CTSA Tissue Transcriptome-Driven Identification of Epidermal Growth Factor as a Chronic Kidney Disease Biomarker • Science Translational Medicine • December 2, 2015 • RDCRN HPV Vaccine Completion and Dose Adherence among Commercially Insured Females Aged 9 through 26 Years in the U.S. • Papillomavirus Research • December 1, 2015 • CTSA Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma • Molecular Imagine and Biology • December 1, 2015 • CTSA Neural Correlates of Visuomotor Learning in Autism • Journal of Child Neurology • December 1, 2015 • CTSA Vitamin D and Anemia: Insights into an Emerging Association • Current Opinion in Endocrinology, Diabetes, and Obesity • December 1, 2015 • CTSA Reducing Perceived Pain Levels During Nonbreast Lymphoscintigraphy • Clinical Nuclear Medicine • December 1, 2015 • CTSA Association between Femur Size and a Focal Defect of the Superior Femoral Neck • Bone • December 1, 2015 • CTSA Brain Injury and Development in Preterm Infants Exposed to Fentanyl • Annals of Pharmacotherapy • December 1, 2015 • CTSA Measuring the HIV Care Continuum Using Public Health Surveillance Data in the United States • Journal of Acquired Immune Deficiency Syndromes • December 1, 2015 • CTSA Examining Pre-Migration Health among Filipino Nurses • Journal of Immigrant and Minority Health • December 1, 2015 • CTSA Key Stakeholders' Perspectives on a Web-based Advance Care Planning Tool for Advanced Lung Disease • Journal of Critical Care • December 1, 2015 • CTSA Longitudinal Impact of a Collaborative Care Model on Employment Outcomes in Bipolar Disorder • Journal of Affective Disorders • December 1, 2015 • CTSA Prior Human Polyomavirus and Papillomavirus Infection and Incident Lung Cancer: A Nested Case-Control Study • Cancer Causes & Control • December 1, 2015 • CTSA "Manejar la Situacion": Partner Notification, Partner Management, and Conceptual Frameworks for HIV/STI Control among MSM in Peru • AIDS Behavior • December 1, 2015 • CTSA Comparing Neonatal Morbidity and Mortality Estimates across Specialty in Periviable Counseling • Journal of Maternal-Fetal & Neonatal Medicine • December 1, 2015 • CTSA Maternal Intuitive Eating as a Moderator of the Association between Concern about Child Weight and Restrictive Child Feeding • Appetite • December 1, 2015 • CTSA November 2015 Combining Micro-Computed Tomography with Histology to Analyze Biomedical Implants for Peripheral Nerve Repair • Journal of Neuroscience Methods • November 30, 2015 • CTSA A New Face of Sleep: The Impact of Post-Learning Sleep on Recognition Memory for Face-Name Associations • Neurobiology of Learning and Memory • November 23, 2015 • CTSA Pioneering Government-Sponsored Drug Repositioning Collaborations: Progress and Learning • Nature Reviews Drug Discovery • November 20, 2015 • New Therapeutic Uses Towards a Hit for Every Target • Nature Reviews Drug Discovery • November 20, 2015 • New Therapeutic Uses Multiple Imputation for Harmonizing Longitudinal Non-Commensurate Measures in Individual Participant Data Meta-Analysis • Statistics in Medicine • November 20, 2015 • CTSA Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol • Sleep • November 19, 2015 • CTSA Randomized Controlled Pilot Trial of Mindfulness-Based Stress Reduction for Breast and Colorectal Cancer Survivors: Effects on Cancer-Related Cognitive Impairment • Journal of Cancer Survivorship • November 19, 2015 • CTSA Improved Detection of Invasive Pulmonary Aspergillosis Arising during Leukemia Treatment Using a Panel of Host Response Proteins and Fungal Antigens • PLOS ONE • November 18, 2015 • CTSA Racial/Ethnic Differences Affecting Adherence to Cancer Screening Guidelines among Women • Journal of Women's Health • November 18, 2015 • CTSA Manipulation of Host Diet to Reduce Gastrointestinal Colonization by the Opportunistic Pathogen Candida albicans • mSphere • November 18, 2015 • CTSA Patient-Reported Impact of Symptoms in Myotonic Dystrophy Type 2 (PRISM-2) • Neurology • November 18, 2015 • CTSA Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma • Journal of Nuclear Medicine • November 12, 2015 • CTSA Loss of Consciousness at Onset of Subarachnoid Hemorrhage as an Important Marker of Early Brain Injury • JAMA Neurology • November 9, 2015 • CTSA Diabetes Screening among Underserved Adults with Severe Mental Illness Who Take Antipsychotic Medications • JAMA Internal Medicine • November 9, 2015 • CTSA A Randomized Trial of Cardiovascular Responses to Energy Drink Consumption in Healthy Adults • Journal of the American Medical Association • November 8, 2015 • CTSA Digital Quantification of miRNA Directly in Plasma Using Integrated Comprehensive Droplet Digital Detection • Lab on a Chip • November 7, 2015 • CTSA Child Care Center Characteristics Associated with Preschoolers’ Physical Activity • American Journal of Preventive Medicine • November 6, 2015 • CTSA Trends in Prescription Drug Use Among Adults in the United States from 1999-2012 • JAMA • November 3, 2015 • CTSA Effect of Sensorineural Hearing Loss on Neurocognitive Functioning in Pediatric Brain Tumor Survivors • Pediatric Blood and Cancer • November 3, 2015 • CTSA Racial and Ethnic Disparities in the Pediatric Hodgkin Lymphoma Population • Pediatric Blood & Cancer • November 2, 2015 • CTSA Low Unesterified:Esterified Eicosapentaenoic Acid (EPA) Plasma Concentration Ratio Is Associated with Bipolar Disorder Episodes, and Omega-3 Plasma Concentrations Are Altered by Treatment • Bipolar Disorders • November 1, 2015 • NCATS State of the Art Review: Depression, Stress, Anxiety, and Cardiovascular Disease • American Journal of Hypertension • November 1, 2015 • CTSA Quantification of Myo-Inositol, 1,5-Anhydro- D-Sorbitol, and D-Chiro-Inositol using High-Performance Liquid Chromatography with Electrochemical Detection in Very Small Volume Clinical Samples • Biomedical Chromatography • November 1, 2015 • CTSA Exposure to Environmental Chemicals and Heavy Metals, and Risk of Pancreatic Cancer • Cancer Causes & Control • November 1, 2015 • CTSA Prognostic Value of Epicardial Fat Volume Measurements by Computed Tomography: A Systematic Review of the Literature • European Radiology • November 1, 2015 • CTSA Overview of Immunodeficiency Disorders • Immunology and Allergy Clinics of North America • November 1, 2015 • CTSA The Impact of Intensive Reading Intervention on Level of Attention in Middle School Students • Journal of Clinical and Adolescent Psychology • November 1, 2015 • CTSA Associations between Adrenocortical Activity and Nicotine Response in Female Smokers by Menstrual Phase • Addictive Behaviors • November 1, 2015 • CTSA Trends in Prescription Drug Use among Adults in the United States from 1999-2012 • JAMA • November 1, 2015 • CTSA Confluence, Not Conflict of Interest: Name Change Necessary • JAMA • November 1, 2015 • CTSA Sunburn, Sun Exposure, and Sun Sensitivity in the Study of Nevi in Children • Annals of Epidemiology • November 1, 2015 • CTSA Muscarinic Acetylcholine Receptor Binding Affinities of Pethidine Analogs • Bioorganic & Medicinal Chemistry Letters • November 1, 2015 • CTSA October 2015 Right Hemisphere Grey Matter Structure and Language Outcomes in Chronic Left Hemisphere Stroke • Brain • October 31, 2015 • CTSA Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration • American Journal of Medicine • October 30, 2015 • CTSA Improving Patient-Centered Care: A Cross-Sectional Survey of Prior Use and Interest in Complementary and Integrative Health Approaches among Hospitalized Oncology Patients • Journal of Alternative and Complementary Medicine • October 27, 2015 • CTSA Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells • Molecular Cancer Research • October 27, 2015 • CTSA Evidence Synthesis Activities of a Hospital Evidence-based Practice Center and Impact on Hospital Decision Making • Journal of Hospital Medicine • October 27, 2015 • CTSA Broadscale Resolving Power Performance of a High Precision Uniform Field Ion Mobility-Mass Spectrometer • Analyst • October 21, 2015 • Tissue Chips Distinct Effects of Trial-Driven and Task Set-Related Control in Primary Visual Cortex • Neuroimage • October 15, 2015 • CTSA Diet Quality of Cancer Survivors and Noncancer Individuals: Results from a National Survey • Cancer • October 13, 2015 • CTSA Prevention of Acute Proximal Junctional Fractures After Long Thoracolumbar Posterior Fusions for Adult Spinal Deformity Using 2-level Cement Augmentation at the Upper Instrumented Vertebra and the Vertebra 1 Level Proximal to the Upper Instrumented Vertebra • Spine • October 1, 2015 • CTSA Thirty-Day Mortality in ED Patients with New Onset Atrial Fibrillation and Actively Treated Cancer • The American Journal of Emergency Medicine • October 1, 2015 • CTSA A Destructive Feedback Loop Mediated by CXCL10 in Central Nervous System Inflammatory Disease • Annals of Neurology • October 1, 2015 • CTSA Outcomes after Warfarin Initiation in a Cohort of Hemodialysis Patients with Newly Diagnosed Atrial Fibrillation • American Journal of Kidney Diseases • October 1, 2015 • CTSA Preparing Tomorrow's Nursing Home Nurses: The Wisconsin Long Term Care Clinical Scholars Program • Gerontology & Geriatrics Education • October 1, 2015 • CTSA Mutant p53 Expression in Fallopian Tube Epithelium Drives Cell Migration • International Journal of Cancer • October 1, 2015 • CTSA Using a Systems Engineering Initiative for Patient Safety to Evaluate a Hospital-wide Daily Chlorhexidine Bathing Intervention • Journal of Nursing Care Quality • October 1, 2015 • CTSA Mini but Mighty: MicroRNAs in the Pathobiology of Periodontal Disease • Periodontology • October 1, 2015 • CTSA Widespread White Matter but Focal Gray Matter Alterations in Depressed Individuals with Thoughts of Death • Early Human Development • October 1, 2015 • CTSA Cesarean Delivery Is Not Associated with Decreased At-Birth Fracture Rates in Osteogenesis Imperfecta • Genetics in Medicine • October 1, 2015 • RDCRN September 2015 Risk of Dementia in Patients with Celiac Disease: A Population-Based Cohort Study • Journal of Alzheimer's Disease • September 29, 2015 • CTSA Adenosine A2A Receptor Plays an Important Role in Radiation-induced Dermal Injury • The Official Journal of the Federation of American Societies for Experimental Biology • September 28, 2015 • CTSA High-Throughput Matrix Screening Identifies Synergistic and Antagonistic Antimalarial Drug Combinations • Scientific Reports • September 25, 2015 • NCGC, Matrix Selective Targeting of JAK/STAT Signaling is Potentiated by Bcl-xL Blockade in IL-2-Dependent Adult T-Cell Leukemia • Proceedings of the National Academy of Sciences • September 22, 2015 • NCGC, Matrix Dissociable Roles of Dopamine and Serotonin Transporter Function in a Rat Model of Negative Urgency • Behavioural Brain Research • September 15, 2015 • CTSA Hospital Variation in Admission to Intensive Care Units for Patients with Acute Myocardial Infarction • American Heart Journal • September 11, 2015 • CTSA Health Conditions and Functional Status in Adults with Autism: A Cross-Sectional Evaluation • Journal of General Internal Medicine • September 11, 2015 • CTSA A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency • New England Journal of Medicine • September 10, 2015 • CTSA Progression to Traditional Cigarette Smoking After Electronic Cigarette Use among U.S. Adolescents and Young Adults • JAMA Pediatrics • September 8, 2015 • CTSA Overdiagnosis of Clostridium difficile Infection in the Molecular Test Era • JAMA Internal Medicine • September 8, 2015 • CTSA The Association of Expanded Access to a Collaborative Midwifery and Laborist Model with Cesarean Delivery Rates • Obstetrics and Gynecology • September 3, 2015 • CTSA Voriconazole Exposure and Risk of Cutaneous Squamous Cell Carcinoma, Aspergillus Colonization, Invasive Aspergillosis and Death in Lung Transplant Recipients • American Journal of Transplantation • September 3, 2015 • CTSA Gain-of-Function p53 Mutants Co-Opt Chromatin Pathways to Drive Cancer Growth • Nature • September 2, 2015 • CTSA A Longitudinal Twin Study of Insomnia Symptoms in Adults • Sleep • September 1, 2015 • CTSA Effect of Menstrual Cycle Phase on Background Parenchymal Uptake at Molecular Breast Imaging • Academic Radiology • September 1, 2015 • CTSA The Barriers to High-Quality Inpatient Pain Management: A Qualitative Study • American Journal of Hospice & Palliative Care • September 1, 2015 • CTSA Association of Hyperchloremia with Hospital Mortality in Critically Ill Septic Patients • Critical Care Medicine • September 1, 2015 • CTSA The Yale Craving Scale: Development and Psychometric Properties • Drug and Alcohol Dependency • September 1, 2015 • CTSA Appreciating Reasons for Nonadherence in Women • Health Care for Women International • September 1, 2015 • CTSA Preoperative Risk Factors for Postoperative Delirium Following Hip Fracture Repair: A Systematic Review • International Journal of Geriatric Psychiatry • September 1, 2015 • CTSA Experience with Fingolimod in Clinical Practice • International Journal of Neuroscience • September 1, 2015 • CTSA Trust and the Ethics of Chronic Pain Management in HIV • Journal of the Association of Nurses in AIDS Care • September 1, 2015 • CTSA Vessel Network Formation in Response to Intermittent Hypoxia is Frequency Dependent • Journal of Bioscience and Bioengineering • September 1, 2015 • Tissue Chip A Novel Role for Thrombopoietin in Regulating Osteoclast Development in Humans and Mice • Journal of Cellular Physiology • September 1, 2015 • CTSA August 2015 Dynamic Reconfiguration of Frontal Brain Networks during Executive Cognition in Humans • Proceedings of the National Academy of Sciences • August 31, 2015 • CTSA Recurrent Stroke in Childhood Cancer Survivors • Neurology • August 26, 2015 • NCATS Automated Analysis of Free Speech Predicts Psychosis Onset in High-Risk Youths • NPJ-Schizophrenia • August 26, 2015 • CTSA Parental Use of Electronic Cigarettes • Academic Pediatrics • August 25, 2015 • CTSA Temporal and Spatial Variation of the Human Microbiota during Pregnancy • Proceedings of the National Academy of Sciences • August 17, 2015 • CTSA Community Surveillance of Respiratory Viruses Among Families in the Utah Better Identification of Germs-Longitudinal Viral Epidemiology (BIG-LoVE) Study • Clinical Infectious Diseases • August 4, 2015 • CTSA An Apoptosis-Enhancing Drug Overcomes Platinum Resistance in a Tumour-Initiating Subpopulation of Ovarian Cancer • Nature Communications • August 3, 2015 • CTSA Optimizing Hybrid Occlusion in Face-Jaw-Teeth Transplantation: A Preliminary Assessment of Real-Time Cephalometry as Part of the Computer-Assisted Planning and Execution Workstation for Craniomaxillofacial Surgery • Plastic and Reconstructive Surgery • August 1, 2015 • CTSA Fractures on Bisphosphonates in Osteoporosis Pseudoglioma Syndrome (OPPG): pQCT Shows Poor Bone Density and Structure • Bone • August 1, 2015 • CTSA Regional Variation of Bone Tissue Properties at the Human Mandibular Condyle • Bone • August 1, 2015 • CTSA Acute Responses to Opioidergic Blockade as a Biomarker of Hedonic Eating among Obese Women Enrolled in a Mindfulness-based Weight Loss Intervention Trial • Appetite • August 1, 2015 • CTSA A Phenotypic In Vitro Model for the Main Determinants of Human Whole Heart Function • Biomaterials • August 1, 2015 • Tissue Chip Impact of Electronic Health Record Technology on the Work and Workflow of Physicians in the Intensive Care Unit • International Journal of Medical Informatics • August 1, 2015 • CTSA Psychometric Evaluation of the Hospital Anxiety and Depression Scale 3 Months after Acute Lung Injury • Journal of Critical Care • August 1, 2015 • CTSA Hospital Readmission after Emergency Room Visit for Cholelithiasis • Journal of Surgical Research • August 1, 2015 • CTSA Innovation or Rebranding, Acute Care Surgery Diffusion will Continue • Journal of Surgical Research • August 1, 2015 • CTSA July 2015 Pain in Community-Dwelling Older Adults with Dementia: Results from the National Health and Aging Trends Study • Journal of the American Geriatrics Society • July 22, 2015 • CTSA The Promise and Peril of Chemical Probes • Nature Chemical Biology • July 21, 2015 • NCGC The Development of a Pediatric Inpatient Experience of Care Measure: Child HCAHPS • Pediatrics • July 20, 2015 • CTSA Initial Benchmarking of the Quality of Medical Care of Childhood-Onset Systemic Lupus Erythematosus • Arthritis Care Research • July 20, 2015 • CTSA Phenotype and Adverse Quality of Life in Boys with Klinefelter Syndrome • Journal of Pediatrics • July 20, 2015 • CTSA Bioactive Products Formed in Humans from Fish Oils • Journal of Lipid Research • July 15, 2015 • CTSA Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays • PLOS ONE • July 15, 2015 • NCGC Inflammation-Associated Declines in Cerebral Vasoreactivity and Cognition in Type 2 Diabetes • Neurology • July 8, 2015 • CTSA Variations in Opioid Receptor Genes in Neonatal Abstinence Syndrome • Drug & Alcohol Dependence • July 7, 2015 • CTSA IFNγ Responses to Pre-erythrocytic and Blood-stage Malaria Antigens Exhibit Differential Associations with Past Exposure and Subsequent Protection • Journal of Infectious Diseases • July 1, 2015 • CTSA Estrogens and Their Precursors in Postmenopausal Women with Early Breast Cancer Receiving Anastrozole • Steroids • July 1, 2015 • CTSA Replication Study of the Milwaukee Inventory for Subtypes of Trichotillomania-Adult Version in a Clinically Characterized Sample • Behavior Modification • July 1, 2015 • CTSA Second Malignant Neoplasms Among Children, Adolescents and Young Adults with Wilms Tumor • Pediatric Blood & Cancer • July 1, 2015 • CTSA Prevalence of Post-Thrombotic Syndrome after Cardiac Catheterization • Pediatric Blood & Cancer • July 1, 2015 • CTSA Safety of Octreotide in Hospitalized Infants • Early Human Development • July 1, 2015 • CTSA Association of Vascular Risk Factors with Cognition in a Multiethnic Sample • Journal of Gerontology • July 1, 2015 • CTSA The Coeliac Stomach: Gastritis in Patients with Coeliac Disease • Alimentary Pharmacology & Therapeutics • July 1, 2015 • CTSA Health Outcomes of Obtaining Housing among Older Homeless Adults • American Journal of Public Health • July 1, 2015 • CTSA Risk Factors for Pancreatitis in Older Women: The Iowa Women's Health Study • Annals of Epidemiology • July 1, 2015 • CTSA Food Order Has a Significant Impact on Postprandial Glucose and Insulin Levels • Diabetes Care • July 1, 2015 • CTSA June 2015 Rehospitalizations Following Sepsis: Common and Costly • Critical Care Medicine • June 30, 2015 • CTSA Skin Cancer Risk Factors and Preventative Behaviors among United States Military Veterans Deployed to Iraq and Afghanistan • Journal of Investigative Dermatology • June 25, 2015 • CTSA Critical Elements in the Medical Evaluation of Suspected Child Physical Abuse • Pediatrics • June 22, 2015 • CTSA Microneedle-Array Patches Loaded with Hypoxia-Sensitive Vesicles Provide Fast Glucose-Responsive Insulin Delivery • PNAS • June 22, 2015 • CTSA Racial/Ethnic Differences in Sleep Disturbances: The Multi-Ethnic Study of Atherosclerosis (MESA) • Sleep • June 19, 2015 • CTSA Corrigendum: The Effect of Poor Sleep Quality on Mood Outcome Differs Between Men and Women: A Longitudinal Study of Bipolar Disorder • Journal of Affective Disorders • June 19, 2015 • CTSA Assessing Differences in Mortality Rates and Risk Factors between Hispanic and Non-Hispanic Patients with Cystic Fibrosis in California • Chest • June 18, 2015 • CTSA Unorthodox Alternative Therapies Marketed to Treat Lyme Disease • Clinical Infectious Diseases • June 15, 2015 • CTSA Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors • New England Journal of Medicine • June 10, 2015 • CTSA Therapeutic Effects of Glatiramer Acetate and Grafted CD115+ Monocytes in a Mouse Model of Alzheimer’s Disease • Brain • June 6, 2015 • CTSA Cost-Effectiveness of Immediate Compared with Delayed Postpartum Etonogestrel Implant Insertion • Obstetrics & Gynecology • June 5, 2015 • CTSA Intrauterine Device Placement during Cesarean Delivery and Continued Use 6 Months Postpartum: A Randomized Controlled Trial • Obstetrics & Gynecology • June 5, 2015 • CTSA Advancing Biological Understanding and Therapeutics Discovery with Small Molecule Probes • Cell • June 4, 2015 • NCGC News Feature: Building Benchtop Human Models • PNAS • June 2, 2015 • Tissue Chip Dietary Intake and Weight Gain Among Adolescents on Depot Medroxyprogesterone Acetate •The Journal of Pediatric and Adolescent Gynecology •June 1, 2015 • CTSA Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat • Journal of Clinical Endocrinology & Metabolism • June 1, 2015 • CTSA A Facilitated Peer Mentoring Program for Junior Faculty to Promote Professional Development and Peer Networking • Academic Medicine • June 1, 2015 • CTSA Intestinal Alkaline Phosphatase to Treat Necrotizing Enterocolitis • Journal of Surgical Research • June 1, 2015 • CTSA Whole Blood Neutrophil Gelatinase-Associated Lipocalin Predicts Acute Kidney Injury in Burn Patients • Journal of Surgical Research • June 1, 2015 • CTSA An Exploratory Short-Term Double-Blind Randomized Trial of Varenicline Versus Nicotine Patch for Smoking Cessation in Women • Addiction • June 1, 2015 • CTSA Low Heat Pain Thresholds in Migraineurs between Attacks • Cephalagia • June 1, 2015 • CTSA Impact of Conditioning Regimen on Outcomes for Patients with Lymphoma Undergoing High-Dose Therapy with Autologous Hematopoietic Cell Transplantation • Biology of Blood and Marrow Transplantation • June 1, 2015 • CTSA Antihypertensive Drug Class and Adherence: An Electronic Monitoring Study • American Journal of Hypertension • June 1, 2015 • CTSA Pharmacological Inhibition of ALDH1A in Mice Decreases All-Trans retinoic Acid Concentrations in a Tissue Specific Manner • Biochemical Pharmacology • June 1, 2015 • CTSA Should Blood Pressure Targets after Lacunar Stroke Vary by Body Size? The SPS3 Trial • American Journal of Hypertension • June 1, 2015 • CTSA The Prognostic Role of the Preoperative Absolute Lymphocyte Count and Absolute Monocyte Count in Patients with Resected Advanced Melanoma • American Journal of Clinical Oncology • June 1, 2015 • CTSA Necrotizing Enterocolitis in Infants with Ductal-dependent Congenital Heart Disease • American Journal of Perinatology • June 1, 2015 • CTSA Targeting NADPH Oxidase with a Novel Dual Nox1/Nox4 Inhibitor Attenuates Renal Pathology in Type 1 Diabetes • American Journal of Physiology • June 1, 2015 • CTSA Intercepting Wrong-Patient Orders in a Computerized Provider Order Entry System • Journal of Gerontology • June 1, 2015 • CTSA Black and Hispanic Perceptions of Asthma Medication in the School Inner-City Asthma Study • Annals of Allergy, Asthma & Immunology • June 1, 2015 • CTSA Rapid Administration Technique of Ketamine for Pediatric Forearm Fracture Reduction: A Dose-finding Study • Annals of Emergency Medicine • June 1, 2015 • CTSA Assessment of Autism Symptoms During the Neonatal Period: Is There Early Evidence of Autism Risk? • American Journal of Occupational Therapy • June 1, 2015 • CTSA May 2015 Sudden Infant Death Syndrome and Residential Altitude • Pediatrics • May 25, 2015 • CTSA Underuse and Overuse of Osteoporosis Screening in a Regional Health System: a Retrospective Cohort Study • Journal of General Internal Medicine • May 19, 2015 • CTSA Tuberous Sclerosis: A New Frontier in Targeted Treatment of Autism • Neurotherapeutics • May 19, 2015 • RDCRN The Association between Continuity of Care and the Overuse of Medical Procedures • JAMA Internal Medicine • May 18, 2015 • CTSA Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR• New England Journal of Medicine • May 17, 2015 • CTSA Longitudinal Changes in Free-Water within the Substantia Nigra of Parkinson’s Disease • Brain • May 16, 2015 • CTSA A Method for Determining δ-aminolevulinic Acid Synthase Activity in Homogenized Cells and Tissues • Clinical Biochemistry • May 8, 2015 • RDCRN Cardiac Involvement in Granulomatosis with Polyangiitis • Journal of Rheumatology • May 1, 2015 • RDCRN Intellectual and adaptive functioning in Sturge-Weber Syndrome • Child Neuropsychology • May 1, 2015 • RDCRN April 2015 Intracranial Mapping of a Cortical Tinnitus System using Residual Inhibition • Current Biology • April 23, 2015 • CTSA Group 3 Innate Lymphoid Cells Mediate Intestinal Selection of Commensal Bacteria-Specific CD4+ T Cells • Science • April 23, 2015 • CTSA Newborn Screening: Evolving Challenges in an Era of Rapid Discovery • JAMA • April 21, 2015 • NCATS Improving Treatment Trial Outcomes for Rett Syndrome: The Development of Rett-specific Anchors for the Clinical Global Impression Scale • Journal of Child Neurology • April 20, 2015 • RDCRN Quantitative Optical Coherence Tomography Angiography of Vascular Abnormalities in the Living Human Eye • PNAS • April 20, 2015 • CTSA Drug-Based Modulation of Endogenous Stem Cells Promotes Functional Remyelination In Vivo • Nature • April 20, 2015 • NCATS Excessive Sugar Consumption May Be a Difficult Habit to Break: A View from the Brain and Body • Addictive Behaviors • April 16, 2015 • CTSA Disease Relapses among Patients with Giant Cell Arteritis: A Prospective, Longitudinal Cohort Study • The Journal of Rheumatology • April 15, 2015 • NCATS Viraemia Suppressed in HIV-1-Infected Humans by Broadly Neutralizing Antibody 3BNC117 • Nature • April 08, 2015 • CTSA Development and validation of a clinical scale for rating the severity of blepharospasm • Movement Disorders • April 1, 2015 • RDCRN History and current status of newborn screening for severe combined immunodeficiency • Seminars in Perinatology • April 1, 2015 • RDCRN Heritability of dietary traits that contribute to nephrolithiasis in a cohort of adult sibships • Journal of Nephrology • April 1, 2015 • RDCRN Subjective Response to Nicotine by Menstrual Phase • Addictive Behaviors • April 01, 2015 • CTSA General and Health-Related Internet Use among an Urban, Community-Based Sample of HIV-Positive Women: Implications for Intervention Development • AIDS Care • April 01, 2015 • CTSA Associations between Parental Ideology and Neural Sensitivity to Cognitive Conflict in Children • Social Neuroscience • April 01, 2015 • CTSA A Rural Appalachian Faith-Placed Smoking Cessation Intervention • Journal of Religion and Health • April 01, 2015 • CTSA March 2015 The Effects of Naltrexone on Subjective Response to Methamphetamine in a Clinical Sample: a Double-Blind, Placebo-Controlled Laboratory Study • Neuropsychopharmacology • March 24, 2015 • CTSA Human Ebola Virus Infection Results in Substantial Immune Activation • Proceedings of the National Academy of Sciences • March 09, 2015 • CTSA Emergency Postexposure Vaccination With Vesicular Stomatitis Virus–Vectored Ebola Vaccine After Needlestick • Journal of the American Medical Association • March 05, 2015 • CTSA Impact of NRAS Mutations for Patients with Advanced Melanoma Treated with Immune Therapies • Cancer Immunology Research • March 03, 2015 • CTSA High-Throughput RNA Profiling via Up-Front Sample Parallelization • Nature Methods • March 02, 2015 • CTSA New Analysis Reexamines the Value of Cancer Care in the United States Compared to Western Europe • Health Affairs • March 02, 2015 • CTSA Gut Microbiome Composition is Associated with Temperament during Early Childhood • Brain, Behavior and Immunity • March 1, 2015 • CTSA Healthcare Workers' Perceptions of Lean: A Context-Sensitive, Mixed Methods Study in Three Swedish Hospitals • Applied Ergonomics • March 01, 2015 • CTSA The Patient Work System: An Analysis of Self-Care Performance Barriers among Elderly Heart Failure Patients and Their Informal Caregivers • Applied Ergonomics • March 01, 2015 • CTSA Validation of Marrow Fat Assessment Using Noninvasive Imaging with Histologic Examination of Human Bone Samples • Bone • March 01, 2015 • CTSA Signaling Pathways Involved in Megakaryocyte-Mediated Proliferation of Osteoblast Lineage Cells • Journal of Cellular Physiology • March 01, 2015 • CTSA Challenges Facing HIV-Positive Persons Who Use Drugs and Their Families in Vietnam • AIDS Care • March 01, 2015 • CTSA Delusions and Prediction Error: Clarifying the Roles of Behavioural and Brain Responses • Cognitive Neuropsychiatry • March 01, 2015 • CTSA Comparison of Survival at Adult versus Pediatric Treatment Centers for Rare Pediatric Tumors in an Adolescent and Young Adult (AYA) Population in the State of Georgia • Pediatric Blood & Cancer • March 01, 2015 • CTSA Health Priorities among Women Recently Released from Jail • American Journal of Health Behavior • March 01, 2015 • CTSA Outcomes after Subtotal Parathyroidectomy for Primary Hyperparathyroidism due to Hyperplasia: Significance of Whole vs. Partial Gland Remnant • Annals of Surgical Oncology • March 01, 2015 • CTSA Preventing Postoperative Hypocalcemia in Patients with Graves Disease: A Prospective Study • Annals of Surgical Oncology • March 01, 2015 • CTSA How Physician Electronic Health Record Screen Sharing Affects Patient and Doctor Non-Verbal Communication in Primary Care • Patient Education and Counseling • March 01, 2015 • CTSA Age and Gender Modulate the Neural Circuitry Supporting Facial Emotion Processing in Adults with Major Depressive Disorder • The American Journal of Geriatric Psychiatry • March 01, 2015 • CTSA Clinical Outcomes of Splenectomy in Children: Report of the Splenectomy in Congenital Hemolytic Anemia Registry • The American Journal of Hematology • March 01, 2015 • CTSA The Association of Resistin with Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosis • Atherosclerosis • March 01, 2015 • CTSA Associations between Muscle-Related Cytokines and Selected Patient Outcomes in the ICU • Biological Research for Nursing • March 01, 2015 • CTSA Delivery of an Engineered HGF Fragment in an Extracellular Matrix-Derived Hydrogel Prevents Negative LV Remodeling Post-Myocardial Infarction • Biomaterials • March 01, 2015 • CTSA Stability of P50 Auditory Sensory Gating during Sleep from Infancy to 4 Years of Age • Brain and Cognition • March 01, 2015 • CTSA Facebook Advertisements Recruit Parents of Children with Cancer for an Online Survey of Web-based Research Preferences • Cancer Nursing • March 01, 2015 • CTSA The Life Changes in Epilepsy Scale: Development and Establishment of Content and Face Validity • Clinical Nurse Specialist • March 01, 2015 • CTSA The Epidemiology and Diagnosis of Invasive Candidiasis among Premature Infants • Clinics in Perinatology • March 01, 2015 • CTSA Current Diagnostic and Therapeutic Strategies in Microvascular Angina • Current Emergency and Hospital Medicine Reports • March 01, 2015 • CTSA February 2015 Multifactorial Analysis of Conditional Reprogramming of Human Keratinocytes • PLoS ONE • February 25, 2015 • NCATS Financing Translation: Analysis of the NCATS Rare-Diseases Portfolio • Science Translational Medicine • February 25, 2015 • NCATS Cardiovascular Risk and Acute Coronary Syndrome in Giant Cell Arteritis: A Population-Based Retrospective Cohort Study • Arthritis Care & Research • February 24, 2015 • CTSA Ethnic Differences in Presentation and Severity of Alcoholic Liver Disease • Alcoholism: Clinical & Experimental Research • February 20, 2015 • CTSA Quantitative High-Throughput Screening Using a Primary Human Three-Dimensional Organotypic Culture Predicts In Vivo Efficacy • Nature Communications • February 17, 2015 • NCATS Biodefense Aims to Simulate Human Bodies by Linking Mini "Organs on Chips" • Scientific American • February 17, 2015 • Tissue Chips Biodefence Researchers Seek 'Homo Chippiens' • Nature • February 17, 2015 • Tissue Chips Mindfulness Meditation and Improvement in Sleep Quality and Daytime Impairment Among Older Adults With Sleep Disturbances: A Randomized Clinical Trial • JAMA Internal Medicine • February 16, 2015 • CTSA Effect of Prior Cancer on Outcomes in Advanced Lung Cancer: Implications for Clinical Trial Eligibility and Accrual • Journal of the National Cancer Institute • February 09, 2015 • CTSA Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics • Cell Systems • February 07, 2015 • CTSA Plant-Based, No-Added-Fat or American Heart Association Diets: Impact on Cardiovascular Risk in Obese Children with Hypercholesterolemia and Their Parents • The Journal of Pediatrics • February 05, 2015 • CTSA Use of the Etonogestrel Implant and Levonorgestrel Intrauterine Device Beyond the U.S. Food and Drug Administration-Approved Duration • Obstetrics & Gynecology • February 04, 2015 • CTSA Relative Contributions of Complications and Failure to Rescue on Mortality in Older Patients Undergoing Pancreatectomy • Annals of Surgery • February 03, 2015 • CTSA Noninvasive Mapping of Pancreatic Inflammation in Recent-Onset Type-1 Diabetes Patients • Proceedings of the National Academy of Sciences • February 03, 2015 • CTSA Discovery of a Novel General Anesthetic Chemotype Using High-Throughput Screening • Anesthesiology • February 01, 2015 • NCGC A Likelihood Ratio Test for Nested Proportions • Statistics in Medicine • February 01, 2015 • CTSA High-Strength, Surface-Porous Polyether-Ether-Ketone for Load-Bearing Orthopedic Implants • Acta Biomaterialia • February 01, 2015 • CTSA Remodeling Characteristics and Collagen Distribution in Biological Scaffold Materials Explanted from Human Subjects after Abdominal Soft Tissue Reconstruction • Annals of Surgery • February 01, 2015 • CTSA The Burn Wound Exudate: An Under-Utilized Resource • Burns • February 01, 2015 • CTSA Maternal and Child Roles in the Feeding Relationship: What are Mothers Doing? • Clinical Pediatrics • February 01, 2015 • CTSA Standardization and Validation of a Novel and Simple Method to Assess Lumbar Dural Sac Size • Clinical Radiology • February 01, 2015 • CTSA An Exploratory Study of Inactive Health Information Seekers • International Journal of Medical Informatics • February 01, 2015 • CTSA Persistent Differences in Asthma Self-Efficacy by Race, Ethnicity, and Income in Adults with Asthma • The Journal of Asthma • February 01, 2015 • CTSA Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder • Neuropsychopharmacology • February 01, 2015 • CTSA JOURNAL CLUB: Molecular Breast Imaging at Reduced Radiation Dose for Supplemental Screening in Mammographically Dense Breasts • American Journal of Roentgenology • February 01, 2015 • CTSA Elevated Risk for Autoimmune Disorders in Iraq and Afghanistan Veterans with Posttraumatic Stress Disorder • Biological Psychiatry • February 01, 2015 • CTSA Early Visual Cortex Reflects Initiation and Maintenance of Task Set • Neuroimaging • February 01, 2015 • CTSA Serum Bicarbonate and Bone Mineral Density in US Adults • American Journal of Kidney Diseases • February 01, 2015 • CTSA Neurophysiological Correlates of Sevoflurane-Induced Unconsciousness • Anesthesiology • February 01, 2015 • CTSA Hair Cortisol in Relation to Sociodemographic and Lifestyle Characteristics in a Multiethnic US Sample • Annals of Epidemiology • February 01, 2015 • CTSA Justified Follow-Up: A Final Intraoperative Parathyroid Hormone (ioPTH) Over 40 pg/mL is Associated with an Increased Risk of Persistence and Recurrence in Primary Hyperparathyroidism • Annals of Surgical Oncology • February 01, 2015 • CTSA Baseline Characteristics Predict Risk of Progression and Response to Combined Medical Therapy for Benign Prostatic Hyperplasia (BPH) • BJU International • February 01, 2015 • CTSA Obesity and Diabetes in an Aging Population: Time to Rethink Definitions and Management? • Clinics in Geriatric Medicine • February 01, 2015 • CTSA Pre-Operative Prediction of Surgical Morbidity in Children: Comparison of Five Statistical Models • Computers in Biology and Medicine • February 01, 2015 • CTSA Human Cardiac Tissue Engineering: From Pluripotent Stem Cells to Heart Repair • Current Opinion in Chemical Engineering • February 01, 2015 • CTSA Lazarus Drugs • The Scientist • February 01, 2015 • New Therapeutic Uses A Bayesian Approach for Instrumental Variable Analysis with Censored Time-to-Event Outcome • Statistics in Medicine • February 01, 2015 • CTSA Head Motion during MRI Acquisition Reduces Gray Matter Volume and Thickness Estimates • Neuroimage • February 01, 2015 • CTSA Metabolically Normal Obese People are Protected from Adverse Effects Following Weight Gain • The Journal of Clinical Investigation • February 01, 2015 • CTSA Loneliness in HIV-Infected Smokers • AIDS Care • February 01, 2015 • CTSA January 2015 US Lawmakers Seek to Revamp Biomedical Research • Nature • January 28, 2015 • NCATS Evening Use of Light-Emitting eReaders Negatively Affects Sleep, Circadian Timing, and Next-Morning Alertness • PNAS • January 27, 2015 • CTSA Causes and Timing of Death in Extremely Premature Infants from 2000 through 2011 • New England Journal of Medicine • January 22, 2015 • CTSA Chlorhexidine Bathing and Health Care-Associated Infections: A Randomized Clinical Trial • Journal of the American Medical Association • January 20, 2015 • CTSA Trends in Use of and Reproductive Outcomes Associated With Intracytoplasmic Sperm Injection • Journal of the American Medical Association • January 20, 2015 • NCATS Dietary Sodium Content, Mortality, and Risk for Cardiovascular Events in Older Adults: The Health, Aging, and Body Composition (Health ABC) Study• JAMA Internal Medicine • January 19, 2015 • CTSA Salt Intake Not Associated with Mortality or Risk of Cardiovascular Disease, Heart Failure in Older Adults • JAMA Internal Medicine • January 19, 2015 • CTSA Population-Based in Vitro Hazard and Concentration–Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study •Environmental Health Perspectives • January 13, 2015 • Tox21 Evidence for Brain Glial Activation in Chronic Pain Patients • Brain • January 12, 2015 • NCATS Potential Overtreatment of Diabetes Mellitus in Older Adults with Tight Glycemic Control • JAMA Internal Medicine • January 12, 2015 • CTSA Bring Out Your Dead • Nature Biotechnology • January 9, 2015 • New Therapeutic Uses Effect of a Moderate Fat Diet with and without Avocados on Lipoprotein Particle Number, Size and Subclasses in Overweight and Obese Adults: A Randomized, Controlled Trial • Journal of the American Heart Association • January 7, 2015 • CTSA Spinoff Company to Develop Rare Disease Drugs • The Scientist • January 7, 2015 • TRND Comprehensive Appraisal of MRI Findings in Sustained RA Remission: Sub-study of the TEAR Trial • Arthritis Care Research • January 7, 2015 • CTSA Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization Data • PLOS Medicine • January 6, 2015 • CTSA Dried Whole-Plant Artemisia annua Slows Evolution of Malaria Drug Resistance and Overcomes Resistance to Artemisinin • Proceedings of the National Academy of Sciences • January 5, 2015 • CTSA Cognitive Dysfunction in Postural Tachycardia Syndrome • Clinical Science• January 01, 2015 • CTSA Multi-Stakeholder Collaboration in the Redesign of Family-Centered Rounds Process • Applied Ergonomics • January 01, 2015 • CTSA Histone Deacetylase Inhibition Destabilizes the Multi-Potent State of Uncommitted Adipose-Derived Mesenchymal Stromal Cells • Journal of Cellular Physiology • January 1, 2015 • CTSA Executive Function Moderates the Relation between Coping and Depressive Symptoms • Anxiety Stress Coping • January 1, 2015 • CTSA Non-Contrast MRI Perfusion Angiosome in Diabetic Feet • European Radiology • January 1, 2015 • CTSA Partnering with Youth to Map Their Neighborhood Environments: A Multilayered GIS Approach • Family & Community Health • January 1, 2015 • CTSA "Doctor, what would you do?": Physicians' Responses to Patient Inquiries about Periviable Delivery • Patient Education and Counseling • January 1, 2015 • CTSA Brief Strategic Family Therapy: Implementing Evidence-Based Models in Community Settings • Psychotherapy Research • January 1, 2015 • CTSA Potential Mitochondrial Toxicants: Tox21 Screen Identifies Chemicals of Interest • Environmental Health Perspectives • January 1, 2015 • Tox21 Quantity of Dietary Protein Intake, but Not Pattern of Intake, Affects Net Protein Balance Primarily through Differences in Protein Synthesis in Older Adults • American Journal of Physiology—Endocrinology and Metabolism • January 1, 2015 • CTSA A Chimeric Human–Mouse Model of Sjögren's Syndrome • Clinical Immunology • January 1, 2015 • CTSA | ||||||||
| 2983 | TRND Clinical Research Studies | For more details about clinical research studies supported by TRND, click on the links below or visit ClinicalTrials.gov. Active Studies Creatine Transporter Deficiency Observational Study of Males With Creatine Transporter Deficiency GNE Myopathy (previously known at Hereditary Inclusion Body Myopathy) A Natural History Study of Patients with GNE Myopathy Niemann-Pick Disease Type C Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C Completed Studies Chronic Lymphocytic Leukemia Phase II Study of Auranofin in Chronic Lymphocytic Leukemia GNE Myopathy (previously known at Hereditary Inclusion Body Myopathy) A Phase I Study to Evaluate the Safety and Tolerability of ManNAc in Subjects GNE Myopathy A Phase II Study of DEX-M74 (ManNac) in Subjects with GNE Myopathy Niemann-Pick Disease Type C1 Hydroxypropyl Beta Cyclodextrin for Niemann-Pick Type C1 Disease | ||||||||
| 2982 | NCATS Plate Washing Initiative Saves Money, Keeps Plastic Out of Landfills | January 2016 UpdateJanuary 2018 UpdateHigh-throughput robots help researchers run screening experiments quickly and efficiently, producing results in one week that would take a scientist 12 years to conduct manually. At NCATS, these robots test thousands of potential drugs and drug combinations, environmental chemicals, and other experimental compounds to gain insights about a wide range of human diseases.Back in 2010, staff at what is now the NCATS high-throughput screening facility were supporting the NIH Molecular Libraries Program, an NIH Common Fund initiative to identify small molecules that potentially could be used as biological probes to explore the basis of health and disease and further developed as drugs. At the end of each set of several thousand experiments, a staff member would remove a stack of plastic plates, each about the size of an index card and a half-inch thick.“We’d throw them in here,” said Sam Michael, NCATS director of automation and compound management, pointing at a “carboy,” a waist-high blue plastic barrel used to collect chemical waste. “We were so busy, there were about 15 of these — I literally didn’t have enough room to work.” Michael also is the acting director of the NCATS Office of Information Technology.The NCATS high-throughput screening facility is part of a laboratory where technicians work among tables and shelves stocked to the brim with equipment, plates and cables, leaving little space for more than a dozen barrels of waste. Michael knew there had to be a better way, and he found one: washing and reusing the plates.Although that solution may sound trivial, it required persuading skeptical biologists that the plates could be cleaned thoroughly and rethinking the entire process of high-throughput screening. Today, experiments that once took thousands of plates can be run with just 40. This innovative idea has saved hundreds of thousands of scientific research dollars and dramatically reduced environmental plastic waste. And now, through a Small Business Innovation Research (SBIR) program grant from NCATS, a private-sector company is building on Michael’s work to develop and commercialize an automated plate cleaner.“That Will Never Work”Biologists are accustomed to working only with new materials. The high-throughput screening process involves sensitive experiments with tiny droplets of liquid; results could be completely thrown off by the merest speck of residue. Michael explained, “When I told biologists, ‘We are going to try to reuse your plate within an experiment,’ the first reaction was, ‘Get out of here; no way!’” But he inevitably convinced some of the researchers to try it.If you held a three-by-five-inch plate in your hand, you would see a fine grid of tiny wells, each about as big around as a pencil lead. A plate the size of an index card holds 1,536 wells. Together, all of the wells in one plate hold about a tablespoon of liquid. That may seem small, but the wells are big enough for chemical reactions. Each one is like a tiny test tube, holding a tiny experiment.For high-throughput screening, a plate starts at a dispenser where small tubes spray the same substance into each well. Sometimes the plate wells hold living cells; during a visit on a late winter Wednesday, enzymes were on deck. Robotic arms transfer plates from one machine to another in assembly line style, with quick, efficient movements and the whirring sounds of precise motors.The next stop for the plate is a machine with a rack of 1,536 tiny metal pins, one for each well. The pins act like a rubber stamp; the “ink” is a plate of compounds from a library of small molecules. The pins dip into the compound plate and then into the wells on the experimental plate, delivering one compound to each well. Each well gets a specific type of molecule that will interact with the enzyme, then the plates sit for a few hours. Finally, another machine takes a picture of each plate so scientists can figure out how each compound affected the reaction in each well.A Clean StartFollowing the traditional process, the plates become trash after imaging; they go to a landfill or incinerator, depending on the kind of waste they contain. But in the process Michael created, the next stop is cleaning. A dispenser alternates spraying deionized water and ethanol into the wells. After each spray, a row of aspirators, like the world’s tiniest vacuum cleaners, passes over the plate to suck the liquid out.The cleaned plates are now ready to go back into the screening process. A plate is only reused within the same assay, or set of experiments. In practice, half of the plates for an assay are being cleaned while the rest are in testing.Before starting each new assay, the NCATS team screens a few test plates to ensure cleaned plates give the same results as new plates. Sometimes the particular chemicals involved in the experiments just can’t be washed out, so the plates can only be used once, the old-fashioned way.Once the assay is complete, the plates are always discarded, but the savings from reuse during screenings are huge. At about $10 per plate, an experiment that previously involved 2,000 plates at a cost of about $20,000 in plastic now costs $400 for those materials — 2 percent of the original expense.So far, this method has saved NCATS almost half a million dollars and kept nearly 50,000 plastic plates from filling up chemical carboys. If that many plates were laid out end to end, they would be taller than Mount McKinley, the highest mountain in North America. The solution also has saved staff time from loading and unloading plates: four solid work weeks, Michael estimated.Disseminating the TechnologyThe creation of the plate-cleaning technology aligns perfectly with the NCATS “3 Ds” approach to translational science. Michael developed an innovative solution to address a translational problem and then demonstrated that the approach worked and could save time, money and environmental waste. The next step was disseminating the technology to benefit the larger scientific community.To reach that audience, Michael thought a small business might be able to scale up and expand the plate-cleaning technology. The Center’s SBIR program helps U.S. small businesses develop and commercialize new translational technologies. Michael worked with Lili Portilla, M.P.A., director of the NCATS Office of Strategic Alliances and SBIR program manager, to issue a contract solicitation for plate cleaning.IonField Systems in Moorestown, New Jersey, responded to the solicitation and secured a Phase 1 SBIR contract from NCATS, then received a follow-on Phase 2 award. IonField already had developed a method called “plasma washing” to clean plastic tips used to move small quantities of liquid in biochemical research. To adapt this method to cleaning plates, the company put a final touch on the process that Michael had envisioned, adding a plasma wash after the rinses with ethanol and water. High-voltage electricity eliminates anything still attached to the plate and even scours off the top layer of the plastic itself.The ultimate plan is to sell the cleaner to academic and industry screening facilities and offer a service for cleaning plates. The development of the cleaning process and service has turned what was once disposable waste into a reusable resource disseminated to other laboratories and pharmaceutical companies nationwide.“This is exactly what the NCATS SBIR contract program is designed to accomplish,” Portilla said, “NCATS identifies a translational technology challenge that small businesses can address, commercialize and disseminate into the marketplace.”“The SBIR program is a great mechanism, and I’m glad somebody can take this NIH technology and make it available to other scientists to speed their high-throughput screening activities,” Michael said.The success of the plate-washing method demonstrates NCATS’ commitment to transforming the way that translational science is conducted. That commitment to innovation can generate much-needed byproducts as well — in this case, a method to reduce plastic waste in the research community.Posted August 2015January 2016 Update: Continued Growth and ExpansionTo meet this new demand from the research community, IonField Systems has expanded from two employees in 2012 to five full-time staff and more than 20 subcontractors. The company reported more than 130 percent growth in 2015 and is on target to achieve even greater percent growth in 2016. IonField recently placed its first PlasmaKnife™ plate cleaner with a major pharmaceutical company, making the SBIR program’s goal of commercializing innovative new technologies a reality.“Overall, this initiative has been a tremendous success, and it’s really due to NCATS’ SBIR program,” Michael said. “The funding mechanism enabled a small company to grow while helping to bring a completely new product to the market to address a need. The program worked exactly as intended by enabling a small business to engage in R&D to create jobs and commercialize a needed technology.”Posted January 2016January 2018 Update: Installation of First Commercial ReleaseAstraZeneca (AZ) and IonField System announced the successful completion of the PlasmaKnife Microplate Cleaning System beta test and the first installation of a commercial release. The PlasmaKnife initially will be used regularly at AZ’s Alderley Park Research Facility, and later at the new AZ Cambridge Research Facility.“IonField is a great small business success story for NCATS,” Portilla said. “NCATS staff identified a translational problem common in drug development and IonField developed a very elegant solution to clean and reuse these expensive microplates.”Posted January 2019 | ||||||||
| 2980 | New CTSA Program Funding Opportunities: Collaborative Innovation Awards | On April 2, 2015, NCATS released two new funding opportunity announcements (FOAs) for Collaborative Innovation Awards, designed to stimulate team-based research across the Clinical and Translational Science Awards (CTSA) consortium. NCATS’ CTSA program supports a national network of medical research institutions — called hubs — that work together to improve the translational research process to get more treatments to more patients more quickly.Translating biomedical discoveries into the clinic is essential to improving human health. However, the current translational process has many barriers, resulting in long delays before a new treatment is available to people who need them.PAR-15-172 and PAR-15-173 solicit proposals for innovative collaborative investigations among three or more CTSA hubs to improve research methods at any step in the translational process. Through these awards, NCATS will foster research collaboration by encouraging teams from multiple hubs to work together to develop, demonstrate and disseminate multisite experimental approaches that overcome translational science roadblocks.“By combining the innovative efforts of three or more CTSA hubs in flexible networks, we aim to enhance the effectiveness of the CTSA consortium to address systemic translational science questions,” said Petra Kaufmann, M.D., M.Sc., NCATS director of clinical innovation.PAR-15-173 solicits pre-applications from interested investigators. Applicants whose proposals are found to be meritorious and relevant to the CTSA program will be invited to submit a full application via PAR-15-172. The first pre-applications are due on June 24, 2015; full applications are due in February 2016.“The CTSA program is designed to transform the translational ecosystem by overcoming barriers in translational science, operations and training,” said NCATS Director Christopher P. Austin, M.D. “The release of this funding opportunity represents an important milestone in a new era of CTSA-driven innovation, collaboratively developing translational solutions to improve human health.”NCATS expects to commit approximately $9 million in fiscal year 2016 funding for multiple five-year awards, depending on available funds. At the full application stage, applicants for clinical projects may request up to $1 million in direct costs annually. For nonclinical projects, applicants may request up to $500,000 annually in direct costs.In developing the FOAs, NCATS carefully considered input about the CTSA program from the National Academy of Medicine (formerly Institute of Medicine), a working group of the NCATS Advisory Council (PDF - 414KB), CTSA investigators, patient groups, other NIH Institutes and Centers, biotechnology and pharmaceutical development organizations, regulatory agencies, and the broader clinical and translational research community. Posted April 2015 | ||||||||
| 2355 | NCATS Support Leads to Clinical Trial to Test Repurposed Cancer Treatment as Alzheimer’s Therapy | As Baby Boomers get older, the number of people with age-related conditions such as cancer and Alzheimer's disease continues to grow. Alzheimer's disease is the most common form of dementia, a group of disorders that cause progressive loss of memory and other mental processes. About 5 million Americans have Alzheimer's disease, and current drug therapies can only ease symptoms of the disease without stopping its progression. New treatments — so-called disease-modifying therapies — are needed to halt Alzheimer's by targeting its underlying mechanisms. Blocking that path to therapeutic success is the costly, complex process of drug development. The average length of time from discovery of a therapeutic target to approval of a new drug is about 14 years. The failure rate during this process exceeds 95 percent. NCATS is addressing these translational bottlenecks through programs such as the Discovering New Therapeutic Uses for Existing Molecules (New Therapeutic Uses) program. Launched in 2012, this initiative matches academic researchers with pharmaceutical industry assets that have undergone significant research and development to accelerate the process of finding new therapies. Now, NCATS is celebrating one of the first promising results from the New Therapeutic Uses program: Center-supported scientists at Yale University School of Medicine have found that an experimental compound originally developed as a cancer therapy potentially could be used to treat Alzheimer's disease. The compound successfully reversed brain problems in mouse models of the condition, and now the researchers are testing it in humans. The results of the animal study were published for early view on March 21, 2015, in the Annals of Neurology. Read the NIH news release. A New Therapeutic Target Back in 2012, Yale neurobiology researcher, neurologist and senior author of the animal study Stephen Strittmatter, M.D., Ph.D., and his colleagues found an important, missing piece of the Alzheimer's puzzle. They wanted to understand more completely the molecular events that occur in the brain to produce symptoms. In Alzheimer's disease, abnormal clumps of amyloid beta protein build up in the brain. These protein clusters damage brain cells (neurons), eventually killing them. However, how amyloid beta harms cells has been unclear. The Yale team discovered that aggregated amyloid beta activates a series of signals within neurons that leads to abnormal functioning and loss of synapses, which are the spaces between neurons that enable the cells to "talk" to each other and form memories. Central to this process is the activation of a protein called Fyn kinase through another molecule, cellular prion protein. These results suggested that a compound that blocks Fyn activity might represent a potential disease-modifying therapy for Alzheimer's. The Power of Crowdsourcing Around the time Strittmatter's Fyn finding emerged, NCATS launched the New Therapeutic Uses program and released a list of pharmaceutical industry assets, inviting scientists to pitch new ideas for diseases that might be treated with those assets. That 2012 list included a Fyn kinase inhibitor, saracatinib (AZD0530 [PDF - 65KB]), developed by biopharmaceutical company AstraZeneca. Strittmatter, along with co-principal investigators Haakon Nygaard, M.D., Ph.D., and Christopher van Dyck, M.D., submitted a proposal to test the hypothesis that saracatinib could improve Alzheimer's-related brain abnormalities. The team received one of the first New Therapeutic Uses awards in June 2013. "AstraZeneca developed saracatinib to treat cancer outside the brain, so nobody had thought to link it to Alzheimer's disease," Strittmatter said. "This connection — between our knowledge of Fyn kinase in the brain and AstraZeneca's information on this compound — would never have happened without the New Therapeutic Uses program." Two types of brain cells, microglia (red, left) and astrocytes (red, right), surround amyloid beta clusters (green) located in the brain of a mouse that exhibits Alzheimer’s-like symptoms. (Credit: Strittmatter Laboratory, Yale University Photo/Adam Kaufman) A Promising Effect in Mice AstraZeneca scientists teamed with the Yale group, providing saracatinib for the mouse study and sharing knowledge and data gathered from previous studies. "No one individual or group has complete knowledge of disease pathways and treatment targets," said Craig Wegner, Ph.D., Head, Boston Emerging Innovations Unit, Scientific Partnering & Alliances within AstraZeneca's Innovative Medicines and Early Development Biotech Unit. "This program successfully unites scientists from government, academia and industry and is a great example of how we are working together to push the boundaries of science." The Yale team gave the experimental drug to mice with Alzheimer's-like symptoms, such as memory problems and age-related buildup of abnormal amyloid beta clusters, modeling the development of the disease in humans. After four weeks, the Alzheimer's mice showed complete reversal of spatial learning and memory loss. When the scientists examined the brains of the mice, they found that the characteristic synapse loss had been fully restored, providing a biological explanation for the memory improvement. The treatment also reduced several other Alzheimer's-related biochemical changes in the mice and did not appear to be toxic. Although many experimental treatments have aimed to reduce abnormal amyloid beta buildup in the brain, this one is unique in that it targets the toxic effects of the protein clusters within a cell, appearing to protect it from damage. The Yale research team also has completed a successful Phase 1b safety study of saracatinib in humans with Alzheimer's disease, showing that the compound reaches the brains of patients at levels similar to those beneficial in mice. The study results have been accepted for publication later in 2015. The data are encouraging, but the researchers cautioned that more human studies are needed to determine if saracatinib is an effective treatment for Alzheimer's. An Accelerated Path to the Clinic Saracatinib's prior development and the Yale team's successful completion of animal and human studies enabled the compound to advance rapidly into a larger, multisite Phase 2a trial in Alzheimer's patients now ongoing. "The speed and efficiency with which this research has advanced has set new standards of excellence, enabling us to jointly push the boundaries of medical science," Wegner said. Using the pre-negotiated NCATS template agreements, which were designed to streamline the legal and administrative process for research collaboration by multiple organizations, "really facilitated our collaboration with Yale, so scientists could be scientists," he added. "Through this project, NCATS and AstraZeneca have provided us with an incredible shortcut in the drug development process and have accelerated the path to finding a more effective Alzheimer's disease treatment," Strittmatter said. In the Phase 2a trial, 152 participants will receive saracatinib or placebo for one year. Researchers will assess safety, tolerability and effectiveness of the experimental drug, and they will use brain imaging to visualize the effect of saracatinib on synapse function — the same feature improved by the drug in mice. Study investigators currently are enrolling older adults with Alzheimer's disease to participate in the trial and expect to have results in about two years. Learn more about the trial via ClinicalTrials.gov. Both human trials were funded by the New Therapeutic Uses program. The Phase 2a study will take place at multiple clinical sites as part of the Alzheimer's Disease Cooperative Study, an initiative for multisite studies sponsored by the National Institute on Aging (NIA) to facilitate the development and testing of new therapeutics for the condition. In addition to funding from NCATS, the NIH Common Fund, NIA, BrightFocus Foundation, Alzheimer's Association and Falk Medical Research Trust provided support for the animal study. "The Yale team's awareness of this new Alzheimer's drug target, combined with AstraZeneca's drug development resources, allowed the rapid advancement of saracatinib to clinical testing, demonstrating the power of NCATS' New Therapeutics Uses crowdsourcing approach," said NCATS Director Christopher P. Austin, M.D. "By reengineering the drug development pipeline through projects like this, we can more quickly deliver new and better treatments to patients." Posted March 2015 | ||||||||
| 1761 | Scientific Publications | September 2016 Predictors Affecting Personal Health Information Management Skills • Informatics for Health & Social Care • September 1, 2016 • CTSA July 2016 Gender Differences in the Response to Impaired Sleep in Adults with Diabetes • Behavioral Sleep Medicine • July 1, 2016 • CTSA The Differential Relationships of Dimensions of Perceived Social Support with Cognitive Function among Older Adults • Aging & Mental Health • July 1, 2016 • CTSA A Two-Step Estimation Approach for Logistic Varying Coefficient Modeling of Longitudinal Data • Journal of Statistical Planning and Inference • July 1, 2016 • CTSA Negative Urgency and Emotion Regulation Predict Positive Smoking Expectancies in Non-Smoking Youth • Addictive Behavior • July 1, 2016 • CTSA Scavenging Dissolved Oxygen via Acoustic Droplet Vaporization • Ultrasonic Sonochemistry • July 1, 2016 • CTSA June 2016 Associations between Smoking and Caffeine Consumption in Two European Cohorts • Addiction • June 1, 2016 • CTSA Functional Independence in Resting-State Connectivity Facilitates Higher-Order Cognition • Brain and Cognition • June 1, 2016 • CTSA Course of Cognitive Impairment following Attempted Suicide in Older Adults • International Journal of Geriatric Psychiatry • June 1, 2016 • CTSA Adults with Sickle Cell Disease May Perform Cognitive Tests as Well as Controls when Processing Speed Is Taken into Account: A Preliminary Case-Control Study • Journal of Advanced Nursing • June 1, 2016 • CTSA Stem Cell Therapy Restores Viscoelastic Properties of Myocardium in Rat Model of Hypertension • Journal of the Mechanical Behavior of Biomedical Materials • June 1, 2016 • CTSA Effects of Aging on Slow-Wave Sleep Dynamics and Human Spatial Navigational Memory Consolidation • Neurobiology of Aging • June 1, 2016 • CTSA Fibroblast Growth Factor Receptor Signaling in Kidney and Lower Urinary Tract Development • Pediatric Nephrology • June 1, 2016 • CTSA The Influence of Knee Pain Location on Symptoms, Functional Status, and Knee-related Quality of Life in Older Adults with Chronic Knee Pain: Data From the Osteoarthritis Initiative • The Clinical Journal of Pain • June 1, 2016 • CTSA Optimization of a Methamphetamine Conjugate Vaccine for Antibody Production in Mice • International Immunopharmacology • June 1, 2016 • CTSA Antihypertensive Medications and Sexual Function in Women: Baseline Data from the SBP Intervention trial (SPRINT) • Journal of Hypertension • June 1, 2016 • CTSA Osteosarcoma Tissues and Cell Lines from Patients with Differing Serum Alkaline Phosphatase Concentrations Display Minimal Differences in Gene Expression Patterns • Veterinary and Comparative Oncology • June 1, 2016 • CTSA Simultaneous Subacute Coronary Artery Stent Thrombosis in a Carrier of Two CYP2C19 Loss-of-Function Polymorphisms (*2/*3) • International Journal of Cardiology • June 1, 2016 • CTSA Data Quality Assessment Framework to Assess Electronic Medical Record Data for Use in Research • International Journal of Medical Informatics • June 1, 2016 • CTSA The Organizational Structure of an Intensive Care Unit Influences Treatment of Hypotension among Critically Ill Patients: A Retrospective Cohort Study • Journal of Critical Care • June 1, 2016 • CTSA GSTZ1 Expression and Chloride Concentrations Modulate Sensitivity of Cancer Cells to Dichloroacetate • Biochimica et Biophysica Acta • June 1, 2016 • CTSA Adverse Birth Outcomes and Childhood Caries: A Cohort Study • Community Dentistry and Oral Epidemiology • June 1, 2016 • CTSA African American Church-based HIV Testing and Linkage to Care Assets, Challenges and Needs • Culture, Health & Sexuality • June 1, 2016 • CTSA The Tobacco-using Periodontal Patient: Role of the Dental Practitioner in Tobacco Cessation and Periodontal Disease Management • Periodontology 2000 • June 1, 2016 • CTSA Adolescents with or at Ultra-High Risk for Bipolar Disorder Exhibit Erythrocyte Docosahexaenoic Acid and Eicosapentaenoic Acid Deficits: A Candidate Prodromal Risk Biomarker • Early Intervention in Psychiatry • June 1, 2016 • CTSA Lethal Neonatal Meningoencephalitis Caused by Multi-Drug Resistant, Highly Virulent Escherichia Coli • Infectious Diseases • June 1, 2016 • CTSA Pyk2 and Megakaryocytes Regulate Osteoblast Differentiation and Migration via Distinct and Overlapping Mechanisms • Journal of Cellular Biochemistry • June 1, 2016 • CTSA Feasibility of a Pocket-PC Based Cognitive Control Intervention in Dementia Spousal Caregivers • Aging & Mental Health • June 1, 2016 • CTSA Mathematical Model to Interpret Localized Reflectance Spectra Measured in the Presence of a Strong Fluorescence Marker • Journal of Biomedical Optics • June 1, 2016 • CTSA May 2016 Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery • Cell • May 26, 2016 • NCATS Taxonomer: An Interactive Metagenomics Analysis Portal for Universal Pathogen Detection and Host mRNA Expression Profiling • Genome Biology • May 26, 2016 • CTSA The Social and Emotional Lives of Overweight, Obese, and Severely Obese Children • Child Development • May 25, 2016 • CTSA Decreased Circulating Levels of Spexin in Obese Children • Journal of Clinical Endocrinology & Metabolism • May 25, 2016 • CTSA Neonatal Phototherapy and Infantile Cancer • Pediatrics • May 23, 2016 • CTSA Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial • JAMA • May 19, 2016 • CTSA Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease • New England Journal of Medicine • May 18, 2016 • CTSA Confronting Ebola as a Sexually Transmitted Infection • Clinical Infectious Diseases • May 15, 2016 • CTSA Tau and Aβ imaging, CSF Measures, and Cognition in Alzheimer's Disease • Science and Translational Medicine • May 11, 2016 • CTSA Nutritional Supplementation to Reduce Child Aggression: A Randomized, Stratified, Single-Blind, Factorial Trial • Journal of Child Psychology and Psychiatry • May 11, 2016 • CTSA Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine: Secondary Analysis of an Open-Label Study • Journal of Clinical Psychiatry • May 10, 2016 • CTSA Marginalized Zero-Inflated Negative Binomial Regression with Application to Dental Caries • Statistics in Medicine • May 10, 2016 • CTSA Association of Environmental Toxins with Amyotrophic Lateral Sclerosis • JAMA Neurology • May 9, 2016 • CTSA From Painkiller to Empathy Killer: Acetaminophen (Paracetamol) Reduces Empathy for Pain • Social Cognitive and Affective Neuroscience • May 5, 2016 • CTSA NMDAR Inhibition-independent Antidepressant Actions of Ketamine Metabolites • Nature • May 4, 2016 • NCGC Prevalence and Predictors of Anxiety and Depression after Completion of Chemotherapy for Childhood Acute Lymphoblastic Leukemia: A Prospective Longitudinal Study • Cancer • May 1, 2016 • CTSA Glioblastoma Induces Vascular Dysregulation in Nonenhancing Peritumoral Regions in Humans • American Journal of Roentgenology • May 1, 2016 • CTSA Models to Predict Prevalence and Transition Dynamics of Methicillin-resistant Staphylococcus Aureus in Community Nursing Homes • American Journal of Infection Control • May 1, 2016 • CTSA Systemic Sclerosis and Perceptions of Quality in Primary Care • The American Journal of the Medical Sciences • May 1, 2016 • CTSA Factors Associated with Smoking Cessation in Pregnancy • American Journal Perinatology • May 1, 2016 • CTSA Early Blood Pressure, Antihypotensive Therapy and Outcomes at 18-22 Months' Corrected Age in Extremely Preterm Infants • Archives of Disease in Childhood • May 1, 2016 • CTSA Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment • American Journal of Geriatric Psychiatry • May 1, 2016 • CTSA Social Resources, Health Promotion Behavior, and Quality of Life in Adults Living with HIV • Applied Nursing Research • May 1, 2016 • CTSA Clinical Characteristics of Sarcoid Arthropathy: A Population-Based Study • Arthritis Care & Research • May 1, 2016 • CTSA Let's Talk about It: Peer Victimization Experiences as Reported by Adolescents with Autism Spectrum Disorder • Autism • May 1, 2016 • CTSA Stability of Phosphatidylethanol in Dry Blood Spot Cards • Alcohol and Alcoholism • May 1, 2016 Association of Mental Health Disorders and Medicaid with ED Admissions for Ambulatory Care-sensitive Condition Conditions • American Journal of Emergency Medicine • May 1, 2016 • CTSA Body Image & Quality of Life: Changes with Gastric Bypass and Body Contouring • Annals of Plastic Surgery • May 1, 2016 • CTSA Academic Abilities and Glycaemic Control in Children and Young People with Type 1 Diabetes Mellitus • Diabetic Medicine • May 1, 2016 • CTSA Point-of-Care Diagnostics for Niche Applications • Biotechnology Advances • May 1, 2016 • CTSA Moderate Chronic Kidney Disease Impairs Bone Quality in C57Bl/6J Mice • Bone • May 1, 2016 • CTSA Task-Switching Ability Protects against the Adverse Effects of Pain on Health: A Longitudinal Study of Older Adults • British Journal of Health Psychology • May 1, 2016 • CTSA Self-Rated Health and Interleukin-6: Longitudinal Relationships in Older Adults • British Journal of Health Psychology • May 1, 2016 • CTSA Prevalence of Diagnosed and Undiagnosed Hepatitis C in a Midwestern Urban Emergency Department • Clinical Infectious Diseases • May 1, 2016 • CTSA Severe Hypoglycemia in Users of Sulfonylurea Antidiabetic Agents and Antihyperlipidemics • Clinical Pharmacology and Therapeutics • May 1, 2016 • CTSA Otitis Media and Related Complications among Children with Autism Spectrum Disorders • Journal of Autism and Developmental Disorders • May 1, 2016 • CTSA Self-Reported Pleasantness Ratings and Examiner-Coded Defensiveness in Response to Touch in Children with ASD: Effects of Stimulus Material and Bodily Location • Journal of Autism and Developmental Disorders • May 1, 2016 • CTSA Parent, Teacher, and Student Perspectives on How Corrective Lenses Improve Child Wellbeing and School Function • Maternal and Child Health Journal • May 1, 2016 • CTSA Stroke Symptoms with Absence of Recognized Stroke Are Associated with Cognitive Impairment and Depressive Symptoms in Older Adults with Diabetes • Journal of Geriatric Psychiatry and Neurology • May 1, 2016 • CTSA Presentation and Effectiveness of Early Treatment of Type 2 Diabetes in Youth: Lessons from the TODAY Study • Pediatric Diabetes • May 1, 2016 • CTSA Testosterone Concentration and Insulin Sensitivity in Young Men with Type 1 and Type 2 Diabetes • Pediatric Diabetes • May 1, 2016 • CTSA Fibroblast Growth Factor-23 and Chronic Allograft Injury in Pediatric Renal Transplant Recipients: A Midwest Pediatric Nephrology Consortium Study • Pediatric Transplantation • May 1, 2016 • CTSA Regulatory Effects of Genomic Translocations at the Human Carboxylesterase-1 (CES1) Gene Locus • Pharmacogenetics and Genomics • May 1, 2016 • CTSA Association between Patient-Provider Communication and Lung Cancer Stigma • Supportive Care in Cancer • May 1, 2016 • CTSA Yield of Urinalysis Screening in Pediatric Cancer Survivors • Pediatric Blood & Cancer • May 1, 2016 • CTSA Gestational Age-Specific Neonatal Morbidity Among Pregnancies Complicated by Advanced Maternal Age: A Population-Based Retrospective Cohort Study • Journal of Maternal-Fetal & Neonatal Medicine • May 1, 2016 • CTSA Glutamine Drives Glutathione Synthesis and Contributes to Radiation Sensitivity of A549 and H460 Lung Cancer Cell Lines • Biochimica et Biophysica Acta • May 1, 2016 • CTSA April 2016 Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia • Diabetes Care • April 18, 2016 • CTSA Biodegradable Antigen-associated PLG Nanoparticles Tolerize Th2-mediated Allergic Airway Inflammation Pre- and Postsensitization • Proceedings of the National Academy of Sciences • April 18, 2016 • NCATS Usefulness of Relative Hypochromia in Risk Stratification for Nonanemic Patients With Chronic Heart Failure • American Journal of Cardiology • April 15, 2016 • CTSA Relation of Atrial Fibrillation in Acute Myocardial Infarction to In-Hospital Complications and Early Hospital Readmission • American Journal of Cardiology • April 15, 2016 • CTSA A Phase 1 Trial to Assess the Safety, Acceptability, Pharmacokinetics, and Pharmacodynamics of a Novel Dapivirine Vaginal Film • Journal of Acquired Immune Deficiency Syndromes • April 15, 2016 • CTSA Association of Get with the Guidelines-Stroke Program Participation and Clinical Outcomes for Medicare Beneficiaries with Ischemic Stroke • Stroke • April 14, 2016 • CTSA Thinking Cap Plus Thinking Zap: tDCS of Frontopolar Cortex Improves Creative Analogical Reasoning and Facilitates Conscious Augmentation of State Creativity in Verb Generation • Cerebral Cortex • April 13, 2016 • CTSA Psychological Factors Associated with Delayed Symptom Resolution in Children with Concussion • Journal of Pediatrics • April 11, 2016 • CTSA Disparities in Use of Human Epidermal Growth Hormone Receptor 2–Targeted Therapy for Early-Stage Breast Cancer • Journal of Clinical Oncology • April 11, 2016 • CTSA Antenatal Betamethasone for Women at Risk for Late Preterm Delivery • New England Journal of Medicine • April 7, 2016 • CTSA RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription • Cell • April 7, 2016 • NCGC Robotic Cystogastrostomy and Debridement of Walled-off Pancreatic Necrosis • Journal of Robotic Surgery • April 2, 2016 • CTSA A Matrix Mentoring Model That Effectively Supports Clinical and Translational Scientists and Increases Inclusion in Biomedical Research: Lessons from the University of Utah • Academic Medicine • April 1, 2016 • CTSA Understanding Career Success and Its Contributing Factors for Clinical and Translational Investigators • Academic Medicine • April 1, 2016 • CTSA Hydrogel Arrays Formed via Differential Wettability Patterning Enable Combinatorial Screening of Stem Cell Behavior • Acta Biomaterialia • April 1, 2016 • Tissue Chips Do High-Risk Young Adults Use the HIV Self-Test Appropriately? Observations from a Think-Aloud Study • AIDS Behavior • April 1, 2016 • CTSA Effect of Angiotensin II Type I Receptor Blockade with Valsartan on Carotid Artery Atherosclerosis: A Double Blind Randomized Clinical Trial Comparing Valsartan and Placebo (EFFERVESCENT) • American Heart Journal • April 1, 2016 • CTSA Association of Atrial Fibrillation Risk Alleles and Response to Acute Rate Control Therapy • American Journal of Emergency Medicine • April 1, 2016 • CTSA Variation in Primary Cesarean Delivery Rates by Individual Physician within a Single-Hospital Laborist Model • American Journal of Obstetrics and Gynecology • April 1, 2016 • CTSA Improving Care for Neonatal Abstinence Syndrome • Pediatrics • April 1, 2016 • CTSA Reinventing the Wheel of Medical Evidence: How the Boot Camp Translation Process Is Making Gains • Health Affairs • April 1, 2016 • CTSA Putting Translational Science on to a Global Stage • Nature Reviews Drug Discovery • April 1, 2016 • NCATS Enhancing Medical Decision-Making Evaluations: Introduction of Normative Data for the Capacity to Consent to Treatment Instrument • Assessment • April 1, 2016 • CTSA Glutamine Drives Glutathione Synthesis and Contributes to Radiation Sensitivity of A549 and H460 Lung Cancer Cell Lines • Biochimica et Biophysica Acta • April 1, 2016 • CTSA Fibrin Matrices Enhance the Transplant and Efficacy of Cytotoxic Stem Cell Therapy for Post-Surgical Cancer • Biomaterials • April 1, 2016 • CTSA Early Injury to Cortical and Cancellous Bone from Induction Chemotherapy for Aadolescents and Young Adults Treated for Acute Lymphoblastic Leukemia • Bone • April 1, 2016 • CTSA Severe Spinal and Chest Deformity Secondary to Neurofibromatosis • Canadian Journal of Anaesthesia • April 1, 2016 • CTSA Eosinophil Resistance to Glucocorticoid-induced Apoptosis Is Mediated by the Transcription Factor NFIL3 • Apoptosis • April 1, 2016 • CTSA Body Composition and Lung Function in Cystic Fibrosis and Their Association with Adiposity and Normal-Weight Obesity • Nutrition • April 1, 2016 • CTSA Hospital Utilization of Nationally Shared Liver Allografts from 2007 to 2012 • World Journal of Surgery • April 1, 2016 • CTSA Transdifferentiation of Human Endothelial Progenitors into Smooth Muscle Cells • Biomaterials • April 1, 2016 • Exploratory/Development Cooperative Agreement Patient Knowledge and Information-Seeking about Personalized Cancer Therapy • International Journal of Medical Informatics • April 1, 2016 • CTSA Deficiencies in the Management of Iron Deficiency Anemia during Childhood • Biomaterials • April 1, 2016 • CTSA Adolescent and Young Adult Patient Engagement and Participation in Survey-Based Research: A Report from the "Resilience in Adolescents and Young Adults With Cancer" Study • Pediatric Blood & Cancer • April 1, 2016 • CTSA March 2016 Mutations in TBCK, Encoding TBC1-Domain-Containing Kinase, Lead to a Recognizable Syndrome of Intellectual Disability and Hypotonia • American Journal of Human Genetics • March 31, 2016 • CTSA Age and Alzheimer’s Disease Gene Expression Profiles Reversed by the Glutamate Modulator Riluzole • Molecular Psychiatry • March 29, 2016 • CTSA Aging with Developmental Disabilities, Part 1: Fragile X–Associated Disorders • Psychiatric Times • March 24, 2016 • CTSA Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous PolyposisA Randomized Clinical Trial • JAMA • March 22, 2016 • CTSA Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration • Stem Cells • March 21, 2016 • CTSA Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery • Advanced Materials • March 17, 2016 • CTSA A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder • Biological Psychiatry • March 15, 2016 • CTSA Biomarkers and Surrogate Endpoints: Developing Common Terminology and Definitions • JAMA • March 15, 2016 • NIH A Phase 1 Randomized Placebo-Controlled Safety and Pharmacokinetic Trial of a Tenofovir Disoproxil Fumarate Vaginal Ring • AIDS • March 13, 2016 • CTSA Structure Property Relationships of Carboxylic Acid Isosteres • Journal of Medicinal Chemistry • March 11, 2016 • NCGC Rare Variant in Scavenger Receptor BI Raises HDL Cholesterol and Increases Risk of Coronary Heart Disease • Science • March 11, 2016 • CTSA Developmental Dynamics of the Preterm Infant Gut Microbiota and Antibiotic Resistome • Nature Microbiology • March 7, 2016 • CTSA Cost-Effectiveness of Tyrosine Kinase Inhibitor Treatment Strategies for Chronic Myeloid Leukemia in Chronic Phase after Generic Entry of Imatinib in the United States • Journal of the National Cancer Institute • March 4, 2016 • CTSA Alcohol and Immediate Risk of Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis • Circulation • March 3, 2016 • CTSA Availability of Outpatient Rehabilitation Services for Children After Traumatic Brain Injury: Differences by Language and Insurance Status • American Journal of Physical Medicine and Rehabilitation• March 1, 2016 • CTSA Recommendations to Facilitate Expanded Access to Investigational Therapies for Seriously Ill Patients • Academic Medicine • March 1, 2016 • CTSA Polygenic Risk for Alcohol Dependence Associates with Alcohol Consumption, Cognitive Function and Social Deprivation in a Population-Based Cohort • Addiction Biology • March 1, 2016 • CTSA Acute Kidney Injury Incidence in Noncritically Ill Hospitalized Children, Adolescents, and Young Adults: A Retrospective Observational Study • American Journal of Kidney Diseases • March 1, 2016 • CTSA Two-Year Trajectory of Fall Risk in People with Parkinson Disease: A Latent Class Analysis • Archives of Physical Medicine and Rehabilitation • March 1, 2016 • CTSA Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery • Advanced Materials • March 1, 2016 • CTSA Association of Red Blood Cell Transfusion, Anemia, and Necrotizing Enterocolitis in Very Low-Birth-Weight Infants • Journal of the American Medical Association • March 1, 2016 • CTSA Adjusting Cyclophosphamide Dose in Obese Patients with Lymphoma Is Safe and Yields Favorable Outcomes after Autologous Hematopoietic Cell Transplantation • Biology of Blood & Marrow Transplantation • March 1, 2016 • CTSA Resveratrol Preserves the Function of Human Platelets Stored for Transfusion • British Journal of Haematology • March 1, 2016 • CTSA Neurological Gait Abnormalities Moderate the Functional Brain Signature of the Posture First Hypothesis • Brain Topography • March 1, 2016 • CTSA Video Imaging of Arytenoid Prolapse • Canadian Journal of Anaesthesia • March 1, 2016 • CTSA Chronic Medical Conditions in Adult Survivors of Retinoblastoma: Results of the Retinoblastoma Survivor Study • Cancer • March 1, 2016 • CTSA Women's Experiences with Doula Support during First-Trimester Surgical Abortion: A Qualitative Study • Contraception • March 1, 2016 • CTSA The Preschool Confusion Assessment Method for the ICU: Valid and Reliable Delirium Monitoring for Critically Ill Infants and Children • Critical Care Medicine • March 1, 2016 • CTSA Using Facebook™ to Recruit College-Age Men for a Human Papillomavirus Vaccine Trial • American Journal of Men’s Health • March 1, 2016 • CTSA Whole Body Creatine and Protein Kinetics in Healthy Men and Women: Effects of Creatine and Amino Acid Supplementation • Amino Acids • March 1, 2016 • CTSA Perioperative Dextromethorphan as an Adjunct for Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials • Anesthesiology • March 1, 2016 • CTSA The Role of Rheumatoid Arthritis (RA) Flare and Cumulative Burden of RA Severity in the Risk of Cardiovascular Disease • Annals of the Rheumatic Diseases • March 1, 2016 • CTSA Oncologists' Perspectives of Their Roles and Responsibilities during Multi-Disciplinary Breast Cancer Follow-Up • Annals of Surgical Oncology • March 1, 2016 • CTSA Sex Hormones, Sex Hormone Binding Globulin, and Vertebral Fractures in Older Men • Bone • March 1, 2016 • CTSA Imaging Features of Radiofrequency Ablation with Heat-Deployed Liposomal Doxorubicin in Hepatic Tumors • Cardiovascular and Interventional Radiology • March 1, 2016 • CTSA Transcriptome Analysis of the Human Striatum in Tourette Syndrome • Biological Psychiatry • March 1, 2016 • CTSA Clinical Significance of Pain at Hospital Discharge Following Traumatic Orthopedic Injury: General Health, Depression, and PTSD Outcomes at 1 Year • Clinical Journal of Pain • March 1, 2016 • CTSA What Is the Outcome of Allograft and Intramedullary Free Fibula (Capanna Technique) in Pediatric and Adolescent Patients with Bone Tumors? • Clinical Orthopaedics and Related Research • March 1, 2016 • CTSA Leg Muscle Mass and Foot Symptoms, Structure, and Function: The Johnston County Osteoarthritis Project • Journals of Gerontology • March 1, 2016 • CTSA Problem-Gambling Severity and Psychiatric Disorders among American-Indian/Alaska Native Adults • Journal of Psychiatric Research • March 1, 2016 • CTSA PET Imaging Evaluation of [(18)F]DBT-10, a Novel Radioligand Specific to α7 Nicotinic Acetylcholine Receptors, in Nonhuman Primates • European Journal of Nuclear Medicine and Molecular Imaging • March 1, 2016 • CTSA The Effect of Prenatal Alcohol Co-Exposure on Neonatal Abstinence Syndrome in Infants Born to Mothers in Opioid Maintenance Treatment • Journal of Maternal-Fetal & Neonatal Medicine • March 1, 2016 • CTSA Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-1 Are Related to Cardiovascular Disease Biomarkers in Obese Adolescents • Pediatric Diabetes • March 1, 2016 • CTSA Azacitidine and Sorafenib Therapy in a Pediatric Patient with Refractory Acute Myeloid Leukemia with Monosomy 7 and Somatic PTPN11 Mutation • Pediatric Blood & Cancer • March 1, 2016 • CTSA Effect of Sensorineural Hearing Loss on Neurocognitive Functioning in Pediatric Brain Tumor Survivors • Pediatric Blood & Cancer • March 1, 2016 • CTSA Optogenetic Activation of Superior Colliculus Neurons Suppresses Seizures Originating in Diverse Brain Networks • Neurobiology of Disease • March 1, 2016 • CTSA Forecasting the Revenues of Local Public Health Departments in the Shadows of the "Great Recession" • Journal of Public Health Management and Practice • March 1, 2016 • CTSA Bridging Research, Practice, and Policy: The "Evidence Academy" Conference Model • Journal of Public Health Management and Practice • March 1, 2016 • CTSA Assessing Capacity for Sustainability of Effective Programs and Policies in Local Health Departments • Journal of Public Health Management and Practice • March 1, 2016 • CTSA Lipid Peroxidation Biomarkers in Adolescents with or at High-Risk for Bipolar Disorder • Journal of Affective Disorders • March 1, 2016 • CTSA Investigating the Mechanical Function of the Cervix during Pregnancy Using Finite Element Models Derived from High-Resolution 3D MRI • Computer Methods in Biomechanics and Biomedical Engineering • March 1, 2016 • CTSA | ||||||||
| 1564 | Connect with NCATS | Stay up-to-date with the latest Center news and information: Receive announcements about NCATS’ news releases, funding opportunities, events, program information and more Get the NCATS e-newsletter highlighting the latest translational science advances, research news and upcoming events delivered directly to your email box Receive updates from the NCATS director on news and other activities of interest to the Center’s stakeholder community. Read feature stories showcasing how NCATS-supported translational research discoveries are turned into tools, methods and treatments Stay informed about NCATS small business funding opportunities, resources, news and events through the SBIR/STTR program Find out how to access NCATS funding opportunities Learn how to work with NCATS Like us on Facebook View our profile on LinkedIn Follow us on Twitter View our videos on YouTube Access photos from our flickr account Donate to NCATS research Contact NCATS staff Collaborate with NCATS scientists | Connect with NCATS to get the latest news, information on funding opportunities, Center updates and more. | Stay up-to-date with the latest Center news and information | Connect with NCATS to get the latest news, information on funding opportunities, Center updates and more. | Stay up-to-date with the latest Center news and information | ||||
| 707 | Past E-Newsletter Issues | The NCATS e-newsletter provides the latest digest of Center news and information. Review past issues below, and subscribe today!2022: Volume 11Issue 1: January 19Issue 2: February 25Issue 3: April 27Issue 4: June 9Issue 5: August 31Issue 6: October 3Issue 7: November 142021: Volume 10Issue 1: January 28Issue 2: February 26Issue 3: March 24Issue 4: April 22Issue 5: June 3Issue 6: August 2Issue 7: November 12020: Volume 9Issue 1: January 27Issue 2: February 27Issue 3: March 31Issue 4: April 30Issue 5: May 29Issue 6: June 30Issue 7: July 31Issue 8: August 31Issue 9: September 30Issue 10: October 29Issue 11: December 1Issue 12: December 212019: Volume 8Issue 1: January 3Issue 2: February 7Issue 3: March 12Issue 4: April 11Issue 5: May 17Issue 6: June 13Issue 7: July 17Issue 8: August 15Issue 9: September 26Issue 10: October 31Issue 11: November 26Issue 12: December 18 | ||||||||
| 683 | NCATS E-Newsletter | Learn more about the Center’s latest research news, announcements, funding opportunities, program accomplishments and events in the NCATS e-newsletter. Subscribe today! Current Issue February 7, 2023 The first newsletter of 2023 features an NIH Director's Blog post about rare diseases by NCATS Director Joni Rutter, Ph.D., the winners of the latest LitCoin Challenge, new research supported by NCATS, and more. Past Issues Looking for a previous article? View archived issues of the NCATS e-newsletter. Social Connections Like us on Facebook Follow us on Twitter View our YouTube channel Contact NCATS Information Officer 301-435-0888 info@ncats.nih.gov | Learn more about NCATS’ latest research news, announcements, funding opportunities, program accomplishments and events in the monthly e-newsletter. | NCATS E-Newsletter | Learn more about NCATS’ latest research news, announcements, funding opportunities, program accomplishments and events in the monthly e-newsletter. | NCATS E-Newsletter | ||||
| 682 | Past Events | 2023 March NCATS Budget Briefing for Fiscal Year 2024 March 14 February Rare Disease Day at NIH Feb. 28 Website • Agenda (PDF - 204KB) • Videocast Virtual 2023 NIH Grants Conference: Funding, Policies & Processes Feb. 1–2 Website • Agenda January NCATS Advisory Council Meeting Jan. 26 Agenda (PDF - 182KB) • Minutes (PDF - 328KB) • Videocast • Federal Register Notice 2022 November The Quest for Innovative Molecular Treatment Modalities for Intractable Disease Targets Nov. 17–18 Website • Agenda • Watch Day 1 • Watch Day 2 If you require a 508-remediation version of the webinar, please contact Karlie Sharma. October NCATS Online Course in Preclinical Translational Science Oct. 26–Dec. 13 MEDI 501: Principles of Preclinical Translational Science • Download the course syllabus (PDF - 238KB) • Download the course flyer (PDF - 428KB) NCATS–NIAID Joint Workshop on Bacteriophage Therapy: Challenges and Solutions to the Development of Bacteriophage Therapy Oct. 25 Website • Agenda Assay Guidance Workshop for High-Throughput Screening and Lead Discovery Oct. 18–19 Website and Agenda Technical Assistance Webinar for the Clinical and Translational Science Award Program Oct. 12 Per NOT-TR-22-034, NCATS conducted a technical assistance webinar for applicants responding to: Clinical and Translational Science Award (UM1 Clinical Trial Optional) (PAR-21-293) Limited Competition: High Impact Specialized Innovation Programs in Clinical and Translational Science for UM1 CTSA Hub Awards (RC2 Clinical Trials Not Allowed) (PAR-21-340) Limited Competition:NCATS Clinical and Translational Science Award (CTSA) Program Research Education Grants Programs (R25 - Clinical Trial Not Allowed) (PAR-21-339) Limited Competition: Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program (T32 Clinical Trial Not Allowed) (PAR-21-338) Limited Competition: Ruth L. Kirschstein National Research Service Award (NRSA) Predoctoral Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program (T32 Clinical Trial Not Allowed) (PAR-21-337) Limited Competition: Mentored Research Career Development Program Award in Clinical and Translational Science Awards (CTSA) Program (K12 Clinical Trial Optional) (PAR-21-336) This webinar provided an overview of these funding opportunity announcements that invite applications for the Clinical and Translational Science Award (CTSA) Program hubs. September NCATS Advisory Council Meeting Sept. 22 Agenda (PDF - 181KB) • Minutes (PDF - 348KB) • Videocast • Federal Register Notice June NCATS Online Course in Translational Science in the COVID-19 Pandemic June 15–Aug. 2 Syllabus (PDF - 222KB) • Flyer (PDF - 371KB) Assay Guidance Workshop on 3-D Tissue Models for Antiviral Drug Development June 7–8 Website • Agenda (PDF - 273KB) • Videocast (Day 1) • Videocast (Day 2) May NCATS Advisory Council Meeting May 19–20 Agenda (PDF - 190KB) • Minutes (PDF - 471KB) • Videocast (Day 1) • Videocast (Day 2) • Federal Register Notice Teatime with NCATS Acting Director Joni Rutter May 18 The 45-minute event featured a short presentation from Joni L. Rutter, Ph.D., NCATS acting director, followed by a conversation moderated by Esther Krofah, M.P.P. , executive director of FasterCures and the Center for Public Health at the Milken Institute, about how we can build relationships, raise awareness and work together to advance the mission of NCATS. Video • Audio Described Video Regulatory Fitness in Rare Disease Clinical Trials May 16–17 Website • Agenda (PDF - 190KB) • Resources • Webcast March NCATS Online Course in Translational Science March 28–May 13 Website • Syllabus (PDF - 261KB) • Flyer (PDF - 419KB) Translational Science Education Roundtable March 10–11 Agenda and Participation List (PDF - 185KB) • Presentation: Joni L Rutter, Ph.D. (PDF - 4.2MB) • Presentation: Jessica Faupel-Badger, Ph.D., MPH (PDF - 2.3MB) • Roundtable Summary (PDF - 258KB) February Rare Disease Day at NIH Feb. 28 Website • Agenda (PDF - 219KB) • Videocast Webinar: Peer Review for Small Business Funding: An Overview of the Process Feb. 24 Tribal Consultation on the NCATS National COVID Cohort Collaborative (N3C) Feb 11 Website • Videocast • Presentation Assay Guidance Workshop for High-Throughput Screening and Lead Discovery (Short Course) Feb. 5 Website January NCATS Online Course in Translational Science in the COVID-19 Pandemic Jan. 31–March 18 Website • Download the course syllabus • Download the course flyer NCATS Advisory Council Meeting Jan. 20–21 Agenda (PDF - 179KB) • Minutes (PDF - 529KB) • Videocast (Day 1) • Videocast (Day 2) • Federal Register Notice 2021 December A Decade of Innovation: How NCATS Is Impacting Translational Science through Small Business Growth Dec. 8 Watch the webinar • Download the transcript (Word — 64KB) • Download the presentation slides (PDF — 1.8MB) NCATS at 10: Improving Health for All Through Translational Science Dec. 7 Website • Agenda (PDF - 148KB) November Assay Guidance Workshop for Cell-Based Assays and Lead Discovery Nov. 16–17 Website Fall 2021 NIH Virtual Seminar on Program Funding and Grants Administration Nov. 1–4 Website October NCATS Online Course in Translational Science in the COVID-19 Pandemic Oct. 25–Dec. 10 Website • Download the course syllabus (PDF - 176KB) • Download the course flyer (PDF - 457KB) September NCATS Advisory Council Meeting Sept. 23–24 Agenda (PDF - 131KB) • Minutes (PDF - 358KB) • Videocast (Day 1) • Videocast (Day 2) • Federal Register Notice 2021 NIH-BIO Summer Series: Improving Diversity in Biotech by Leveraging SBIR/STTR Opportunities Sept. 14 Assay Guidance Manual Virtual Workshop on DNA-Encoded Libraries for Lead Discovery Sept. 1–2 Agenda August NCATS Online Course in Translational Science Aug. 30–Oct. 15 Website • Syllabus (PDF - 205KB) • Flyer (PDF - 512KB) June NCATS Online Course in Translational Science June 14–July 30 Website • Download the course syllabus (PDF - 176KB) • Download the course flyer (PDF - 334KB) LitCoin Stakeholder Feedback Workshop June 17–18 Website & Agenda Gene-Targeted Therapies: Early Diagnosis and Equitable Delivery June 3, June 10 and June 17 Website • Agenda - Day 1 (PDF - 248KB) • Agenda - Day 2 (PDF - 258KB) • Agenda - Day 3 (PDF - 249KB) • VideoCast (Day 1) • VideoCast (Day 2) • VideoCast (Day 3) NCATS Advisory Council Meeting June 10–11 Agenda (PDF - 176KB) • Minutes (PDF - 512KB) • Videocast (Day 1) • Videocast (Day 2) • Federal Register Notice May Federal Technology Transfer: Measuring Impact, Innovation & Efficiencies May 13–14 Website • Agenda • WebEx Recording (Day 1) • WebEx Recording (Day 2) • Workshop Report April Pre-Application Webinar for RFA-TR-21-001: New Chemistries for Un-drugged Targets through A Specialized Platform for Innovative Research Exploration (ASPIRE) Collaborative Research Program April 7 RFA-TR-21-001 • RFA-TR-21-002 March NIH Space Chat with Astronaut Kate Rubins March 26 YouTube Video Pre-Application Webinar for NCATS RFA-TR-21-008, Multi-disciplinary Machine-assisted, Genomic Analysis and Clinical Approaches to Shortening the Rare Diseases Diagnostic Odyssey March 12 Webpage Rare Disease Day at NIH March 1 Website • Agenda (PDF - 484KB) • VideoCast February Rare Diseases Reddit “Ask Me Anything” Feb. 23 Highlights January NCATS Advisory Council Meeting Jan. 14–15 Agenda (PDF - 246KB) • Minutes (PDF - 298KB) • WebEx Recording (Day 1, Not available) • WebEx Recording (Day 2) • Federal Register Notice 2020 November Virtual Workshop on Systemic Immunogenicity Considerations for AAV-Mediated Gene Therapy Nov. 30 – Dec. 1 Website • Agenda (PDF - 171KB) • VideoCast (Day 1) • VideoCast (Day 2) 2020 NIH Rural Health Seminar: Challenges in the Era of COVID-19 Nov. 18–19 Website Assay Guidance Workshop for High-Throughput Screening and Lead Discovery Nov. 18–19 Website NIH Virtual SARS-CoV-2 Antiviral Therapeutics Summit Nov. 6 Website • Agenda (PDF - 185KB) • Hosts & Presenters • NIH VideoCast • Summit Report (PDF - 1.5MB) October Pre-Application Webinar for NCATS RFA-TR-20-031 and RFA-TR-20-032, Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases Oct. 15 Frequently asked questions for RFA-TR-20-031 (PDF - 134KB) For more information about the webinar, see NOT-TR-20-038. Pre-Application Webinar for NCATS RFA-TR-20-030, Multi-disciplinary Machine-assisted, Genomic Analysis and Clinical Approaches to Shortening the Rare Diseases Diagnostic Odyssey Oct. 6 View the webinar slides (PDF - 968KB) • Download responses to questions asked during the webinar (PDF - 146KB) For more information about the webinar, see NOT-TR-20-037. September NCATS Advisory Council Meeting Sept 17–18 Agenda (PDF - 231KB) • Minutes (PDF - 311KB) • WebEx Recording (Day 1) • WebEx Recording (Day 2) • Federal Register Notice NCATS Online Course in Translational Science Sept. 8 – Oct. 23 Download the course flyer (PDF - 508KB) • Read the course syllabus (PDF - 152KB) July Transforming Translational Science July 24 Website June NCATS Online Course in Translational Science June 15 – July 31 Download the course flyer (PDF - 334KB) • Course Syllabus (PDF - 162KB) May NCATS Advisory Council Meeting May 14 Agenda (PDF - 286KB) • Minutes (PDF - 338KB) • WebEx Recording • Federal Register Notice March Linking Research to Rural Communities with the NIH National Center for Advancing Translational Sciences Webinar March 31 February Rare Disease Day at NIH Feb. 28 Website • Agenda (PDF - 218KB) • Videocast • Feature Story January Expanding AAV Manufacturing Capacity for Rare Disease Gene Therapies Jan. 28–29 Website • Videocast NCATS Advisory Council and CAN Review Board Meeting Jan. 16 Agenda (PDF - 218KB) • Minutes (PDF - 295KB) • WebEx Recording • Advisory Council Federal Register Notice • CAN Review Board Federal Register Notice Assay Guidance Workshop for High-Throughput Screening and Lead Discovery Jan. 25 Website/Agenda 2019 December NCATS Day 2019: Conversations on Responsible Data Sharing Dec. 17 Website • Agenda • Videocast Cures Acceleration Network Review Board Meeting Dec. 13 Agenda (PDF - 149KB) • Minutes (PDF - 311KB) • WebEx Recording • Federal Register Notice Repurposing Off-Patent Drugs: Research & Regulatory Challenges Dec. 5–6 Website/Agenda/Registration • Videocast November Inaugural NIH Rural Health Seminar Nov. 18 Website/Agenda • Videocast September Ask an Astronaut: Biomedical Science Edition Sept. 23 Website NCATS Advisory Council and CAN Review Board Meeting Sept. 19 Agenda (PDF - 253KB)• Minutes (PDF - 265KB) • Videocast • Advisory Council Federal Register Notice (amended) • CAN Review Board Federal Register Notice Assay Guidance Workshop for High-Throughput Screening and Lead Discovery Sept. 11–12 June Machine Intelligence in Healthcare: Perspectives on Trustworthiness, Explainability, Usability and Transparency June 11 Website • Agenda (PDF - 140KB) • Webcast CNS Immunogenicity Considerations for AAV-mediated Gene Therapy June 11 Website • Agenda (PDF - 164KB) • Videocast May NCATS Advisory Council and CAN Review Board Meeting May 16 Agenda (PDF - 190KB) • Minutes (PDF - 454KB) • Videocast • Federal Register Notice RE(ACT) Congress AMERICA — International Congress on Research of Rare and Orphan Diseases May 8–11 Website • Program April Accelerating Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome April 4–5 Website • Agenda • Webcast (Day 1) • Webcast (Day 2) March Assay Development Principles and Good Research Practices for Rigor and Reproducibility in In Vitro Toxicology (AM03) March 10 Website/Agenda February Rare Disease Day at NIH Feb. 28 Website • Agenda (PDF - 176KB)• Videocast • Feature Story Twitter Chat on Rare Diseases Feb. 22 Website The Opioid Crisis and the Future of Addiction and Pain Therapeutics: Opportunities, Tools, and Technologies Symposium Feb. 7–8 Website • Agenda (PDF - 135KB) Natural Products and Pain: The Search for Novel Non-Opioid Analgesics Feb. 6 Website/Agenda Assay Guidance Workshop for High-Throughput Screening and Lead Discovery Feb. 2 Website/Agenda January NCATS Advisory Council and CAN Review Board Meeting Jan. 10 Agenda (PDF - 159KB) • Minutes (PDF - 340KB) • WebEx Recording • Federal Register Notice 2018 December Cures Acceleration Network Review Board Meeting Dec. 14 Agenda (PDF - 107KB) • Minutes (PDF - 374KB) • WebEx Recording • Federal Register Notice November Driving Innovation: NCATS Programs to Support Small Businesses Nov. 27 October Collaborations across NCATS’ Trial Innovation Network Oct. 30 CTSA Program Vision: Current Initiatives and Future Goals Oct. 9 September NCATS Day 2018: Engaging Patients and Communities for Smarter Science Sept. 28 Website • Agenda (PDF - 36KB) • Videocast • Posters (PDF - 400KB) • Photos • Participant Roster (PDF - 847KB) • Community Engagement Resources • Patient Engagement Resource (PDF 421KB) • NCATS Fact Sheet (PDF - 351KB) NCATS Advisory Council and CAN Review Board Meeting Sept. 27 Agenda (PDF - 179KB) • Minutes (PDF - 268KB) • Videocast • Federal Register Notice Single IRB Review for Multi-Site Research Resource and Infrastructure Development Workshop Sept. 12 Website Assay Guidance Workshop for High-Throughput Screening and Lead Discovery Sept. 10–11 Website • Agenda August The Growing Promise of Gene Therapy Approaches to Rare Diseases Aug. 20–21 Website • Agenda (PDF - 168KB) • Videocast June Addressing the Opioid Crisis Through Translational Science “Un-Meeting” June 2 Website May NCATS Advisory Council and CAN Review Board Meeting May 10 Agenda (PDF - 145KB) • Minutes (PDF - 303KB) • Videocast • Federal Register Notice Leveraging Community Engagement and Informatics-Based Tools to Increase Participant Recruitment and Retention May 4 Website April Organs- and Tissues-on-Chips Conference April 8–12 Website/Agenda March Assay Guidance Workshop for High-Throughput Screening and Lead Discovery March 26–27 Agenda Rare Disease Day at NIH March 1 Website • Agenda (PDF - 150KB) • Videocast • Feature Story February Twitter Chat on Rare Diseases Feb. 23 Website 3-D Printing: Medicine’s New Dimension Feb. 13 Website January NCATS Advisory Council and CAN Review Board Meeting Jan. 11 Agenda (PDF - 145KB) • Minutes (PDF - 224KB) • Videocast • Federal Register Notice 2017 December Cures Acceleration Network Review Board Virtual Meeting Dec. 15 Agenda (PDF - 101KB) • Minutes (PDF - 170KB) • Federal Register Notice November NIH Extracellular RNA Communication Consortium 9th Investigators’ Meeting Nov. 6–7 Website October Second Strategic Partnerships for Drug Repurposing Forum Oct. 26–27 Website • Agenda NCATS Data Translator Meeting Oct. 25 Website/Agenda Assay Guidance Workshop for High-Throughput Screening and Lead Discovery Oct. 23 Website • Agenda Automated Chemical Synthesis Workshop Oct. 19–20 Translational Research Symposium 2017: Found in Translation Oct. 4 Website September Workshop on Translational Challenges of Induced Pluripotent Stem Cells Sept. 26 Videocast Translational Medicine 2017: Enhancing Predictivity in Medicines Development Sept. 24–26 European Reference Networks on Rare Neurological Diseases Webinar Sept. 13 Website NCATS Toolkit for Patient-Focused Therapy Development: Demonstration and Dissemination Meeting Sept. 8 Website • Agenda (PDF - 77KB) • Videocast NCATS Advisory Council and CAN Review Board Meeting Sept. 7 Agenda (PDF - 164KB) • Minutes (PDF - 188KB) • Videocast • Federal Register Notice August The Science of Caregiving: Bringing Voices Together Aug. 7–8 Website • Agenda (PDF - 257KB) Assay Guidance Workshop for High-Throughput Screening and Lead Discovery Aug. 7 Agenda July Quantitative Systems Pharmacology and Drug Discovery: Filling the Gaps in Current Models of the R&D Process for Neurotherapeutics July 26–27 Website Global Foundation for Peroxisomal Disorders (GFPD) 2017 Scientific Conference: Development of Therapies for Peroxisome Biogenesis Disorders July 13–14 Website June NCATS Day — Partnering with Patients for Smarter Science June 30 Website • Agenda (PDF - 549KB) • Event Photos May NCATS Advisory Council and CAN Review Board Meeting May 4 Agenda (PDF - 114KB) • Minutes (PDF - 216KB) • Videocast April The NIH Microphysiological Systems Program: Tissues-on-Chips for Drug Safety and Efficacy Studies April 24 March Engineered Cells and Tissues as Platforms for Discovery and Therapy (K1) March 9–12 Agenda Rare and Undiagnosed Diseases: Discover and Models of Precision Therapy (C2) March 5–8 Agenda February Rare Disease Day at NIH Feb. 27 Website • Agenda (PDF - 134KB) • Videocast Twitter Chat on Rare Diseases Feb. 21 Website Third International Rare Diseases Research Consortium (IRDiRC) Conference Feb. 8–9 Website • Agenda Assay Guidance Workshop for High-Throughput Screening and Lead Discovery Feb. 4 Website January NCATS Advisory Council and CAN Review Board Meeting Jan. 12 Agenda (PDF - 77KB) • Minutes (PDF - 220KB) • Meeting Information 2016 December NCATS SBIR/STTR Twitter Chat Dec. 12 Cures Acceleration Network (CAN) Review Board Virtual Meeting Dec. 9 Agenda (PDF - 115KB) • Minutes(PDF - 214KB) • Federal Register Notice Therapeutically Relevant Bioassays Webinar Dec. 7 Website October Assay Guidance Workshop for High-Throughput Screening and Lead Discovery Oct. 27 International Conference on Rare Diseases and Orphan Drugs (ICORD) Oct. 19–22 Website New Frontiers in 3-D Cell Culture–Based Screening Technologies Oct. 13 September NCATS Advisory Council and CAN Review Board Meeting Sept. 15 Agenda (PDF - 156KB) • Minutes (PDF - 169KB) • Videocast • Federal Register Notice Tissue Chips in Space Informational Webinar Sept. 6 NIH Guide Notice • Related Information August SBIR Contract Solicitation Pre-Proposal Webinar Aug. 24 NIH Guide Notice July Securing SBIR and STTR Funding: Support for Women Entrepreneurs and Researchers in Biotech July 14 Transform Tox Testing Challenge: Innovating for Metabolism Semi-Finalists Workshop July 8 Website June NCATS Advisory Council and CAN Review Board Meeting June 13 Agenda (PDF - 150KB) • Minutes (PDF - 192KB) • Federal Register Notice Best Practices of Biomedical Research: Improving Reproducibility and Transparency of Preclinical Research Conference June 9–10 Trans-Agency Blood Brain Interface Workshop 2016 June 7–8 Videocast April Pfizer CTI at NIH Workshop April 14 Assay Guidance Workshop for High-Throughput Screening and Lead Discovery April 5–6 Agenda (PDF - 45KB) March NIH Translational Science Training Program Boot Camp March 31 – April 1 Website Society of Toxicology 55th Annual Meeting and ToxExpo March 13–17 Website RE(ACT) Congress — International Congress on Research of Rare and Orphan Diseases March 9–12 Website Accelerating Innovation: Funding for Women Entrepreneurs in Biotechnology and Health Care Webinar March 2 February WORLDSymposium™ 2016 Feb. 29 – March 4 Website Rare Disease Day at NIH Feb. 29 Website • Agenda (PDF - 178KB) • Videocast NIH Twitter Chat: Rare Diseases Feb. 22 Website January NCATS Advisory Council and CAN Review Board Meeting Jan. 14 Agenda (PDF - 80KB) • Minutes (PDF - 220KB) • Meeting Information 2015 December Cures Acceleration Network (CAN) Review Board Virtual Meeting Dec. 11 Agenda (PDF - 65KB) • Minutes (PDF - 192KB) • Slides (PDF - 572KB) • Federal Register Notice November Common Rule Meeting: Enhancing and Clarifying Consent Forms and Establishing Standard Safeguards Nov. 18 RARE Webinar: Introducing NCATS’ ORDR Director Petra Kaufmann Nov. 17 12th Annual Meeting DIA Japan 2015 Nov. 15–17 Website NCATS Strategic Plan Town Hall Webinar Nov. 10 View Slides (PDF - 910KB) NCATS Small Business Funding Opportunities Webinar Nov. 10 2015 CURED Eosinophilic Gastrointestinal Disease Patient Research Symposium Nov. 6–8 Website Common Rule Meeting: Revising and Expanding the Scope of the Common Rule Nov. 5 NCATS Strategic Plan Town Hall Webinar Nov. 4 View Slides (PDF - 910KB) 2015 Federal Laboratory Consortium for Technology Transfer (FLC) Mid-Atlantic Regional Meeting & I2C Conference Nov. 2–3 Seventh Annual Partnering for Cures Conference Nov. 1–3 Website October Common Rule Meeting: Streamlining Institutional Review Board Review Oct. 29 10th Annual Translational Stem Cell Research Conference Oct. 28–29 Website NCATS Strategic Plan Town Hall Webinar Oct. 26 View Slides (PDF - 910KB) Rare Diseases and Orphan Products Breakthrough Summit Oct. 21–22 Website Common Rule Meeting: Requiring Consent for Research with Biospecimens and Allowing Broad Consent Oct. 14 2015 Erdheim Chester Disease Medical Symposium and Patient & Family Gathering Oct. 8 Website September 27th Annual Fanconi Anemia Research Fund Scientific Symposium Sept. 17–20 Website C&EN Virtual Symposium: Advances in Drug Discovery and Development Sept. 16 NCATS Advisory Council and CAN Review Board Meeting Sep. 3 Meeting Information August Genomic Integrity Aug. 1–5 July Fourth International RASopathies Symposium July 17–19 Website Assay Guidance Workshop for High-Throughput Screening and Lead Discovery July 17 Personalized Medicine: Novel Biologic Therapies for Rare Eosinophilic Disorders July 14 June Technical Assistance Video for CTSA Recruitment Innovation Centers June 22 Access the Video NCATS Advisory Council and CAN Review Board Meeting June 18 Meeting Information Webinar: Funding Opportunities for Early-Stage Companies June 11 May Second EATRIS Conference: Building Bridges in Translational Medicine May 27–28 Webinar: Funding and Resources to Catalyze Translation from Lab to Patient May 13 April International Society for Extracellular Vesicles (ISEV) Annual Meeting and Joint Education Day April 23–26 Translational Science 2015 April 16–18 Website Pfizer's Centers for Therapeutic Innovation (CTI) Seminar and One-on-One Meetings for NIH Intramural Researchers April 13–14 February Rare Disease Day at NIH Feb. 27 Website • Agenda (PDF - 123KB) • Videocast Fifth AIMBE/NIH Workshop on Validation and Qualification of New In Vitro Tools and Models for the Preclinical Drug Discovery Process Feb. 12 Society for Laboratory Automation and Screening (SLAS) 4th Annual Conference & Exhibition Feb. 7–11 January NCATS Advisory Council and CAN Review Board Meeting Jan. 15 Meeting Information Workshop to Explore the Ethical, Legal and Social Implications of Citizen Science Jan. 13–14 Website 2014 December Cures Acceleration Network (CAN) Review Board Meeting Dec. 12 Agenda (PDF - 108KB) • Minutes (PDF - 256KB) Intellectual Property Webinar Series: Patents, Trademarks, and Copyrights Dec. 9–11 November Partnering for Cures Nov. 16–18 Website Small Business Grants (SBIR/STTR) Webinar for Applicants Nov. 7 Webinar October Next-Generation R&D Partnerships: The NCATS Success Story Oct. 29 Website Addressing Irreproducibility in Target Validation Oct. 23 Website 16th Annual NIH Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Conference Oct. 21–23 September NCATS Advisory Council and CAN Review Board Meeting Sept. 19 Agenda (PDF - 93KB) • Minutes (PDF - 255KB) August National Conference on Engaging Patients, Families, and Communities in all Phases of Translational Research to Improve Health Aug. 21–22 Website May NCATS Advisory Council and CAN Review Board Meeting May 16 Minutes (PDF - 643KB) • Federal Register Notice • Agenda (PDF - 67KB) • Working Group Report on the IOM CTSA Report (PDF - 414KB) March Fourth AIMBE/NIH Workshop on Validation and Qualification of New In Vitro Tools and Models for the Preclinical Drug Discovery Process March 6–7 Website NIH SBIR/STTR Pre-Submission Update Webinar March 6 Videocast • Resources February Rare Disease Day at NIH Feb. 28 Website • Agenda (PDF - 188KB) • Videocast January NCATS Advisory Council and CAN Review Board Meeting Jan. 16 Agenda (PDF - 67KB) • Minutes (PDF - 220KB) • Videocast • Federal Register Notice 2013 December Cures Acceleration Network (CAN) Review Board Meeting Dec. 12 Agenda (PDF - 56KB) • Minutes (PDF - 455KB) Reddit AMA (Ask Me Anything): Rare Diseases and the Research Process Dec. 4 Chat Link November Technical Assistance Webinar for RFA-RM-13-011 "Development of a Knowledge Management Center for Illuminating the Druggable Genome (U54)" Illuminating the Druggable Genome (IDG) Pre-Application Meeting Nov. 1 October Global Genes | RARE Webinar Series Understanding Rare Disease Registries (Part Two) Oct. 23 Website September NCATS Advisory Council and CAN Review Board Meeting Sept. 16 Agenda (PDF - 72KB) • Minutes (PDF - 431KB) • Videocast NCATS Research and Development Day Sept. 12 Website • Agenda (PDF - 314KB) August 6th Annual Clinical and Translational Science Award (CTSA) National Conference Science of Community Engaged Research: Future Directions Aug. 22–23 Website July Global Genes | RARE Webinar Series Understanding Rare Disease Registries (Part One) July 31 Website June Adaptive Designs for Clinical Trials: Opportunities for Translational Research June 10 6th Annual Clinical Research Management Workshop June 3–4 May NCATS Advisory Council and CAN Review Board Meeting May 17 Agenda (PDF - 138KB) • Minutes (PDF - 306KB) • Videocast April Translational Science 2013: Increasing the Value of Your Research through Team Science April 17–19 Website NIH Biospecimens Interest Group (BIG) April 4 February Rare Disease Day at NIH Feb. 28–March 1 Website • Agenda (PDF - 206KB) • Videocast - Day 1 • Videocast - Day 2 January NCATS Advisory Council and CAN Review Board Meeting Jan. 23 Agenda (PDF - 98KB) • Minutes (PDF - 530KB) • Videocast 2012 November FDA-NIH Workshop: The Science of Small Clinical Trials Nov. 27–28 Website October 2012 Sleep Research Network Meeting Oct. 22–23 3rd Annual Conference on Clinical Research for Rare Diseases Oct. 2 NIH Microphysiological Systems Program: First Investigators’ Meeting Oct. 1–2 September NCATS Advisory Council and CAN Review Board Meeting Sept. 14 Council Agenda (PDF - 94KB) • CAN Review Board Agenda (PDF - 254KB) • Minutes (PDF - 228KB) (Corrigendum) (PDF - 81KB) • Videocast • Federal Register Notice Gene Transfer and Rare Diseases Workshop Sept. 13 August 5th Annual National CTSA Community Engagement Conference: Methods, Metrics and Outcomes: Evaluating the Success of Community Engaged Research Aug. 23–24 July CTSA Public-Private Partnerships Webinar Series Prize4Life & NIH Program on Public-Private Partnerships July 25 CTSA Technical Assistance Webinar for RFA-TR-12-006 July 23 June CTSA Public-Private Partnerships Webinar Series Looking for the Win-Win: How Regeneron's Public-Private Partnerships Fuel Innovation June 27 Therapeutics Discovery Technical Assistance Webinar June 25 5th Annual Clinical Research Management Workshop: Learning by Doing: Applying Evidence-based Tools to Re-engineer Clinical Research Management June 4–5 Maximizing the Goals of the Cures Acceleration Network to Accelerate the Development of New Drugs and Diagnostics: A Workshop June 4–5 Website May Rare Diseases: The Challenges Presented by Biospecimens, Patient Registries, Electronic Heath Records and Bioethics May 31 Videocast CTSA Public-Private Partnerships Webinar Series The International Clinical Compound Library (ICCL): Accelerating the Development of New Therapies for Many Global Unmet Medical Needs May 23 NCATS’ Therapeutics for Rare and Neglected Diseases Program Road Show May 22 Workshop on Natural History Studies of Rare Disease: Meeting the Needs of Drug Development and Research May 16–17 March Collaboration in Action March 21 February Rare Disease Day at NIH Feb. 29 Website • Agenda (PDF - 207KB) • Videocast Virtual Town Hall with NCATS Leadership Feb. 27 Fiscal Year 2013 Budget in Brief: Strengthening Health and Opportunity for All Americans Feb. 13 NCATS Congressional Justification (PDF - 783KB) 2011 February Rare Disease Day at NIH Feb. 28 Website • Agenda (PDF - 120KB) |
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