2987 |
Scientific Publications 2014 |
December 2014
Eplerenone for Early Cardiomyopathy in Duchenne Muscular Dystrophy: A Randomised, Double-Blind, Placebo-Controlled Trial • The Lancet Neurology • December 29, 2014 • NCATS
Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy • Journal of the American Medical Association • December 24, 2014 • NCATS
Distinct Gene Signatures in Aortic Tissue from ApoE-/- Mice Exposed to Pathogens or Western Diet • BMC Genomics • December 24, 2014 • CTSA
Effect of an Enhanced Medical Home on Serious Illness and Cost of Care Among High-Risk Children With Chronic Illness: A Randomized Clinical Trial• Journal of the American Medical Association • December 24, 2014 • CTSA
Maternal High-Fat Diet and Obesity Compromise Fetal Hematopoiesis •Molecular Metabolism • December 23, 2014 • CTSA
Evening Use of Light-Emitting eReaders Negatively Affects Sleep, Circadian Timing, and Next-Morning Alertness • Proceedings of the National Academy of Sciences • December 22, 2014 • CTSA
Identification of 53 Compounds that Block Ebola Virus-like Particle Entry via a Repurposing Screen of Approved Drugs • Emerging Microbes & Infections • December 17, 2014 • NCATS
Effects of High vs Low Glycemic Index of Dietary Carbohydrate on Cardiovascular Disease Risk Factors and Insulin Sensitivity: The OmniCarb Randomized Clinical Trial • Journal of the American Medical Association • December 17, 2014 • CTSA
Furin-Mediated Sequential Delivery of Anticancer Cytokine and Small-Molecule Drug Shuttled by Graphene • Advanced Materials • December 15, 2014 • CTSA
Bisphosphonates Inactivate Human EGFRs to Exert Antitumor Actions •Proceedings of the National Academy of Sciences • December 11, 2014 • CTSA
Very Early Administration of Progesterone for Acute Traumatic Brain Injury• New England Journal of Medicine • December 10, 2014 • NCATS
A Clinical Trial of Progesterone for Severe Traumatic Brain Injury • New England Journal of Medicine • December 10, 2014 • NCATS
UbcH7 regulates 53BP1 stability and DSB repair • Proceedings of the National Academy of Sciences • December 09, 2014 • CTSA
Prevention of Type II Diabetes Mellitus in Qatar: Who is at Risk? • Qatar Medical Journal • December 09, 2014 • CTSA
Associations Between Initial Water Pipe Tobacco Smoking and Snus Use and Subsequent Cigarette Smoking • JAMA Pediatrics • December 08, 2014 • NCATS
Urinary Creatinine Excretion, Bioelectrical Impedance Analysis, and Clinical Outcomes in Patients with CKD: The CRIC Study • Clinical Journal of the American Society of Nephrology • December 05, 2014 • CTSA
The Shape of Things to Come: 3D Printing in Medicine • Journal of the American Medical Association • December 03, 2014 • Tissue Chips
Use of Whole Genome Sequencing for Diagnosis and Discovery in the Cancer Genetics Clinic • EBioMedicine • December 03, 2014 • CTSA
Risk-Benefit Profiles of Women Using Tamoxifen for Chemoprevention •Journal of the National Cancer Institute • December 03, 2014 • NCATS
Prevalence of Chronic Axial Pain, Inflammatory Back Pain and Spondyloarthritis in Diagnosed Psoriasis • Arthritis Care & Research • December 02, 2014 • CTSA
Markov Transition Model to Dementia with Death as a Competing Event •Computational Statistics & Data Analysis • December 01, 2014 • CTSA
Uncoupling Angiogenesis and Inflammation in Peripheral Artery Disease with Therapeutic Peptide-loaded Microgels • Biomaterials • December 01, 2014 • New Therapeutic Uses
Differences in Quit Attempts between Non-Hispanic Black and White Daily Smokers: The Role of Smoking Motives • Addictive Behavior • December 01, 2014 • CTSA
Influence of Sensitization on the Discriminative Stimulus Effects of Methylphenidate in Mice • Behavioural Pharmacology • December 01, 2014 • CTSA
The Contraceptive CHOICE Project Round Up: What We Did and What We Learned • Clinical Obstetrics and Gynecology • December 01, 2014 • CTSA
What Are the Advantages and Disadvantages of Imaging Modalities to Diagnose Wear-Related Corrosion Problems? • Clinical Orthopedics and Related Research • December 01, 2014 • CTSA
Islet Cell Transplant and the Incorporation of Tregs • Current Opinion in Organ Transplantation • December 01, 2014 • CTSA
Height as an Independent Anthropomorphic Risk Factor for Colorectal Cancer • European Journal of Gastroenterology & Hepatology • December 01, 2014 • CTSA
Household Food Insecurity Associated with Antiretroviral Therapy Adherence Among HIV-Infected Patients in Windhoek, Namibia • Journal of Acquired Immune Deficiency Syndromes • December 01, 2014 • CTSA
Predictors of Response to Vagus Nerve Stimulation in Childhood-Onset Medically Refractory Epilepsy • Journal of Child Neurology • December 01, 2014 • CTSA
Safety of Research Bronchoscopy in Critically Ill Patients • Journal of Critical Care • December 01, 2014 • CTSA
Experiences with Capnography in Acute Care Settings: A Mixed-Methods Analysis of Clinical Staff • Journal of Critical Care • December 01, 2014 • CTSA
Accelerating Sequences in the Presence of Metal by Exploiting the Spatial Distribution of Off-Resonance • Magnetic Resonance in Medicine • December 01, 2014 • CTSA
Otologic Outcomes After Blast Injury: The Boston Marathon Experience •Otology & Neurotology • December 01, 2014 • CTSA
Multiple Testing under Dependence via Semiparametric Graphical Models •Proceedings of the International Conference on Machine Learning • December 01, 2014 • CTSA
Community College Pathways: Improving the U.S. Physician Workforce Pipeline • Academic Medicine • December 01, 2014 • CTSA
Modulation of Coronary Heart Disease Risk by Insulin Resistance in Subjects with Normal Glucose Tolerance or Prediabetes • Academic Diabetologica • December 01, 2014 • CTSA
Sampling Methodologies for Epidemiologic Surveillance of Men Who Have Sex with Men and Transgender Women in Latin America: An Empiric Comparison of Convenience Sampling, Time Space Sampling, and Respondent Driven Sampling • AIDS Behavior • December 01, 2014 • CTSA
Hyperfiltration is Associated with the Development of Microalbuminuria in Patients with Sickle Cell Anemia • American Journal of Hematology • December 01, 2014 • CTSA
Identification of Asthma Phenotypes in a Tertiary Care Medical Center •American Journal of the Medical Sciences • December 01, 2014 • CTSA
Development and Validation of a Risk Factor Scoring System for First-Trimester Prediction of Preeclampsia • American Journal of Perinatology• December 01, 2014 • CTSA
Strong Start for Mothers and Newborns: Implications for Prenatal Care Delivery • Current Opinion in Obstetrics & Gynecology • December 01, 2014 • CTSA
Cardiorespiratory Fitness in Older Adult Women: Relationships with Serum 25-Hydroxyvitamin D • Endocrine • December 01, 2014 • CTSA
Drug Discoverers Chart Path to Tackling Data Irreproducibility • Nature Reviews Drug Discovery • December 01, 2014 • NCATS
Melittin-Glutathione S-Transferase Fusion Protein Exhibits Anti-Inflammatory Properties and Minimal Toxicity • European Journal of Pharmaceutical Sciences • December 01, 2014 • CTSA
A Randomized Controlled Trial of Intranasal Ketamine in Major Depressive Disorder • Biological Psychiatry • December 01, 2014 • CTSA
Tailgating and Pregaming by College Students with Alcohol Offenses: Patterns of Alcohol Use and Beliefs • Substance Use & Misuse • December 01, 2014 • CTSA
Interplay of Physical Mechanisms and Biofilm Processes: Review of Microfluidic Methods • Lab on a Chip • December 01, 2014 • CTSA
Fatigability Disrupts Cognitive Processes' Regulation of Inflammatory Reactivity in Old Age • The American Journal of Geriatric Psychiatry • December 01, 2014 • CTSA
High-Throughput Viability Assay Using an Autonomously Bioluminescent Cell Line with a Bacterial Lux Reporter • Journal of Laboratory Animation• December 01, 2014 • TRND
Hydroxylated Tropolones Inhibit Hepatitis B Virus Replication by Blocking the Viral Ribonuclease H Activity • Antimicrobial Agents and Chemotherapy • December 01, 2014 • NCGC
Discovery of Novel Antigiardiasis Drug Candidates • Antimicrobial Agents and Chemotherapy • December 01, 2014 • NCGC
BioAssay Research Database (BARD): Chemical Biology and Probe-Development Enabled by Structured Metadata and Result Types • Nucleic Acids Research • December 01, 2014 • NCGC
Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression • Journal of Biomolecular Screening • December 01, 2014 • NCGC
Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans • Diabetes • December 01, 2014 • CTSA
November 2014
Influence of the Timing of Antiretroviral Therapy on the Potential for Normalization of Immune Status in Human Immunodeficiency Virus 1–Infected Individuals • JAMA Internal Medicine • November 24, 2014 • CTSA
Longitudinal Assessment of High Blood Pressure in Children with Nonalcoholic Fatty Liver Disease • PLOS • November 24, 2014 • CTSA
Selective Inhibition of 12-Lipoxygenase Protects Islets and Beta Cells from Inflammatory Cytokine-Mediated Beta Cell Dysfunction • Diabetologia • November 23, 2014 • NCGC
Genome Editing-Enabled HTS Assays Expand Drug Target Pathways for Charcot-Marie-Tooth Disease • ACS Chemical Biology • November 21, 2014 • NCGC
HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events • New England Journal of Medicine • November 18, 2014 • CTSA
Suppression of the FOXM1 Transcriptional Programme via Novel Small Molecule Inhibition • Nature Communications • November 12, 2014 • NCGC
Modeling Non-Syndromic Autism and the Impact of TRPC6 Disruption in Human Neurons • Molecular Psychiatry • November 11, 2014 • NCGC
Time Trends in Incidence, Clinical Features and Cardiovascular Disease in Ankylosing Spondylitis Over 3 Decades: A Population-Based Study •Arthritis Care & Research • November 10, 2014 • CTSA
The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva • Clinical Chemistry • November 06, 2014 • exRNA
Raman and Coherent Anti-Stokes Raman Scattering Microscopy Studies of Changes in Lipid Content and Composition in Hormone-Treated Breast and Prostate Cancer Cells • Journal of Biomedical Optics • November 01, 2014 • CTSA
Delay Discounting Rates: A Strong Prognostic Indicator of Smoking Relapse• Addictive Behavior • November 01, 2014 • CTSA
Differential Associations between Impulsivity and Risk-Taking and Brain Activations Underlying Working Memory in Adolescents • Addictive Behavior • November 01, 2014 • CTSA
Stimulated Recall Methodology for Assessing Work System Barriers and Facilitators in Family-Centered Rounds in a Pediatric Hospital • Applied Ergonomics • November 01, 2014 • CTSA
How Different Types of Users Develop Trust in Technology: A Qualitative Analysis of the Antecedents of Active and Passive User Trust in a Shared Technology • Applied Ergonomics • November 01, 2014 • CTSA
Dreams, Reality and Memory: Confabulations in Lucid Dreamers Implicate Reality-Monitoring Dysfunction in Dream Consciousness • Cognitive Neuropsychiatry • November 01, 2014 • CTSA
Decreased Levels of BAG3 in a Family with a Rare Variant and in Idiopathic Dilated Cardiomyopathy • Journal of Cellular Physiology • November 01, 2014 • CTSA
Initial Evidence that GLP-1 Receptor Blockade Fails to Suppress Postprandial Satiety or Promote Food Intake in Humans • Appetite • November 01, 2014 • CTSA
Association between Achizophrenia Symptoms and Neurocognition on Mobility in Older Adults with Schizophrenia • Aging & Mental Health • November 01, 2014 • CTSA
Correcting Oral Contraceptive Pharmacokinetic Alterations Due to Obesity: A Randomized Controlled Trial • Contraception • November 01, 2014 • CTSA
Outbreak of Type A Foodborne Botulism at a Boarding School, Uganda, 2008 • Epidemiology and Infection • November 01, 2014 • CTSA
Family History of Psychosis as a Predictor or Protective Factor of Social Maladjustment in a Population at Clinical High Risk for Psychosis •Psychiatry Research • November 01, 2014 • CTSA
Weighted Hurdle Regression Method for Joint Modeling of Cardiovascular Events Likelihood and Rate in the US Dialysis Population • Statistics in Medicine • November 01, 2014 • CTSA
Instrument Development of the UNC Dry Eye Management Scale • Cornea • November 01, 2014 • CTSA
A Custom Correlation Coefficient (CCC) Approach for Fast Identification of Multi-SNP Association Patterns in Genome-Wide SNPs Data • Genetic Epidemiology • November 01, 2014 • CTSA
Evolution of Mosquito Preference for Humans Linked to an Odorant Receptor • Nature • November 01, 2014 • CTSA
October 2014
ERK and β-Arrestin Interaction: A Converging Point of Signaling Pathways for Multiple Types of Cell Surface Receptors • Journal of Biomolecular Screening • October 31, 2014 • NCGC
Promoterless Gene Targeting without Nucleases Ameliorates Haemophilia B in Mice • Nature • October 29, 2014 • CTSA
NCATS Advisory Council Recommends Strategies to Strengthen CTSA Program • Clinical and Translational Science • October 28, 2014 • CTSA
Presentation of Prescription and Nonprescription Opioid Overdoses to US Emergency Departments • Journal of the American Medical Association• October 27, 2014 • CTSA
Human-Subjects Research: The Ethics Squad • Nature • October 21, 2014 • CTSA
Clinical Exome Sequencing for Genetic Identification of Rare Mendelian Disorders • Journal of the American Medical Association • October 18, 2014 • CTSA
The Heritability of Insomnia Progression during Childhood/Adolescence: Results from a Longitudinal Twin Study • Sleep • October 17, 2014 • NCATS
Inheritance of Rare Functional GCKR Variants and Their Contribution to Triglyceride Levels in Families • Human Molecular Genetics • October 15, 2014 • NCGC
Current Approaches for the Discovery of Drugs that Deter Substance and Drug Abuse • Expert Opinion on Drug Discovery • October 15, 2014 • NCGC
Maternal Age Effect and Severe Germ-Line Bottleneck in the Inheritance of Human Mitochondrial DNA • Proceedings of the National Academy of Sciences • October 13, 2014 • CTSA
Oral, Capsulized, Frozen Fecal Microbiota Transplantation for RelapsingClostridium difficile Infection • Journal of the American Medical Association • October 11, 2014 • CTSA
A Quality Improvement Project Sustainably Decreased Time to Onset of Active Physical Therapy Intervention in Patients with Acute Lung Injury •Annals of the American Thoracic Society • October 11, 2014 • CTSA
Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential • Environmental Health Perspectives • October 10, 2014 • Tox21
A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency • New England Journal of Medicine • October 09, 2014 • CTSA
Synthesis and Structure-Activity Relationship Studies of N-Benzyl-2-phenylpyrimidin-4-amine Derivatives as Potent USP1/UAF1 Deubiquitinase Inhibitors with Anticancer Activity against Nonsmall Cell Lung Cancer •Journal of Medicinal Chemistry • October 09, 2014 • NCGC
Physician Decision Making and Trends in the Use of Cardiac Stress Testing in the United States: An Analysis of Repeated Cross-sectional Data • Annals of Internal Medicine • October 07, 2014 • CTSA
Platelet 12-LOX is Essential for FcγRIIa-Mediated Platelet Activation •Blood • October 02, 2014 • NCGC
Sex Differences in Benzodiazepine Use in the HIV-Infected Population •AIDS Care • October 01, 2014 • CTSA
Stroke Survivors' Endorsement of a "Stress Belief Model" of Stroke Prevention Predicts Control of Risk Factors for Recurrent Stroke •Psychology, Health & Medicine • October 01, 2014 • CTSA
Neural Plasticity in Fathers of Human Infants • Social Neuroscience • October 01, 2014 • CTSA
Adverse Pregnancy Outcomes among Women with Prior Spontaneous or Induced Abortions • American Journal of Perinatology • October 01, 2014 • CTSA
Upper-Body Obese Women are Resistant to Postprandial Stimulation of Protein Synthesis • Clinical Nutrition • October 01, 2014 • CTSA
Regulation of the Extrarenal CYP27B1-Hydroxylase • The Journal of Steroid Biochemistry and Molecular Biology • October 01, 2014 • CTSA
Impaired Glycemia and Alzheimer's Disease • Neurobiology of Aging • October 01, 2014 • CTSA
Effects of Acute Sleep Deprivation on Motor and Reversal Learning in Mice• Neurobiology of Learning and Memory • October 01, 2014 • CTSA
Limiting Acute Respiratory Distress Syndrome in the Emergency Department: A Survey of US Academic Emergency Medicine Physicians •European Journal of Emergency Medicine • October 01, 2014 • CTSA
Changes in Mammographic Density over Time in Breast Cancer Cases and Women at High Risk for Breast Cancer • International Journal of Cancer • October 01, 2014 • CTSA
25(OH) Vitamin D Suppresses Macrophage Adhesion and Migration by Downregulation of ER Stress and Scavenger Receptor A1 in Type 2 Diabetes• Journal of Steroid Biochemistry and Molecular Biology • October 01, 2014 • CTSA
Elevation of 11β-Hydroxysteroid Dehydrogenase Type 2 Activity in Holocaust Survivor Offspring: Evidence for an Intergenerational Effect of Maternal Trauma Exposure • Psychoneuroendocrinology • October 01, 2014 • CTSA
Outcome-Adaptive Randomization for a Delayed Outcome with a Short-Term Predictor: Imputation-Based Designs • Statistics in Medicine • October 01, 2014 • CTSA
Protein Polymer Nanoparticles Engineered as Chaperones Protect Against Apoptosis in Human Retinal Pigment Epithelial Cells • Journal of Controlled Release • October 01, 2014 • CTSA
Investigation of Galectin-3 Function in the Reproductive Tract by Identification of Binding Ligands in Human Seminal Plasma • American Journal of Reproductive Immunology • October 01, 2014 • CTSA
Evaluation of Myocardial Function in Patients with Rheumatoid Arthritis Using Strain Imaging by Speckle-Tracking Echocardiography • Annals of the Rheumatic Diseases • October 01, 2014 • CTSA
Role for Putative Hepatocellular Carcinoma Stem Cell Subpopulations in Biological Response to Incomplete Thermal Ablation: In Vitro and In Vivo Pilot Study • Cardiovascular and Interventional Radiology • October 01, 2014 • CTSA
Opportunities to Reduce Children's Excessive Consumption of Calories from Beverages • Clinical Pediatrics • October 01, 2014 • CTSA
Physical Activity Predicts Microstructural Integrity in Memory-Related Networks in Very Old Adults • The Journals of Gerontology • October 01, 2014 • CTSA
Cranial Radiation Exposure During Cerebral Catheter Angiography •Journal of Neurointerventional Surgery • October 01, 2014 • CTSA
Smoking-Related Cotinine Levels and Host Responses in Chronic Periodontitis • Journal of Periodontal Research • October 01, 2014 • CTSA
The First Synthesis of the Antiangiogenic Homoisoflavanone, Cremastranone • Organic & Biomolecular Chemistry • October 01, 2014 • CTSA
Digital Breast Tomosynthesis: Studies of the Effects of Acquisition Geometry on Contrast-to-Noise Ratio and Observer Preference of Low-Contrast Objects in Breast Phantom Images • Physics in Medicine and Biology • October 01, 2014 • CTSA
Heck Products of Parthenolide and Melampomagnolide-B as Anticancer Modulators that Modify Cell Cycle Progression • European Journal of Medicine Chemistry • October 01, 2014 • CTSA
Using Social Media in Research: New Ethics for a New Meme? • American Journal of Bioethics • October 01, 2014 • CTSA
Community, Context, and the Contrasting Roles of Clinicians and Researchers: Challenges Raised by Statutory Rape • American Journal of Bioethics • October 01, 2014 • CTSA
The Moral and Legal Need to Disclose Despite a Certificate of Confidentiality • American Journal of Bioethics • October 01, 2014 • CTSA
Frequency of Angina Pectoris and Secondary Events in Patients with Stable Coronary Heart Disease (from the Heart and Soul Study) • American Journal of Cardiology • October 01, 2014 • CTSA
Increasing Childhood Influenza Vaccination: A Cluster Randomized Trial •American Journal of Preventive Medicine • October 01, 2014 • CTSA
Factorial Experiments: Efficient Tools for Evaluation of Intervention Components • American Journal of Preventive Medicine • October 01, 2014 • CTSA
Walking and Proximity to the Urban Growth Boundary and Central Business District • American Journal of Preventive Medicine • October 01, 2014 • CTSA
Common Selective Serotonin Reuptake Inhibitor Side Effects in Older Adults Associated with Genetic Polymorphisms in the Serotonin Transporter and Receptors: Data from a Randomized Controlled Trial •American Journal of Geriatric Psychiatry • October 01, 2014 • CTSA
The Intracellular Ca(2+) Channel MCOLN1 is Required for Sarcolemma Repair to Prevent Muscular Dystrophy • ACS Chemical Biology • October 01, 2014 • NCGC
Designing Innovative Therapies for Neuropathic Pain: Pros and Cons of Target-Based Drug Discovery • Journal of the Peripheral Nervous System • October 01, 2014 • NCGC
Bayesian Hierarchical Model for Multiple Repeated Measures and Survival Data: An Application to Parkinson's Disease • Statistics in Medicine • October 01, 2014 • CTSA
Interferon-γ Release Assays for the Evaluation of Tuberculosis Infection •Journal of the American Medical Association • October 01, 2014 • CTSA
Genetic Variant in Folate Homeostasis is Associated with Lower Warfarin Dose in African Americans • Blood • October 01, 2014 • CTSA
Provision of No-Cost, Long-Acting Contraception and Teenage Pregnancy •The New England Journal of Medicine • October 01, 2014 • CTSA
Angiosarcoma Outcomes and Prognostic Factors: A 25-Year Single Institution Experience • American Journal of Clinical Oncology • October 01, 2014 • CTSA
Adjuvant GM-CSF Improves Survival in High-Risk Stage IIIC Melanoma: A Single-Center Study • American Journal of Clinical Oncology • October 01, 2014 • CTSA
What is the Optimal Gestational Age for Women with Gestational Diabetes Type A1 to Deliver? • American Journal of Obstetrics and Gynecology • October 01, 2014 • CTSA
September2014
Covalent Small Molecule Inhibitors of Ca2+-Bound S100B • Biochemistry • September 30, 2014 • NCGC
Engineering Bacterial Transcription Regulation to Create a Synthetic In Vitro Two-Hybrid System for Protein Interaction Assays • Journal of the American Chemical Society • September 26, 2014 • NCGC
Conventional Surgery May Trump Radiosurgery for Some Early Lung Cancers • Clinical Oncology • September 25, 2014 • NCATS
Segmentation Precision of Abdominal Anatomy for MRI-Based Radiotherapy• Medical Dosimetry • September 22, 2014 • CTSA
Identification of Small Molecule Modulators of Gene Transcription with Anticancer Activity • Nature Medicine • September 16, 2014 • NCGC
Comparison of Baroreflex Sensitivity with a Fall and Rise in Blood Pressure Induced by the Valsalva Manoeuvre • Clinical Science • September 01, 2014 • CTSA
Improving Cervical Cancer Screening Rates in an Urban HIV Clinic • AIDS Care • September 01, 2014 • CTSA
The Effects of Extended Bedtimes on Sleep Duration and Food Desire in Overweight Young Adults: A Home-Based Intervention • Appetite • September 01, 2014 • CTSA
Adolescent Adrenocortical Activity and Adiposity: Differences by Sex and Exposure to Early Maternal Depression • Psychoneuroendocrinology • September 01, 2014 • CTSA
Branched-Linear and Agglomerate Protein Polymers as Vaccine Platforms •Biomaterials • September 01, 2014 • CTSA
Insights into Reference Point Indentation Involving Human Cortical Bone: Sensitivity to Tissue Anisotropy and Mechanical Behavior • Journal of the Mechanical Behavior of Biomedical Materials • September 01, 2014 • CTSA
Microbubble Array Diffusion Assay for the Detection of Cell Secreted Factors • Lab Chip • September 01, 2014 • CTSA
A Multiplexed Chip-Based Assay System for Investigating the Functional Development of Human Skeletal Myotubes In Vitro • Journal of Biotechnology • September 01, 2014 • New Therapeutic Uses
Non-Invasive Management of Vasovagal Syncope • Autonomic Neuroscience: Basic and Clinical • September 01, 2014 • CTSA
Ongoing Clinical Trials for Vasovagal Syncope: Where are we in 2014? •Autonomic Neuroscience: Basic and Clinical • September 01, 2014 • CTSA
Is Alzheimer's Disease a Systemic Disease? • Biochimica et Biophysica Acta• September 01, 2014 • CTSA
Predicting Mortality from Burns: The Need for Age-Group-Specific Models• Burns • September 01, 2014 • CTSA
Antiretroviral Therapy and Efficacy after Virologic Failure on First-line Boosted Protease Inhibitor Regimens • Clinical Infectious Diseases • September 01, 2014 • CTSA
Influenza Vaccination of Pregnant Women and Protection of Their Infants• The New England Journal of Medicine • September 01, 2014 • CTSA
Long-Term Follow-up after Bariatric Surgery: A Systematic Review •Journal of the American Medical Association • September 01, 2014 • CTSA
Individual and Contextual-Level Factors Associated with Continuity of Care for Adults with Schizophrenia • Administration and Policy in Mental Health • September 01, 2014 • CTSA
Effects of Stress and Depression on Inflammatory Immune Parameters in Pregnancy • American Journal of Obstetrics and Gynecology • September 01, 2014 • CTSA
The Biology and Medicine of Microphysiological Systems • Experimental Biology and Medicine • September 01, 2014 • Tissue Chips
August 2014
Sickle Cell Drug Candidate under Development • Journal of the American Medical Association • August 27, 2014 • TRND
RUC-4: A Novel αIIbβ3 Antagonist for Prehospital Therapy of Myocardial Infarction • Arteriosclerosis, Thrombosis, and Vascular Biology • August 21, 2014 • NCGC
Inhibition of HERG Potassium Channels by Domiphen Bromide and Didecyl Dimethylammonium Bromide • European Journal of Pharmacology • August 15, 2014 • NCGC
Atypical Presentation of GNE Myopathy with Asymmetric Hand Weakness •Neuromuscular Disorders • August 07, 2014 • TRND
A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein • PLOS One • August 05, 2014 • NCGC
NIH Program Keeps Sickle Cell Disease Drug Alive • Chemical & Engineering News • August 04, 2014 • TRND
Depression Severity is Associated with Increased Risk Behaviors and Decreased CD4 Cell Counts • AIDS Care • August 01, 2014 • CTSA
Colorectal Cancer among Koreans Living in South Korea Versus California: Incidence, Mortality, and Screening Rates • Ethnicity & Health • August 01, 2014 • CTSA
Dalhousie Dyspnea and Perceived Exertion Scales: Psychophysical Properties in Children and Adolescents • Respiratory Physiology & Neurobiology • August 01, 2014 • CTSA
New Frontiers in Obstructive Sleep Apnoea • Clinical Science • August 01, 2014 • CTSA
TBX2 Blocks Myogenesis and Promotes Proliferation in Rhabdomyosarcoma Cells • International Journal of Cancer • August 01, 2014 • CTSA
Longitudinal Changes in Airway Remodeling and Air Trapping in Severe Asthma • Academic Radiology • August 01, 2014 • CTSA
The Influence of Herbs and Spices on Overall Liking of Reduced Fat Food •Appetite • August 01, 2014 • CTSA
Recent Advances in the Application of Metabolomics to Alzheimer's Disease • Biochimica et Biophysica Acta • August 01, 2014 • CTSA
Effects of Problem Solving Therapy on Mental Health Outcomes in Family Caregivers of Persons with a New Diagnosis of Mild Cognitive Impairment or Early Dementia: A Randomized Controlled Trial • The American Journal of Geriatric Psychiatry • August 01, 2014 • CTSA
A Phase I Dose Escalation Study of Oral Bexarotene in Combination with Intravenous Decitabine in Patients with AML • American Journal of Hematology • August 01, 2014 • CTSA
The Necessity-Concerns Framework: A Multidimensional Theory Benefits from Multidimensional Analysis • Annals of Behavioral Medicine • August 01, 2014 • CTSA
Pain Hypervigilance is Associated with Greater Clinical Pain Severity and Enhanced Experimental Pain Sensitivity among Adults with Symptomatic Knee Osteoarthritis • Annals of Behavioral Medicine • August 01, 2014 • CTSA
MICA, a Gene Contributing Strong Susceptibility to Ankylosing Spondylitis• Annals of the Rheumatic Diseases • August 01, 2014 • CTSA
Hepatitis B Virus Replication is Blocked by a 2-Hydroxyisoquinoline-1,3(2H,4H)-Dione (HID) Inhibitor of the Viral Ribonuclease H Activity •Antiviral Research • August 01, 2014 • CTSA
Perivascular Adipose Tissue and Coronary Vascular Disease •Arteriosclerosis, Thrombosis, and Vascular Biology • August 01, 2014 • CTSA
Folding Graft Copolymer with Pendant Drug Segments for Co-Delivery of Anticancer Drugs • Biomaterials • August 01, 2014 • CTSA
Dipeptidyl-Peptidase-4 Inhibitors and Pancreatic Cancer: A Cohort Study •Diabetes, Obesity & Metabolism • August 01, 2014 • CTSA
The Clinical Translation Gap in Child Health Exercise Research: A Call for Disruptive Innovation • Clinical and Translational Science • August 01, 2014 • CTSA
Cardiovascular Phenotype in HFpEF Patients with or without Diabetes: A RELAX Trial Ancillary Study • Journal of the American College of Cardiology • August 01, 2014 • CTSA
The Effectiveness of Post-Offer Pre-Placement Nerve Conduction Screening for Carpal Tunnel Syndrome • Journal of Occupational and Environmental Medicine • August 01, 2014 • CTSA
Health Care Worker Exposures to the Antibacterial Agent Triclosan •Journal of Occupational and Environmental Medicine • August 01, 2014 • CTSA
The Platelet: Life on the Razor's Edge between Hemorrhage and Thrombosis • Transfusion • August 01, 2014 • CTSA
July 2014
Modulation of HCV Replication after Combination Antiretroviral Therapy in HCV/HIV Co-Infected Patients • Science Translational Medicine • July 23, 2014 • CTSA
The Increasing Urgency for Standards in Basic Biologic Research • Cancer Research • July 17, 2014 • NCGC
Biochemical Assays for the Discovery of TDP1 Inhibitors • Cancer Research• July 17, 2014 • NCGC
Tofacitinib Suppresses Antibody Responses to Protein Therapeutics in Murine Hosts • Molecular Cancer Therapeutics • July 14, 2014 • NCGC
Profiling of the Tox21 10K Compound Library for Agonists and Antagonists of the Estrogen Receptor Alpha Signaling Pathway • Scientific Reports • July 11, 2014 • Tox21
Gender and Risk Behaviors for HIV and Sexually Transmitted Infections among Recently Released Inmates: A Prospective Cohort Study • AIDS Care• July 01, 2014 • CTSA
Depressive Symptoms, Self-Esteem, HIV Symptom Management Self-Efficacy and Self-Compassion in People Living with HIV • AIDS Care • July 01, 2014 • CTSA
Cognition and Mood in Perimenopause: A Systematic Review and Meta-Analysis • The Journal of Steroid Biochemistry & Molecular Biology • July 01, 2014 • CTSA
Targeting the Mevalonate Cascade as a New Therapeutic Approach in Heart Disease, Cancer and Pulmonary Disease • Pharmacology & Therapeutics • July 01, 2014 • CTSA
Selective Inhibition of Class I but Not Class IIb Histone Deacetylases Exerts Cardiac Protection from Ischemia Reperfusion • Journal of Molecular and Cellular Cardiology • July 01, 2014 • CTSA
Transmural Heterogeneity of Cellular Level Power Output is Reduced in Human Heart Failure • Journal of Molecular and Cellular Cardiology • July 01, 2014 • CTSA
Protein Energy Wasting in Children with Chronic Kidney Disease •Pediatric Nephrology • July 01, 2014 • CTSA
Micromolded Gelatin Hydrogels for Extended Culture of Engineered Cardiac Tissues • Biomaterials • July 01, 2014 • Tissue Chips
Spreading Depression Requires Microglia and is Decreased by Their M2a Polarization from Environmental Enrichment • Glia • July 01, 2014 • exRNA
Environmental Risks and Children's Health: What can PRAMS Tell Us? •Maternal and Child Health Journal • July 01, 2014 • CTSA
Joint Model for a Diagnostic Test without a Gold Standard in the Presence of a Dependent Terminal Event • Statistics in Medicine • July 01, 2014 • CTSA
Allergens on Desktop Surfaces in Preschools and Elementary Schools of Urban Children with Asthma • Allergy • July 01, 2014 • CTSA
Elevated Double Negative T Cells in Pediatric Autoimmunity • Journal of Clinical Immunology • July 01, 2014 • CTSA
Distributions of Positive Signals in Pyrosequencing • Journal of Mathematical Biology • July 01, 2014 • CTSA
Structural Insight into Exosite Binding and Discovery of Novel Exosite Inhibitors of Botulinum Neurotoxin Serotype A Through in Silico Screening• Journal of Computer-Aided Molecular Design • July 01, 2014 • NCGC
Summary of International Guidelines for Physical Activity After Pregnancy• Obstetrical & Gynecological Survey • July 01, 2014 • CTSA
Change in Adiposity Minimally Affects the Lipid Profile in Youth with Recent Onset Type 1 Diabetes • Pediatric Diabetes • July 01, 2014 • CTSA
June 2014
The NIH-Industry New Therapeutic Uses Pilot Program: Demonstrating the Power of Crowdsourcing • Mary Ann Liebert, Inc. • June 26, 2014 • New Therapeutic Uses
Refining Prognosis in Small Intestinal Neuroendocrine Tumors • The Oncology Report • June 23, 2014 • NCATS
Performance of High School Adolescents on Functional Gait and Balance Measures • Pediatric Physical Therapy • June 21, 2014 • CTSA
Macrophage Models of Gaucher Disease for Evaluating Disease Pathogenesis and Candidate Drugs • Science Translational Medicine • June 11, 2014 • NCGC
RNAi Therapies: Drugging the Undruggable • Science Translational Medicine • June 11, 2014 • exRNA
Expanding Rare Disease Drug Trials Based on Shared Molecular Etiology •Nature Biotechnology • June 09, 2014 • ORDR
Collaborative Development of 2-Hydroxypropyl-β-Cyclodextrin for the Treatment of Niemann-Pick Type C1 Disease • Current Topics in Medicinal Chemistry • June 06, 2014 • TRND
Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy •Journal of Biomolecular Screening • June 06, 2014 • NCGC
Overcoming Drug Development Bottlenecks with Repurposing: Old Drugs Learn New Tricks • Nature Medicine • June 05, 2014 • New Therapeutic Uses
The Feasibility, Acceptance, and Key Features of a Prevention-Focused Oral Health Education Program for HIV+ Adults • AIDS Care • June 01, 2014 • CTSA
The Interaction between Sleep-Disordered Breathing and Apolipoprotein E genotype on Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Cognitively Normal Elderly Individuals • Neurobiology of Aging • June 01, 2014 • CTSA
Investigation of Triggering Receptor Expressed on Myeloid Cells 2 Variant in the Wisconsin Registry for Alzheimer's Prevention • Neurobiology of Aging • June 01, 2014 • CTSA
A Test of the Diathesis-Stress Model in the Emergency Department: Who Develops PTSD after an Acute Coronary Syndrome? • Journal of Psychiatric Research • June 01, 2014 • CTSA
The Thioredoxin Reductase-1 Inhibitor Aurothioglucose Attenuates Lung Injury and Improves Survival in a Murine Model of Acute Respiratory Distress Syndrome • Antioxidants & Redox Signaling • June 01, 2014 • CTSA
Association of APOE Polymorphisms and Stressful Life Events with Dementia in a Pakistani Population • Neuroscience Letters • June 01, 2014 • CTSA
In Vitro Transport Characteristics of EFdA, A Novel Nucleoside Reverse Transcriptase Inhibitor Using Caco-2 and MDCKII Cell Monolayers •European Journal of Pharmacology • June 01, 2014 • CTSA
ABCC9 Gene Polymorphism is Associated with Hippocampal Sclerosis of Aging Pathology • Acta Neuropathologica • June 01, 2014 • CTSA
Clinical Features of Methamphetamine-Induced Paranoia and Preliminary Genetic Association with DBH-1021C→T in a Thai Treatment Cohort •Addiction • June 01, 2014 • CTSA
Suicide and Death Ideation in Older Adults Obtaining Aging Services • The American Journal of Geriatric Psychiatry • June 01, 2014 • CTSA
Vascular Endothelial Function and Self-Reported Sleep • The American Journal of the Medical Sciences • June 01, 2014 • CTSA
Contralaterally Controlled Functional Electrical Stimulation for Recovery of Elbow Extension and Hand Opening After Stroke: A Pilot Case Series Study • American Journal of Physical Medicine & Rehabilitation • June 01, 2014 • CTSA
Pharmaceutical Amyloidosis Associated with Subcutaneous Insulin and Enfuvirtide Administration • Amyloid • June 01, 2014 • CTSA
Treatment Options for Hypertriglyceridemia: From Risk Reduction to Pancreatitis • Best Practice & Research • June 01, 2014 • CTSA
The Role of EVI1 in Myeloid Malignancies • Blood Cells, Molecules & Diseases • June 01, 2014 • CTSA
Simulation Curriculum Can Improve Medical Student Assessment and Management of Acute Coronary Syndrome during a Clinical Practice Exam• American Journal of the Medical Sciences • June 01, 2014 • CTSA
Matrix Biology of Idiopathic Pulmonary Fibrosis: A Workshop Report of the National Heart, Lung, and Blood Institute • The American Journal of Pathology • June 01, 2014 • CTSA
Botulinum Toxin Type A Injections for Cervical and Shoulder Girdle Myofascial Pain Using an Enriched Protocol Design • Anesthesia and Analgesia • June 01, 2014 • CTSA
Effect of Vitamin D-Binding Protein Genotype on the Development of Asthma in Children • Annals of Allergy, Asthma & Immunology • June 01, 2014 • CTSA
Dynamic Interplay of Flow and Collagen Stabilizes Primary Hepatocytes Culture in a Microfluidic Platform • Lab on a Chip • June 01, 2014 • Tissue Chips
May 2014
Usefulness of Elevated Urine Neopterin Levels in Assessing Cardiac Dysfunction and Exercise Ventilation Inefficiency in Patients with Chronic Systolic Heart Failure • The American Journal of Cardiology • May 30, 2014 • CTSA
Targeting Human Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Phosphatase and Tensin Homolog (PTEN) Deficient Melanoma Cells for Personalized Therapy • OncoTarget • May 30, 2014 • NCGC
A Multiplex High-Throughput Gene Expression Assay to Simultaneously Detect Disease and Functional Markers in Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium • Stem Cells Translational Medicine • May 29, 2014 • CTSA
Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial •Journal of the American Medical Association • May 27, 2014 • CTSA
Genomic Analysis of Invasive Human Bone Marrow Derived Mesenchymal Stem Cells • Journal of Bone Marrow Research • May 23, 2014 • NCGC
Research Resource: Modulators of Glucocorticoid Receptor Activity Identified By a New High-Throughput Screening Assay • Molecular Endocrinology • May 21, 2014 • NCGC
Modeling the Mitochondrial Cardiomyopathy of Barth Syndrome with Induced Pluripotent Stem Cell and Heart-on-Chip Technologies • Nature Medicine • May 11, 2014 • Tissue Chips
Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin and Other Platinum Complexes • Cancer Research • May 08, 2014 • NCGC
Research into Rare Diseases of Childhood • Journal of the American Medical Association • May 07, 2014 • ORDR
A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1 • ChemMedChem • May 07, 2014 • NCGC
Lomofungin and Dilomofungin: Inhibitors of MBNL1-CUG RNA Binding with Distinct Cellular Effects • Nucleic Acids Research • May 05, 2014 • NCGC
Antimicrobial Prophylaxis for Children with Vesicoureteral Reflux • The New England Journal of Medicine • May 04, 2014 • CTSA
Genomic and Protein Expression Analysis Reveals Flap Endonuclease 1 (FEN1) as a Key Biomarker in Breast and Ovarian Cancer • Molecular Oncology • May 04, 2014 • NCGC
Mutation Update for GNE Gene Variants Associated with GNE Myopathy •Human Mutation • May 02, 2014 • TRND
Personality and Alcohol-Related Outcomes among Mandated College Students: Descriptive Norms, Injunctive Norms, and College-Related Alcohol Beliefs as Mediators • Addictive Behavior • May 01, 2014 • CTSA
"Go4Life" Exercise Counseling, Accelerometer Feedback, and Activity Levels in Older People • Archives of Gerontology and Geriatrics • May 01, 2014 • CTSA
Brain Activity during Complex Imagined Gait Tasks in Parkinson Disease •Clinical Neurophysiology • May 01, 2014 • CTSA
Does Limb Preconditioning Reduce Pain After Total Knee Arthroplasty? A Randomized, Double-blind Study • Clinical Orthopaedics and Related Research • May 01, 2014 • CTSA
Serum 25-Hydroxyvitamin D Concentration Does Not Independently Predict Incident Diabetes in Older Women • Diabetic Medicine • May 01, 2014 • CTSA
A Case Report of Cognitive Behavioural Therapy for Social Anxiety in an Ultra-High-Risk Patient • Early Intervention in Psychiatry • May 01, 2014 • CTSA
Anterior-Posterior Cerebral blood Volume Gradient in Human Subiculum •Hippocampus • May 01, 2014 • CTSA
Midlife Measurements of White Matter Microstructure Predict Subsequent Regional White Matter Atrophy in Healthy Adults • Human Brain Mapping• May 01, 2014 • CTSA
Novel Cell-based Hepatitis C Virus Infection Assay for Quantitative High-Throughput Screening of Anti-Hepatitis C Virus Compounds •Antimicrobial Agents and Chemotherapy • May 01, 2014 • NCGC
April 2014
Vast majority of ED Visits for Acute Heart Failure Become Admissions •The Oncology Report • April 30, 2014 • NCATS
Identification of Novel PARP Inhibitors Using a Cell-based TDP1 Inhibitory Assay in a Quantitative High-Throughput Screening Platform • DNA Repair• April 29, 2014 • NCGC
Discovery and Characterization of a G Protein-Biased Agonist that Inhibits β-arrestin Recruitment to the D2 Dopamine Receptor • Molecular Pharmacology • April 22, 2014 • NCGC
Allosteric Inhibitors of the Eya2 Phosphatase Are Selective and Inhibit Eya2-mediated Migration • Journal of Biological Chemistry • April 22, 2014 • NCGC
Identification of Thyroid Hormone Receptor Active Compounds Using a Quantitative High-Throughput Screening Platform • Current Chemical Genomics and Translational Medicine • April 17, 2014 • Tox21
Engineered Tracheas, Corneas and Arteries Enter Clinical Testing •Nature Biotechnology • April 08, 2014 • NCATS
An Implementation Evaluation of the Community Engagement and Planning Intervention in the CPIC Depression Care Improvement Trial •Community Mental Health Journal • April 01, 2014 • CTSA
Value of Targeted Prostate Biopsy Using Magnetic Resonance-Ultrasound Fusion in Men with Prior Negative Biopsy and Elevated Prostate-Specific Antigen • European Urology • April 01, 2014 • CTSA
Long Chain n-3 Polyunsaturated Fatty Acids and Incidence Rate of Coronary Artery Calcification in Japanese Men in Japan and White Men in the USA: Population-Based Prospective Cohort Study • Heart • April 01, 2014 • CTSA
Pharmacotherapy for Mood Disorders in Pregnancy: A Review of Pharmacokinetic Changes and Clinical Recommendations for Therapeutic Drug Monitoring • Journal of Clinical Psychopharmacology • April 01, 2014 • CTSA
Evaluation of Amigas Latinas Motivando el Alma (ALMA): A Pilot Promotora Intervention Focused on Stress and Coping among Immigrant Latinas • Journal of Immigrant and Minority Health • April 01, 2014 • CTSA
Socio-Ecological Influences on Health-Care Access and Navigation Among Persons of Mexican Descent Living on the U.S./Mexico Border • Journal of Immigrant and Minority Health • April 01, 2014 • CTSA
Can a Minimal Intervention Reduce Secondhand Smoke Exposure among Children with Asthma from Low Income Minority Families? Results of a Randomized Trial • Journal of Immigrant and Minority Health • April 01, 2014 • CTSA
Regional White Matter Hyperintensities: Aging, Alzheimer's Disease Risk, and Cognitive Function • Neurobiology of Aging • April 01, 2014 • CTSA
Can a Questionnaire Predict Vitamin D Status in Postmenopausal Women?• Public Health Nutrition • April 01, 2014 • CTSA
Associations between Adjuvant Endocrine Therapy and Onset of Physical and Emotional Concerns among Breast Cancer Survivors • Supportive Care in Cancer • April 01, 2014 • CTSA
Metabolic Syndrome Components and Their Response to Lifestyle and Metformin Interventions are Associated with Differences in Diabetes Risk in Persons with Impaired Glucose Tolerance • Diabetes, Obesity & Metabolism • April 01, 2014 • CTSA
In Vivo Visuotopic Brain Mapping with Manganese-Enhanced MRI and Resting-State Functional Connectivity MRI • NeuroImage • April 01, 2014 • CTSA
Survivors Versus Nonsurvivors Postburn: Differences in Inflammatory and Hypermetabolic Trajectories • Annals of Surgery • April 01, 2014 • CTSA
Impact of Obesity on the Survival of Patients with Early-Stage Squamous Cell Carcinoma of the Oral Tongue • Cancer • April 01, 2014 • CTSA
Racial Variation in the Quality of Surgical Care for Bladder Cancer •Cancer • April 01, 2014 • CTSA
Concordance of PCR and Culture from Nasal Swabs for Detection of Methicillin-Resistant Staphylococcus Aureus in a Setting of Concurrent Antistaphylococcal Antibiotics • Journal of Clinical Microbiology • April 01, 2014 • CTSA
The Aspartate Metabolism Pathway is Differentiable in Human Hepatocellular Carcinoma: Transcriptomics and (13) C-Isotope-Based Metabolomics • NMR in Biomedicine • April 01, 2014 • CTSA
Regulators Adopt More Orphan Drugs • Nature • April 01, 2014 • ORDR
A DERL3-Associated Defect in the Degradation of SLC2A1 Mediates the Warburg Effect • Nature Communications • April 01, 2014 • NCGC
Potent and Selective Inhibitors of Human Reticulocyte 12/15- Lipoxygenase as Anti-Stroke Therapies • Journal of Medicinal Chemistry • April 01, 2014 • NCGC
March 2014
Biochemical, Cellular and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1 • Journal of Biological Chemistry • March 25, 2014 • NCGC
Discovery, Optimization, and Characterization of Novel D2 Dopamine Receptor Selective Antagonists • Journal of Medicinal Chemistry • March 25, 2014 • NCGC
A High-Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp • PLoS One • March 25, 2014 • NCGC
GNE Myopathy: New Name and New Mutation Nomenclature •Neuromuscular Disorders • March 13, 2014 • TRND
Clinical Interpretation and Implications of Whole-Genome Sequencing •Journal of the American Medical Association • March 12, 2014 • CTSA
Cerebral Maturation on Amplitude-Integrated Electroencephalography and Perinatal Exposures in Preterm Infants • Acta Paediatrica • March 01, 2014 • CTSA
A Qualitative Study of Work-Life Choices in Academic Internal Medicine •Advances in Health Sciences Education • March 01, 2014 • CTSA
Development of a Program Logic Model and Evaluation Plan for a Participatory Ergonomics Intervention in Construction • American Journal of Industrial Medicine • March 01, 2014 • CTSA
The Effect of Maternal Body Mass Index on Perinatal Outcomes in Women with Diabetes • American Journal of Perinatology • March 01, 2014 • CTSA
Misoprostol for Intrauterine Device Insertion in Nulliparous Women: A Randomized Controlled Trial • American Journal of Obstetrics and Gynecology • March 01, 2014 • CTSA
From Vital Signs to Clinical Outcomes for Patients with Sepsis: A Machine Learning Basis for a Clinical Decision Support System • Journal of the American Medical Informatics Association • March 01, 2014 • CTSA
Chronic mTOR Activation Promotes Cell Survival in Merkel Cell Carcinoma• Cancer Letters • March 01, 2014 • CTSA
The Ron Receptor Tyrosine Kinase Activates c-Abl to Promote Cell Proliferation through Tyrosine Phosphorylation of PCNA in Breast Cancer• Oncogene • March 01, 2014 • CTSA
The Survival Times of Malaria-Infected Mice are Prolonged More by Several New Two-Carbon-Linked Artemisinin-Derived Dimer Carbamates than by the Trioxane Antimalarial Drug Artemether • Bioorganic & Medicinal Chemistry Letters • March 01, 2014 • NCGC
February 2014
Remyelination: Are Exosomes Containing microRNA the Answer? • Multiple Sclerosis Discovery Forum • February 13, 2014 • exRNA
High-Throughput Screen Identifies a Roadmap for Combination Drug Trials • Nature Reviews Clinical Oncology • February 11, 2014 • NCATS
Long Non-Coding RNA in Liver Disease • Hepatology • February 03, 2014 • exRNA
Occurrence of Multiorgan Dysfunction in Pediatric Burn Patients: Incidence and Clinical Outcome • Annals of Surgery • February 02, 2014 • CTSA
Characterizing Smoking, Cessation Services, and Quit Interest across Outpatient Substance Abuse Treatment Modalities • Journal of Substance Abuse Treatment • February 01, 2014 • CTSA
Late-Outgrowth Endothelial Progenitors from Patients with Coronary Artery Disease: Endothelialization of Confluent Stromal Cell Layers • Acta Biomaterialia • February 01, 2014 • Tissue Chips
Three-Dimensional Filamentous Human Diseased Cardiac Tissue Model •Biomaterials • February 01, 2014 • Tissue Chips
A Pilot Investigation of the Association of Genetic Polymorphisms Regulating Corticotrophin-Releasing Hormone with Post-Traumatic Stress and Depressive Symptoms in Medical-Surgical Intensive Care Unit Survivors • Journal of Critical Care • February 01, 2014 • CTSA
Hypertension in the Teenager • Pediatric Clinics of North America • February 01, 2014 • CTSA
Magnetoactive Sponges for Dynamic Control of Microfluidic Flow Patterns in Microphysiological Systems • Lab Chip • February 01, 2014 • Tissue Chips
Effects of Age on Bone mRNA Levels of Sclerostin and Other Genes Relevant to Bone Metabolism in Humans • Bone • February 01, 2014 • CTSA
Genetic Polymorphisms Regulating Dopamine Signaling in the Frontal Cortex Interact to Affect Target Detection under High Working Memory Load • Journal of Cognitive Neuroscience • February 01, 2014 • CTSA
Virologic Correlates of Anti-CMV IgG Levels in HIV-1-Infected Men • The Journal of Infectious Diseases • February 01, 2014 • CTSA
Age-related Changes in the Structure and Function of Prefrontal Cortex-Amygdala Circuitry in Children and Adolescents: A Multi-Modal Imaging Approach • Neuroimage • February 01, 2014 • CTSA
Parent Perspectives on Decisions to Participate in a Phase I Hepatocyte Transplant Trial • Pediatric Transplantation • February 01, 2014 • CTSA
Differential Involvement of E2A-Corepressor Interactions in Distinct Leukemogenic Pathways • Nucleic Acids Research • February 01, 2014 • CTSA
Playing Well with Others! Initiating and Sustaining Successful Collaborations between Industry, Academia and Government • Current Topics in Medicinal Chemistry • February 01, 2014 • NCATS
Leveraging Public Private Partnerships to Innovate under Challenging Budget Times • Current Topics in Medicinal Chemistry • February 01, 2014 • NCATS
Youth and Environmental Enrichment Generate Serum Exosomes Containing miR-219 that Promote CNS Myelination • Glia • February 01, 2014 • exRNA
A Proposal for Integrated Efficacy-to-Effectiveness (E2E) Clinical Trials •Clinical Pharmacology & Therapeutics • February 01, 2014 • CTSA
January 2014
Urine MicroRNA as Potential Biomarkers of Autosomal Dominant Polycystic Kidney Disease Progression: Description of miRNA Profiles at Baseline • PLoS One • January 29, 2014 • exRNA
Dynamic Biodistribution of Extracellular Vesicles In Vivo Using a Multimodal Imaging Reporter • ACS Nano • January 28, 2014 • exRNA
High-throughput Combinatorial Screening Identifies Drugs that Cooperate with Ibrutinib to Kill Activated B-cell–like Diffuse Large B-cell Lymphoma Cells • Proceedings of the National Academy of Sciences • January 27, 2014 • NCATS
Disease Research: Rare Insights • Nature • January 15, 2014 • TRND
IFNγ Stimulated Dendritic Cell Exosomes as a Potential Therapeutic for Remyelination • Journal of Neuroimmunology • January 15, 2014 • exRNA
Clinical Presentation and Outcomes of Cardiovascular Implantable Electronic Device Infections in Hemodialysis Patients • American Journal of Kidney Diseases • January 10, 2014 • CTSA
Roles of Parathyroid Hormone (PTH) Receptor and Reactive Oxygen Species in Hyperlipidemia-Induced PTH Resistance in Preosteoblasts •Journal of Cellular Biochemistry • January 01, 2014 • CTSA
Comparison between Two Labeled Agents in Mice Using a Coinjection-Ratio Approach in Contrast to a Conventional Group Approach • Nuclear Medicine and Biology • January 01, 2014 • CTSA
Maternal High-Fat Diet Consumption during the Perinatal Period Programs Offspring Behavior • Physiology & Behavior • January 01, 2014 • CTSA
Bias Associated with Using the Estimated Propensity Score as a Regression Covariate • Statistics in Medicine • January 01, 2014 • CTSA
A GEE Approach to Determine Sample Size for Pre- and Post-Intervention Experiments with Dropout • Computational Statistics & Data Analysis • January 01, 2014 • CTSA
Regional Differences in the Developmental Trajectory of Lateralization of the Language Network • Human Brain Mapping • January 01, 2014 • CTSA
Feed-Forward Hierarchical Model of the Ventral Visual Stream Applied to Functional Brain Image Classification • Human Brain Mapping • January 01, 2014 • CTSA
Interaction between Genetic Variants and Exposure to Hurricane Katrina on Post-Traumatic Stress and Post-Traumatic Growth: A Prospective Analysis of Low-Income Adults • Journal of Affective Disorders • January 01, 2014 • CTSA
Contribution of Very Low-Density Lipoprotein Triglyceride Fatty Acids to Postabsorptive Free Fatty Acid Flux in Obese Humans • Metabolism • January 01, 2014 • CTSA
Innovation in Therapeutics Development at the NCATS •Neuropsychopharmacology • January 01, 2014 • NCATS
PELP1: A Review of PELP1 Interactions, Signaling, and Biology • Molecular and Cellular Endocrinology • January 01, 2014 • CTSA
Variants in Two Adjacent Genes, EGLN2 and CYP2A6, Influence Smoking Behavior Related to Disease Risk via Different Mechanisms • Human Molecular Genetics • January 01, 2014 • CTSA
Treatment of Cancer Micrometastasis Using a Multicomponent Chain-like Nanoparticle • Journal of Controlled Diseases • January 01, 2014 • CTSA
General Medical Burden in Bipolar Disorder: Findings from the LiTMUS Comparative Effectiveness Trial • Acta Psychiatrica Scandinavica • January 01, 2014 • CTSA
Obesity, Outcomes and Quality of Care: Body Mass Index Increases the Risk of Wound-related Complications in Colon Cancer Surgery • American Journal of Surgery • January 01, 2014 • CTSA
The Diurnal and Nocturnal Effect of Travoprost With SofZia on Intraocular Pressure and Ocular Perfusion Pressure • American Journal of Ophthalmology • January 01, 2014 • CTSA
Ceramides and Cardiac Function in Children with Chronic Kidney Disease •Pediatric Nephrology • January 01, 2014 • CTSA
Rejuvenation of Chondrogenic Potential in a Young Stem Cell Microenvironment • Biomaterials • January 01, 2014 • CTSA
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Scientific Publications 2015 |
December 2015
Treatment of Vitamin D Deficiency in Predominantly Hispanic and Black Adolescents: A Randomized Clinical Trial • Journal of Pediatrics • December 18, 2015 • CTSA
Circulating Sex Hormones and Risk of Uterine Fibroids: Study of Women's Health Across the Nation (SWAN) • Journal of Clinical Endocrinology and Metabolism • December 11, 2015 • CTSA
Changes in Receipt of Cancer Screening in Medicare Beneficiaries Following the Affordable Care Act • Journal of the National Cancer Institute • December 6, 2015 • CTSA
Tissue Transcriptome-Driven Identification of Epidermal Growth Factor as a Chronic Kidney Disease Biomarker • Science Translational Medicine • December 2, 2015 • RDCRN
HPV Vaccine Completion and Dose Adherence among Commercially Insured Females Aged 9 through 26 Years in the U.S. • Papillomavirus Research • December 1, 2015 • CTSA
Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma • Molecular Imagine and Biology • December 1, 2015 • CTSA
Neural Correlates of Visuomotor Learning in Autism • Journal of Child Neurology • December 1, 2015 • CTSA
Vitamin D and Anemia: Insights into an Emerging Association • Current Opinion in Endocrinology, Diabetes, and Obesity • December 1, 2015 • CTSA
Reducing Perceived Pain Levels During Nonbreast Lymphoscintigraphy • Clinical Nuclear Medicine • December 1, 2015 • CTSA
Association between Femur Size and a Focal Defect of the Superior Femoral Neck • Bone • December 1, 2015 • CTSA
Brain Injury and Development in Preterm Infants Exposed to Fentanyl • Annals of Pharmacotherapy • December 1, 2015 • CTSA
Measuring the HIV Care Continuum Using Public Health Surveillance Data in the United States • Journal of Acquired Immune Deficiency Syndromes • December 1, 2015 • CTSA
Examining Pre-Migration Health among Filipino Nurses • Journal of Immigrant and Minority Health • December 1, 2015 • CTSA
Key Stakeholders' Perspectives on a Web-based Advance Care Planning Tool for Advanced Lung Disease • Journal of Critical Care • December 1, 2015 • CTSA
Longitudinal Impact of a Collaborative Care Model on Employment Outcomes in Bipolar Disorder • Journal of Affective Disorders • December 1, 2015 • CTSA
Prior Human Polyomavirus and Papillomavirus Infection and Incident Lung Cancer: A Nested Case-Control Study • Cancer Causes & Control • December 1, 2015 • CTSA
"Manejar la Situacion": Partner Notification, Partner Management, and Conceptual Frameworks for HIV/STI Control among MSM in Peru • AIDS Behavior • December 1, 2015 • CTSA
Comparing Neonatal Morbidity and Mortality Estimates across Specialty in Periviable Counseling • Journal of Maternal-Fetal & Neonatal Medicine • December 1, 2015 • CTSA
Maternal Intuitive Eating as a Moderator of the Association between Concern about Child Weight and Restrictive Child Feeding • Appetite • December 1, 2015 • CTSA
November 2015
Combining Micro-Computed Tomography with Histology to Analyze Biomedical Implants for Peripheral Nerve Repair • Journal of Neuroscience Methods • November 30, 2015 • CTSA
A New Face of Sleep: The Impact of Post-Learning Sleep on Recognition Memory for Face-Name Associations • Neurobiology of Learning and Memory • November 23, 2015 • CTSA
Pioneering Government-Sponsored Drug Repositioning Collaborations: Progress and Learning • Nature Reviews Drug Discovery • November 20, 2015 • New Therapeutic Uses
Towards a Hit for Every Target • Nature Reviews Drug Discovery • November 20, 2015 • New Therapeutic Uses
Multiple Imputation for Harmonizing Longitudinal Non-Commensurate Measures in Individual Participant Data Meta-Analysis • Statistics in Medicine • November 20, 2015 • CTSA
Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol • Sleep • November 19, 2015 • CTSA
Randomized Controlled Pilot Trial of Mindfulness-Based Stress Reduction for Breast and Colorectal Cancer Survivors: Effects on Cancer-Related Cognitive Impairment • Journal of Cancer Survivorship • November 19, 2015 • CTSA
Improved Detection of Invasive Pulmonary Aspergillosis Arising during Leukemia Treatment Using a Panel of Host Response Proteins and Fungal Antigens • PLOS ONE • November 18, 2015 • CTSA
Racial/Ethnic Differences Affecting Adherence to Cancer Screening Guidelines among Women • Journal of Women's Health • November 18, 2015 • CTSA
Manipulation of Host Diet to Reduce Gastrointestinal Colonization by the Opportunistic Pathogen Candida albicans • mSphere • November 18, 2015 • CTSA
Patient-Reported Impact of Symptoms in Myotonic Dystrophy Type 2 (PRISM-2) • Neurology • November 18, 2015 • CTSA
Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma • Journal of Nuclear Medicine • November 12, 2015 • CTSA
Loss of Consciousness at Onset of Subarachnoid Hemorrhage as an Important Marker of Early Brain Injury • JAMA Neurology • November 9, 2015 • CTSA
Diabetes Screening among Underserved Adults with Severe Mental Illness Who Take Antipsychotic Medications • JAMA Internal Medicine • November 9, 2015 • CTSA
A Randomized Trial of Cardiovascular Responses to Energy Drink Consumption in Healthy Adults • Journal of the American Medical Association • November 8, 2015 • CTSA
Digital Quantification of miRNA Directly in Plasma Using Integrated Comprehensive Droplet Digital Detection • Lab on a Chip • November 7, 2015 • CTSA
Child Care Center Characteristics Associated with Preschoolers’ Physical Activity • American Journal of Preventive Medicine • November 6, 2015 • CTSA
Trends in Prescription Drug Use Among Adults in the United States from 1999-2012 • JAMA • November 3, 2015 • CTSA
Effect of Sensorineural Hearing Loss on Neurocognitive Functioning in Pediatric Brain Tumor Survivors • Pediatric Blood and Cancer • November 3, 2015 • CTSA
Racial and Ethnic Disparities in the Pediatric Hodgkin Lymphoma Population • Pediatric Blood & Cancer • November 2, 2015 • CTSA
Low Unesterified:Esterified Eicosapentaenoic Acid (EPA) Plasma Concentration Ratio Is Associated with Bipolar Disorder Episodes, and Omega-3 Plasma Concentrations Are Altered by Treatment • Bipolar Disorders • November 1, 2015 • NCATS
State of the Art Review: Depression, Stress, Anxiety, and Cardiovascular Disease • American Journal of Hypertension • November 1, 2015 • CTSA
Quantification of Myo-Inositol, 1,5-Anhydro- D-Sorbitol, and D-Chiro-Inositol using High-Performance Liquid Chromatography with Electrochemical Detection in Very Small Volume Clinical Samples • Biomedical Chromatography • November 1, 2015 • CTSA
Exposure to Environmental Chemicals and Heavy Metals, and Risk of Pancreatic Cancer • Cancer Causes & Control • November 1, 2015 • CTSA
Prognostic Value of Epicardial Fat Volume Measurements by Computed Tomography: A Systematic Review of the Literature • European Radiology • November 1, 2015 • CTSA
Overview of Immunodeficiency Disorders • Immunology and Allergy Clinics of North America • November 1, 2015 • CTSA
The Impact of Intensive Reading Intervention on Level of Attention in Middle School Students • Journal of Clinical and Adolescent Psychology • November 1, 2015 • CTSA
Associations between Adrenocortical Activity and Nicotine Response in Female Smokers by Menstrual Phase • Addictive Behaviors • November 1, 2015 • CTSA
Trends in Prescription Drug Use among Adults in the United States from 1999-2012 • JAMA • November 1, 2015 • CTSA
Confluence, Not Conflict of Interest: Name Change Necessary • JAMA • November 1, 2015 • CTSA
Sunburn, Sun Exposure, and Sun Sensitivity in the Study of Nevi in Children • Annals of Epidemiology • November 1, 2015 • CTSA
Muscarinic Acetylcholine Receptor Binding Affinities of Pethidine Analogs • Bioorganic & Medicinal Chemistry Letters • November 1, 2015 • CTSA
October 2015
Right Hemisphere Grey Matter Structure and Language Outcomes in Chronic Left Hemisphere Stroke • Brain • October 31, 2015 • CTSA
Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration • American Journal of Medicine • October 30, 2015 • CTSA
Improving Patient-Centered Care: A Cross-Sectional Survey of Prior Use and Interest in Complementary and Integrative Health Approaches among Hospitalized Oncology Patients • Journal of Alternative and Complementary Medicine • October 27, 2015 • CTSA
Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells • Molecular Cancer Research • October 27, 2015 • CTSA
Evidence Synthesis Activities of a Hospital Evidence-based Practice Center and Impact on Hospital Decision Making • Journal of Hospital Medicine • October 27, 2015 • CTSA
Broadscale Resolving Power Performance of a High Precision Uniform Field Ion Mobility-Mass Spectrometer • Analyst • October 21, 2015 • Tissue Chips
Distinct Effects of Trial-Driven and Task Set-Related Control in Primary Visual Cortex • Neuroimage • October 15, 2015 • CTSA
Diet Quality of Cancer Survivors and Noncancer Individuals: Results from a National Survey • Cancer • October 13, 2015 • CTSA
Prevention of Acute Proximal Junctional Fractures After Long Thoracolumbar Posterior Fusions for Adult Spinal Deformity Using 2-level Cement Augmentation at the Upper Instrumented Vertebra and the Vertebra 1 Level Proximal to the Upper Instrumented Vertebra • Spine • October 1, 2015 • CTSA
Thirty-Day Mortality in ED Patients with New Onset Atrial Fibrillation and Actively Treated Cancer • The American Journal of Emergency Medicine • October 1, 2015 • CTSA
A Destructive Feedback Loop Mediated by CXCL10 in Central Nervous System Inflammatory Disease • Annals of Neurology • October 1, 2015 • CTSA
Outcomes after Warfarin Initiation in a Cohort of Hemodialysis Patients with Newly Diagnosed Atrial Fibrillation • American Journal of Kidney Diseases • October 1, 2015 • CTSA
Preparing Tomorrow's Nursing Home Nurses: The Wisconsin Long Term Care Clinical Scholars Program • Gerontology & Geriatrics Education • October 1, 2015 • CTSA
Mutant p53 Expression in Fallopian Tube Epithelium Drives Cell Migration • International Journal of Cancer • October 1, 2015 • CTSA
Using a Systems Engineering Initiative for Patient Safety to Evaluate a Hospital-wide Daily Chlorhexidine Bathing Intervention • Journal of Nursing Care Quality • October 1, 2015 • CTSA
Mini but Mighty: MicroRNAs in the Pathobiology of Periodontal Disease • Periodontology • October 1, 2015 • CTSA
Widespread White Matter but Focal Gray Matter Alterations in Depressed Individuals with Thoughts of Death • Early Human Development • October 1, 2015 • CTSA
Cesarean Delivery Is Not Associated with Decreased At-Birth Fracture Rates in Osteogenesis Imperfecta • Genetics in Medicine • October 1, 2015 • RDCRN
September 2015
Risk of Dementia in Patients with Celiac Disease: A Population-Based Cohort Study • Journal of Alzheimer's Disease • September 29, 2015 • CTSA
Adenosine A2A Receptor Plays an Important Role in Radiation-induced Dermal Injury • The Official Journal of the Federation of American Societies for Experimental Biology • September 28, 2015 • CTSA
High-Throughput Matrix Screening Identifies Synergistic and Antagonistic Antimalarial Drug Combinations • Scientific Reports • September 25, 2015 • NCGC, Matrix
Selective Targeting of JAK/STAT Signaling is Potentiated by Bcl-xL Blockade in IL-2-Dependent Adult T-Cell Leukemia • Proceedings of the National Academy of Sciences • September 22, 2015 • NCGC, Matrix
Dissociable Roles of Dopamine and Serotonin Transporter Function in a Rat Model of Negative Urgency • Behavioural Brain Research • September 15, 2015 • CTSA
Hospital Variation in Admission to Intensive Care Units for Patients with Acute Myocardial Infarction • American Heart Journal • September 11, 2015 • CTSA
Health Conditions and Functional Status in Adults with Autism: A Cross-Sectional Evaluation • Journal of General Internal Medicine • September 11, 2015 • CTSA
A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency • New England Journal of Medicine • September 10, 2015 • CTSA
Progression to Traditional Cigarette Smoking After Electronic Cigarette Use among U.S. Adolescents and Young Adults • JAMA Pediatrics • September 8, 2015 • CTSA
Overdiagnosis of Clostridium difficile Infection in the Molecular Test Era • JAMA Internal Medicine • September 8, 2015 • CTSA
The Association of Expanded Access to a Collaborative Midwifery and Laborist Model with Cesarean Delivery Rates • Obstetrics and Gynecology • September 3, 2015 • CTSA
Voriconazole Exposure and Risk of Cutaneous Squamous Cell Carcinoma, Aspergillus Colonization, Invasive Aspergillosis and Death in Lung Transplant Recipients • American Journal of Transplantation • September 3, 2015 • CTSA
Gain-of-Function p53 Mutants Co-Opt Chromatin Pathways to Drive Cancer Growth • Nature • September 2, 2015 • CTSA
A Longitudinal Twin Study of Insomnia Symptoms in Adults • Sleep • September 1, 2015 • CTSA
Effect of Menstrual Cycle Phase on Background Parenchymal Uptake at Molecular Breast Imaging • Academic Radiology • September 1, 2015 • CTSA
The Barriers to High-Quality Inpatient Pain Management: A Qualitative Study • American Journal of Hospice & Palliative Care • September 1, 2015 • CTSA
Association of Hyperchloremia with Hospital Mortality in Critically Ill Septic Patients • Critical Care Medicine • September 1, 2015 • CTSA
The Yale Craving Scale: Development and Psychometric Properties • Drug and Alcohol Dependency • September 1, 2015 • CTSA
Appreciating Reasons for Nonadherence in Women • Health Care for Women International • September 1, 2015 • CTSA
Preoperative Risk Factors for Postoperative Delirium Following Hip Fracture Repair: A Systematic Review • International Journal of Geriatric Psychiatry • September 1, 2015 • CTSA
Experience with Fingolimod in Clinical Practice • International Journal of Neuroscience • September 1, 2015 • CTSA
Trust and the Ethics of Chronic Pain Management in HIV • Journal of the Association of Nurses in AIDS Care • September 1, 2015 • CTSA
Vessel Network Formation in Response to Intermittent Hypoxia is Frequency Dependent • Journal of Bioscience and Bioengineering • September 1, 2015 • Tissue Chip
A Novel Role for Thrombopoietin in Regulating Osteoclast Development in Humans and Mice • Journal of Cellular Physiology • September 1, 2015 • CTSA
August 2015
Dynamic Reconfiguration of Frontal Brain Networks during Executive Cognition in Humans • Proceedings of the National Academy of Sciences • August 31, 2015 • CTSA
Recurrent Stroke in Childhood Cancer Survivors • Neurology • August 26, 2015 • NCATS
Automated Analysis of Free Speech Predicts Psychosis Onset in High-Risk Youths • NPJ-Schizophrenia • August 26, 2015 • CTSA
Parental Use of Electronic Cigarettes • Academic Pediatrics • August 25, 2015 • CTSA
Temporal and Spatial Variation of the Human Microbiota during Pregnancy • Proceedings of the National Academy of Sciences • August 17, 2015 • CTSA
Community Surveillance of Respiratory Viruses Among Families in the Utah Better Identification of Germs-Longitudinal Viral Epidemiology (BIG-LoVE) Study • Clinical Infectious Diseases • August 4, 2015 • CTSA
An Apoptosis-Enhancing Drug Overcomes Platinum Resistance in a Tumour-Initiating Subpopulation of Ovarian Cancer • Nature Communications • August 3, 2015 • CTSA
Optimizing Hybrid Occlusion in Face-Jaw-Teeth Transplantation: A Preliminary Assessment of Real-Time Cephalometry as Part of the Computer-Assisted Planning and Execution Workstation for Craniomaxillofacial Surgery • Plastic and Reconstructive Surgery • August 1, 2015 • CTSA
Fractures on Bisphosphonates in Osteoporosis Pseudoglioma Syndrome (OPPG): pQCT Shows Poor Bone Density and Structure • Bone • August 1, 2015 • CTSA
Regional Variation of Bone Tissue Properties at the Human Mandibular Condyle • Bone • August 1, 2015 • CTSA
Acute Responses to Opioidergic Blockade as a Biomarker of Hedonic Eating among Obese Women Enrolled in a Mindfulness-based Weight Loss Intervention Trial • Appetite • August 1, 2015 • CTSA
A Phenotypic In Vitro Model for the Main Determinants of Human Whole Heart Function • Biomaterials • August 1, 2015 • Tissue Chip
Impact of Electronic Health Record Technology on the Work and Workflow of Physicians in the Intensive Care Unit • International Journal of Medical Informatics • August 1, 2015 • CTSA
Psychometric Evaluation of the Hospital Anxiety and Depression Scale 3 Months after Acute Lung Injury • Journal of Critical Care • August 1, 2015 • CTSA
Hospital Readmission after Emergency Room Visit for Cholelithiasis • Journal of Surgical Research • August 1, 2015 • CTSA
Innovation or Rebranding, Acute Care Surgery Diffusion will Continue • Journal of Surgical Research • August 1, 2015 • CTSA
July 2015
Pain in Community-Dwelling Older Adults with Dementia: Results from the National Health and Aging Trends Study • Journal of the American Geriatrics Society • July 22, 2015 • CTSA
The Promise and Peril of Chemical Probes • Nature Chemical Biology • July 21, 2015 • NCGC
The Development of a Pediatric Inpatient Experience of Care Measure: Child HCAHPS • Pediatrics • July 20, 2015 • CTSA
Initial Benchmarking of the Quality of Medical Care of Childhood-Onset Systemic Lupus Erythematosus • Arthritis Care Research • July 20, 2015 • CTSA
Phenotype and Adverse Quality of Life in Boys with Klinefelter Syndrome • Journal of Pediatrics • July 20, 2015 • CTSA
Bioactive Products Formed in Humans from Fish Oils • Journal of Lipid Research • July 15, 2015 • CTSA
Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays • PLOS ONE • July 15, 2015 • NCGC
Inflammation-Associated Declines in Cerebral Vasoreactivity and Cognition in Type 2 Diabetes • Neurology • July 8, 2015 • CTSA
Variations in Opioid Receptor Genes in Neonatal Abstinence Syndrome • Drug & Alcohol Dependence • July 7, 2015 • CTSA
IFNγ Responses to Pre-erythrocytic and Blood-stage Malaria Antigens Exhibit Differential Associations with Past Exposure and Subsequent Protection • Journal of Infectious Diseases • July 1, 2015 • CTSA
Estrogens and Their Precursors in Postmenopausal Women with Early Breast Cancer Receiving Anastrozole • Steroids • July 1, 2015 • CTSA
Replication Study of the Milwaukee Inventory for Subtypes of Trichotillomania-Adult Version in a Clinically Characterized Sample • Behavior Modification • July 1, 2015 • CTSA
Second Malignant Neoplasms Among Children, Adolescents and Young Adults with Wilms Tumor • Pediatric Blood & Cancer • July 1, 2015 • CTSA
Prevalence of Post-Thrombotic Syndrome after Cardiac Catheterization • Pediatric Blood & Cancer • July 1, 2015 • CTSA
Safety of Octreotide in Hospitalized Infants • Early Human Development • July 1, 2015 • CTSA
Association of Vascular Risk Factors with Cognition in a Multiethnic Sample • Journal of Gerontology • July 1, 2015 • CTSA
The Coeliac Stomach: Gastritis in Patients with Coeliac Disease • Alimentary Pharmacology & Therapeutics • July 1, 2015 • CTSA
Health Outcomes of Obtaining Housing among Older Homeless Adults • American Journal of Public Health • July 1, 2015 • CTSA
Risk Factors for Pancreatitis in Older Women: The Iowa Women's Health Study • Annals of Epidemiology • July 1, 2015 • CTSA
Food Order Has a Significant Impact on Postprandial Glucose and Insulin Levels • Diabetes Care • July 1, 2015 • CTSA
June 2015
Rehospitalizations Following Sepsis: Common and Costly • Critical Care Medicine • June 30, 2015 • CTSA
Skin Cancer Risk Factors and Preventative Behaviors among United States Military Veterans Deployed to Iraq and Afghanistan • Journal of Investigative Dermatology • June 25, 2015 • CTSA
Critical Elements in the Medical Evaluation of Suspected Child Physical Abuse • Pediatrics • June 22, 2015 • CTSA
Microneedle-Array Patches Loaded with Hypoxia-Sensitive Vesicles Provide Fast Glucose-Responsive Insulin Delivery • PNAS • June 22, 2015 • CTSA
Racial/Ethnic Differences in Sleep Disturbances: The Multi-Ethnic Study of Atherosclerosis (MESA) • Sleep • June 19, 2015 • CTSA
Corrigendum: The Effect of Poor Sleep Quality on Mood Outcome Differs Between Men and Women: A Longitudinal Study of Bipolar Disorder • Journal of Affective Disorders • June 19, 2015 • CTSA
Assessing Differences in Mortality Rates and Risk Factors between Hispanic and Non-Hispanic Patients with Cystic Fibrosis in California • Chest • June 18, 2015 • CTSA
Unorthodox Alternative Therapies Marketed to Treat Lyme Disease • Clinical Infectious Diseases • June 15, 2015 • CTSA
Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors • New England Journal of Medicine • June 10, 2015 • CTSA
Therapeutic Effects of Glatiramer Acetate and Grafted CD115+ Monocytes in a Mouse Model of Alzheimer’s Disease • Brain • June 6, 2015 • CTSA
Cost-Effectiveness of Immediate Compared with Delayed Postpartum Etonogestrel Implant Insertion • Obstetrics & Gynecology • June 5, 2015 • CTSA
Intrauterine Device Placement during Cesarean Delivery and Continued Use 6 Months Postpartum: A Randomized Controlled Trial • Obstetrics & Gynecology • June 5, 2015 • CTSA
Advancing Biological Understanding and Therapeutics Discovery with Small Molecule Probes • Cell • June 4, 2015 • NCGC
News Feature: Building Benchtop Human Models • PNAS • June 2, 2015 • Tissue Chip
Dietary Intake and Weight Gain Among Adolescents on Depot Medroxyprogesterone Acetate •The Journal of Pediatric and Adolescent Gynecology •June 1, 2015 • CTSA
Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat • Journal of Clinical Endocrinology & Metabolism • June 1, 2015 • CTSA
A Facilitated Peer Mentoring Program for Junior Faculty to Promote Professional Development and Peer Networking • Academic Medicine • June 1, 2015 • CTSA
Intestinal Alkaline Phosphatase to Treat Necrotizing Enterocolitis • Journal of Surgical Research • June 1, 2015 • CTSA
Whole Blood Neutrophil Gelatinase-Associated Lipocalin Predicts Acute Kidney Injury in Burn Patients • Journal of Surgical Research • June 1, 2015 • CTSA
An Exploratory Short-Term Double-Blind Randomized Trial of Varenicline Versus Nicotine Patch for Smoking Cessation in Women • Addiction • June 1, 2015 • CTSA
Low Heat Pain Thresholds in Migraineurs between Attacks • Cephalagia • June 1, 2015 • CTSA
Impact of Conditioning Regimen on Outcomes for Patients with Lymphoma Undergoing High-Dose Therapy with Autologous Hematopoietic Cell Transplantation • Biology of Blood and Marrow Transplantation • June 1, 2015 • CTSA
Antihypertensive Drug Class and Adherence: An Electronic Monitoring Study • American Journal of Hypertension • June 1, 2015 • CTSA
Pharmacological Inhibition of ALDH1A in Mice Decreases All-Trans retinoic Acid Concentrations in a Tissue Specific Manner • Biochemical Pharmacology • June 1, 2015 • CTSA
Should Blood Pressure Targets after Lacunar Stroke Vary by Body Size? The SPS3 Trial • American Journal of Hypertension • June 1, 2015 • CTSA
The Prognostic Role of the Preoperative Absolute Lymphocyte Count and Absolute Monocyte Count in Patients with Resected Advanced Melanoma • American Journal of Clinical Oncology • June 1, 2015 • CTSA
Necrotizing Enterocolitis in Infants with Ductal-dependent Congenital Heart Disease • American Journal of Perinatology • June 1, 2015 • CTSA
Targeting NADPH Oxidase with a Novel Dual Nox1/Nox4 Inhibitor Attenuates Renal Pathology in Type 1 Diabetes • American Journal of Physiology • June 1, 2015 • CTSA
Intercepting Wrong-Patient Orders in a Computerized Provider Order Entry System • Journal of Gerontology • June 1, 2015 • CTSA
Black and Hispanic Perceptions of Asthma Medication in the School Inner-City Asthma Study • Annals of Allergy, Asthma & Immunology • June 1, 2015 • CTSA
Rapid Administration Technique of Ketamine for Pediatric Forearm Fracture Reduction: A Dose-finding Study • Annals of Emergency Medicine • June 1, 2015 • CTSA
Assessment of Autism Symptoms During the Neonatal Period: Is There Early Evidence of Autism Risk? • American Journal of Occupational Therapy • June 1, 2015 • CTSA
May 2015
Sudden Infant Death Syndrome and Residential Altitude • Pediatrics • May 25, 2015 • CTSA
Underuse and Overuse of Osteoporosis Screening in a Regional Health System: a Retrospective Cohort Study • Journal of General Internal Medicine • May 19, 2015 • CTSA
Tuberous Sclerosis: A New Frontier in Targeted Treatment of Autism • Neurotherapeutics • May 19, 2015 • RDCRN
The Association between Continuity of Care and the Overuse of Medical Procedures • JAMA Internal Medicine • May 18, 2015 • CTSA
Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR• New England Journal of Medicine • May 17, 2015 • CTSA
Longitudinal Changes in Free-Water within the Substantia Nigra of Parkinson’s Disease • Brain • May 16, 2015 • CTSA
A Method for Determining δ-aminolevulinic Acid Synthase Activity in Homogenized Cells and Tissues • Clinical Biochemistry • May 8, 2015 • RDCRN
Cardiac Involvement in Granulomatosis with Polyangiitis • Journal of Rheumatology • May 1, 2015 • RDCRN
Intellectual and adaptive functioning in Sturge-Weber Syndrome • Child Neuropsychology • May 1, 2015 • RDCRN
April 2015
Intracranial Mapping of a Cortical Tinnitus System using Residual Inhibition • Current Biology • April 23, 2015 • CTSA
Group 3 Innate Lymphoid Cells Mediate Intestinal Selection of Commensal Bacteria-Specific CD4+ T Cells • Science • April 23, 2015 • CTSA
Newborn Screening: Evolving Challenges in an Era of Rapid Discovery • JAMA • April 21, 2015 • NCATS
Improving Treatment Trial Outcomes for Rett Syndrome: The Development of Rett-specific Anchors for the Clinical Global Impression Scale • Journal of Child Neurology • April 20, 2015 • RDCRN
Quantitative Optical Coherence Tomography Angiography of Vascular Abnormalities in the Living Human Eye • PNAS • April 20, 2015 • CTSA
Drug-Based Modulation of Endogenous Stem Cells Promotes Functional Remyelination In Vivo • Nature • April 20, 2015 • NCATS
Excessive Sugar Consumption May Be a Difficult Habit to Break: A View from the Brain and Body • Addictive Behaviors • April 16, 2015 • CTSA
Disease Relapses among Patients with Giant Cell Arteritis: A Prospective, Longitudinal Cohort Study • The Journal of Rheumatology • April 15, 2015 • NCATS
Viraemia Suppressed in HIV-1-Infected Humans by Broadly Neutralizing Antibody 3BNC117 • Nature • April 08, 2015 • CTSA
Development and validation of a clinical scale for rating the severity of blepharospasm • Movement Disorders • April 1, 2015 • RDCRN
History and current status of newborn screening for severe combined immunodeficiency • Seminars in Perinatology • April 1, 2015 • RDCRN
Heritability of dietary traits that contribute to nephrolithiasis in a cohort of adult sibships • Journal of Nephrology • April 1, 2015 • RDCRN
Subjective Response to Nicotine by Menstrual Phase • Addictive Behaviors • April 01, 2015 • CTSA
General and Health-Related Internet Use among an Urban, Community-Based Sample of HIV-Positive Women: Implications for Intervention Development • AIDS Care • April 01, 2015 • CTSA
Associations between Parental Ideology and Neural Sensitivity to Cognitive Conflict in Children • Social Neuroscience • April 01, 2015 • CTSA
A Rural Appalachian Faith-Placed Smoking Cessation Intervention • Journal of Religion and Health • April 01, 2015 • CTSA
March 2015
The Effects of Naltrexone on Subjective Response to Methamphetamine in a Clinical Sample: a Double-Blind, Placebo-Controlled Laboratory Study • Neuropsychopharmacology • March 24, 2015 • CTSA
Human Ebola Virus Infection Results in Substantial Immune Activation • Proceedings of the National Academy of Sciences • March 09, 2015 • CTSA
Emergency Postexposure Vaccination With Vesicular Stomatitis Virus–Vectored Ebola Vaccine After Needlestick • Journal of the American Medical Association • March 05, 2015 • CTSA
Impact of NRAS Mutations for Patients with Advanced Melanoma Treated with Immune Therapies • Cancer Immunology Research • March 03, 2015 • CTSA
High-Throughput RNA Profiling via Up-Front Sample Parallelization • Nature Methods • March 02, 2015 • CTSA
New Analysis Reexamines the Value of Cancer Care in the United States Compared to Western Europe • Health Affairs • March 02, 2015 • CTSA
Gut Microbiome Composition is Associated with Temperament during Early Childhood • Brain, Behavior and Immunity • March 1, 2015 • CTSA
Healthcare Workers' Perceptions of Lean: A Context-Sensitive, Mixed Methods Study in Three Swedish Hospitals • Applied Ergonomics • March 01, 2015 • CTSA
The Patient Work System: An Analysis of Self-Care Performance Barriers among Elderly Heart Failure Patients and Their Informal Caregivers • Applied Ergonomics • March 01, 2015 • CTSA
Validation of Marrow Fat Assessment Using Noninvasive Imaging with Histologic Examination of Human Bone Samples • Bone • March 01, 2015 • CTSA
Signaling Pathways Involved in Megakaryocyte-Mediated Proliferation of Osteoblast Lineage Cells • Journal of Cellular Physiology • March 01, 2015 • CTSA
Challenges Facing HIV-Positive Persons Who Use Drugs and Their Families in Vietnam • AIDS Care • March 01, 2015 • CTSA
Delusions and Prediction Error: Clarifying the Roles of Behavioural and Brain Responses • Cognitive Neuropsychiatry • March 01, 2015 • CTSA
Comparison of Survival at Adult versus Pediatric Treatment Centers for Rare Pediatric Tumors in an Adolescent and Young Adult (AYA) Population in the State of Georgia • Pediatric Blood & Cancer • March 01, 2015 • CTSA
Health Priorities among Women Recently Released from Jail • American Journal of Health Behavior • March 01, 2015 • CTSA
Outcomes after Subtotal Parathyroidectomy for Primary Hyperparathyroidism due to Hyperplasia: Significance of Whole vs. Partial Gland Remnant • Annals of Surgical Oncology • March 01, 2015 • CTSA
Preventing Postoperative Hypocalcemia in Patients with Graves Disease: A Prospective Study • Annals of Surgical Oncology • March 01, 2015 • CTSA
How Physician Electronic Health Record Screen Sharing Affects Patient and Doctor Non-Verbal Communication in Primary Care • Patient Education and Counseling • March 01, 2015 • CTSA
Age and Gender Modulate the Neural Circuitry Supporting Facial Emotion Processing in Adults with Major Depressive Disorder • The American Journal of Geriatric Psychiatry • March 01, 2015 • CTSA
Clinical Outcomes of Splenectomy in Children: Report of the Splenectomy in Congenital Hemolytic Anemia Registry • The American Journal of Hematology • March 01, 2015 • CTSA
The Association of Resistin with Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosis • Atherosclerosis • March 01, 2015 • CTSA
Associations between Muscle-Related Cytokines and Selected Patient Outcomes in the ICU • Biological Research for Nursing • March 01, 2015 • CTSA
Delivery of an Engineered HGF Fragment in an Extracellular Matrix-Derived Hydrogel Prevents Negative LV Remodeling Post-Myocardial Infarction • Biomaterials • March 01, 2015 • CTSA
Stability of P50 Auditory Sensory Gating during Sleep from Infancy to 4 Years of Age • Brain and Cognition • March 01, 2015 • CTSA
Facebook Advertisements Recruit Parents of Children with Cancer for an Online Survey of Web-based Research Preferences • Cancer Nursing • March 01, 2015 • CTSA
The Life Changes in Epilepsy Scale: Development and Establishment of Content and Face Validity • Clinical Nurse Specialist • March 01, 2015 • CTSA
The Epidemiology and Diagnosis of Invasive Candidiasis among Premature Infants • Clinics in Perinatology • March 01, 2015 • CTSA
Current Diagnostic and Therapeutic Strategies in Microvascular Angina • Current Emergency and Hospital Medicine Reports • March 01, 2015 • CTSA
February 2015
Multifactorial Analysis of Conditional Reprogramming of Human Keratinocytes • PLoS ONE • February 25, 2015 • NCATS
Financing Translation: Analysis of the NCATS Rare-Diseases Portfolio • Science Translational Medicine • February 25, 2015 • NCATS
Cardiovascular Risk and Acute Coronary Syndrome in Giant Cell Arteritis: A Population-Based Retrospective Cohort Study • Arthritis Care & Research • February 24, 2015 • CTSA
Ethnic Differences in Presentation and Severity of Alcoholic Liver Disease • Alcoholism: Clinical & Experimental Research • February 20, 2015 • CTSA
Quantitative High-Throughput Screening Using a Primary Human Three-Dimensional Organotypic Culture Predicts In Vivo Efficacy • Nature Communications • February 17, 2015 • NCATS
Biodefense Aims to Simulate Human Bodies by Linking Mini "Organs on Chips" • Scientific American • February 17, 2015 • Tissue Chips
Biodefence Researchers Seek 'Homo Chippiens' • Nature • February 17, 2015 • Tissue Chips
Mindfulness Meditation and Improvement in Sleep Quality and Daytime Impairment Among Older Adults With Sleep Disturbances: A Randomized Clinical Trial • JAMA Internal Medicine • February 16, 2015 • CTSA
Effect of Prior Cancer on Outcomes in Advanced Lung Cancer: Implications for Clinical Trial Eligibility and Accrual • Journal of the National Cancer Institute • February 09, 2015 • CTSA
Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics • Cell Systems • February 07, 2015 • CTSA
Plant-Based, No-Added-Fat or American Heart Association Diets: Impact on Cardiovascular Risk in Obese Children with Hypercholesterolemia and Their Parents • The Journal of Pediatrics • February 05, 2015 • CTSA
Use of the Etonogestrel Implant and Levonorgestrel Intrauterine Device Beyond the U.S. Food and Drug Administration-Approved Duration • Obstetrics & Gynecology • February 04, 2015 • CTSA
Relative Contributions of Complications and Failure to Rescue on Mortality in Older Patients Undergoing Pancreatectomy • Annals of Surgery • February 03, 2015 • CTSA
Noninvasive Mapping of Pancreatic Inflammation in Recent-Onset Type-1 Diabetes Patients • Proceedings of the National Academy of Sciences • February 03, 2015 • CTSA
Discovery of a Novel General Anesthetic Chemotype Using High-Throughput Screening • Anesthesiology • February 01, 2015 • NCGC
A Likelihood Ratio Test for Nested Proportions • Statistics in Medicine • February 01, 2015 • CTSA
High-Strength, Surface-Porous Polyether-Ether-Ketone for Load-Bearing Orthopedic Implants • Acta Biomaterialia • February 01, 2015 • CTSA
Remodeling Characteristics and Collagen Distribution in Biological Scaffold Materials Explanted from Human Subjects after Abdominal Soft Tissue Reconstruction • Annals of Surgery • February 01, 2015 • CTSA
The Burn Wound Exudate: An Under-Utilized Resource • Burns • February 01, 2015 • CTSA
Maternal and Child Roles in the Feeding Relationship: What are Mothers Doing? • Clinical Pediatrics • February 01, 2015 • CTSA
Standardization and Validation of a Novel and Simple Method to Assess Lumbar Dural Sac Size • Clinical Radiology • February 01, 2015 • CTSA
An Exploratory Study of Inactive Health Information Seekers • International Journal of Medical Informatics • February 01, 2015 • CTSA
Persistent Differences in Asthma Self-Efficacy by Race, Ethnicity, and Income in Adults with Asthma • The Journal of Asthma • February 01, 2015 • CTSA
Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder • Neuropsychopharmacology • February 01, 2015 • CTSA
JOURNAL CLUB: Molecular Breast Imaging at Reduced Radiation Dose for Supplemental Screening in Mammographically Dense Breasts • American Journal of Roentgenology • February 01, 2015 • CTSA
Elevated Risk for Autoimmune Disorders in Iraq and Afghanistan Veterans with Posttraumatic Stress Disorder • Biological Psychiatry • February 01, 2015 • CTSA
Early Visual Cortex Reflects Initiation and Maintenance of Task Set • Neuroimaging • February 01, 2015 • CTSA
Serum Bicarbonate and Bone Mineral Density in US Adults • American Journal of Kidney Diseases • February 01, 2015 • CTSA
Neurophysiological Correlates of Sevoflurane-Induced Unconsciousness • Anesthesiology • February 01, 2015 • CTSA
Hair Cortisol in Relation to Sociodemographic and Lifestyle Characteristics in a Multiethnic US Sample • Annals of Epidemiology • February 01, 2015 • CTSA
Justified Follow-Up: A Final Intraoperative Parathyroid Hormone (ioPTH) Over 40 pg/mL is Associated with an Increased Risk of Persistence and Recurrence in Primary Hyperparathyroidism • Annals of Surgical Oncology • February 01, 2015 • CTSA
Baseline Characteristics Predict Risk of Progression and Response to Combined Medical Therapy for Benign Prostatic Hyperplasia (BPH) • BJU International • February 01, 2015 • CTSA
Obesity and Diabetes in an Aging Population: Time to Rethink Definitions and Management? • Clinics in Geriatric Medicine • February 01, 2015 • CTSA
Pre-Operative Prediction of Surgical Morbidity in Children: Comparison of Five Statistical Models • Computers in Biology and Medicine • February 01, 2015 • CTSA
Human Cardiac Tissue Engineering: From Pluripotent Stem Cells to Heart Repair • Current Opinion in Chemical Engineering • February 01, 2015 • CTSA
Lazarus Drugs • The Scientist • February 01, 2015 • New Therapeutic Uses
A Bayesian Approach for Instrumental Variable Analysis with Censored Time-to-Event Outcome • Statistics in Medicine • February 01, 2015 • CTSA
Head Motion during MRI Acquisition Reduces Gray Matter Volume and Thickness Estimates • Neuroimage • February 01, 2015 • CTSA
Metabolically Normal Obese People are Protected from Adverse Effects Following Weight Gain • The Journal of Clinical Investigation • February 01, 2015 • CTSA
Loneliness in HIV-Infected Smokers • AIDS Care • February 01, 2015 • CTSA
January 2015
US Lawmakers Seek to Revamp Biomedical Research • Nature • January 28, 2015 • NCATS
Evening Use of Light-Emitting eReaders Negatively Affects Sleep, Circadian Timing, and Next-Morning Alertness • PNAS • January 27, 2015 • CTSA
Causes and Timing of Death in Extremely Premature Infants from 2000 through 2011 • New England Journal of Medicine • January 22, 2015 • CTSA
Chlorhexidine Bathing and Health Care-Associated Infections: A Randomized Clinical Trial • Journal of the American Medical Association • January 20, 2015 • CTSA
Trends in Use of and Reproductive Outcomes Associated With Intracytoplasmic Sperm Injection • Journal of the American Medical Association • January 20, 2015 • NCATS
Dietary Sodium Content, Mortality, and Risk for Cardiovascular Events in Older Adults: The Health, Aging, and Body Composition (Health ABC) Study• JAMA Internal Medicine • January 19, 2015 • CTSA
Salt Intake Not Associated with Mortality or Risk of Cardiovascular Disease, Heart Failure in Older Adults • JAMA Internal Medicine • January 19, 2015 • CTSA
Population-Based in Vitro Hazard and Concentration–Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study •Environmental Health Perspectives • January 13, 2015 • Tox21
Evidence for Brain Glial Activation in Chronic Pain Patients • Brain • January 12, 2015 • NCATS
Potential Overtreatment of Diabetes Mellitus in Older Adults with Tight Glycemic Control • JAMA Internal Medicine • January 12, 2015 • CTSA
Bring Out Your Dead • Nature Biotechnology • January 9, 2015 • New Therapeutic Uses
Effect of a Moderate Fat Diet with and without Avocados on Lipoprotein Particle Number, Size and Subclasses in Overweight and Obese Adults: A Randomized, Controlled Trial • Journal of the American Heart Association • January 7, 2015 • CTSA
Spinoff Company to Develop Rare Disease Drugs • The Scientist • January 7, 2015 • TRND
Comprehensive Appraisal of MRI Findings in Sustained RA Remission: Sub-study of the TEAR Trial • Arthritis Care Research • January 7, 2015 • CTSA
Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization Data • PLOS Medicine • January 6, 2015 • CTSA
Dried Whole-Plant Artemisia annua Slows Evolution of Malaria Drug Resistance and Overcomes Resistance to Artemisinin • Proceedings of the National Academy of Sciences • January 5, 2015 • CTSA
Cognitive Dysfunction in Postural Tachycardia Syndrome • Clinical Science• January 01, 2015 • CTSA
Multi-Stakeholder Collaboration in the Redesign of Family-Centered Rounds Process • Applied Ergonomics • January 01, 2015 • CTSA
Histone Deacetylase Inhibition Destabilizes the Multi-Potent State of Uncommitted Adipose-Derived Mesenchymal Stromal Cells • Journal of Cellular Physiology • January 1, 2015 • CTSA
Executive Function Moderates the Relation between Coping and Depressive Symptoms • Anxiety Stress Coping • January 1, 2015 • CTSA
Non-Contrast MRI Perfusion Angiosome in Diabetic Feet • European Radiology • January 1, 2015 • CTSA
Partnering with Youth to Map Their Neighborhood Environments: A Multilayered GIS Approach • Family & Community Health • January 1, 2015 • CTSA
"Doctor, what would you do?": Physicians' Responses to Patient Inquiries about Periviable Delivery • Patient Education and Counseling • January 1, 2015 • CTSA
Brief Strategic Family Therapy: Implementing Evidence-Based Models in Community Settings • Psychotherapy Research • January 1, 2015 • CTSA
Potential Mitochondrial Toxicants: Tox21 Screen Identifies Chemicals of Interest • Environmental Health Perspectives • January 1, 2015 • Tox21
Quantity of Dietary Protein Intake, but Not Pattern of Intake, Affects Net Protein Balance Primarily through Differences in Protein Synthesis in Older Adults • American Journal of Physiology—Endocrinology and Metabolism • January 1, 2015 • CTSA
A Chimeric Human–Mouse Model of Sjögren's Syndrome • Clinical Immunology • January 1, 2015 • CTSA
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TRND Clinical Research Studies |
For more details about clinical research studies supported by TRND, click on the links below or visit ClinicalTrials.gov.
Active Studies
Creatine Transporter Deficiency
Observational Study of Males With Creatine Transporter Deficiency
GNE Myopathy (previously known at Hereditary Inclusion Body Myopathy)
A Natural History Study of Patients with GNE Myopathy
Niemann-Pick Disease Type C
Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C
Completed Studies
Chronic Lymphocytic Leukemia
Phase II Study of Auranofin in Chronic Lymphocytic Leukemia
GNE Myopathy (previously known at Hereditary Inclusion Body Myopathy)
A Phase I Study to Evaluate the Safety and Tolerability of ManNAc in Subjects GNE Myopathy
A Phase II Study of DEX-M74 (ManNac) in Subjects with GNE Myopathy
Niemann-Pick Disease Type C1
Hydroxypropyl Beta Cyclodextrin for Niemann-Pick Type C1 Disease
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2982 |
NCATS Plate Washing Initiative Saves Money, Keeps Plastic Out of Landfills |
January 2016 UpdateJanuary 2018 UpdateHigh-throughput robots help researchers run screening experiments quickly and efficiently, producing results in one week that would take a scientist 12 years to conduct manually. At NCATS, these robots test thousands of potential drugs and drug combinations, environmental chemicals, and other experimental compounds to gain insights about a wide range of human diseases.Back in 2010, staff at what is now the NCATS high-throughput screening facility were supporting the NIH Molecular Libraries Program, an NIH Common Fund initiative to identify small molecules that potentially could be used as biological probes to explore the basis of health and disease and further developed as drugs. At the end of each set of several thousand experiments, a staff member would remove a stack of plastic plates, each about the size of an index card and a half-inch thick.“We’d throw them in here,” said Sam Michael, NCATS director of automation and compound management, pointing at a “carboy,” a waist-high blue plastic barrel used to collect chemical waste. “We were so busy, there were about 15 of these — I literally didn’t have enough room to work.” Michael also is the acting director of the NCATS Office of Information Technology.The NCATS high-throughput screening facility is part of a laboratory where technicians work among tables and shelves stocked to the brim with equipment, plates and cables, leaving little space for more than a dozen barrels of waste. Michael knew there had to be a better way, and he found one: washing and reusing the plates.Although that solution may sound trivial, it required persuading skeptical biologists that the plates could be cleaned thoroughly and rethinking the entire process of high-throughput screening. Today, experiments that once took thousands of plates can be run with just 40. This innovative idea has saved hundreds of thousands of scientific research dollars and dramatically reduced environmental plastic waste. And now, through a Small Business Innovation Research (SBIR) program grant from NCATS, a private-sector company is building on Michael’s work to develop and commercialize an automated plate cleaner.“That Will Never Work”Biologists are accustomed to working only with new materials. The high-throughput screening process involves sensitive experiments with tiny droplets of liquid; results could be completely thrown off by the merest speck of residue. Michael explained, “When I told biologists, ‘We are going to try to reuse your plate within an experiment,’ the first reaction was, ‘Get out of here; no way!’” But he inevitably convinced some of the researchers to try it.If you held a three-by-five-inch plate in your hand, you would see a fine grid of tiny wells, each about as big around as a pencil lead. A plate the size of an index card holds 1,536 wells. Together, all of the wells in one plate hold about a tablespoon of liquid. That may seem small, but the wells are big enough for chemical reactions. Each one is like a tiny test tube, holding a tiny experiment.For high-throughput screening, a plate starts at a dispenser where small tubes spray the same substance into each well. Sometimes the plate wells hold living cells; during a visit on a late winter Wednesday, enzymes were on deck. Robotic arms transfer plates from one machine to another in assembly line style, with quick, efficient movements and the whirring sounds of precise motors.The next stop for the plate is a machine with a rack of 1,536 tiny metal pins, one for each well. The pins act like a rubber stamp; the “ink” is a plate of compounds from a library of small molecules. The pins dip into the compound plate and then into the wells on the experimental plate, delivering one compound to each well. Each well gets a specific type of molecule that will interact with the enzyme, then the plates sit for a few hours. Finally, another machine takes a picture of each plate so scientists can figure out how each compound affected the reaction in each well.A Clean StartFollowing the traditional process, the plates become trash after imaging; they go to a landfill or incinerator, depending on the kind of waste they contain. But in the process Michael created, the next stop is cleaning. A dispenser alternates spraying deionized water and ethanol into the wells. After each spray, a row of aspirators, like the world’s tiniest vacuum cleaners, passes over the plate to suck the liquid out.The cleaned plates are now ready to go back into the screening process. A plate is only reused within the same assay, or set of experiments. In practice, half of the plates for an assay are being cleaned while the rest are in testing.Before starting each new assay, the NCATS team screens a few test plates to ensure cleaned plates give the same results as new plates. Sometimes the particular chemicals involved in the experiments just can’t be washed out, so the plates can only be used once, the old-fashioned way.Once the assay is complete, the plates are always discarded, but the savings from reuse during screenings are huge. At about $10 per plate, an experiment that previously involved 2,000 plates at a cost of about $20,000 in plastic now costs $400 for those materials — 2 percent of the original expense.So far, this method has saved NCATS almost half a million dollars and kept nearly 50,000 plastic plates from filling up chemical carboys. If that many plates were laid out end to end, they would be taller than Mount McKinley, the highest mountain in North America. The solution also has saved staff time from loading and unloading plates: four solid work weeks, Michael estimated.Disseminating the TechnologyThe creation of the plate-cleaning technology aligns perfectly with the NCATS “3 Ds” approach to translational science. Michael developed an innovative solution to address a translational problem and then demonstrated that the approach worked and could save time, money and environmental waste. The next step was disseminating the technology to benefit the larger scientific community.To reach that audience, Michael thought a small business might be able to scale up and expand the plate-cleaning technology. The Center’s SBIR program helps U.S. small businesses develop and commercialize new translational technologies. Michael worked with Lili Portilla, M.P.A., director of the NCATS Office of Strategic Alliances and SBIR program manager, to issue a contract solicitation for plate cleaning.IonField Systems in Moorestown, New Jersey, responded to the solicitation and secured a Phase 1 SBIR contract from NCATS, then received a follow-on Phase 2 award. IonField already had developed a method called “plasma washing” to clean plastic tips used to move small quantities of liquid in biochemical research. To adapt this method to cleaning plates, the company put a final touch on the process that Michael had envisioned, adding a plasma wash after the rinses with ethanol and water. High-voltage electricity eliminates anything still attached to the plate and even scours off the top layer of the plastic itself.The ultimate plan is to sell the cleaner to academic and industry screening facilities and offer a service for cleaning plates. The development of the cleaning process and service has turned what was once disposable waste into a reusable resource disseminated to other laboratories and pharmaceutical companies nationwide.“This is exactly what the NCATS SBIR contract program is designed to accomplish,” Portilla said, “NCATS identifies a translational technology challenge that small businesses can address, commercialize and disseminate into the marketplace.”“The SBIR program is a great mechanism, and I’m glad somebody can take this NIH technology and make it available to other scientists to speed their high-throughput screening activities,” Michael said.The success of the plate-washing method demonstrates NCATS’ commitment to transforming the way that translational science is conducted. That commitment to innovation can generate much-needed byproducts as well — in this case, a method to reduce plastic waste in the research community.Posted August 2015January 2016 Update: Continued Growth and ExpansionTo meet this new demand from the research community, IonField Systems has expanded from two employees in 2012 to five full-time staff and more than 20 subcontractors. The company reported more than 130 percent growth in 2015 and is on target to achieve even greater percent growth in 2016. IonField recently placed its first PlasmaKnife™ plate cleaner with a major pharmaceutical company, making the SBIR program’s goal of commercializing innovative new technologies a reality.“Overall, this initiative has been a tremendous success, and it’s really due to NCATS’ SBIR program,” Michael said. “The funding mechanism enabled a small company to grow while helping to bring a completely new product to the market to address a need. The program worked exactly as intended by enabling a small business to engage in R&D to create jobs and commercialize a needed technology.”Posted January 2016January 2018 Update: Installation of First Commercial ReleaseAstraZeneca (AZ) and IonField System announced the successful completion of the PlasmaKnife Microplate Cleaning System beta test and the first installation of a commercial release. The PlasmaKnife initially will be used regularly at AZ’s Alderley Park Research Facility, and later at the new AZ Cambridge Research Facility.“IonField is a great small business success story for NCATS,” Portilla said. “NCATS staff identified a translational problem common in drug development and IonField developed a very elegant solution to clean and reuse these expensive microplates.”Posted January 2019 |
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New CTSA Program Funding Opportunities: Collaborative Innovation Awards |
On April 2, 2015, NCATS released two new funding opportunity announcements (FOAs) for Collaborative Innovation Awards, designed to stimulate team-based research across the Clinical and Translational Science Awards (CTSA) consortium. NCATS’ CTSA program supports a national network of medical research institutions — called hubs — that work together to improve the translational research process to get more treatments to more patients more quickly.Translating biomedical discoveries into the clinic is essential to improving human health. However, the current translational process has many barriers, resulting in long delays before a new treatment is available to people who need them.PAR-15-172 and PAR-15-173 solicit proposals for innovative collaborative investigations among three or more CTSA hubs to improve research methods at any step in the translational process. Through these awards, NCATS will foster research collaboration by encouraging teams from multiple hubs to work together to develop, demonstrate and disseminate multisite experimental approaches that overcome translational science roadblocks.“By combining the innovative efforts of three or more CTSA hubs in flexible networks, we aim to enhance the effectiveness of the CTSA consortium to address systemic translational science questions,” said Petra Kaufmann, M.D., M.Sc., NCATS director of clinical innovation.PAR-15-173 solicits pre-applications from interested investigators. Applicants whose proposals are found to be meritorious and relevant to the CTSA program will be invited to submit a full application via PAR-15-172. The first pre-applications are due on June 24, 2015; full applications are due in February 2016.“The CTSA program is designed to transform the translational ecosystem by overcoming barriers in translational science, operations and training,” said NCATS Director Christopher P. Austin, M.D. “The release of this funding opportunity represents an important milestone in a new era of CTSA-driven innovation, collaboratively developing translational solutions to improve human health.”NCATS expects to commit approximately $9 million in fiscal year 2016 funding for multiple five-year awards, depending on available funds. At the full application stage, applicants for clinical projects may request up to $1 million in direct costs annually. For nonclinical projects, applicants may request up to $500,000 annually in direct costs.In developing the FOAs, NCATS carefully considered input about the CTSA program from the National Academy of Medicine (formerly Institute of Medicine), a working group of the NCATS Advisory Council (PDF - 414KB), CTSA investigators, patient groups, other NIH Institutes and Centers, biotechnology and pharmaceutical development organizations, regulatory agencies, and the broader clinical and translational research community. Posted April 2015 |
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NCATS Support Leads to Clinical Trial to Test Repurposed Cancer Treatment as Alzheimer’s Therapy |
As Baby Boomers get older, the number of people with age-related conditions such as cancer and Alzheimer's disease continues to grow. Alzheimer's disease is the most common form of dementia, a group of disorders that cause progressive loss of memory and other mental processes. About 5 million Americans have Alzheimer's disease, and current drug therapies can only ease symptoms of the disease without stopping its progression. New treatments — so-called disease-modifying therapies — are needed to halt Alzheimer's by targeting its underlying mechanisms.
Blocking that path to therapeutic success is the costly, complex process of drug development. The average length of time from discovery of a therapeutic target to approval of a new drug is about 14 years. The failure rate during this process exceeds 95 percent.
NCATS is addressing these translational bottlenecks through programs such as the Discovering New Therapeutic Uses for Existing Molecules (New Therapeutic Uses) program. Launched in 2012, this initiative matches academic researchers with pharmaceutical industry assets that have undergone significant research and development to accelerate the process of finding new therapies.
Now, NCATS is celebrating one of the first promising results from the New Therapeutic Uses program: Center-supported scientists at Yale University School of Medicine have found that an experimental compound originally developed as a cancer therapy potentially could be used to treat Alzheimer's disease. The compound successfully reversed brain problems in mouse models of the condition, and now the researchers are testing it in humans. The results of the animal study were published for early view on March 21, 2015, in the Annals of Neurology. Read the NIH news release.
A New Therapeutic Target
Back in 2012, Yale neurobiology researcher, neurologist and senior author of the animal study Stephen Strittmatter, M.D., Ph.D., and his colleagues found an important, missing piece of the Alzheimer's puzzle. They wanted to understand more completely the molecular events that occur in the brain to produce symptoms.
In Alzheimer's disease, abnormal clumps of amyloid beta protein build up in the brain. These protein clusters damage brain cells (neurons), eventually killing them. However, how amyloid beta harms cells has been unclear.
The Yale team discovered that aggregated amyloid beta activates a series of signals within neurons that leads to abnormal functioning and loss of synapses, which are the spaces between neurons that enable the cells to "talk" to each other and form memories. Central to this process is the activation of a protein called Fyn kinase through another molecule, cellular prion protein. These results suggested that a compound that blocks Fyn activity might represent a potential disease-modifying therapy for Alzheimer's.
The Power of Crowdsourcing
Around the time Strittmatter's Fyn finding emerged, NCATS launched the New Therapeutic Uses program and released a list of pharmaceutical industry assets, inviting scientists to pitch new ideas for diseases that might be treated with those assets. That 2012 list included a Fyn kinase inhibitor, saracatinib (AZD0530 [PDF - 65KB]), developed by biopharmaceutical company AstraZeneca. Strittmatter, along with co-principal investigators Haakon Nygaard, M.D., Ph.D., and Christopher van Dyck, M.D., submitted a proposal to test the hypothesis that saracatinib could improve Alzheimer's-related brain abnormalities. The team received one of the first New Therapeutic Uses awards in June 2013.
"AstraZeneca developed saracatinib to treat cancer outside the brain, so nobody had thought to link it to Alzheimer's disease," Strittmatter said. "This connection — between our knowledge of Fyn kinase in the brain and AstraZeneca's information on this compound — would never have happened without the New Therapeutic Uses program."
Two types of brain cells, microglia (red, left) and astrocytes (red, right), surround amyloid beta clusters (green) located in the brain of a mouse that exhibits Alzheimer’s-like symptoms. (Credit: Strittmatter Laboratory, Yale University Photo/Adam Kaufman)
A Promising Effect in Mice
AstraZeneca scientists teamed with the Yale group, providing saracatinib for the mouse study and sharing knowledge and data gathered from previous studies.
"No one individual or group has complete knowledge of disease pathways and treatment targets," said Craig Wegner, Ph.D., Head, Boston Emerging Innovations Unit, Scientific Partnering & Alliances within AstraZeneca's Innovative Medicines and Early Development Biotech Unit. "This program successfully unites scientists from government, academia and industry and is a great example of how we are working together to push the boundaries of science."
The Yale team gave the experimental drug to mice with Alzheimer's-like symptoms, such as memory problems and age-related buildup of abnormal amyloid beta clusters, modeling the development of the disease in humans. After four weeks, the Alzheimer's mice showed complete reversal of spatial learning and memory loss. When the scientists examined the brains of the mice, they found that the characteristic synapse loss had been fully restored, providing a biological explanation for the memory improvement.
The treatment also reduced several other Alzheimer's-related biochemical changes in the mice and did not appear to be toxic. Although many experimental treatments have aimed to reduce abnormal amyloid beta buildup in the brain, this one is unique in that it targets the toxic effects of the protein clusters within a cell, appearing to protect it from damage.
The Yale research team also has completed a successful Phase 1b safety study of saracatinib in humans with Alzheimer's disease, showing that the compound reaches the brains of patients at levels similar to those beneficial in mice. The study results have been accepted for publication later in 2015. The data are encouraging, but the researchers cautioned that more human studies are needed to determine if saracatinib is an effective treatment for Alzheimer's.
An Accelerated Path to the Clinic
Saracatinib's prior development and the Yale team's successful completion of animal and human studies enabled the compound to advance rapidly into a larger, multisite Phase 2a trial in Alzheimer's patients now ongoing. "The speed and efficiency with which this research has advanced has set new standards of excellence, enabling us to jointly push the boundaries of medical science," Wegner said.
Using the pre-negotiated NCATS template agreements, which were designed to streamline the legal and administrative process for research collaboration by multiple organizations, "really facilitated our collaboration with Yale, so scientists could be scientists," he added.
"Through this project, NCATS and AstraZeneca have provided us with an incredible shortcut in the drug development process and have accelerated the path to finding a more effective Alzheimer's disease treatment," Strittmatter said.
In the Phase 2a trial, 152 participants will receive saracatinib or placebo for one year. Researchers will assess safety, tolerability and effectiveness of the experimental drug, and they will use brain imaging to visualize the effect of saracatinib on synapse function — the same feature improved by the drug in mice. Study investigators currently are enrolling older adults with Alzheimer's disease to participate in the trial and expect to have results in about two years. Learn more about the trial via ClinicalTrials.gov.
Both human trials were funded by the New Therapeutic Uses program. The Phase 2a study will take place at multiple clinical sites as part of the Alzheimer's Disease Cooperative Study, an initiative for multisite studies sponsored by the National Institute on Aging (NIA) to facilitate the development and testing of new therapeutics for the condition. In addition to funding from NCATS, the NIH Common Fund, NIA, BrightFocus Foundation, Alzheimer's Association and Falk Medical Research Trust provided support for the animal study.
"The Yale team's awareness of this new Alzheimer's drug target, combined with AstraZeneca's drug development resources, allowed the rapid advancement of saracatinib to clinical testing, demonstrating the power of NCATS' New Therapeutics Uses crowdsourcing approach," said NCATS Director Christopher P. Austin, M.D. "By reengineering the drug development pipeline through projects like this, we can more quickly deliver new and better treatments to patients."
Posted March 2015
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Scientific Publications |
September 2016
Predictors Affecting Personal Health Information Management Skills • Informatics for Health & Social Care • September 1, 2016 • CTSA
July 2016
Gender Differences in the Response to Impaired Sleep in Adults with Diabetes • Behavioral Sleep Medicine • July 1, 2016 • CTSA
The Differential Relationships of Dimensions of Perceived Social Support with Cognitive Function among Older Adults • Aging & Mental Health • July 1, 2016 • CTSA
A Two-Step Estimation Approach for Logistic Varying Coefficient Modeling of Longitudinal Data • Journal of Statistical Planning and Inference • July 1, 2016 • CTSA
Negative Urgency and Emotion Regulation Predict Positive Smoking Expectancies in Non-Smoking Youth • Addictive Behavior • July 1, 2016 • CTSA
Scavenging Dissolved Oxygen via Acoustic Droplet Vaporization • Ultrasonic Sonochemistry • July 1, 2016 • CTSA
June 2016
Associations between Smoking and Caffeine Consumption in Two European Cohorts • Addiction • June 1, 2016 • CTSA
Functional Independence in Resting-State Connectivity Facilitates Higher-Order Cognition • Brain and Cognition • June 1, 2016 • CTSA
Course of Cognitive Impairment following Attempted Suicide in Older Adults • International Journal of Geriatric Psychiatry • June 1, 2016 • CTSA
Adults with Sickle Cell Disease May Perform Cognitive Tests as Well as Controls when Processing Speed Is Taken into Account: A Preliminary Case-Control Study • Journal of Advanced Nursing • June 1, 2016 • CTSA
Stem Cell Therapy Restores Viscoelastic Properties of Myocardium in Rat Model of Hypertension • Journal of the Mechanical Behavior of Biomedical Materials • June 1, 2016 • CTSA
Effects of Aging on Slow-Wave Sleep Dynamics and Human Spatial Navigational Memory Consolidation • Neurobiology of Aging • June 1, 2016 • CTSA
Fibroblast Growth Factor Receptor Signaling in Kidney and Lower Urinary Tract Development • Pediatric Nephrology • June 1, 2016 • CTSA
The Influence of Knee Pain Location on Symptoms, Functional Status, and Knee-related Quality of Life in Older Adults with Chronic Knee Pain: Data From the Osteoarthritis Initiative • The Clinical Journal of Pain • June 1, 2016 • CTSA
Optimization of a Methamphetamine Conjugate Vaccine for Antibody Production in Mice • International Immunopharmacology • June 1, 2016 • CTSA
Antihypertensive Medications and Sexual Function in Women: Baseline Data from the SBP Intervention trial (SPRINT) • Journal of Hypertension • June 1, 2016 • CTSA
Osteosarcoma Tissues and Cell Lines from Patients with Differing Serum Alkaline Phosphatase Concentrations Display Minimal Differences in Gene Expression Patterns • Veterinary and Comparative Oncology • June 1, 2016 • CTSA
Simultaneous Subacute Coronary Artery Stent Thrombosis in a Carrier of Two CYP2C19 Loss-of-Function Polymorphisms (*2/*3) • International Journal of Cardiology • June 1, 2016 • CTSA
Data Quality Assessment Framework to Assess Electronic Medical Record Data for Use in Research • International Journal of Medical Informatics • June 1, 2016 • CTSA
The Organizational Structure of an Intensive Care Unit Influences Treatment of Hypotension among Critically Ill Patients: A Retrospective Cohort Study • Journal of Critical Care • June 1, 2016 • CTSA
GSTZ1 Expression and Chloride Concentrations Modulate Sensitivity of Cancer Cells to Dichloroacetate • Biochimica et Biophysica Acta • June 1, 2016 • CTSA
Adverse Birth Outcomes and Childhood Caries: A Cohort Study • Community Dentistry and Oral Epidemiology • June 1, 2016 • CTSA
African American Church-based HIV Testing and Linkage to Care Assets, Challenges and Needs • Culture, Health & Sexuality • June 1, 2016 • CTSA
The Tobacco-using Periodontal Patient: Role of the Dental Practitioner in Tobacco Cessation and Periodontal Disease Management • Periodontology 2000 • June 1, 2016 • CTSA
Adolescents with or at Ultra-High Risk for Bipolar Disorder Exhibit Erythrocyte Docosahexaenoic Acid and Eicosapentaenoic Acid Deficits: A Candidate Prodromal Risk Biomarker • Early Intervention in Psychiatry • June 1, 2016 • CTSA
Lethal Neonatal Meningoencephalitis Caused by Multi-Drug Resistant, Highly Virulent Escherichia Coli • Infectious Diseases • June 1, 2016 • CTSA
Pyk2 and Megakaryocytes Regulate Osteoblast Differentiation and Migration via Distinct and Overlapping Mechanisms • Journal of Cellular Biochemistry • June 1, 2016 • CTSA
Feasibility of a Pocket-PC Based Cognitive Control Intervention in Dementia Spousal Caregivers • Aging & Mental Health • June 1, 2016 • CTSA
Mathematical Model to Interpret Localized Reflectance Spectra Measured in the Presence of a Strong Fluorescence Marker • Journal of Biomedical Optics • June 1, 2016 • CTSA
May 2016
Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery • Cell • May 26, 2016 • NCATS
Taxonomer: An Interactive Metagenomics Analysis Portal for Universal Pathogen Detection and Host mRNA Expression Profiling • Genome Biology • May 26, 2016 • CTSA
The Social and Emotional Lives of Overweight, Obese, and Severely Obese Children • Child Development • May 25, 2016 • CTSA
Decreased Circulating Levels of Spexin in Obese Children • Journal of Clinical Endocrinology & Metabolism • May 25, 2016 • CTSA
Neonatal Phototherapy and Infantile Cancer • Pediatrics • May 23, 2016 • CTSA
Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial • JAMA • May 19, 2016 • CTSA
Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease • New England Journal of Medicine • May 18, 2016 • CTSA
Confronting Ebola as a Sexually Transmitted Infection • Clinical Infectious Diseases • May 15, 2016 • CTSA
Tau and Aβ imaging, CSF Measures, and Cognition in Alzheimer's Disease • Science and Translational Medicine • May 11, 2016 • CTSA
Nutritional Supplementation to Reduce Child Aggression: A Randomized, Stratified, Single-Blind, Factorial Trial • Journal of Child Psychology and Psychiatry • May 11, 2016 • CTSA
Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine: Secondary Analysis of an Open-Label Study • Journal of Clinical Psychiatry • May 10, 2016 • CTSA
Marginalized Zero-Inflated Negative Binomial Regression with Application to Dental Caries • Statistics in Medicine • May 10, 2016 • CTSA
Association of Environmental Toxins with Amyotrophic Lateral Sclerosis • JAMA Neurology • May 9, 2016 • CTSA
From Painkiller to Empathy Killer: Acetaminophen (Paracetamol) Reduces Empathy for Pain • Social Cognitive and Affective Neuroscience • May 5, 2016 • CTSA
NMDAR Inhibition-independent Antidepressant Actions of Ketamine Metabolites • Nature • May 4, 2016 • NCGC
Prevalence and Predictors of Anxiety and Depression after Completion of Chemotherapy for Childhood Acute Lymphoblastic Leukemia: A Prospective Longitudinal Study • Cancer • May 1, 2016 • CTSA
Glioblastoma Induces Vascular Dysregulation in Nonenhancing Peritumoral Regions in Humans • American Journal of Roentgenology • May 1, 2016 • CTSA
Models to Predict Prevalence and Transition Dynamics of Methicillin-resistant Staphylococcus Aureus in Community Nursing Homes • American Journal of Infection Control • May 1, 2016 • CTSA
Systemic Sclerosis and Perceptions of Quality in Primary Care • The American Journal of the Medical Sciences • May 1, 2016 • CTSA
Factors Associated with Smoking Cessation in Pregnancy • American Journal Perinatology • May 1, 2016 • CTSA
Early Blood Pressure, Antihypotensive Therapy and Outcomes at 18-22 Months' Corrected Age in Extremely Preterm Infants • Archives of Disease in Childhood • May 1, 2016 • CTSA
Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment • American Journal of Geriatric Psychiatry • May 1, 2016 • CTSA
Social Resources, Health Promotion Behavior, and Quality of Life in Adults Living with HIV • Applied Nursing Research • May 1, 2016 • CTSA
Clinical Characteristics of Sarcoid Arthropathy: A Population-Based Study • Arthritis Care & Research • May 1, 2016 • CTSA
Let's Talk about It: Peer Victimization Experiences as Reported by Adolescents with Autism Spectrum Disorder • Autism • May 1, 2016 • CTSA
Stability of Phosphatidylethanol in Dry Blood Spot Cards • Alcohol and Alcoholism • May 1, 2016
Association of Mental Health Disorders and Medicaid with ED Admissions for Ambulatory Care-sensitive Condition Conditions • American Journal of Emergency Medicine • May 1, 2016 • CTSA
Body Image & Quality of Life: Changes with Gastric Bypass and Body Contouring • Annals of Plastic Surgery • May 1, 2016 • CTSA
Academic Abilities and Glycaemic Control in Children and Young People with Type 1 Diabetes Mellitus • Diabetic Medicine • May 1, 2016 • CTSA
Point-of-Care Diagnostics for Niche Applications • Biotechnology Advances • May 1, 2016 • CTSA
Moderate Chronic Kidney Disease Impairs Bone Quality in C57Bl/6J Mice • Bone • May 1, 2016 • CTSA
Task-Switching Ability Protects against the Adverse Effects of Pain on Health: A Longitudinal Study of Older Adults • British Journal of Health Psychology • May 1, 2016 • CTSA
Self-Rated Health and Interleukin-6: Longitudinal Relationships in Older Adults • British Journal of Health Psychology • May 1, 2016 • CTSA
Prevalence of Diagnosed and Undiagnosed Hepatitis C in a Midwestern Urban Emergency Department • Clinical Infectious Diseases • May 1, 2016 • CTSA
Severe Hypoglycemia in Users of Sulfonylurea Antidiabetic Agents and Antihyperlipidemics • Clinical Pharmacology and Therapeutics • May 1, 2016 • CTSA
Otitis Media and Related Complications among Children with Autism Spectrum Disorders • Journal of Autism and Developmental Disorders • May 1, 2016 • CTSA
Self-Reported Pleasantness Ratings and Examiner-Coded Defensiveness in Response to Touch in Children with ASD: Effects of Stimulus Material and Bodily Location • Journal of Autism and Developmental Disorders • May 1, 2016 • CTSA
Parent, Teacher, and Student Perspectives on How Corrective Lenses Improve Child Wellbeing and School Function • Maternal and Child Health Journal • May 1, 2016 • CTSA
Stroke Symptoms with Absence of Recognized Stroke Are Associated with Cognitive Impairment and Depressive Symptoms in Older Adults with Diabetes • Journal of Geriatric Psychiatry and Neurology • May 1, 2016 • CTSA
Presentation and Effectiveness of Early Treatment of Type 2 Diabetes in Youth: Lessons from the TODAY Study • Pediatric Diabetes • May 1, 2016 • CTSA
Testosterone Concentration and Insulin Sensitivity in Young Men with Type 1 and Type 2 Diabetes • Pediatric Diabetes • May 1, 2016 • CTSA
Fibroblast Growth Factor-23 and Chronic Allograft Injury in Pediatric Renal Transplant Recipients: A Midwest Pediatric Nephrology Consortium Study • Pediatric Transplantation • May 1, 2016 • CTSA
Regulatory Effects of Genomic Translocations at the Human Carboxylesterase-1 (CES1) Gene Locus • Pharmacogenetics and Genomics • May 1, 2016 • CTSA
Association between Patient-Provider Communication and Lung Cancer Stigma • Supportive Care in Cancer • May 1, 2016 • CTSA
Yield of Urinalysis Screening in Pediatric Cancer Survivors • Pediatric Blood & Cancer • May 1, 2016 • CTSA
Gestational Age-Specific Neonatal Morbidity Among Pregnancies Complicated by Advanced Maternal Age: A Population-Based Retrospective Cohort Study • Journal of Maternal-Fetal & Neonatal Medicine • May 1, 2016 • CTSA
Glutamine Drives Glutathione Synthesis and Contributes to Radiation Sensitivity of A549 and H460 Lung Cancer Cell Lines • Biochimica et Biophysica Acta • May 1, 2016 • CTSA
April 2016
Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia • Diabetes Care • April 18, 2016 • CTSA
Biodegradable Antigen-associated PLG Nanoparticles Tolerize Th2-mediated Allergic Airway Inflammation Pre- and Postsensitization • Proceedings of the National Academy of Sciences • April 18, 2016 • NCATS
Usefulness of Relative Hypochromia in Risk Stratification for Nonanemic Patients With Chronic Heart Failure • American Journal of Cardiology • April 15, 2016 • CTSA
Relation of Atrial Fibrillation in Acute Myocardial Infarction to In-Hospital Complications and Early Hospital Readmission • American Journal of Cardiology • April 15, 2016 • CTSA
A Phase 1 Trial to Assess the Safety, Acceptability, Pharmacokinetics, and Pharmacodynamics of a Novel Dapivirine Vaginal Film • Journal of Acquired Immune Deficiency Syndromes • April 15, 2016 • CTSA
Association of Get with the Guidelines-Stroke Program Participation and Clinical Outcomes for Medicare Beneficiaries with Ischemic Stroke • Stroke • April 14, 2016 • CTSA
Thinking Cap Plus Thinking Zap: tDCS of Frontopolar Cortex Improves Creative Analogical Reasoning and Facilitates Conscious Augmentation of State Creativity in Verb Generation • Cerebral Cortex • April 13, 2016 • CTSA
Psychological Factors Associated with Delayed Symptom Resolution in Children with Concussion • Journal of Pediatrics • April 11, 2016 • CTSA
Disparities in Use of Human Epidermal Growth Hormone Receptor 2–Targeted Therapy for Early-Stage Breast Cancer • Journal of Clinical Oncology • April 11, 2016 • CTSA
Antenatal Betamethasone for Women at Risk for Late Preterm Delivery • New England Journal of Medicine • April 7, 2016 • CTSA
RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription • Cell • April 7, 2016 • NCGC
Robotic Cystogastrostomy and Debridement of Walled-off Pancreatic Necrosis • Journal of Robotic Surgery • April 2, 2016 • CTSA
A Matrix Mentoring Model That Effectively Supports Clinical and Translational Scientists and Increases Inclusion in Biomedical Research: Lessons from the University of Utah • Academic Medicine • April 1, 2016 • CTSA
Understanding Career Success and Its Contributing Factors for Clinical and Translational Investigators • Academic Medicine • April 1, 2016 • CTSA
Hydrogel Arrays Formed via Differential Wettability Patterning Enable Combinatorial Screening of Stem Cell Behavior • Acta Biomaterialia • April 1, 2016 • Tissue Chips
Do High-Risk Young Adults Use the HIV Self-Test Appropriately? Observations from a Think-Aloud Study • AIDS Behavior • April 1, 2016 • CTSA
Effect of Angiotensin II Type I Receptor Blockade with Valsartan on Carotid Artery Atherosclerosis: A Double Blind Randomized Clinical Trial Comparing Valsartan and Placebo (EFFERVESCENT) • American Heart Journal • April 1, 2016 • CTSA
Association of Atrial Fibrillation Risk Alleles and Response to Acute Rate Control Therapy • American Journal of Emergency Medicine • April 1, 2016 • CTSA
Variation in Primary Cesarean Delivery Rates by Individual Physician within a Single-Hospital Laborist Model • American Journal of Obstetrics and Gynecology • April 1, 2016 • CTSA
Improving Care for Neonatal Abstinence Syndrome • Pediatrics • April 1, 2016 • CTSA
Reinventing the Wheel of Medical Evidence: How the Boot Camp Translation Process Is Making Gains • Health Affairs • April 1, 2016 • CTSA
Putting Translational Science on to a Global Stage • Nature Reviews Drug Discovery • April 1, 2016 • NCATS
Enhancing Medical Decision-Making Evaluations: Introduction of Normative Data for the Capacity to Consent to Treatment Instrument • Assessment • April 1, 2016 • CTSA
Glutamine Drives Glutathione Synthesis and Contributes to Radiation Sensitivity of A549 and H460 Lung Cancer Cell Lines • Biochimica et Biophysica Acta • April 1, 2016 • CTSA
Fibrin Matrices Enhance the Transplant and Efficacy of Cytotoxic Stem Cell Therapy for Post-Surgical Cancer • Biomaterials • April 1, 2016 • CTSA
Early Injury to Cortical and Cancellous Bone from Induction Chemotherapy for Aadolescents and Young Adults Treated for Acute Lymphoblastic Leukemia • Bone • April 1, 2016 • CTSA
Severe Spinal and Chest Deformity Secondary to Neurofibromatosis • Canadian Journal of Anaesthesia • April 1, 2016 • CTSA
Eosinophil Resistance to Glucocorticoid-induced Apoptosis Is Mediated by the Transcription Factor NFIL3 • Apoptosis • April 1, 2016 • CTSA
Body Composition and Lung Function in Cystic Fibrosis and Their Association with Adiposity and Normal-Weight Obesity • Nutrition • April 1, 2016 • CTSA
Hospital Utilization of Nationally Shared Liver Allografts from 2007 to 2012 • World Journal of Surgery • April 1, 2016 • CTSA
Transdifferentiation of Human Endothelial Progenitors into Smooth Muscle Cells • Biomaterials • April 1, 2016 • Exploratory/Development Cooperative Agreement
Patient Knowledge and Information-Seeking about Personalized Cancer Therapy • International Journal of Medical Informatics • April 1, 2016 • CTSA
Deficiencies in the Management of Iron Deficiency Anemia during Childhood • Biomaterials • April 1, 2016 • CTSA
Adolescent and Young Adult Patient Engagement and Participation in Survey-Based Research: A Report from the "Resilience in Adolescents and Young Adults With Cancer" Study • Pediatric Blood & Cancer • April 1, 2016 • CTSA
March 2016
Mutations in TBCK, Encoding TBC1-Domain-Containing Kinase, Lead to a Recognizable Syndrome of Intellectual Disability and Hypotonia • American Journal of Human Genetics • March 31, 2016 • CTSA
Age and Alzheimer’s Disease Gene Expression Profiles Reversed by the Glutamate Modulator Riluzole • Molecular Psychiatry • March 29, 2016 • CTSA
Aging with Developmental Disabilities, Part 1: Fragile X–Associated Disorders • Psychiatric Times • March 24, 2016 • CTSA
Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous PolyposisA Randomized Clinical Trial • JAMA • March 22, 2016 • CTSA
Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration • Stem Cells • March 21, 2016 • CTSA
Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery • Advanced Materials • March 17, 2016 • CTSA
A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder • Biological Psychiatry • March 15, 2016 • CTSA
Biomarkers and Surrogate Endpoints: Developing Common Terminology and Definitions • JAMA • March 15, 2016 • NIH
A Phase 1 Randomized Placebo-Controlled Safety and Pharmacokinetic Trial of a Tenofovir Disoproxil Fumarate Vaginal Ring • AIDS • March 13, 2016 • CTSA
Structure Property Relationships of Carboxylic Acid Isosteres • Journal of Medicinal Chemistry • March 11, 2016 • NCGC
Rare Variant in Scavenger Receptor BI Raises HDL Cholesterol and Increases Risk of Coronary Heart Disease • Science • March 11, 2016 • CTSA
Developmental Dynamics of the Preterm Infant Gut Microbiota and Antibiotic Resistome • Nature Microbiology • March 7, 2016 • CTSA
Cost-Effectiveness of Tyrosine Kinase Inhibitor Treatment Strategies for Chronic Myeloid Leukemia in Chronic Phase after Generic Entry of Imatinib in the United States • Journal of the National Cancer Institute • March 4, 2016 • CTSA
Alcohol and Immediate Risk of Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis • Circulation • March 3, 2016 • CTSA
Availability of Outpatient Rehabilitation Services for Children After Traumatic Brain Injury: Differences by Language and Insurance Status • American Journal of Physical Medicine and Rehabilitation• March 1, 2016 • CTSA
Recommendations to Facilitate Expanded Access to Investigational Therapies for Seriously Ill Patients • Academic Medicine • March 1, 2016 • CTSA
Polygenic Risk for Alcohol Dependence Associates with Alcohol Consumption, Cognitive Function and Social Deprivation in a Population-Based Cohort • Addiction Biology • March 1, 2016 • CTSA
Acute Kidney Injury Incidence in Noncritically Ill Hospitalized Children, Adolescents, and Young Adults: A Retrospective Observational Study • American Journal of Kidney Diseases • March 1, 2016 • CTSA
Two-Year Trajectory of Fall Risk in People with Parkinson Disease: A Latent Class Analysis • Archives of Physical Medicine and Rehabilitation • March 1, 2016 • CTSA
Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery • Advanced Materials • March 1, 2016 • CTSA
Association of Red Blood Cell Transfusion, Anemia, and Necrotizing Enterocolitis in Very Low-Birth-Weight Infants • Journal of the American Medical Association • March 1, 2016 • CTSA
Adjusting Cyclophosphamide Dose in Obese Patients with Lymphoma Is Safe and Yields Favorable Outcomes after Autologous Hematopoietic Cell Transplantation • Biology of Blood & Marrow Transplantation • March 1, 2016 • CTSA
Resveratrol Preserves the Function of Human Platelets Stored for Transfusion • British Journal of Haematology • March 1, 2016 • CTSA
Neurological Gait Abnormalities Moderate the Functional Brain Signature of the Posture First Hypothesis • Brain Topography • March 1, 2016 • CTSA
Video Imaging of Arytenoid Prolapse • Canadian Journal of Anaesthesia • March 1, 2016 • CTSA
Chronic Medical Conditions in Adult Survivors of Retinoblastoma: Results of the Retinoblastoma Survivor Study • Cancer • March 1, 2016 • CTSA
Women's Experiences with Doula Support during First-Trimester Surgical Abortion: A Qualitative Study • Contraception • March 1, 2016 • CTSA
The Preschool Confusion Assessment Method for the ICU: Valid and Reliable Delirium Monitoring for Critically Ill Infants and Children • Critical Care Medicine • March 1, 2016 • CTSA
Using Facebook™ to Recruit College-Age Men for a Human Papillomavirus Vaccine Trial • American Journal of Men’s Health • March 1, 2016 • CTSA
Whole Body Creatine and Protein Kinetics in Healthy Men and Women: Effects of Creatine and Amino Acid Supplementation • Amino Acids • March 1, 2016 • CTSA
Perioperative Dextromethorphan as an Adjunct for Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials • Anesthesiology • March 1, 2016 • CTSA
The Role of Rheumatoid Arthritis (RA) Flare and Cumulative Burden of RA Severity in the Risk of Cardiovascular Disease • Annals of the Rheumatic Diseases • March 1, 2016 • CTSA
Oncologists' Perspectives of Their Roles and Responsibilities during Multi-Disciplinary Breast Cancer Follow-Up • Annals of Surgical Oncology • March 1, 2016 • CTSA
Sex Hormones, Sex Hormone Binding Globulin, and Vertebral Fractures in Older Men • Bone • March 1, 2016 • CTSA
Imaging Features of Radiofrequency Ablation with Heat-Deployed Liposomal Doxorubicin in Hepatic Tumors • Cardiovascular and Interventional Radiology • March 1, 2016 • CTSA
Transcriptome Analysis of the Human Striatum in Tourette Syndrome • Biological Psychiatry • March 1, 2016 • CTSA
Clinical Significance of Pain at Hospital Discharge Following Traumatic Orthopedic Injury: General Health, Depression, and PTSD Outcomes at 1 Year • Clinical Journal of Pain • March 1, 2016 • CTSA
What Is the Outcome of Allograft and Intramedullary Free Fibula (Capanna Technique) in Pediatric and Adolescent Patients with Bone Tumors? • Clinical Orthopaedics and Related Research • March 1, 2016 • CTSA
Leg Muscle Mass and Foot Symptoms, Structure, and Function: The Johnston County Osteoarthritis Project • Journals of Gerontology • March 1, 2016 • CTSA
Problem-Gambling Severity and Psychiatric Disorders among American-Indian/Alaska Native Adults • Journal of Psychiatric Research • March 1, 2016 • CTSA
PET Imaging Evaluation of [(18)F]DBT-10, a Novel Radioligand Specific to α7 Nicotinic Acetylcholine Receptors, in Nonhuman Primates • European Journal of Nuclear Medicine and Molecular Imaging • March 1, 2016 • CTSA
The Effect of Prenatal Alcohol Co-Exposure on Neonatal Abstinence Syndrome in Infants Born to Mothers in Opioid Maintenance Treatment • Journal of Maternal-Fetal & Neonatal Medicine • March 1, 2016 • CTSA
Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-1 Are Related to Cardiovascular Disease Biomarkers in Obese Adolescents • Pediatric Diabetes • March 1, 2016 • CTSA
Azacitidine and Sorafenib Therapy in a Pediatric Patient with Refractory Acute Myeloid Leukemia with Monosomy 7 and Somatic PTPN11 Mutation • Pediatric Blood & Cancer • March 1, 2016 • CTSA
Effect of Sensorineural Hearing Loss on Neurocognitive Functioning in Pediatric Brain Tumor Survivors • Pediatric Blood & Cancer • March 1, 2016 • CTSA
Optogenetic Activation of Superior Colliculus Neurons Suppresses Seizures Originating in Diverse Brain Networks • Neurobiology of Disease • March 1, 2016 • CTSA
Forecasting the Revenues of Local Public Health Departments in the Shadows of the "Great Recession" • Journal of Public Health Management and Practice • March 1, 2016 • CTSA
Bridging Research, Practice, and Policy: The "Evidence Academy" Conference Model • Journal of Public Health Management and Practice • March 1, 2016 • CTSA
Assessing Capacity for Sustainability of Effective Programs and Policies in Local Health Departments • Journal of Public Health Management and Practice • March 1, 2016 • CTSA
Lipid Peroxidation Biomarkers in Adolescents with or at High-Risk for Bipolar Disorder • Journal of Affective Disorders • March 1, 2016 • CTSA
Investigating the Mechanical Function of the Cervix during Pregnancy Using Finite Element Models Derived from High-Resolution 3D MRI • Computer Methods in Biomechanics and Biomedical Engineering • March 1, 2016 • CTSA
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