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Tissue Chips for Modeling the Immune System

Understanding the human immune system is key to diagnosing and managing a number of physiological conditions — from wound healing and natural responses to such pathogens as flu viruses to cancer and autoimmune diseases. Furthermore, the immune system’s wound healing and repair processes can be impaired by such diseases as diabetes, which affects more than 30 million people in the United States. Gaining a better understanding of the immune system and its interactions with other physiological systems is a critical research need.

To help address this need, in 2019, the National Institute of Biomedical Imaging and Bioengineering and NCATS funded four research projects focused on developing tissue chips that model components of the human immune system.

The awards are part of the broader Tissue Chip program and were made in response to PAR-19-138.   

Montana State University  

Integration of Mononuclear Phagocytes Into the Human Gastrointestinal GOFlowChip for Investigation of Luminal Antigen Sampling

Principal Investigators: Seth T. Walk, Ph.D., Diane Bimczok, D.V.M., Ph.D., and James Nolen Wilking, Ph.D.       
Grant Number: 1-U01-EB-029242-01

University of Colorado Denver  

A Microphysiological Mimicry of Human Lung–Bone Marrow Organ-Organ Cross-Talk On-a-Chip

Principal Investigator: Kambez Hajipouran Benam, D.Phil.       
Grant Number: 1-U01-EB-029085-01

Massachusetts Institute of Technology  

Microvascular Permeability, Inflammation and Lesion Physiology in Endometriosis: A Microphysiological Systems Approach

Principal Investigator: Linda G. Griffith, Ph.D.       
Grant Number: 1-U01-EB-029132-01

University of Virginia  

A Spatially Organized Microphysiological Model of a Human Lymph Node    

Principal Investigator: Rebecca R. Pompano, Ph.D.       
Grant Number: 1-U01-EB-029127-01