Children’s Hospital of Philadelphia

Lung Host Defense in Microgravity

Principal Investigators: George Scott Worthen, M.D., and Dongeun Huh, M.D. 
Implementation Partners: Space Technology and Advanced Research Systems, Inc., SpacePharma, Inc., and University of Pennsylvania 
Grant Number: 1-UG3-TR-002198-01

First Flight: May 4, 2019

Emulate, Inc., Boston

Organs-on-Chips as a Platform for Studying Effects of Microgravity on Human Physiology: Blood-Brain-Barrier-Chip in Health and Disease

Principal Investigators: Christopher D. Hinojosa, Emulate, Inc., and Katia P. Karalis, D.S., M.D., Children’s Hospital Boston 
Implementation Partner: Space Tango, Inc. 
Grant Number: 1-UG3-TR-002188-01

First Flight: May 4, 2019    
Second Flight: December 21, 2021

Massachusetts Institute of Technology, Cambridge

Cartilage-Bone-Synovium Microphysiological System: Musculoskeletal Disease Biology in Space

Principal Investigators: Alan J. Grodzinsky, Sc.D., M.S., and Murat Cirit, Ph.D. 
Implementation Partner: Techshot, Inc. 
Grant Number: 1-UG3-TR-002186-01

First Flight: May 4, 2019    
Second Flight: Dec. 6, 2020

University of California, San Francisco

Microgravity as Model for Immunological Senescence and its Impact on Tissue Stem Cells and Regeneration

Principal Investigators: Sonja Schrepfer, M.D., Ph.D., Tobias Deuse, M.D., and Heath J. Mills, Ph.D. 
Implementation Partner: Space Technology and Advanced Research Systems, Inc. 
Grant Number: 1-UG3-TR-002192-01

First Flight: Dec. 5, 2018    
Second Flight: July 14, 2022

University of Washington, Seattle

Effects of Microgravity on the Structure and Function of Proximal and Distal Tubule Microphysiological System

Principal Investigators: Jonathan Himmelfarb, M.D., and Edward J. Kelly, M.S., Ph.D. 
Implementation Partner: BioServe Space Technologies 
Grant Number: 1-UG3-TR-002178-01

First Flight: May 4, 2019    
Second Flight: June 3, 2021