Skip to main content
HHS Logo U.S. Department of Health & Human Services NIH logo National Institutes of Health

Clinical Innovation

A model of heart muscle cells that carry a genetic mutation on an artificial surface.
New Clinical Trials on a Chip Program Could Improve Drug Development Process

To improve the success rate of late-stage clinical trials of investigational drugs, the new NCATS-led Clinical Trials on a Chip program has awarded 10 inaugural grants to develop tissue chips to inform clinical trial design.

Watch the New I Am Translational Science Video with Christopher P. Austin

In the latest installment of #IAmTranslationalScience, former NCATS Director Christopher P. Austin, M.D., explains the importance of translational science in addressing urgent public health needs.

Clinical & Translational Science Awards (CTSA) Program

The CTSA Program is designed to strengthen and support the entire spectrum of translational research from scientific discovery to improved patient care.

Rare Diseases Clinical Research Network (RDCRN)

The RDCRN is designed to advance medical research on rare diseases by facilitating collaboration, study enrollment and data sharing.

Patient Registries

Patient and contact registries are key tools that help researchers identify potential clinical study participants, including healthy volunteers.

Clinical Research Toolbox

NCATS supports clinical research tools that facilitate trial design, patient recruitment and partnerships for commercialization.

Clinical & Translational Science Awards (CTSA) Program

The CTSA Program is designed to strengthen and support the entire spectrum of translational research from scientific discovery to improved patient care.

Rare Diseases Clinical Research Network (RDCRN)

The RDCRN is designed to advance medical research on rare diseases by facilitating collaboration, study enrollment and data sharing.

Patient Registries

Patient and contact registries are key tools that help researchers identify potential clinical study participants, including healthy volunteers.

Clinical Research Toolbox

NCATS supports clinical research tools that facilitate trial design, patient recruitment and partnerships for commercialization.

Work with Us

NCATS aims to address common barriers in clinical and translational research that scientists nationwide face every day, with the goal of delivering more treatments to more patients more quickly.

Contact the Division of Clinical Innovation

Learn more about NCATS’ Achievements in Advancing Translational Sciences.

Clinical Trials

NCATS programs support a broad range of clinical research, including clinical trials. NCATS authorization (PDF - 133KB) limits specific support for clinical trials only through the end of Phase II for all diseases and conditions, and through the end of phase III for a rare disease or condition.

Addressing Clinical Research Challenges

Researchers nationwide face common barriers in clinical and translational research that can delay the development of new interventions for patients in need. These challenges include:

  • Difficulties in recruiting, mentoring and retaining a critical mass of qualified clinical and translational investigators
  • Increased research costs and complexity
  • Low patient recruitment and retention in clinical research studies
  • Inflexible study designs
  • Increased regulatory burdens

NCATS supports innovative programs, such as the Clinical and Translational Science Awards (CTSA) Program and Rare Diseases Clinical Research Network (RDCRN), to help address these challenges.