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Clinical Innovation

I am Translational Science hashtag and NIH logo.
Watch the latest I Am Translational Science Video About ACTIV-6

In the latest video installment, Sarah E. Dunsmore, Ph.D., project manager for ACTIV-6, explains how the clinical study aims to identify new treatments for people with mild to moderate COVID-19 symptoms.

Illustration of a cytokine storm response to infection with the new coronavirus SARS-CoV-2.
NCATS-Supported Clinical Trial Shows Survival Improvement for People Hospitalized with COVID-19

NCATS coordinated and oversaw the ACTIV-1 Immune Modulators clinical trial, which found that two immune modulator drugs substantially improved clinical status and reduced deaths for adults hospitalized with COVID-19.

Clinical & Translational Science Awards (CTSA) Program

The CTSA Program is designed to strengthen and support the entire spectrum of translational research from scientific discovery to improved patient care.

Rare Diseases Clinical Research Network (RDCRN)

The RDCRN program is designed to advance medical research on rare diseases by facilitating collaboration, study enrollment and data sharing.

Patient Registries

Patient and contact registries are key tools that help researchers identify potential clinical study participants, including healthy volunteers.

Clinical Research Toolbox

NCATS supports clinical research tools that facilitate trial design, patient recruitment and partnerships for commercialization.

Clinical & Translational Science Awards (CTSA) Program

The CTSA Program is designed to strengthen and support the entire spectrum of translational research from scientific discovery to improved patient care.

Rare Diseases Clinical Research Network (RDCRN)

The RDCRN program is designed to advance medical research on rare diseases by facilitating collaboration, study enrollment and data sharing.

Patient Registries

Patient and contact registries are key tools that help researchers identify potential clinical study participants, including healthy volunteers.

Clinical Research Toolbox

NCATS supports clinical research tools that facilitate trial design, patient recruitment and partnerships for commercialization.

Work with Us

NCATS aims to address common barriers in clinical and translational research that scientists nationwide face every day, with the goal of delivering more treatments to more patients more quickly.

Contact the Division of Clinical Innovation

Learn more about NCATS’ Achievements in Advancing Translational Sciences.

Clinical Trials

NCATS programs support a broad range of clinical research, including clinical trials. NCATS authorization (PDF - 133KB) limits specific support for clinical trials only through the end of Phase II for all diseases and conditions, and through the end of phase III for a rare disease or condition.

Addressing Clinical Research Challenges

Researchers nationwide face common barriers in clinical and translational research that can delay the development of new interventions for patients in need. These challenges include:

  • Difficulties in recruiting, mentoring and retaining a critical mass of qualified clinical and translational investigators
  • Increased research costs and complexity
  • Low patient recruitment and retention in clinical research studies
  • Inflexible study designs
  • Increased regulatory burdens

NCATS supports innovative programs, such as the Clinical and Translational Science Awards (CTSA) Program and Rare Diseases Clinical Research Network (RDCRN), to help address these challenges.