NCATS develops novel approaches to improve the process of joining basic science discoveries with initial testing of therapies in humans.
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Research
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Preclinical Innovation
Organoids Provide Clues to SARS-CoV-2 Brain Infection
A team of researchers used organoids — tiny 3-D tissue models of human brain development — to better understand brain infections caused by SARS-CoV-2.
Researchers Identify Drugs That Protect Endoplasmic Reticulum Function
NIH researchers identified five U.S. Food and Drug Administration–approved drugs that help maintain healthy calcium levels in the endoplasmic reticulum and prevent proteins from fleeing, which could point to therapies for many diseases.
NCATS’ Matrix Screening Platform Helps Researchers Discover Drug Combination to Treat SCLC
Researchers from NCATS and the National Cancer Institute teamed up to identify and test different drug combinations against small cell lung cancer (SCLC).
Improving the Drug Development ProcessCreating and testing innovative methods to improve and accelerate the drug development process and find new treatments for patients faster.
Repurposing DrugsDiscovering new uses for approved drugs to provide the quickest possible transition from bench to bedside.
Testing & Predictive ModelsDeveloping better model systems for drug and toxicity testing.
Core TechnologiesUsing state-of-the-art resources to enable the ongoing operation of all NCATS translational research activities.
Improving the Drug Development Process
Creating and testing innovative methods to improve and accelerate the drug development process and find new treatments for patients faster.
Discovering new uses for approved drugs to provide the quickest possible transition from bench to bedside.
Developing better model systems for drug and toxicity testing.
Using state-of-the-art resources to enable the ongoing operation of all NCATS translational research activities.
Work with Us
NCATS preclinical programs and resources focus on key obstacles and inefficiencies in the translational process, overcoming bottlenecks that slow the development of new treatments for patients.
Learn more about how to access NCATS programs and expertise.
Inside the NCATS Laboratories
Take a video tour of our labs and see firsthand how our researchers work to get more treatments to more patients more quickly.
Learn more about NCATS’ Achievements in Advancing Translational Sciences.
NCATS Programs & Resources Supporting Preclinical Innovation
- 3-D Tissue Bioprinting Program
- Biomedical Data Translator
- Bridging Interventional Development Gaps (BrIDGs)
- Chemistry Technology
- Discovering New Therapeutic Uses for Existing Molecules (New Therapeutic Uses)
- Extracellular RNA Communication
- Matrix Combination Screening
- NCATS Chemical Genomics Center (NCGC)
- NCATS Pharmaceutical Collection
- Pfizer's Centers for Therapeutic Innovation (CTI) for NIH Researchers
- RNA Interference (RNAi)
- Stem Cell Translation Laboratory (SCTL)
- Therapeutics for Rare and Neglected Diseases (TRND)
- Tissue Chip for Drug Screening
- Toxicology in the 21st Century (Tox21)
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