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Preclinical Innovation

Illustration of a virus delivering genetic material into a cell.
PaVe-GT: Paving the Way for Rare Disease Gene Therapies

The NCATS-led Platform Vector Gene Therapy (PaVe-GT) pilot project seeks to increase the efficiency of clinical trial startup by using the same gene delivery system and manufacturing methods for multiple rare disease gene therapies.

The effects of compounds on melanoma cells
Collaborating to Overcome Roadblocks to Advance Melanoma Therapy

NCATS scientists used high-throughput screening to help colleagues at NCI identify existing compounds and drugs that could lead to improvements in a therapy for a form of metastatic melanoma, a potentially deadly skin cancer.

Improving the Drug Development Process

Creating and testing innovative methods to improve and accelerate the drug development process and find new treatments for patients faster.

Repurposing Drugs

Discovering new uses for approved drugs to provide the quickest possible transition from bench to bedside.

Testing & Predictive Models

Developing better model systems for drug and toxicity testing.

Core Technologies

Using state-of-the-art resources to enable the ongoing operation of all NCATS translational research activities.

Improving the Drug Development Process

Creating and testing innovative methods to improve and accelerate the drug development process and find new treatments for patients faster.

Repurposing Drugs

Discovering new uses for approved drugs to provide the quickest possible transition from bench to bedside.

Testing & Predictive Models

Developing better model systems for drug and toxicity testing.

Core Technologies

Using state-of-the-art resources to enable the ongoing operation of all NCATS translational research activities.