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Preclinical Innovation

Endoplasmic reticulum proteins in human cells lit up in green, red and yellow using fluorescent technology.
Researchers Identify Drugs That Protect Endoplasmic Reticulum Function

NIH researchers identified five U.S. Food and Drug Administration–approved drugs that help maintain healthy calcium levels in the endoplasmic reticulum and prevent proteins from fleeing, which could point to therapies for many diseases.

Lung cancer cells
NCATS’ Matrix Screening Platform Helps Researchers Discover Drug Combination to Treat SCLC

Researchers from NCATS and the National Cancer Institute teamed up to identify and test different drug combinations against small cell lung cancer (SCLC).

Improving the Drug Development Process

Creating and testing innovative methods to improve and accelerate the drug development process and find new treatments for patients faster.

Repurposing Drugs

Discovering new uses for approved drugs to provide the quickest possible transition from bench to bedside.

Testing & Predictive Models

Developing better model systems for drug and toxicity testing.

Core Technologies

Using state-of-the-art resources to enable the ongoing operation of all NCATS translational research activities.

Improving the Drug Development Process

Creating and testing innovative methods to improve and accelerate the drug development process and find new treatments for patients faster.

Repurposing Drugs

Discovering new uses for approved drugs to provide the quickest possible transition from bench to bedside.

Testing & Predictive Models

Developing better model systems for drug and toxicity testing.

Core Technologies

Using state-of-the-art resources to enable the ongoing operation of all NCATS translational research activities.