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Improving the Drug Development Process

Nerves involved in detecting an itch and sensing pain
An Itch to Scratch: Scientists Identify Potential New Approach to Chronic Problem

People with chronically itchy skin, take heart. NCATS researchers report that blocking a receptor on the surface of spinal cord neurons may help relieve the constant need to scratch. The study appeared online in Science Translational Medicine.

New assay plate for measuring protein samples through tiny dots of liquid.
New Method Could Help Find Potential Treatments for Rare Diseases

Scientists in NCATS’ Assay Development and Screening Technology program are developing new methods for screening small molecules that could help researchers test possible drugs and develop new treatments for many diseases.

Target Identification & Validation

Developing new approaches and technologies to identify and validate potential drug targets in a more efficient and predictable way.

Assay Development & Screening

Enhancing testing systems to assess the effects of chemical compounds on cellular, molecular or biochemical processes of interest.

Probe Development & Lead Optimization

Creating probes to investigate biological processes and optimizing them to become potential drug candidates.

Core Technologies

Using state-of-the-art resources to enable the ongoing operation of all NCATS translational research activities.

Target Identification & Validation

Developing new approaches and technologies to identify and validate potential drug targets in a more efficient and predictable way.

Assay Development & Screening

Enhancing testing systems to assess the effects of chemical compounds on cellular, molecular or biochemical processes of interest.

Probe Development & Lead Optimization

Creating probes to investigate biological processes and optimizing them to become potential drug candidates.

Core Technologies

Using state-of-the-art resources to enable the ongoing operation of all NCATS translational research activities.

Work with Us

NCATS pre-clinical programs and resources focus on key obstacles and inefficiencies in the translational process, overcoming bottlenecks that slow the development of new treatments for patients.

Learn more about how to access NCATS programs and expertise.

Learn more about NCATS’ Achievements in Advancing Translational Sciences.

Translational Science Spectrum

Learn more about the science of translation.