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Improving the Drug Development Process

Nerves involved in detecting an itch and sensing pain
An Itch to Scratch: Scientists Identify Potential New Approach to Chronic Problem

People with chronically itchy skin, take heart. NCATS researchers report that blocking a receptor on the surface of spinal cord neurons may help relieve the constant need to scratch. The study appeared online in Science Translational Medicine.

Quantitative high-throughput screening data.
Rapid Test Unveils Promising Therapies for Myositis

A team of NCATS researchers developed an approach to rapidly test thousands of existing drugs to identify promising therapies for myositis, a rare muscle disease.

Target Identification & Validation

Developing new approaches and technologies to identify and validate potential drug targets in a more efficient and predictable way.

Assay Development & Screening

Enhancing testing systems to assess the effects of chemical compounds on cellular, molecular or biochemical processes of interest.

Photo of a diverse group of young researchers at a lab bench using pipettes.
Probe Development & Lead Optimization

Creating probes to investigate biological processes and optimizing them to become potential drug candidates.

A researcher works with induced pluripotent stem cells in a laboratory.
Core Technologies

Using state-of-the-art resources to enable the ongoing operation of all NCATS translational research activities.

Close-up photo of a gloved hand calibrating a robot.

Target Identification & Validation

Developing new approaches and technologies to identify and validate potential drug targets in a more efficient and predictable way.

Photo of a diverse group of young researchers at a lab bench using pipettes.

Assay Development & Screening

Enhancing testing systems to assess the effects of chemical compounds on cellular, molecular or biochemical processes of interest.

A researcher works with induced pluripotent stem cells in a laboratory.

Probe Development & Lead Optimization

Creating probes to investigate biological processes and optimizing them to become potential drug candidates.

Close-up photo of a gloved hand calibrating a robot.

Core Technologies

Using state-of-the-art resources to enable the ongoing operation of all NCATS translational research activities.

Work with Us

NCATS pre-clinical programs and resources focus on key obstacles and inefficiencies in the translational process, overcoming bottlenecks that slow the development of new treatments for patients.

Learn more about how to access NCATS programs and expertise.

Learn more about NCATS’ Achievements in Advancing Translational Sciences.

Translational Science Spectrum

Learn more about the science of translation.