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The cyclic peptide ipglycermide (iPGM) binds to an iPGM enzyme, blocking the enzyme’s activity

Scientists Advance Parasite and Bacteria Research

NCATS and University of Tokyo scientists have identified the first inhibitor of an enzyme thought to be a potential drug target for fighting disease-causing parasites and bacteria.


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NCATS pre-clinical programs and resources focus on key obstacles and inefficiencies in the translational process, overcoming bottlenecks that slow the development of new treatments for patients.

Learn more about how to access NCATS programs and expertise.

Improving the Drug Development Process

Creating and testing innovative methods to improve and accelerate the drug development process and find new treatments for patients faster. Learn more.

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Target Identification & Validation

Developing new approaches and technologies to identify and validate potential drug targets in a more efficient and predictable way.

    Assay Development & Screening

    Enhancing testing systems to assess the effects of chemical compounds on cellular, molecular or biochemical processes of interest.

    Probe Development & Lead Optimization

    Creating probes to investigate biological processes and optimizing them to become potential drug candidates.

      Core Technologies

      Using state-of-the-art resources to enable the ongoing operation of all NCATS translational research activities.

      Innovation in the Drug Development Process

      NCATS strives to create and test innovative methods and technologies that will enhance the development, testing and implementation of new drugs, diagnostics and other interventions. By improving the process by which these interventions are developed, NCATS aims to make translational science more efficient, less expensive and less risky. In this way, NCATS complements the work of the private sector and other NIH Institutes and Centers.