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Research Activities

Our programs, projects and other research activities tackle ongoing challenges in translational research so that new treatments and other health solutions can reach people faster.

Research Activities at NCATS

Through our research activities, we overcome roadblocks that slow progress on developing treatments for many different diseases and that can lead to inequities in clinical outcomes. Explore the range of initiatives we support at NCATS and beyond.

Learn About NCATS Research Topics

3-D Tissue Bioprinting Program

Our scientists are creating and using 3-D printing techniques to make tissue models that closely resemble the complex structure and organization of our cells.

A Specialized Platform for Innovative Research Exploration (ASPIRE)

Through this program, we are building an end-to-end solution for finding, designing and testing new molecules with the potential to become new treatments.

Analytical Chemistry

Our analytical chemistry experts and state-of-the-art lab support early-stage chemical development by analyzing and purifying small molecules and other compounds.

Antiviral Program for Pandemics (APP)

This multi-agency effort to develop safe and effective oral antiviral medications for future pandemics leverages our in-house drug discovery and development expertise and technologies.

Assay Development and Screening Technology (ADST)

Our scientists explore and develop new ways to quickly test and screen potential drug candidates, often in collaboration with disease foundations.

Automation

Our automation experts work closely with our lab scientists to support various research activities, including high-throughput screening, and assay development and optimization.

Bespoke Gene Therapy Consortium (BGTC)

We help lead this public-private partnership program that focuses on developing platforms and standards to speed the development and delivery of gene therapies for rare diseases.

Bridging Interventional Development Gaps (BrIDGs)

This in-house program helps researchers in advancing promising therapeutic agents through late-stage preclinical development to clinical testing.

Chemistry Technology

Our chemistry technology experts develop small molecules and screening methods that can be used by other scientists to drive innovations in therapeutic development.

Compound Management

Our compound management team uses sophisticated and automated techniques to supply chemicals for NCATS screening experiments to uncover new treatments for diseases.

Discovering New Therapeutic Uses for Existing Molecules (New Therapeutic Uses)

Awarded projects aim to streamline the process of discovering new treatments and cures for diseases by identifying new uses for existing assets that have already gone through significant development steps.

Functional Genomics Lab

Our functional genomics experts work with collaborators from across NIH institutes and centers to design and use functional genomics technology to advance drug discovery and knowledge about health and disease.

Informatics

This NCATS team works with scientists to make sense of data from large experiments to inform decisions that advance translational research.

Matrix Combination Screening

Our experts use matrix combination screening technology to quickly identify promising drug combinations with the most potential to help patients.

OpenDataPortal

Our OpenData Portal is an open and accessible platform for sharing COVID-19-related drug repurposing data and experiments involving approved drugs.

Last updated on November 8, 2023