Xinh-Xinh Nguyen, Ph.D.

Translational Science Interagency Fellow

Division of Preclinical Innovation
Early Translation Branch
3-D Tissue Bioprinting Laboratory
National Center for Advancing Translational Sciences
National Institutes of Health

Biography

Xinh-Xinh Nguyen completed her postdoctoral training as a Translational Science Interagency Fellow (TSIF) from 2021 to 2024 under the mentorship of Marc Ferrer, Ph.D. (National Center for Advancing Translational Science, National Institutes of Health, NCATS/NIH) and Kyung Sung, Ph.D. (United States Food and Drug Administration, FDA), she worked to develop 3-D immunocompetent organ models to study inflammatory skin conditions and to evaluate the effects of cell-based immunological therapies using mesenchyme stromal cells (MSCs) to treat inflammatory diseases.

Nguyen earned her Ph.D. from the Medical University of South Carolina.

Select Publications

Nguyen XX, Sanderson M, Helke K, Feghali-Bostwick C. Phenotypic characterization of transgenic mice expressing human IGFBP-5. Int J Mol Sci. 2020;22(1):335. Available from: https://www.mdpi.com/1422-0067/22/1/335
Nguyen XX, Nishimoto T, Takihara T, Mlakar L, Bradshaw A, Feghali-Bostwick C. Lysyl oxidase directly contributes to extracellular matrix production and fibrosis in systemic sclerosis. 2021;320(1):L29-L40. Am J Physiol Lung Cell Mol Physiol. Available from: https://journals.physiology.org/doi/abs/10.1152/ajplung.00173.2020?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
Herro R, Miki H, Seth GS, et al. TL1A promotes lung tissue fibrosis and airway remodeling. J Immunol. 2019;205(9):2414-2422. Available from: https://www.jimmunol.org/content/205/9/2414.long
van de Vlekkert D, Demmers J, Nguyen XX, et al. Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis. Sci Adv. 2019;5(7):eaav3270. Available from: https://advances.sciencemag.org/content/5/7/eaav3270
Nguyen XX, Muhammad L, Nietert PJ, Feghali-Bostwick C. IGFBP-5 promotes fibrosis via increasing its own expression and that of other pro-fibrotic mediators. Front. Endocrinol. 2018;9:601. Available from: https://www.frontiersin.org/articles/10.3389/fendo.2018.00601/full