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Ashok Silval, Ph.D.

Translational Science Interagency Fellow

National Center for Advancing Translational Sciences
National Institutes of Health

Biography

Ashok Silval, Ph.D.

Ashok Silval, Ph.D.

Ashok Silval received his Master of Science in Pharmaceutical Sciences from Southern Illinois University Edwardsville, followed by a Ph.D. in Pharmaceutical Sciences from Texas Tech University Health Sciences Center in October 2023, where he conducted research under the guidance of Dr. Maciej Markiewski. Silval's doctoral work focused on exploring how the most common single-nucleotide polymorphism (SNP) of the TP53 gene at codon 72 influences immune system regulation. Prior to joining the Translational Science Interagency Fellowship (TSIF), Silval worked as a Postdoctoral Research Associate at TTUHSC in Dr. Magdalena Karbowniczek’s lab, where he studied the role of extracellular vesicles derived from Lymphangioleiomyomatosis (LAM) cells in lung metastasis of LAM disease.

Currently, as a fellow in the TSIF program, Silval is collaborating with mentors Dr. Elizabeth Ottinger and Dr. Venkata Mangalampalli from NCATS, and Dr. Nirjal Bhattarai from FDA. His project aims to develop innovative strategies to enhance adeno-associated virus (AAV) vectors for gene therapy, with a particular focus on designing AAV capsid to reduce immunogenicity and prevent anti-drug antibody responses. Silval is excited to gain expertise in translational science and deepen my understanding of the regulatory processes involved in gene therapy products.

Select Publications

  1. Silwal, A., Reese, B., Patel, B., Li, Y., Kolev, M. V., La-Beck, N. M., ... & Markiewski, M. M. (2024). TP53 Codon 72 Polymorphism Impacts Macrophage Activation through Reactive Oxygen Species–Dependent Cell Signaling Alterations. The Journal of Immunology. https://doi.org/10.4049/jimmunol.2400212
  2. Kalvala, A. K., Silwal, A., Patel, B., Kasetti, A., Shetty, K., Cho, J. H., ... & Karbowniczek, M. (2024). Extracellular vesicles regulate metastable phenotypes of lymphangioleiomyomatosis cells via shuttling ATP synthesis to pseudopodia and activation of integrin adhesion complexes. bioRxiv, 2024-09. https://doi.org/10.1101/2024.09.09.611297
  3. Patel, B., Silwal, A., Eltokhy, M. A., Gaikwad, S., Curcic, M., Patel, J., & Prasad, S. (2024). Deciphering CD59: Unveiling Its Role in Immune Microenvironment and Prognostic Significance. Cancers, 16(21), 3699. https://doi.org/10.3390/cancers16213699
  4. Silwal, A., House, A., Sandoval, K., Vijeth, S., Umbaugh, D., Crider, A., ... & Witt, K. A. (2022). Novel Somatostatin Receptor-4 Agonist SM-I-26 Mitigates Lipopolysaccharide-Induced Inflammatory Gene Expression in Microglia. Neurochemical Research, 47(3), 768-780. https://doi.org/10.1007/s11064-021-03482-z
  5. Reese, B., Silwal, A., Daugherity, E., Daugherity, M., Arabi, M., Daly, P., ... & Markiewski, M. M. (2020). Complement as prognostic biomarker and potential therapeutic target in renal cell carcinoma. The Journal of Immunology, 205(11), 3218-3229. https://doi.org/10.4049/jimmunol.2000511
  6. Oladejo, M., Nguyen, H. M., Silwal, A., Reese, B., Paulishak, W., Markiewski, M. M., & Wood, L. M. (2022). Listeria-based immunotherapy directed against CD105 exerts anti-angiogenic and anti-tumor efficacy in renal cell carcinoma. Frontiers in Immunology, 13, 1038807. https://doi.org/10.3389/fimmu.2022.1038807
  7. Ghouse, S. M., Vadrevu, S. K., Manne, S., Reese, B., Patel, J., Patel, B., ... & Markiewski, M. M. (2020). Therapeutic targeting of vasculature in the premetastatic and metastatic niches reduces lung metastasis. The Journal of Immunology, 204(4), 990-1000. https://doi.org/10.4049/jimmunol.1901208

Last updated on December 3, 2024